Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Polypodium Leucotomos/Calaguala Extract Ingredients & Drug Interactions

by Herbadiet

Polypodium Leucotomos/Calaguala Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Polypodium Leucotomos/Calaguala Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Polypodium Leucotomos/Calaguala Extract is a dietary supplement by Herbadiet with 1 active ingredient. Its ingredients are commonly taken for sun sensitivity and sunburn protection, skin conditions like vitiligo and melasma, polymorphic light eruption.Based on those ingredients, 643 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Polypodium leucotomos whole plant extract powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Polypodium Leucotomos/Calaguala Extract by Herbadiet

Ask about any prescription or over-the-counter medication and we check it for interactions with Polypodium Leucotomos/Calaguala Extract by Herbadiet — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Polypodium Leucotomos/Calaguala Extract by Herbadiet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: Polypodium leucotomos whole plant extract powder, a plant-derived ingredient made from the entire fern plant. There are no inactive ingredients in this formulation.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Polypodium Leucotomos's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Natural skin support.
  • We looked for evidence on: Atopic dermatitis (eczema), Melasma, Polymorphous light eruption (PMLE), Sunburn, Vitiligo, photoaging — and 2 related terms.
  • The closest evidence on file: Polypodium Leucotomos is rated "Insufficient Reliable Evidence To Rate" for Atopic dermatitis (eczema) (Natural Medicines).
  • Also on file: Polypodium Leucotomos is rated "Insufficient Reliable Evidence To Rate" for Melasma, Sunburn, Vitiligo, Polymorphous light eruption (PMLE).

The evidence we have does not establish that Polypodium leucotomos relieves dementia, atopic dermatitis (eczema), actinic keratoses (rough sun-damaged patches on skin), cutaneous lupus erythematosus (a lupus skin condition), or photodamage from psoralen-UVA treatment. All of these uses are rated as having insufficient reliable evidence to make a claim.

If you're thinking about trying it for one of these conditions, talk with your doctor about whether the available research supports its use for your situation.

The evidence, ingredient by ingredient Polypodium Leucotomos

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Polypodium leucotomos has been generally well tolerated in studies, but how safe it is over the long term isn't well established. The most common side effect reported, though rare, is itching.

Because there isn't enough safety data in pregnancy, the evidence advises against using this product if you're pregnant. Safety while breastfeeding is also unknown, so avoidance is the safer choice if you're nursing.

If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before considering this supplement.

Side effects, ingredient by ingredient Polypodium Leucotomos

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Polypodium Leucotomos.
  • The most serious interaction on file is rated Minor.
  • For scale: 644 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take medications metabolized by the liver enzyme CYP3A4 — including many heart drugs, blood pressure medications, immunosuppressants, statins, and others — check your specific prescriptions with your doctor or pharmacist before starting this product. Polypodium leucotomos may slow how your liver breaks down these drugs and raise their levels in your body, though the real-world significance of this effect is still unclear.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Polypodium leucotomos may be worth exploring if you're interested in its traditional uses and your doctor agrees, but the evidence for its effectiveness is not yet established. The main caution is its potential to slow how your liver clears certain medications — especially if you take heart, blood pressure, or immune drugs.

Before you start, check your medications with the tool on this page and confirm with your own doctor or pharmacist that it's safe to combine with what you're taking.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Polypodium Leucotomos/Calaguala Extract, straight from the product label.

Brand Herbadiet
Net contents 0 Not Present
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 244375
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Polypodium Leucotomos/Calaguala Extract by Herbadiet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
240 mg
Maximum serving Sizes:
480 mg
IngredientAmount% DV
Polypodium leucotomos whole plant extract powder240 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Natural Skin Support Standardized Extract Powder Derived from Polypodium Leucotomos Plant

Free of fillers, binders, artificial ingredients, dairy, soy, wheat, gluten, yeast

V Vegan

Ethically Sourced Scientifically Tested Premium Grade Ingredients

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take up to 480 mg, or as directed by your physician

Precautions

Keep out of reach of children.

Pregnant or lactating women should consult your physician before use.

Storage

Store in a dry, cool & dark.

FDA Disclaimer Statement

Warning: This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Batch No. ARK-P73

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Polypodium Leucotomos/Calaguala Extract by Herbadiet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Polypodium Leucotomos/Calaguala Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Polypodium Leucotomos/Calaguala Extract by Herbadiet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size240 mg Dosage formPowder Amounts shown are per serving.

Polypodium leucotomos whole plant extract powder

Interacts with
643 drugs
240 mg per serving

Polypodium leucotomos is a fern extract taken by mouth, mostly studied as an add-on to (not a replacement for) sunscreen and for certain light-trigger...

Polypodium leucotomos whole plant extract powder monograph & interactions
Interaction report

Polypodium Leucotomos/Calaguala Extract by Herbadiet Drug Interactions

Want to check YOUR meds against Polypodium Leucotomos/Calaguala Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
643Drugs
643 Minor

Ingredients driving the most interactions

Polypodium leucotomos whole plant extract powder 643

Individual Drug Interactions

The ingredients in Polypodium Leucotomos/Calaguala Extract interact with 643 drugs. Click any drug to see the details.

1 of the 1 ingredient in Polypodium Leucotomos/Calaguala Extract interact with drugs. Each result below shows which ingredient is responsible. Polypodium leucotomos whole plant extract powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Polypodium Leucotomos/Calaguala Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Polypodium leucotomos whole plant extract powder1 drug type · 643 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggests that Polypodium leucotomos can decrease the metabolism of midazolam by a mechanism possibly related to the inhibition of CYP3A4. However, a small study in humans suggests that taking Polypodium leucotomos with midazolam does not affect the metabolism of midazolam.

Likelihood Unlikely Evidence B
Polypodium leucotomos whole plant extract powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Polypodium Leucotomos/Calaguala Extract, from the product label.

Herbadiet

See all Herbadiet products
Name
Arkure Health Care
Street Address
11, Sector - 14
City
Rohtak
State
Haryana
ZipCode
124001
Web Address
www.herbadiet.in
Pharmacist Counseling Corner

Polypodium Leucotomos/Calaguala Extract by Herbadiet: Common Questions

Does Polypodium Leucotomos/Calaguala Extract by Herbadiet interact with any medications?
Yes. Based on its ingredients, Polypodium Leucotomos/Calaguala Extract has a known interaction with 643 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Polypodium Leucotomos/Calaguala Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data in pregnancy, so the evidence advises against using it if you're pregnant. Safety while breastfeeding is also unknown, so avoidance is the safer choice if you're nursing. Talk with your doctor or pharmacist before considering it if you're in either situation.
What are the side effects?
Polypodium leucotomos has been generally well tolerated in studies. The only side effect reported in the literature is itching, and it's rare.
Does it actually work for skin conditions like eczema or psoriasis?
The evidence we hold doesn't establish that it works for atopic dermatitis (eczema), actinic keratoses, lupus skin conditions, or sun damage from PUVA treatment — all are rated as having insufficient reliable evidence to rate. If you're considering it for a skin condition, talk with your dermatologist about what the current research supports.
How long can I safely take this?
While Polypodium leucotomos has been well tolerated in studies, how safe it is over the long term isn't well established. If you plan to use it for an extended period, check in with your doctor or pharmacist.
Is this product a filler-free supplement?
Yes — this powder contains only the active ingredient Polypodium leucotomos extract with no inactive ingredients listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Polypodium Leucotomos/Calaguala Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Polypodium Leucotomos/Calaguala Extract label
Go deeper

The Full Monographs Behind Polypodium Leucotomos/Calaguala Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Polypodium Leucotomos

Interacts with 643 drugs

Polypodium leucotomos is a fern extract taken by mouth, mostly studied as an add-on to (not a replacement for) sunscreen and for certain light-triggered skin conditions. Some early research...

Read the full Polypodium Leucotomos monograph →
Sources

Sources & How We Checked

Polypodium Leucotomos/Calaguala Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Polypodium Leucotomos 2 references
  1. Goh CL, Chuah SY, Tien S, Thng G, Vitale MA, Delgado-Rubin A. Double-blind, placebo-controlled trial to evaluate the effectiveness of Polypodium leucotomos extract in the treatment of melasma in Asian skin: a pilot study. J Clin Aesthet Dermatol 2018;11(3
  2. Shinya K, Nishimura Y, Ryu K, et al. Short-term administration of Polypodium leucotomos extract does not inhibit CYP3A4-mediated metabolism of midazolam in healthy subjects: an open-label, two-period, fixed-sequence study. Int J Dermatol 2022.

See these in context on the Polypodium Leucotomos monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team