Premier Protease Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Premier Protease against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Premier Protease is a dietary supplement by Premier Research Labs with 1 active ingredient. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Premier Protease by Premier Research Labs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Premier Protease contains one active ingredient: protease, a proteolytic enzyme that breaks down proteins. The other ingredients are the inactive excipients mineralized red algae, potato dextrin, and the vegetable capsule itself.
Does it work?
Couldn't assess
The evidence we hold does not establish an effectiveness rating for protease in this product.
How safe is it?
Well-documented data
Protease is generally well tolerated for most adults, though digestive upset or allergic reactions are possible. Safety has not been established in pregnancy, so it's best avoided during pregnancy unless your doctor prescribes it.
During breastfeeding, there is little safety data, and medical advice is recommended before use. Rarely, people exposed to proteolytic enzymes occupationally have developed allergic responses — including allergic rhinoconjunctivitis or asthma — though this typically occurs with airborne exposure in industrial settings rather than with oral supplements.
Meds to double-check
No known interactions
No interactions are documented in our data for protease. Still, check your exact medications with the search tool on this page or confirm with your own doctor or pharmacist before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Premier Protease is a single-ingredient protease supplement that is generally well tolerated in adults. If you're pregnant, breastfeeding, or have a history of allergies to enzymes, talk it over with your doctor or pharmacist first.
Check any medications you take with the search tool here or confirm with your own healthcare provider before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Premier Protease, straight from the product label.
| Brand | Premier Research Labs |
|---|---|
| Barcode (UPC) | 807735029463 |
| Net contents | 60 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 22, 2020 |
| DSLD ID | 219175 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Premier Protease by Premier Research Labs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Protease | 438 mg | -- |
Other ingredients: mineralized Red Algae, Potato Dextrin, Vegetable Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use. Take 1 capsule, 2 times daily, preferably between meals, or as directed by a health professional.
Formula
This formula features a highly concentrated form of protease vegan enzymes which promote the breakdown of protein
Highly purified protease vegan enzymes made with a proprietary fermentation process, yielding fully active vegan enzymes.
Formulation
This formula features a highly concentrated form of protease vegan enzymes which promote the breakdown of protein
They are active over a wide pH range (about 3.5-8.5) and promote and the body's natural digestive process.
Premier protein digestive support
PRL's quality guarantee
Pure vegan
No added magnesium stearate
Potency verified Purity verified Forensic tested for adulterants No chemical or radiation sterilization Pathogen microbiology performed Heavy metal tested FDA-monitored cGMP facility
Hemoglobin Units on the Tyrosine base
Highly purified protease vegan enzymes made with a proprietary fermentation process, yielding fully active vegan enzymes.
PRL's quality program. Manufactured to avoid: added magnesium stearate (an undesirable exipient), artificial colors, artificial flavors or artificial preservatives
Precautions
Tamper Seal: Use only if inner seal is intact.
Consult your health care practitioner if you are nursing/lactating, taking medication or have a medical condition, before taking this or any other product.
Keep out of reach of children.
Manufactured in a cGMP compliant facility for superior quality assurance
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
A Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Premier Protease by Premier Research Labs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Premier Protease by Premier Research Labs
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsOther (inactive) ingredients: Mineralized Red Algae, Potato Dextrin, Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.
Premier Protease by Premier Research Labs Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Premier Protease. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Premier Protease, from the product label.
Premier Research Labs
See all Premier Research Labs products- Name
- Premier Research Labs, LP
- Street Address
- 3500-B Wadley Place
- City
- Austin
- State
- Texas
- ZipCode
- 78728
Premier Protease by Premier Research Labs: Common Questions
Does Premier Protease by Premier Research Labs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is protease and what does it do?
Can I take Premier Protease if I'm pregnant?
Is it safe to use while breastfeeding?
What side effects might I experience?
Does it interact with any medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Premier Protease is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Premier Protease’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Premier Protease's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC