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Dietary supplement

Andrographis Paniculata Extract Powder Ingredients & Drug Interactions

by Materia Organica

Andrographis Paniculata Extract Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Andrographis Paniculata Extract Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Andrographis Paniculata Extract Powder is a dietary supplement by Materia Organica with 1 active ingredient. Its ingredients are commonly taken for common cold and flu symptoms, upper respiratory infections, sore throat.Based on those ingredients, 413 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Andrographis paniculata Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Andrographis Paniculata Extract Powder by Materia Organica

Ask about any prescription or over-the-counter medication and we check it for interactions with Andrographis Paniculata Extract Powder by Materia Organica — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Andrographis Paniculata Extract Powder by Materia Organica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains one active ingredient: andrographis paniculata extract. That's it — no fillers or other inactive ingredients listed.

Andrographis is a plant used in traditional medicine, and the extract concentrates its active compounds, particularly andrographolide.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: immune support and respiratory health.
  • We looked for evidence on: Acute bronchitis, Influenza, Upper respiratory tract infection (URTI), Rhinosinusitis, Tonsillopharyngitis, Coronavirus disease 2019 (COVID-19) — and 3 related terms.
  • The strongest evidence on file: Andrographis is rated "Possibly Effective" for Tonsillopharyngitis (Natural Medicines).
  • Also on file: Andrographis is rated "Insufficient Reliable Evidence To Rate" for Acute bronchitis, Upper respiratory tract infection (URTI), Influenza, Rhinosinusitis, and more.

The research we have suggests andrographis is possibly effective for ulcerative colitis and tonsillopharyngitis (sore throat and swollen tonsils), as well as osteoarthritis. For familial Mediterranean fever, we don't have enough reliable evidence to rate it either way.

If you're considering this for one of those conditions, talk with your doctor about whether the evidence fits your situation.

The evidence, ingredient by ingredient Andrographis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use is generally well tolerated, but long-term safety and product quality aren't well established — so don't assume it's safe to take indefinitely without checking in. The most common side effects at normal doses are stomach discomfort, nausea, diarrhea, headache, fatigue, dizziness, taste changes, rash, and itching.

Rare but serious reactions include severe allergic reactions and anaphylaxis. Higher doses (5–10 mg/kg of the active andrographolide compound or above) and longer use (over 14 days) raise the risk of side effects.

Skin reactions are frequent enough to watch for: rashes, itching, hives, and in rare cases, severe reactions like Stevens-Johnson syndrome. During pregnancy, the safety data advises against use because of theoretical and animal-study concerns about reproduction.

There isn't enough safety information for breastfeeding, so avoid it while nursing. If you're pregnant or planning to be, or if you're breastfeeding, talk with your pharmacist or doctor before taking this.

Side effects, ingredient by ingredient Andrographis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Andrographis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 413 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this, double-check with your pharmacist if you're on blood pressure medications, blood thinners or antiplatelet drugs (like warfarin or aspirin), or immunosuppressants — those carry Moderate-severity risks. Also flag etoricoxib (Arcoxia), celecoxib (Celebrex), and glipizide (Glucotrol) if you take them, even though the risks are Minor.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Andrographis may help with sore throat, ulcerative colitis, or osteoarthritis if the evidence appeals to you, but it's not your move if you take blood pressure meds, blood thinners, or immunosuppressants without a conversation first. Stick to short-term use at normal doses and watch for rash, nausea, or diarrhea.

Check your medications with the tool on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Andrographis Paniculata Extract Powder, straight from the product label.

Brand Materia Organica
Barcode (UPC) AP10297-50g
Net contents 50 Gram(s); 1.76 Ounce(s)
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 286064
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Andrographis Paniculata Extract Powder by Materia Organica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
200
UPC/BARCODE
AP10297-50g
IngredientAmount% DV
Andrographis paniculata Extract, Powder500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

800-661-6851 903-763-8233

Formula

Andrographis Paniculata Extract Powder (Andrographolide 5% by HPLC)

Star-K (Kosher)

100% Andrographis Paniculata Extract Powder Andrographolide 5% by HPLC

Formulation

Product of India

This Andrographis Paniculata Powder is water-extracted (a petroleum-solvent-free process), preserving its natural nutrients and beneficial qualities.

This powder is water-soluble, rendering it much more bioavailable than ordinary leaf powders or even extract powders.

Water-extracted & water-soluble Vacuum dried to retain micronutrients (not spray dried) Better bioavailability & potency

No fillers, additives or other ingredients Non GMO, vegetarian/vegan

Non GMO, vegetarian/vegan

Only a small amount is needed

Processed in a state-of-the-art facility with FSSC 22000, WHO GMP Certifications. Tested in independent 3rd-party US labs.

Seals/Symbols

Star-K (Kosher)

Suggested/Recommended/Usage/Directions

Directions: Mix 1/4 teaspoon (500 mg) into tea, juice, or your favorite smoothie.

Precautions

For best results, consult your physician.

Keep out of reach of children.

Storage

Store in sealed container in a dry, cool area.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Andrographis Paniculata Extract Powder by Materia Organica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Andrographis Paniculata Extract Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Andrographis Paniculata Extract Powder by Materia Organica

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Servings per container200 Amounts shown are per serving.

Andrographis paniculata Extract, Powder

Interacts with
413 drugs
500 mg per serving Form: Andrographolide

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...

Andrographis paniculata Extract, Powder monograph & interactions
Interaction report

Andrographis Paniculata Extract Powder by Materia Organica Drug Interactions

Want to check YOUR meds against Andrographis Paniculata Extract Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
413Drugs
408 Moderate 5 Minor

Ingredients driving the most interactions

Andrographis paniculata Extract, Powder 413

Individual Drug Interactions

The ingredients in Andrographis Paniculata Extract Powder interact with 413 drugs. Click any drug to see the details.

1 of the 1 ingredient in Andrographis Paniculata Extract Powder interact with drugs. Each result below shows which ingredient is responsible. Andrographis paniculata Extract, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Andrographis Paniculata Extract Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Andrographis paniculata Extract, Powder6 drug types · 413 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal and laboratory studies suggest that andrographis has antiplatelet effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that andrographis has hypotensive effects.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Laboratory research suggests that andrographolide has immunostimulant activity.

Likelihood Possible Evidence D
Celecoxib (Celebrex)

Theoretically, andrographis extract might increase the maximum concentration and time to peak concentration of celecoxib. The clinical significance of these changes is unclear.
Animal research suggests that andrographis extract taken orally increases the maximum concentration and time to peak concentration of celecoxib but does not appear to impact the area under the curve.

Likelihood Possible Evidence D
Etoricoxib (Arcoxia)

Theoretically, andrographis might decrease the absorption of etoricoxib, although the clinical significance is unclear.
Animal research shows that andrographis extract, or the constituent andrographolide, taken orally with etoricoxib decreases the bioavailability of etoricoxib. However, this reduced bioavailability is not correlated with a reduction in the anti-inflammatory effects of etoricoxib in arthritic mice models. The clinical significance of this interaction is unclear.

Likelihood Possible Evidence D
Glipizide (Glucotrol)

Theoretically, andrographis extract might increase the maximum concentration and area under the curve of glipizide; however, opposite effects are seen with the constituent, andrographolide. The clinical significance of this interaction is unclear.
Animal research suggests that andrographis extract taken orally with glipizide in diabetes-induced rats increases the maximum concentration and area under the curve of glipizide. However, the opposite effect is seen with the constituent, andrographolide, in which the maximum concentration and area under the curve are decreased when taken with glipizide.

Likelihood Possible Evidence D
Andrographis paniculata Extract, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Andrographis Paniculata Extract Powder, from the product label.

Materia Organica

See all Materia Organica products
Name
Materia Organica
Street Address
706C E. Goode Street
City
Quitman
State
TX
ZipCode
75783
Phone Number
800-613-6311
Web Address
www.MateriaOrganica.com
Pharmacist Counseling Corner

Andrographis Paniculata Extract Powder by Materia Organica: Common Questions

Does Andrographis Paniculata Extract Powder by Materia Organica interact with any medications?
Yes. Based on its ingredients, Andrographis Paniculata Extract Powder has a known interaction with 413 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Andrographis Paniculata Extract Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on blood pressure medication?
Not without checking first. Andrographis may lower your blood pressure further, which could cause dizziness or fainting. Talk to your pharmacist or doctor before starting — they can watch your numbers closely if you both decide to go ahead.
What are the most common side effects?
Stomach discomfort, nausea, diarrhea, headache, fatigue, dizziness, taste changes, and rash or itching are the typical ones. Rashes are reported fairly often, so keep an eye on your skin. Serious allergic reactions are rare but possible.
How long can I safely take this?
Short-term use is generally well tolerated, but long-term safety isn't well established. Doses of 5–10 mg/kg of andrographolide (the active compound) or higher, or use beyond 14 days, raise the risk of side effects. Ask your pharmacist about the dose and duration that fits your situation.
Can I take this if I'm pregnant or breastfeeding?
No. Safety data advises against use during pregnancy because of concerns about reproduction. There also isn't enough safety information for breastfeeding. Talk with your doctor before conception or if you're planning to breastfeed.
Does this really work for sore throat?
The research suggests it's possibly effective for sore throat and swollen tonsils. That's a modest claim — the evidence shows promise, but it's not a sure thing. It's worth trying if you're interested, but don't count on it as a replacement for medical care if your symptoms are severe.
Is this product quality consistent?
That's the honest question we can't answer from our data. Quality and long-term safety of andrographis products aren't well established, so pick a reputable brand and talk to your pharmacist about their standards.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Andrographis Paniculata Extract Powder label
Go deeper

The Full Monographs Behind Andrographis Paniculata Extract Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Andrographis

Interacts with 413 drugs

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten how long they last. The evidence is limi...

Read the full Andrographis monograph →
Sources

Sources & How We Checked

Andrographis Paniculata Extract Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Andrographis 26 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Thamlikitkul V, Dechatiwongse T, Theerapong S, et al. Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med Assoc Thai 1991;74:437-42.
  3. Zhang CY, Tan BK. Mechanisms of cardiovascular activity of Andrographis paniculata in the anaesthetized rat. J Ethnopharmacol 1997;56:97-101. PubMed
  4. Zhao HY, Fang WY. Antithrombotic effects of Andrographis paniculata nees in preventing myocardial infarction. Chin Med J (Engl) 1991;104:770-5.
  5. Amroyan E, Gabrielian E, Panossian A, et al. Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine 1999;6:27-31. PubMed
  6. Zhang C, Kuroyangi M, Tan BK. Cardiovascular activity of 14-deoxy-11,12-didehydroandrographolide in the anaesthetised rat and isolated right atria. Pharmacol Res 1998;38:413-7. PubMed
  7. Puri A, Saxena R, Saxena RP, et al. Immunostimulant agents from Andrographis paniculata. J Nat Prod 1993;56:995-9. PubMed
  8. Melchoir J, Spasov AA, Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan Jang) in the treatment of uncomplicated upper-respirator
  9. Calabrese C, Berman SH, Babish JG, et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res 2000;14:333-8. PubMed
  10. Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9:589-97 PubMed
  11. Poolsup N, Suthisisang C, Prathanturarug S, et al. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther 2004;29:37-45. PubMed
  12. Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med 2004;70:293-8.
  13. Kligler, B., Ulbricht, C., Basch, E., Kirkwood, C. D., Abrams, T. R., Miranda, M., Singh Khalsa, K. P., Giles, M., Boon, H., and Woods, J. Andrographis paniculata for the treatment of upper respiratory infection: a systematic review by the natural standa
  14. Burgos, R. A., Hancke, J. L., Bertoglio, J. C., Aguirre, V., Arriagada, S., Calvo, M., and Caceres, D. D. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled tria
  15. Saxena, R. C., Singh, R., Kumar, P., Yadav, S. C., Negi, M. P., Saxena, V. S., Joshua, A. J., Vijayabalaji, V., Goudar, K. S., Venkateshwarlu, K., and Amit, A. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis pa
  16. Tang, T., Targan, S. R., Li, Z. S., Xu, C., Byers, V. S., and Sandborn, W. J. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine. Aliment.Pharmacol Ther 2011;33(2) PubMed
  17. Sandborn, W. J., Targan, S. R., Byers, V. S., Rutty, D. A., Mu, H., Zhang, X., and Tang, T. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013;108(1):90-98. PubMed
  18. Melchior, J., Palm, S., and Wikman, G. Controlled clinical study of standardized Andrographis paniculata extract in common cold - a pilot trial. Phytomedicine. 1997;3(4):315-318. PubMed
  19. Balap A, Atre B, Lohidasan S, et al. Pharmacokinetic and pharmacodynamic herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide with etoricoxib after oral administration in rats. J Ethnopharmacol. 2016 May 13;183:9-17. PubMed
  20. Bertoglio JC, Baumgartner M, Palma R, et al. Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study. BMC Neurol. 2016; 16(1):77. PubMed
  21. Suwankesawong W, Saokaew S, Permsuwan U, et al. Characterization of hypersensitivity reactions reported among Andrographis paniculata users in Thailand using Health Product Vigilance Center (HPVC) database. BMC Complement Altern Med. 2014; 14:515. PubMed
  22. Ciampi E, Uribe-San-Martin R, Cárcamo C, et al. Efficacy of andrographolide in not active progressive multiple sclerosis: a prospective exploratory double-blind, parallel-group, randomized, placebo-controlled trial. BMC Neurol 2020;20(1):173. PubMed
  23. Worakunphanich W, Thavorncharoensap M, Youngkong S, Thadanipon K, Thakkinstian A. Safety of Andrographis paniculata: A systematic review and meta-analysis. Pharmacoepidemiol Drug Saf 2021;30(6):727-739.
  24. More SJ, Tandulwadkar SS, Balap AR, Lohidasan S, Sinnathambi A, Mahadik KR. Effect of Andrographis paniculata extract and Andrographolide on the pharmacokinetics of Aceclofenac and Celecoxib in rats. Futur J Pharm Sci. 2023;9(1):1. PubMed
  25. Sundhani E, Nugroho AE, Nurrochmad A, Puspitasari I, Amalia Prihati D, Lukitaningsih E. Pharmacokinetic Herb-Drug Interactions of Glipizide with Andrographis paniculata (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC Method. M PubMed
  26. Shang YX, Shen C, Stub T, et al. Adverse Effects of Andrographolide Derivative Medications Compared to the Safe use of Herbal Preparations of Andrographis paniculata: Results of a Systematic Review and Meta-Analysis of Clinical Studies. Front Pharmacol 20 PubMed

See these in context on the Andrographis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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