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Dietary supplement

Poria Mushroom Extract Ingredients & Drug Interactions

by Nootropics Depot

Poria Mushroom Extract label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Poria Mushroom Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Poria Mushroom Extract is a dietary supplement by Nootropics Depot with 1 active ingredient. Its ingredients are commonly taken for fluid retention and swelling, digestive complaints, sleep and calming support.Based on those ingredients, 417 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Poria. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Poria Mushroom Extract by Nootropics Depot

Ask about any prescription or over-the-counter medication and we check it for interactions with Poria Mushroom Extract by Nootropics Depot — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Poria Mushroom Extract by Nootropics Depot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: poria mushroom extract. Poria is a fungus traditionally used in herbal medicine, and this extract concentrates its compounds into powder form.

The product has no other inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Poria Mushroom product and its label doesn't state a use — see Poria Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish how well poria mushroom extract works for any of its traditional uses. The data rates it as having insufficient reliable evidence for cancer, chronic fatigue syndrome, dementia, diabetes, diabetic kidney damage, and diarrhea.

That means studies so far haven't given us a clear answer either way — not that it definitely doesn't work, just that the science isn't there yet to make a firm claim.

The evidence, ingredient by ingredient Poria Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Poria mushroom extract is generally well tolerated based on its long history in traditional medicine, but human safety data are limited, so we don't know all the possible effects yet. Allergic reactions have been reported rarely, including allergic rhinitis and allergic asthma.

The safety information during pregnancy and breastfeeding isn't reliable enough to recommend use — talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing before taking this product.

Side effects, ingredient by ingredient Poria Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Poria Mushroom.
  • The most serious interaction on file is rated Moderate.
  • For scale: 417 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking poria mushroom extract, double-check with your doctor or pharmacist if you take sedatives or other central nervous system depressants (like sleep aids or anti-anxiety medications), anticholinergic drugs (for overactive bladder, Parkinson's, or certain poisonings), or cholinergic medications (that boost acetylcholine levels). These Moderate-severity interactions haven't been proven in humans, but animal data suggest poria may alter how they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Poria mushroom extract is a traditional fungal preparation that hasn't been well studied in humans for any specific condition. If you take sedatives, anticholinergic drugs, or cholinergic medications, check with your doctor or pharmacist before adding this supplement — the animal research suggests it may interact with how these drugs work.

It's not recommended during pregnancy or breastfeeding without personalized medical guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Poria Mushroom Extract, straight from the product label.

Brand Nootropics Depot
Net contents 0.35 Ounce(s); 10 Gram(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232493
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Poria Mushroom Extract by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 Gram(s)
Maximum serving Sizes:
0.5 Gram(s)
Servings per container
20
IngredientAmount% DV
Poria500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Beta-Glucan minimum content: 55%

FDA Statement of Identity

Dietary Supplement

General Statements

Disclaimer: Transfer scoops are not accurate. A mg scale is needed to measure dosages.

Precautions

Always consult with a qualified health physician before taking any new dietary supplement.

Warning: Keep out of reach of children. Do not take if under 18, pregnant/nursing, have any medical conditions or taking Rx/OTC drugs.

Do not take if under 18, pregnant/nursing, have any medical conditions or taking Rx/OTC drugs.

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the FDA.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 500mg 1-2 times daily.

Formulation

Non GMO

USDA Organic

Seals/Symbols

USDA Organic

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Poria Mushroom Extract by Nootropics Depot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Poria Mushroom Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Poria Mushroom Extract by Nootropics Depot

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.5 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Poria

Interacts with
417 drugs
500 mg per serving

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scient...

Poria monograph & interactions
Interaction report

Poria Mushroom Extract by Nootropics Depot Drug Interactions

Want to check YOUR meds against Poria Mushroom Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
417Drugs
417 Moderate

Ingredients driving the most interactions

Poria 417

Individual Drug Interactions

The ingredients in Poria Mushroom Extract interact with 417 drugs. Click any drug to see the details.

1 of the 1 ingredient in Poria Mushroom Extract interact with drugs. Each result below shows which ingredient is responsible. Poria

Each ingredient & the kinds of drugs it affects

For each ingredient in Poria Mushroom Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Poria3 drug types · 417 drugs

Anticholinergic Drugs

Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Poria full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Poria Mushroom Extract, from the product label.

Nootropics Depot

See all Nootropics Depot products
Name
Nootropics Depot
Street Address
8380 S. Kyrene Rd. Ste. 110
City
Tempe
State
AZ
ZipCode
85284
Pharmacist Counseling Corner

Poria Mushroom Extract by Nootropics Depot: Common Questions

Does Poria Mushroom Extract by Nootropics Depot interact with any medications?
Yes. Based on its ingredients, Poria Mushroom Extract has a known interaction with 417 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Poria Mushroom Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is poria mushroom extract safe during pregnancy?
The safety data aren't reliable enough to recommend it during pregnancy. Talk with your doctor or pharmacist before taking it if you're pregnant or planning to become pregnant — they can help you weigh the risks and benefits for your situation.
Can I take this while breastfeeding?
No reliable safety information exists for breastfeeding. It's recommended that you avoid it while nursing unless your doctor or pharmacist advises otherwise after reviewing your individual circumstances.
Does poria mushroom extract actually work for anything?
The data we have doesn't establish reliable effectiveness for any condition — including cancer, chronic fatigue, dementia, diabetes, or diarrhea. There's not enough human research yet to say whether it works or doesn't.
What side effects should I watch for?
Allergic reactions have been reported rarely, including allergic rhinitis and allergic asthma. Beyond that, human safety data are limited, so other side effects may exist that we don't know about yet.
What is poria mushroom, and why is it in supplements?
Poria is a fungus that's been used in traditional herbal medicine for centuries. It's thought to have various health benefits, though human research supporting those claims is sparse.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Poria Mushroom Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Poria Mushroom Extract label
Go deeper

The Full Monographs Behind Poria Mushroom Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Poria Mushroom

Interacts with 417 drugs

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...

Read the full Poria Mushroom monograph →
Sources

Sources & How We Checked

Poria Mushroom Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Poria Mushroom 3 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
  3. Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.

See these in context on the Poria Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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