Avatrombopag

Generic name: Pronounced as (a" va trom' boe pag)
Brand names
  • Doptelet®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 11/15/2021

Avatrombopag is used to treat thrombocytopenia (a low number of platelets [type of blood cell needed for blood clotting]) in people with chronic (ongoing) liver disease who are scheduled to have a medical or dental procedure to help prevent bleeding complications. It is also used to treat thrombocytopenia in people with chronic immune thrombocytopenia (ITP; an ongoing condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood) who were not helped with another treatment. Avatrombopag is in a class of medications called thrombopoietin (TPO) receptor agonists. It works by causing the body to produce more platelets.

Avatrombopag comes as a tablet to take by mouth. For the treatment of thrombocytopenia in people with chronic liver disease who are scheduled to have a procedure, it is usually taken with food once a day for 5 days, starting 10 to 13 days before the procedure. For the treatment of thrombocytopenia in people with ITP, it is usually taken once daily with food for as long as directed. Take avatrombopag at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take avatrombopag exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

For the treatment of thrombocytopenia in people with ITP, your doctor will probably start you on a low dose of avatrombopag and may adjust your dose, depending on your response to the medication.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking avatrombopag,

  • tell your doctor and pharmacist if you are allergic to avatrombopag, any other medications, or any of the ingredients in avatrombopag tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: fluconazole or rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Many other medications may also interact with avatrombopag, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had a blood clot, or a genetic condition that could lead to blood clots.

  • tell your doctor if you are pregnant, or plan to become pregnant. If you become pregnant while taking avatrombopag, call your doctor.

  • tell your doctor if you are breastfeeding. Your doctor will probably tell you not to breastfeed during your treatment and for 2 weeks after your final dose.

Unless your doctor tells you otherwise, continue your normal diet.

If you are taking avatrombopag to treat thrombocytopenia just before a procedure, take the missed dose as soon as you remember it. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule, but be sure to finish taking all of the medication (even if they are not taken 5 days in a row). Do not take a double dose to make up for a missed one.

If you are taking avatrombopag to treat chronic immune thrombocytopenia, take the missed dose as soon as you remember it. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Avatrombopag may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • extreme tiredness

    • headache

    • nosebleeds or gum bleeding

    • joint pain

  • Some side effects can be serious. If you experience any of these symptoms call your doctor immediately:

    • swollen, painful, red, or tender leg

    • shortness of breath, fever, cough, chest pain, or fast heartbeat

    • stomach pain or tenderness

    • swelling of hands or feet

  • Avatrombopag may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • swollen, painful, red or tender leg

  • shortness of breath, cough, chest pain, fast heartbeat

  • stomach pain or tenderness

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before you start treatment to decide your dose of avatrombopag and on the day of the procedure.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Repaglinide can be increased when combined with Avatrombopag.
Montelukast Montelukast The metabolism of Montelukast can be increased when combined with Avatrombopag.
Leflunomide Leflunomide Avatrombopag may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Nevirapine Nevirapine The metabolism of Nevirapine can be increased when combined with Avatrombopag.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be increased when combined with Avatrombopag.
Candesartan Candesartan The metabolism of Candesartan can be increased when combined with Avatrombopag.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be increased when combined with Avatrombopag.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Avatrombopag can be increased when it is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Avatrombopag may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Paregoric Paregoric The serum concentration of Avatrombopag can be increased when it is combined with Morphine.
Ranitidine Ranitidine The excretion of Ranitidine can be decreased when combined with Avatrombopag.
Reserpine Reserpine The serum concentration of Avatrombopag can be increased when it is combined with Reserpine.
Sumatriptan Sumatriptan Avatrombopag may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The serum concentration of Avatrombopag can be increased when it is combined with Tacrolimus.
Famotidine Injection Famotidine Injection The excretion of Famotidine can be decreased when combined with Avatrombopag.
Fluconazole Injection Fluconazole Injection The serum concentration of Avatrombopag can be increased when it is combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Hydromorphone can be increased when combined with Avatrombopag.
Morphine Injection Morphine Injection The serum concentration of Avatrombopag can be increased when it is combined with Morphine.
Zidovudine Injection Zidovudine Injection Avatrombopag may decrease the excretion rate of Zidovudine which could result in a higher serum level.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Avatrombopag.
Ondansetron Ondansetron The metabolism of Ondansetron can be increased when combined with Avatrombopag.
Torsemide Torsemide The metabolism of Torasemide can be increased when combined with Avatrombopag.
Alosetron Alosetron The metabolism of Alosetron can be increased when combined with Avatrombopag.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be increased when combined with Avatrombopag.
Meloxicam Meloxicam The metabolism of Meloxicam can be increased when combined with Avatrombopag.
Trimipramine Trimipramine The metabolism of Trimipramine can be increased when combined with Avatrombopag.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Avatrombopag.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Avatrombopag.
Zonisamide Zonisamide The serum concentration of Avatrombopag can be increased when it is combined with Zonisamide.
Ezetimibe Ezetimibe Avatrombopag may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Atazanavir Atazanavir The metabolism of Atazanavir can be increased when combined with Avatrombopag.
Almotriptan Almotriptan The metabolism of Almotriptan can be increased when combined with Avatrombopag.
Eletriptan Eletriptan The metabolism of Eletriptan can be increased when combined with Avatrombopag.
Rosuvastatin Rosuvastatin Avatrombopag may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Vardenafil Vardenafil The serum concentration of Avatrombopag can be increased when it is combined with Vardenafil.
Tegaserod Tegaserod Avatrombopag may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Progesterone Progesterone The metabolism of Progesterone can be increased when combined with Avatrombopag.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be increased when combined with Avatrombopag.
Duloxetine Duloxetine The metabolism of Duloxetine can be increased when combined with Avatrombopag.
Bosentan Bosentan The metabolism of Bosentan can be increased when combined with Avatrombopag.
Cefditoren Cefditoren The excretion of Cefdinir can be decreased when combined with Avatrombopag.
Erlotinib Erlotinib The metabolism of Erlotinib can be increased when combined with Avatrombopag.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be increased when combined with Avatrombopag.
Voriconazole Voriconazole The metabolism of Voriconazole can be increased when combined with Avatrombopag.
Ramelteon Ramelteon The metabolism of Ramelteon can be increased when combined with Avatrombopag.
Tipranavir Tipranavir The serum concentration of Avatrombopag can be increased when it is combined with Tipranavir.
Ranolazine Ranolazine The serum concentration of Avatrombopag can be increased when it is combined with Ranolazine.
Imatinib Imatinib Avatrombopag may decrease the excretion rate of Imatinib which could result in a higher serum level.
Sitagliptin Sitagliptin The serum concentration of Avatrombopag can be increased when it is combined with Sitagliptin.
Gefitinib Gefitinib Avatrombopag may decrease the excretion rate of Gefitinib which could result in a higher serum level.
Paliperidone Paliperidone The serum concentration of Avatrombopag can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Avatrombopag.
Clofarabine Injection Clofarabine Injection The excretion of Clofarabine can be decreased when combined with Avatrombopag.
Oxaliplatin Injection Oxaliplatin Injection Avatrombopag may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Posaconazole Posaconazole The serum concentration of Avatrombopag can be increased when it is combined with Posaconazole.
Pemetrexed Injection Pemetrexed Injection The excretion of Pemetrexed can be decreased when combined with Avatrombopag.
Sorafenib Sorafenib The metabolism of Avatrombopag can be increased when combined with Sorafenib.
Dronabinol Dronabinol The metabolism of Dronabinol can be increased when combined with Avatrombopag.
Lapatinib Lapatinib The serum concentration of Avatrombopag can be increased when it is combined with Lapatinib.
Dasatinib Dasatinib Avatrombopag may decrease the excretion rate of Dasatinib which could result in a higher serum level.
Ivermectin Ivermectin Avatrombopag may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Temsirolimus Temsirolimus The serum concentration of Avatrombopag can be increased when it is combined with Temsirolimus.
Nilotinib Nilotinib The serum concentration of Avatrombopag can be increased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Avatrombopag can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Bexarotene can be increased when combined with Avatrombopag.
Doripenem Injection Doripenem Injection The excretion of Doripenem can be decreased when combined with Avatrombopag.
Etravirine Etravirine The metabolism of Etravirine can be increased when combined with Avatrombopag.
Mitoxantrone Injection Mitoxantrone Injection Avatrombopag may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Tretinoin Tretinoin The metabolism of Tretinoin can be increased when combined with Avatrombopag.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Avatrombopag.
Leucovorin Injection Leucovorin Injection The excretion of Leucovorin can be decreased when combined with Avatrombopag.
Irinotecan Injection Irinotecan Injection Avatrombopag may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Silodosin Silodosin The serum concentration of Avatrombopag can be increased when it is combined with Silodosin.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be increased when combined with Avatrombopag.
Prasugrel Prasugrel The metabolism of Prasugrel can be increased when combined with Avatrombopag.
Lacosamide Lacosamide The metabolism of Lacosamide can be increased when combined with Avatrombopag.
Everolimus Everolimus The serum concentration of Avatrombopag can be increased when it is combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Avatrombopag can be increased when it is combined with Tolvaptan.
Dronedarone Dronedarone The serum concentration of Avatrombopag can be increased when it is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection Avatrombopag may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Saxagliptin Saxagliptin The excretion of Saxagliptin can be decreased when combined with Avatrombopag.
Romidepsin Injection Romidepsin Injection The serum concentration of Avatrombopag can be increased when it is combined with Romidepsin.
Tapentadol Tapentadol The metabolism of Tapentadol can be increased when combined with Avatrombopag.
Topotecan Topotecan Avatrombopag may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Avatrombopag.
Pitavastatin Pitavastatin Avatrombopag may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Avatrombopag can be increased when combined with Cabazitaxel.
Linagliptin Linagliptin The serum concentration of Avatrombopag can be increased when it is combined with Linagliptin.
Telaprevir Telaprevir The serum concentration of Avatrombopag can be increased when it is combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Avatrombopag.
Rivaroxaban Rivaroxaban Avatrombopag may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The serum concentration of Avatrombopag can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Avatrombopag.
Vandetanib Vandetanib The serum concentration of Avatrombopag can be increased when it is combined with Vandetanib.
Clobazam Clobazam The serum concentration of Avatrombopag can be increased when it is combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Avatrombopag can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Vismodegib can be increased when combined with Avatrombopag.
Ivacaftor Ivacaftor The serum concentration of Avatrombopag can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The serum concentration of Axitinib can be increased when it is combined with Avatrombopag.
Crizotinib Crizotinib The serum concentration of Avatrombopag can be increased when it is combined with Crizotinib.
Cabergoline Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Avatrombopag.
Ambrisentan Ambrisentan The serum concentration of Avatrombopag can be increased when it is combined with Ambrisentan.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Avatrombopag can be increased when it is combined with Carfilzomib.
Enzalutamide Enzalutamide The serum concentration of Avatrombopag can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Avatrombopag can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The serum concentration of Avatrombopag can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Avatrombopag.
Teriflunomide Teriflunomide Avatrombopag may decrease the excretion rate of Teriflunomide which could result in a higher serum level.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be increased when combined with Avatrombopag.
Ponatinib Ponatinib The metabolism of Avatrombopag can be increased when combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Avatrombopag can be increased when it is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Avatrombopag can be increased when it is combined with Trastuzumab emtansine.
Apixaban Apixaban Avatrombopag may decrease the excretion rate of Apixaban which could result in a higher serum level.
Canagliflozin Canagliflozin The serum concentration of Avatrombopag can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be increased when combined with Avatrombopag.
Ospemifene Ospemifene The metabolism of Ospemifene can be increased when combined with Avatrombopag.
Dolutegravir Dolutegravir Avatrombopag may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Afatinib Afatinib The serum concentration of Avatrombopag can be increased when it is combined with Afatinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Avatrombopag.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be increased when combined with Avatrombopag.
Lomitapide Lomitapide The serum concentration of Avatrombopag can be increased when it is combined with Lomitapide.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be increased when combined with Avatrombopag.
Simeprevir Simeprevir The serum concentration of Avatrombopag can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir Avatrombopag may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be increased when combined with Avatrombopag.
Ceritinib Ceritinib The serum concentration of Avatrombopag can be increased when it is combined with Ceritinib.
Belinostat Injection Belinostat Injection The serum concentration of Avatrombopag can be increased when it is combined with Belinostat.
Idelalisib Idelalisib Avatrombopag may decrease the excretion rate of Idelalisib which could result in a higher serum level.
Testosterone Injection Testosterone Injection Avatrombopag may decrease the excretion rate of Testosterone which could result in a higher serum level.
Vorapaxar Vorapaxar The serum concentration of Avatrombopag can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Avatrombopag can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Avatrombopag can be increased when it is combined with Edoxaban.
Riociguat Riociguat Avatrombopag may decrease the excretion rate of Riociguat which could result in a higher serum level.
Nintedanib Nintedanib The serum concentration of Avatrombopag can be increased when it is combined with Nintedanib.
Palbociclib Palbociclib Avatrombopag may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Lenvatinib Lenvatinib Avatrombopag may decrease the excretion rate of Lenvatinib which could result in a higher serum level.
Panobinostat Panobinostat The serum concentration of Avatrombopag can be increased when it is combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The metabolism of Haloperidol can be increased when combined with Avatrombopag.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Avatrombopag can be increased when it is combined with Isavuconazonium.
Flibanserin Flibanserin The serum concentration of Avatrombopag can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Avatrombopag can be increased when it is combined with Rolapitant.
Daclatasvir Daclatasvir The serum concentration of Avatrombopag can be increased when it is combined with Daclatasvir.
Eluxadoline Eluxadoline The excretion of Eluxadoline can be decreased when combined with Avatrombopag.
Cobimetinib Cobimetinib The serum concentration of Avatrombopag can be increased when it is combined with Cobimetinib.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Avatrombopag.
Osimertinib Osimertinib Avatrombopag may decrease the excretion rate of Osimertinib which could result in a higher serum level.
Lesinurad Lesinurad The metabolism of Lesinurad can be increased when combined with Avatrombopag.
Dexamethasone Injection Dexamethasone Injection The excretion of Dexamethasone can be decreased when combined with Avatrombopag.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be increased when combined with Avatrombopag.
Venetoclax Venetoclax The serum concentration of Avatrombopag can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Avatrombopag can be increased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Avatrombopag can be increased when it is combined with Selexipag.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be increased when combined with Avatrombopag.
Rucaparib Rucaparib The serum concentration of Avatrombopag can be increased when it is combined with Rucaparib.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Avatrombopag.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be increased when combined with Avatrombopag.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Avatrombopag.
Neratinib Neratinib The serum concentration of Avatrombopag can be increased when it is combined with Neratinib.
Enasidenib Enasidenib The metabolism of Avatrombopag can be increased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Avatrombopag can be increased when it is combined with Inotuzumab ozogamicin.
Copanlisib Injection Copanlisib Injection Avatrombopag may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Delafloxacin Delafloxacin Avatrombopag may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib Avatrombopag may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Avatrombopag.
Ertugliflozin Ertugliflozin Avatrombopag may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be increased when combined with Avatrombopag.
Apalutamide Apalutamide The serum concentration of Avatrombopag can be decreased when it is combined with Apalutamide.
Baricitinib Baricitinib The serum concentration of Avatrombopag can be increased when it is combined with Baricitinib.
Eliglustat Eliglustat The serum concentration of Avatrombopag can be increased when it is combined with Eliglustat.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Avatrombopag.
Ivosidenib Ivosidenib The serum concentration of Avatrombopag can be increased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag Avatrombopag may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix Elagolix The serum concentration of Avatrombopag can be increased when it is combined with Elagolix.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be increased when combined with Avatrombopag.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be increased when combined with Avatrombopag.
Duvelisib Duvelisib Avatrombopag may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Avatrombopag.
Sarecycline Sarecycline The serum concentration of Avatrombopag can be increased when it is combined with Sarecycline.
Talazoparib Talazoparib Avatrombopag may decrease the excretion rate of Talazoparib which could result in a higher serum level.
Gilteritinib Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Avatrombopag.
Glasdegib Glasdegib Avatrombopag may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be increased when combined with Avatrombopag.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Avatrombopag.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Avatrombopag.
Rifamycin Rifamycin The serum concentration of Avatrombopag can be increased when it is combined with Rifamycin.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Avatrombopag.
Acyclovir Ophthalmic Acyclovir Ophthalmic The excretion of Acyclovir can be decreased when combined with Avatrombopag.
Erdafitinib Erdafitinib The serum concentration of Avatrombopag can be increased when it is combined with Erdafitinib.
Alpelisib Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Avatrombopag.
Cladribine Cladribine Avatrombopag may decrease the excretion rate of Cladribine which could result in a higher serum level.
Darolutamide Darolutamide Avatrombopag may decrease the excretion rate of Darolutamide which could result in a higher serum level.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be increased when combined with Avatrombopag.
Entrectinib Entrectinib The serum concentration of Avatrombopag can be increased when it is combined with Entrectinib.
Istradefylline Istradefylline The serum concentration of Istradefylline can be increased when it is combined with Avatrombopag.
Pitolisant Pitolisant The serum concentration of Avatrombopag can be increased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Avatrombopag can be increased when it is combined with Fedratinib.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Avatrombopag.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be increased when combined with Avatrombopag.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Avatrombopag.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Avatrombopag.
Voxelotor Voxelotor The metabolism of Voxelotor can be increased when combined with Avatrombopag.
Avapritinib Avapritinib The metabolism of Avapritinib can be increased when combined with Avatrombopag.
Lasmiditan Lasmiditan The serum concentration of Avatrombopag can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Avatrombopag.
Tazemetostat Tazemetostat Avatrombopag may decrease the excretion rate of Tazemetostat which could result in a higher serum level.
Ozanimod Ozanimod Avatrombopag may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib Avatrombopag may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Avatrombopag.
Tucatinib Tucatinib Avatrombopag may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Avatrombopag.
Ripretinib Ripretinib Avatrombopag may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Lemborexant Lemborexant The serum concentration of Avatrombopag can be increased when it is combined with Lemborexant.
Fostemsavir Fostemsavir Avatrombopag may decrease the excretion rate of Fostemsavir which could result in a higher serum level.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Avatrombopag.
Pralsetinib Pralsetinib Avatrombopag may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Avatrombopag.
Indomethacin Indomethacin The excretion of Indomethacin can be decreased when combined with Avatrombopag.
Mefenamic Acid Mefenamic Acid The metabolism of Mefenamic acid can be increased when combined with Avatrombopag.
Naproxen Naproxen The metabolism of Naproxen can be increased when combined with Avatrombopag.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be increased when combined with Avatrombopag.
Methotrexate Injection Methotrexate Injection Avatrombopag may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Primidone Primidone The metabolism of Primidone can be increased when combined with Avatrombopag.
Diazepam Diazepam The metabolism of Diazepam can be increased when combined with Avatrombopag.
Tetracycline Tetracycline The excretion of Tetracycline can be decreased when combined with Avatrombopag.
Dapsone Dapsone The metabolism of Dapsone can be increased when combined with Avatrombopag.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be increased when combined with Avatrombopag.
Methadone Methadone The metabolism of Methadone can be increased when combined with Avatrombopag.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be increased when combined with Avatrombopag.
Sulfasalazine Sulfasalazine Avatrombopag may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Hydrocortisone Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Avatrombopag.
Doxorubicin Doxorubicin Avatrombopag may decrease the excretion rate of Doxorubicin which could result in a higher serum level.
Dactinomycin Dactinomycin Avatrombopag may decrease the excretion rate of Dactinomycin which could result in a higher serum level.
Prazosin Prazosin Avatrombopag may decrease the excretion rate of Prazosin which could result in a higher serum level.
Cimetidine Cimetidine The excretion of Cimetidine can be decreased when combined with Avatrombopag.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Avatrombopag.
Loperamide Loperamide The serum concentration of Avatrombopag can be increased when it is combined with Loperamide.
Daunorubicin Daunorubicin Avatrombopag may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Avatrombopag may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Avatrombopag.
Loxapine Loxapine The serum concentration of Avatrombopag can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Chloroquine can be increased when combined with Avatrombopag.
Quinine Quinine The serum concentration of Avatrombopag can be increased when it is combined with Quinine.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be increased when combined with Avatrombopag.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Avatrombopag.
Quinidine Quinidine The serum concentration of Avatrombopag can be increased when it is combined with Quinidine.
Valproic Acid Valproic Acid The excretion of Valproic acid can be decreased when combined with Avatrombopag.
Tamoxifen Tamoxifen The metabolism of Avatrombopag can be increased when combined with Tamoxifen.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be increased when combined with Avatrombopag.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be increased when combined with Avatrombopag.
Tolazamide Tolazamide The metabolism of Tolazamide can be increased when combined with Avatrombopag.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be increased when combined with Avatrombopag.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Avatrombopag.
Hydrochlorothiazide Hydrochlorothiazide The excretion of Hydrochlorothiazide can be decreased when combined with Avatrombopag.
Folic Acid Folic Acid Avatrombopag may decrease the excretion rate of Folic acid which could result in a higher serum level.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Avatrombopag.
Mercaptopurine Mercaptopurine The excretion of Mercaptopurine can be decreased when combined with Avatrombopag.
Allopurinol Allopurinol Avatrombopag may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Clomiphene Clomiphene The serum concentration of Avatrombopag can be increased when it is combined with Clomifene.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be increased when combined with Avatrombopag.
Colchicine Colchicine The serum concentration of Avatrombopag can be increased when it is combined with Colchicine.
Cefaclor Cefaclor The excretion of Cefaclor can be decreased when combined with Avatrombopag.
Cefazolin Injection Cefazolin Injection The excretion of Cefazolin can be decreased when combined with Avatrombopag.
Cephalexin Cephalexin The excretion of Cephalexin can be decreased when combined with Avatrombopag.
Ketoconazole Ketoconazole The serum concentration of Avatrombopag can be increased when it is combined with Ketoconazole.
Vincristine Injection Vincristine Injection Avatrombopag may decrease the excretion rate of Vincristine which could result in a higher serum level.
Captopril Captopril The excretion of Captopril can be decreased when combined with Avatrombopag.
Vinblastine Vinblastine The serum concentration of Avatrombopag can be increased when it is combined with Vinblastine.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be increased when combined with Avatrombopag.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be increased when combined with Avatrombopag.
Diltiazem Diltiazem The metabolism of Diltiazem can be increased when combined with Avatrombopag.
Verapamil Verapamil The serum concentration of Avatrombopag can be increased when it is combined with Verapamil.
Piroxicam Piroxicam The metabolism of Piroxicam can be increased when combined with Avatrombopag.
Bumetanide Bumetanide The excretion of Bumetanide can be decreased when combined with Avatrombopag.
Etoposide Etoposide Avatrombopag may decrease the excretion rate of Etoposide which could result in a higher serum level.
Glyburide Glyburide Avatrombopag may decrease the excretion rate of Glyburide which could result in a higher serum level.
Glipizide Glipizide The metabolism of Glipizide can be increased when combined with Avatrombopag.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be increased when combined with Avatrombopag.
Amiodarone Amiodarone The metabolism of Amiodarone can be increased when combined with Avatrombopag.
Lovastatin Lovastatin The metabolism of Lovastatin can be increased when combined with Avatrombopag.
Diclofenac Diclofenac The metabolism of Diclofenac can be increased when combined with Avatrombopag.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be increased when combined with Avatrombopag.
Clozapine Clozapine The metabolism of Clozapine can be increased when combined with Avatrombopag.
Idarubicin Idarubicin The metabolism of Idarubicin can be increased when combined with Avatrombopag.
Clarithromycin Clarithromycin The serum concentration of Avatrombopag can be increased when it is combined with Clarithromycin.
Etodolac Etodolac The metabolism of Etodolac can be increased when combined with Avatrombopag.
Nabumetone Nabumetone The metabolism of Nabumetone can be increased when combined with Avatrombopag.
Pravastatin Pravastatin Avatrombopag may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Quinapril Quinapril The excretion of Quinapril can be decreased when combined with Avatrombopag.
Simvastatin Simvastatin The serum concentration of Avatrombopag can be increased when it is combined with Simvastatin.
Teniposide Injection Teniposide Injection Avatrombopag may decrease the excretion rate of Teniposide which could result in a higher serum level.
Itraconazole Itraconazole The serum concentration of Avatrombopag can be increased when it is combined with Itraconazole.
Bisoprolol Bisoprolol The serum concentration of Avatrombopag can be increased when it is combined with Bisoprolol.
Zolpidem Zolpidem The metabolism of Zolpidem can be increased when combined with Avatrombopag.
Doxazosin Doxazosin The metabolism of Doxazosin can be increased when combined with Avatrombopag.
Omeprazole Omeprazole The metabolism of Omeprazole can be increased when combined with Avatrombopag.
Cisapride Cisapride The metabolism of Cisapride can be increased when combined with Avatrombopag.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be increased when combined with Avatrombopag.
Venlafaxine Venlafaxine The metabolism of Venlafaxine can be increased when combined with Avatrombopag.
Losartan Losartan The metabolism of Losartan can be increased when combined with Avatrombopag.
Valacyclovir Valacyclovir The excretion of Valaciclovir can be decreased when combined with Avatrombopag.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be increased when combined with Avatrombopag.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Avatrombopag.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Avatrombopag.
Nicardipine Nicardipine The metabolism of Nicardipine can be increased when combined with Avatrombopag.
Bupropion Bupropion The metabolism of Bupropion can be increased when combined with Avatrombopag.
Saquinavir Saquinavir The serum concentration of Avatrombopag can be increased when it is combined with Saquinavir.
Lamivudine Lamivudine Avatrombopag may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Avatrombopag may decrease the excretion rate of Riluzole which could result in a higher serum level.
Glimepiride Glimepiride The metabolism of Glimepiride can be increased when combined with Avatrombopag.
Anastrozole Anastrozole The metabolism of Anastrozole can be increased when combined with Avatrombopag.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Avatrombopag.
Ritonavir Ritonavir The serum concentration of Avatrombopag can be increased when it is combined with Ritonavir.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be increased when combined with Avatrombopag.
Zileuton Zileuton The metabolism of Zileuton can be increased when combined with Avatrombopag.
Valsartan Valsartan The metabolism of Valsartan can be increased when combined with Avatrombopag.
Donepezil Donepezil Avatrombopag may decrease the excretion rate of Donepezil which could result in a higher serum level.
Fexofenadine Fexofenadine The serum concentration of Avatrombopag can be increased when it is combined with Fexofenadine.
Carvedilol Carvedilol The serum concentration of Avatrombopag can be increased when it is combined with Carvedilol.
Selegiline Selegiline The metabolism of Selegiline can be increased when combined with Avatrombopag.
Sertraline Sertraline The metabolism of Sertraline can be increased when combined with Avatrombopag.
Propafenone Propafenone The serum concentration of Avatrombopag can be increased when it is combined with Propafenone.
Raloxifene Raloxifene Avatrombopag may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Irbesartan Irbesartan The metabolism of Irbesartan can be increased when combined with Avatrombopag.
Capecitabine Capecitabine The metabolism of Capecitabine can be increased when combined with Avatrombopag.
Sildenafil Sildenafil The serum concentration of Avatrombopag can be increased when it is combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be increased when combined with Avatrombopag.
Celecoxib Celecoxib Avatrombopag may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be increased when combined with Avatrombopag.
Tolterodine Tolterodine The metabolism of Tolterodine can be increased when combined with Avatrombopag.
Thalidomide Thalidomide The metabolism of Thalidomide can be increased when combined with Avatrombopag.
Oseltamivir Oseltamivir The excretion of Oseltamivir can be decreased when combined with Avatrombopag.
Nateglinide Nateglinide The metabolism of Nateglinide can be increased when combined with Avatrombopag.
Terbinafine Terbinafine The metabolism of Terbinafine can be increased when combined with Avatrombopag.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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