Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Potassium Gluconate Ingredients & Drug Interactions

by Origin

Potassium Gluconate label
See full label image
Other (e.g. Tea Bag) Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Potassium Gluconate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Potassium Gluconate is a dietary supplement by Origin with 1 active ingredient. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 62 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Potassium Gluconate by Origin

Ask about any prescription or over-the-counter medication and we check it for interactions with Potassium Gluconate by Origin — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Potassium Gluconate by Origin

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Potassium” is listed as a grouped ingredient — the label gives one combined amount (99 mg) without saying how much of each component you get.

This product contains one active ingredient: potassium, supplied as 595 mg of potassium gluconate. Potassium is an essential mineral your body needs for nerve signaling, muscle contraction, and heart rhythm.

The inactive ingredients are crospovidone, stearic acid, silica, cellulose coating, and vegetable magnesium stearate — these are fillers and binders that help hold the tablet together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: potassium for muscle and nerve health.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't have effectiveness data on file for this product. Potassium supplements are used to correct low potassium levels (hypokalemia) when diet alone isn't enough, but whether this particular dose works for that purpose isn't established in our data.

Your doctor or pharmacist can tell you whether a supplement is right for your situation and what dose you need.

The evidence, ingredient by ingredient Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from your regular diet is safe for everyone. As a supplement, though, it's trickier.

It's generally well tolerated when taken by mouth, but the most common side effects are stomach discomfort — abdominal pain, nausea, vomiting, diarrhea, and gas. Rarely, very high blood potassium levels can cause serious heart rhythm problems, low blood pressure, and confusion.

People with kidney disease are at higher risk because their kidneys can't clear excess potassium the way healthy kidneys do. During pregnancy, potassium from food is fine, but supplements should only be used under medical guidance.

The same applies to breastfeeding — check with your doctor before using a supplement while nursing. If you have kidney problems, heart disease, or take any medications that affect potassium, talk with your doctor or pharmacist before starting this product.

Side effects, ingredient by ingredient Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Potassium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 62 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check your medications for potassium-sparing diuretics (like spironolactone), ACE inhibitors (like lisinopril or enalapril), and angiotensin receptor blockers (like losartan or valsartan). All three carry a Moderate risk of dangerously high blood potassium when combined with a potassium supplement.

Use the medication search tool on this page to confirm your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Potassium Gluconate is for people whose doctor has identified a need to boost potassium intake beyond diet. If you take a water pill, blood-pressure medication (especially an ACE inhibitor or ARB), or have kidney problems, you absolutely need to check with your doctor or pharmacist before adding this supplement — high blood potassium can be dangerous.

Make the medication checker on this page your first stop.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Potassium Gluconate, straight from the product label.

Brand Origin
Barcode (UPC) 756880010065
Net contents 250 Caplet(s); 595 mg
Market status On market
Date entered into DSLD Aug 24, 2012
DSLD ID 12309
Product type Mineral
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Potassium Gluconate by Origin, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
1 Caplet(s)
UPC/BARCODE
756880010065
IngredientAmount% DV
Potassium99 mg3%
from 595 mg Potassium Gluconate595 mg--

Other ingredients: Crospovidone, Stearic Acid, Silica, Cellulose Coating, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

WARNING: Pregnant or lactating women should consult a doctor before using any product.

Do not exceed recommended dose. Excessive intake may cause adverse reactions.

NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18.

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN.

Consult your doctor before use if you have, or have had, ANY HEALTH CONDITION or if you are taking ANY MEDICATIONS OR REMEDIES including OTC medications, or are planning any medical procedure.

Discontinue use and consult your doctor if any adverse reactions occur, such as gastrointestinal discomfort.

General Statements

Potassium is a major mineral needed for well-being.* As an essential nutrient, Potassium is important for muscle and nerve health and works with sodium to promote fluid balance in the body.*

ACTUAL SIZE

CHELATED VALUE SIZE

SUPPORTS FLUID BALANCE*

Made in U.S.A.

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) caplet daily, preferably with a meal. As a reminder, discuss the supplements and medications you take with your health care providers.

General

PROD. NO 1006 B1111 03A 094 02 1293 TD272456V

FDA Statement of Identity

DIETARY SUPPLEMENT

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

STORE IN A DRY PLACE AND AVOID EXCESSIVE HEAT.

Brand IP Statement(s)

(C) 2005 Target Brands, Inc. All Rights Reserved.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Potassium Gluconate by Origin label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Potassium Gluconate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Potassium Gluconate by Origin

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Potassium

Interacts with
62 drugs
99 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Other (inactive) ingredients: Crospovidone, Stearic Acid, Silica, Cellulose Coating, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Potassium Gluconate by Origin Drug Interactions

Want to check YOUR meds against Potassium Gluconate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
62Drugs
62 Moderate

Ingredients driving the most interactions

Potassium 62

Individual Drug Interactions

The ingredients in Potassium Gluconate interact with 62 drugs. Click any drug to see the details.

1 of the 1 ingredient in Potassium Gluconate interact with drugs. Each result below shows which ingredient is responsible. Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Potassium Gluconate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Potassium Gluconate, from the product label.

Origin

See all Origin products
Name
Target Corporation
City
Minneapolis
State
MN
ZipCode
55403
Pharmacist Counseling Corner

Potassium Gluconate by Origin: Common Questions

Does Potassium Gluconate by Origin interact with any medications?
Yes. Based on its ingredients, Potassium Gluconate has a known interaction with 62 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Potassium Gluconate contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's in potassium gluconate? Is it just potassium?
Yes — the active ingredient is potassium supplied as 595 mg of potassium gluconate. The rest are inactive fillers like cellulose and silica that help form the tablet.
Can I take this while pregnant or breastfeeding?
Potassium from your diet is fine. For supplements during pregnancy or breastfeeding, check with your doctor first — they'll tell you whether you need one and at what dose, based on your individual situation.
What side effects might I notice?
Most common are stomach symptoms: belly pain, nausea, vomiting, diarrhea, or gas. Serious side effects like heart rhythm problems are rare but happen when blood potassium gets too high, especially if you have kidney problems.
Is this safe if I have kidney disease?
No, not without your doctor's say-so. People with kidney disease can't clear excess potassium the way healthy kidneys do, so this supplement can raise your blood potassium to dangerous levels. Definitely talk with your doctor before using it.
Why do I need to check my blood pressure medications?
Medications like ACE inhibitors and ARBs already reduce how much potassium your kidneys clear. Adding a potassium supplement on top raises your blood potassium too high. Your doctor or pharmacist needs to know before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Potassium Gluconate is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Potassium Gluconate label
Go deeper

The Full Monographs Behind Potassium Gluconate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

Potassium Gluconate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team