Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Pregnenolone Drops Ingredients & Drug Interactions

by Energetix

Pregnenolone Drops label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone Drops against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone Drops is a dietary supplement by Energetix with 3 active ingredients. Its ingredients are commonly taken for high cholesterol, vitamin b3 deficiency (pellagra), heart health support.Based on those ingredients, 1,221 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dehydroepiandrosterone, Vitamin B3, Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pregnenolone Drops by Energetix

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone Drops by Energetix — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone Drops by Energetix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Pregnenolone Drops contains three active ingredients: vitamin B3 (niacin), DHEA (dehydroepiandrosterone), and pregnenolone. Vitamin B3 is a B vitamin essential for energy and cellular function.

DHEA and pregnenolone are both hormonal precursors—molecules your body can convert into other steroid hormones like estrogen, testosterone, and progesterone. The product is delivered as a liquid suspension in a base of glycerin, deionized water, soy lecithin, and castor oil, with added cranberry flavor, stevia, potassium sorbate as a preservative, zinc gluconate, mixed tocopherols, and trace minerals as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: hormonal support.
  • We looked for evidence on: Adrenal insufficiency, Partial androgen deficiency, Menopausal symptoms, Vaginal atrophy, Sexual dysfunction, DHEA deficiency — and 1 related terms.
  • The strongest evidence on file: Dhea is rated "Likely Effective" for Vaginal atrophy (Natural Medicines).
  • Also on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms.
  • Also on file: Dhea is rated "Insufficient Reliable Evidence To Rate" for Adrenal insufficiency, Sexual dysfunction, Menopausal symptoms, Partial androgen deficiency.

Vitamin B3 is likely effective for pellagra (a niacin-deficiency disease) and possibly effective for HIV/AIDS-related dyslipidemia and metabolic syndrome. DHEA is likely effective for vaginal atrophy and possibly effective for infertility, aging skin, and depression.

Pregnenolone, however, has insufficient reliable evidence in our data for the conditions listed—including Alzheimer's disease, autism spectrum disorder, back pain, alcohol use disorder, and bipolar disorder. If you're considering this product for a specific condition, check with your own doctor or pharmacist about what the research actually shows for your situation.

The evidence, ingredient by ingredient Niacin Dhea Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B3 in normal dietary amounts is safe, but high supplemental doses can cause flushing (affecting up to 70% of users at higher doses), stomach upset, and in rare cases liver injury, muscle damage, low blood platelet counts, or vision changes. DHEA is generally well tolerated short-term at typical doses, but long-term use raises theoretical concerns about cancer risk.

Common side effects include acne, headache, sleep problems, mood changes, and in women, deepening voice, increased facial hair, and irregular periods. Pregnenolone is generally well tolerated but has limited human safety data; reported effects include acne, agitation, diarrhea, drowsiness, hair loss, and mood changes.

Pregnancy and breastfeeding: the safety data advises against DHEA and pregnenolone during pregnancy; vitamin B3 at normal and prenatal vitamin doses is likely safe, but high-dose niacin should be avoided unless prescribed. For breastfeeding, there is not enough safety information on DHEA and pregnenolone—talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Niacin Dhea Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Pregnenolone, Dhea, Niacin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,222 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check whether you use blood thinners or antiplatelet drugs (moderate risk of bleeding), antidepressants (moderate psychiatric risk from DHEA), blood pressure medications (moderate risk of very low blood pressure from vitamin B3), diabetes drugs (moderate risk of raised blood sugar from vitamin B3), cholesterol or statin drugs (moderate muscle-damage risk from vitamin B3), cancer medications including aromatase inhibitors, tamoxifen, or fulvestrant (moderate loss of effectiveness from DHEA and pregnenolone), benzodiazepines or sedatives (moderate reduced sedation from pregnenolone), or any hormone-based contraceptives or hormone therapy (effects may be enhanced by pregnenolone and DHEA). Also check if you take the sleep medication triazolam, gout medications, liver-damaging drugs, or bile acid sequestrants.

Discuss your full medication list with your own doctor or pharmacist before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines a B vitamin with two hormone-like compounds and carries moderate interactions with blood thinners, diabetes drugs, blood pressure meds, cancer medications, antidepressants, benzodiazepines, and several others. It's not suitable during pregnancy, and long-term safety—especially with DHEA—isn't fully established.

If you take any prescription medication, check it against this product's interactions before starting, and discuss with your own doctor or pharmacist whether it's appropriate for your health and goals.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone Drops, straight from the product label.

Brand Energetix
Barcode (UPC) 364578100303
Net contents 2 fl. Oz.; 59.1 mL
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 22933
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone Drops by Energetix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
59
UPC/BARCODE
364578100303
IngredientAmount% DV
Vitamin B34 mg20%
Dehydroepiandrosterone0.75 mg--
Pregnenolone15 mg--

Other ingredients: Glycerin, deionized Water, Soy Lecithin, Castor Oil, natural Cranberry flavor, Mixed Tocopherols, Stevia rebaudiana extract, Potassium Sorbate, Zinc Gluconate, Trace Minerals

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

10080138 {recycle} Please recycle

- The Energetic Difference -

Liquid Form for Optimal Assimilation

HORMONAL SUPPORT

Formulation

Gluten-free.

Suggested/Recommended/Usage/Directions

Take 1 mL (about 30 drops) orally twice daily, or as directed by your healthcare professional. Shake well.

Formula

Dietary Supplement

Precautions

Tamper-proof. Do not use if safety seal is broken or missing.

Keep out of reach of children.

Storage

Store in cool, dry place out of direct sunlight.

General

r08-09

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone Drops by Energetix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone Drops label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone Drops by Energetix

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container59 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B3

Interacts with
727 drugs
4 mg per serving Form: Niacinamide

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Vitamin B3 monograph & interactions

Dehydroepiandrosterone

Interacts with
776 drugs
0.75 mg per serving

DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits. The evidence is mixed...

Dehydroepiandrosterone monograph & interactions

Pregnenolone

Interacts with
82 drugs
15 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Glycerin, Deionized Water, Soy Lecithin, Castor Oil, Natural Cranberry flavor, Mixed Tocopherols, Stevia rebaudiana extract, Potassium Sorbate, Zinc Gluconate, Trace Minerals. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone Drops by Energetix Drug Interactions

Want to check YOUR meds against Pregnenolone Drops?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,221Drugs
1,221 Moderate

Ingredients driving the most interactions

Dehydroepiandrosterone 776
Vitamin B3 727
Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone Drops interact with 1,221 drugs. Click any drug to see the details.

3 of the 3 ingredients in Pregnenolone Drops interact with drugs. Each result below shows which ingredient is responsible. Dehydroepiandrosterone Vitamin B3 Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone Drops with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dehydroepiandrosterone10 drug types · 776 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Human and laboratory research show that DHEA and DHEA-S can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, DHEA might increase the risk of psychiatric adverse events when used with antidepressants.
In a human case report, the use of a selective serotonin reuptake inhibitor (SSRI) with DHEA caused a manic episode. Concern for this interaction may be greater in younger individuals with higher baseline DHEA levels.

Likelihood Possible Evidence D
Aromatase Inhibitors

Theoretically, DHEA might interfere with the clinical effects of aromatase inhibitors.
DHEA is a potent estrogen agonist, which may antagonize the anti-estrogen activity of aromatase inhibitors.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Some preliminary evidence shows that DHEA may inhibit CYP3A4; however, the clinical significance of this potential interaction is not known.

Likelihood Possible Evidence D
Fulvestrant (Faslodex)

Theoretically, DHEA might interfere with the anti-estrogen effects of fulvestrant.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist action of fulvestrant in estrogen-receptor positive cancer cells.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, DHEA might interfere with the anti-estrogen effects of tamoxifen.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist activity of tamoxifen in estrogen-receptor positive cancer cells.

Likelihood Possible Evidence D
Triazolam (Halcion)

DHEA can increase blood levels of triazolam.
Administration of DHEA 200 mg daily for two weeks was shown to inhibit the cytochrome P450 3A4 (CYP3A4) metabolism of triazolam. This inhibition appears to be due to DHEA-S, rather than DHEA.

Likelihood Probable Evidence D
Tuberculosis Vaccine

DHEA might reduce the effectiveness of the tuberculosis vaccine.
Animal research shows that high doses of DHEA can reduce the efficacy of the Bacillus Calmette-Guérin (BCG) tuberculosis vaccine.

Likelihood Possible Evidence D
Estrogens

Theoretically, DHEA might increase the effects and adverse effects of estrogen therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. Also, in clinical research, estrogen-progestin oral contraceptives and conjugated estrogens reduce blood levels of DHEA and DHEA-S. The clinical significance of these findings is unclear.

Likelihood Possible Evidence D
Testosterone

Theoretically, DHEA might increase the effects and side effects of testosterone therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. The clinical significance of these findings is unclear.

Likelihood Possible Evidence D
Dehydroepiandrosterone full monograph & interactions

Vitamin B315 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
Vitamin B3 full monograph & interactions

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone Drops, from the product label.

Energetix

See all Energetix products
Name
Energetix
Street Address
209 W. Deerfield Lane
City
Dahlonega
State
GA
ZipCode
30533
Pharmacist Counseling Corner

Pregnenolone Drops by Energetix: Common Questions

Does Pregnenolone Drops by Energetix interact with any medications?
Yes. Based on its ingredients, Pregnenolone Drops has a known interaction with 1,221 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone Drops contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No—the safety data advises against DHEA and pregnenolone during pregnancy, and there isn't enough information to know whether DHEA and pregnenolone are safe while breastfeeding. Vitamin B3 at normal dietary and prenatal vitamin doses is considered likely safe, but high-dose niacin should be avoided unless your doctor prescribes it. Talk with your own doctor or pharmacist before use if you're pregnant or nursing.
What's the flushing I've heard about with niacin?
Flushing—a warm, tingling sensation on the face and upper body—is a common side effect of niacin, occurring in up to 70% of users at higher doses. It's caused by blood vessel dilation and may include burning, redness, itching, or hives. The effect usually fades within two weeks of regular use, and taking niacin with food may help reduce it.
Is DHEA safe for long-term use?
DHEA is generally well tolerated short-term at typical doses, but there is some concern that long-term oral use may be linked to a greater cancer risk. Common side effects include acne, headache, sleep problems, mood changes, and in women, deepening voice and increased facial hair. Use only under guidance from a healthcare professional.
What does pregnenolone do?
Pregnenolone is a hormone precursor—your body can convert it into other steroid hormones like estrogen, testosterone, and progesterone. In our data, evidence for most conditions is insufficient. If you're taking it for a specific health goal, check with your doctor or pharmacist about whether research supports that use.
Can I take this with my blood pressure or diabetes medication?
Not without checking first. Vitamin B3 in this product may lower blood pressure further (raising hypotension risk) and may raise blood sugar, reducing diabetes medication effectiveness. Run your exact medications through the interaction checker on this page, and talk with your own doctor or pharmacist before starting.
What are the inactive ingredients?
The liquid base contains glycerin, deionized water, soy lecithin, and castor oil. Added for flavor, preservation, and nutrition are cranberry flavor, stevia, potassium sorbate, zinc gluconate, mixed tocopherols, and trace minerals. If you have soy or other allergies, check this list carefully.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone Drops label
Go deeper

The Full Monographs Behind Pregnenolone Drops’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph → Herb & supplement monograph

Dhea

Interacts with 776 drugs

DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits. The evidence is mixed and limited for most uses, and because...

Read the full Dhea monograph → Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone Drops's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 170 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Niacin 66 references
  1. Garg R, Malinow MR, Pettinger M, et al. Niacin treatment increases plasma homocysteine levels. Am Heart J 1999;138:1082-7.
  2. Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
  3. Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol 1987;2:10-32. PubMed
  4. Guyton JR, Blazing MA, Hagar J, et al. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group. Arch Intern Med 2000;160:1177-84. PubMed
  5. Gibbons LW, Gonzalez V, Gordon N, Grundy S. The prevalence of side effects with regular and sustained-release nicotinic acid. Am J Med 1995;99:378-85. PubMed
  6. Whelan AM, Price SO, Fowler SF, Hainer BL. The effect of aspirin on niacin-induced cutaneous reactions. J Fam Pract 1992;34:165-8.
  7. Jungnickel PW, Maloley PA, Vander Tuin EL, et al. Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions. J Gen Intern Med 1997;12:591-6. PubMed
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See these in context on the Niacin monograph →

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Pregnenolone 6 references
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See these in context on the Pregnenolone monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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