Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Premium Bee Pollen 1000 Plus Complex Ingredients & Drug Interactions

by American Health

Premium Bee Pollen 1000 Plus Complex label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Premium Bee Pollen 1000 Plus Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Premium Bee Pollen 1000 Plus Complex is a dietary supplement by American Health with 3 active ingredients. Its ingredients are commonly taken for cold sores and herpes lesions (topical), sore throat and mouth sores, wound and skin healing.Based on those ingredients, 1,036 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bee Propolis, Royal Jelly, Bee Pollen. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Premium Bee Pollen 1000 Plus Complex by American Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Premium Bee Pollen 1000 Plus Complex by American Health — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Premium Bee Pollen 1000 Plus Complex by American Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 3 active ingredients: bee propolis, bee pollen, and royal jelly — all harvested from the hive. Propolis is a resinous mixture bees use to seal their hives; bee pollen is the pollen they collect and pack into granules; and royal jelly is a nutrient-rich secretion they feed to their larvae.

The inactive ingredients are vegetable cellulose (the capsule), dicalcium phosphate, stearic acid, crospovidone, silica, and vegetable magnesium stearate — common binders and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: General energy, vitality, and immune support.
  • We looked for evidence on: Athletic performance, Cancer-related fatigue, Chemotherapy-related fatigue, Common cold, Malnutrition, Muscle fatigue — and 4 related terms.
  • The closest evidence on file: Bee Pollen is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Royal Jelly is rated "Possibly Ineffective" for Physical performance.
  • Also on file: Propolis is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Common cold, Muscle fatigue, Upper respiratory tract infection (URTI), and more.

The evidence for these ingredients is mixed and often thin. Bee propolis is possibly effective for oral mucositis (mouth sores) and cold sores (herpes labialis), and possibly effective for diabetes — though data on that last one is limited.

Bee pollen shows insufficient evidence for most uses we have on file; the one rating we hold is possibly ineffective for athletic performance, allergic rhinitis, and diabetes. Royal jelly is possibly effective for menopausal symptoms but possibly ineffective for allergic rhinitis, physical performance, and diabetes.

For several other conditions listed in our data (dengue fever for propolis; amenorrhea, benign prostatic hyperplasia, and breast cancer hot flashes for bee pollen; androgenic alopecia for royal jelly), the evidence is too sparse to rate either way.

The evidence, ingredient by ingredient Propolis Bee Pollen Royal Jelly

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

All three ingredients are generally well tolerated by most people when taken by mouth, but allergic reactions — sometimes severe — are possible, especially in anyone sensitive to bee products. The most common side effect reported is headache with propolis (about 7% in one trial at higher doses).

Serious but rare reactions include anaphylaxis and severe allergic swelling. Royal jelly poses higher allergic risk in people with a history of asthma or atopy (a tendency toward allergies), with reports of life-threatening reactions in those groups.

Bee pollen carries rare risk of acute liver inflammation and kidney injury. All three ingredients should be avoided during pregnancy and breastfeeding because there isn't enough safety data to know either way — talk with your doctor or pharmacist before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Propolis Bee Pollen Royal Jelly

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Bee Pollen, Propolis, Royal Jelly.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 1,037 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your pharmacist if you take warfarin (Coumadin) or any blood thinner — the risk of bleeding is moderate and documented in case reports. Also flag blood-pressure-lowering drugs (from royal jelly), other blood thinners like aspirin or clopidogrel (Plavix), and any medications your liver processes, especially through the CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, or CYP2E1 pathways (bee propolis).

Your pharmacist can check your specific medications against these.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is built on traditional bee ingredients with some evidence backing propolis for mouth sores and cold sores. If you take warfarin, any other blood thinner, blood-pressure medication, or drugs processed through your liver, check with your pharmacist first — the interaction risks are real.

Anyone with a history of bee allergies or pollen sensitivities should steer clear. If you're pregnant or breastfeeding, there isn't enough safety data to be confident; talk it through with your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Premium Bee Pollen 1000 Plus Complex, straight from the product label.

Brand American Health
Barcode (UPC) 076630043908
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Jun 24, 2016
DSLD ID 60421
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Premium Bee Pollen 1000 Plus Complex by American Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
076630043908
IngredientAmount% DV
Bee Propolis10 mg--
Bee Pollen1000 mg--
Royal Jelly10 mg--

Other ingredients: Vegetable Cellulose, Dicalcium Phosphate, Stearic Acid, Crospovidone, Silica, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Bee Propolis is a by-product of Royal Jelly, the highly complex substance fed to queen bees. This superfood is a naturally rich source of bioflavonoids and includes trace vitamins, minerals, amino acids, proteins and carbohydrates. As a dietary supplement, Bee Pollen Complex supplies all three of the rare nutritional substances derived from bees in one convenient high-strength complex.

Visit www.AmericanHealthUS.com for our complete line of products

Harvested from the Hive

Discover the best that Mother Nature has to offer with Bee Pollen Complex.

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) tablet one or two times daily, preferably with meals.

Formulation

Vegetarian Formula

No Gluten, No Yeast, No Wheat, No Milk or Milk Derivatives, No Lactose, No Soy, No Egg, No Corn, No Grapefruit, No Sugar, No Starch, No Preservatives, No Artificial Color, No Artificial Flavor, No Sodium.

Seals/Symbols

LABORATORY TESTED GUARANTEED QUALITY

Brand IP Statement(s)

2015 American Health, Inc.

General

PROD. NO. 4390 B55374 09B

Formula

With bee pollen, propolis and royal jelly

It contains all of the goodness of Bee Pollen plus the beneficial properties of Bee Propolis and Royal Jelly.

FDA Statement of Identity

Dietary Supplement

Precautions

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Avoid this product if you are allergic to bees or bee products.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Premium Bee Pollen 1000 Plus Complex by American Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Premium Bee Pollen 1000 Plus Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Premium Bee Pollen 1000 Plus Complex by American Health

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bee Propolis

Interacts with
921 drugs
10 mg per serving

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...

Bee Propolis monograph & interactions

Bee Pollen

Interacts with
2 drugs
1000 mg per serving

Bee pollen is a nutrient-rich product collected by bees and marketed as a 'superfood' for energy and immune support, but solid human evidence for most...

Bee Pollen monograph & interactions

Royal Jelly

Interacts with
174 drugs
10 mg per serving

Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune su...

Royal Jelly monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Dicalcium Phosphate, Stearic Acid, Crospovidone, Silica, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Premium Bee Pollen 1000 Plus Complex by American Health Drug Interactions

Want to check YOUR meds against Premium Bee Pollen 1000 Plus Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,036Drugs
1,036 Moderate

Ingredients driving the most interactions

Bee Propolis 921
Royal Jelly 174
Bee Pollen 2

Individual Drug Interactions

The ingredients in Premium Bee Pollen 1000 Plus Complex interact with 1,036 drugs. Click any drug to see the details.

3 of the 3 ingredients in Premium Bee Pollen 1000 Plus Complex interact with drugs. Each result below shows which ingredient is responsible. Bee Propolis Royal Jelly Bee Pollen

Each ingredient & the kinds of drugs it affects

For each ingredient in Premium Bee Pollen 1000 Plus Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bee Propolis8 drug types · 921 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.

Likelihood Possible Evidence D
Bee Propolis full monograph & interactions

Royal Jelly2 drug types · 174 drugs

Antihypertensive Drugs

Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that royal jelly might lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Royal jelly might increase the risk of bleeding when taken with warfarin.
In one case, an 87-year-old male who was previously stabilized on warfarin developed hematuria and was found to have an INR of 7.29 after taking a royal jelly supplement for one week.

Likelihood Possible Evidence D
Royal Jelly full monograph & interactions

Bee Pollen1 drug type · 2 drugs

Warfarin (Coumadin)

There is some concern that bee pollen might interact with warfarin and increase the risk of bleeding.
In one case report, a patient on warfarin had a stable international normalized ratio (INR) of 1.9-3.3 for 9 months. The patient's INR was found to be 7.1 after starting bee pollen granules one teaspoon twice daily for approximately one month. The patient's warfarin dose was decreased by approximately 11% in order to return the INR to the therapeutic range while continuing the bee pollen supplement.

Likelihood Possible Evidence D
Bee Pollen full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Premium Bee Pollen 1000 Plus Complex, from the product label.

American Health

See all American Health products
Name
American Health, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
800-445-7137
Pharmacist Counseling Corner

Premium Bee Pollen 1000 Plus Complex by American Health: Common Questions

Does Premium Bee Pollen 1000 Plus Complex by American Health interact with any medications?
Yes. Based on its ingredients, Premium Bee Pollen 1000 Plus Complex has a known interaction with 1,036 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Premium Bee Pollen 1000 Plus Complex contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm allergic to pollen or bee products?
No — this product is made entirely from bee-derived ingredients. If you have a history of pollen allergies, bee allergies, or asthma, you're at higher risk for serious allergic reactions, including anaphylaxis. Talk with your pharmacist or doctor before considering it.
Can I take this while pregnant or breastfeeding?
The safety data for all three ingredients is too thin during pregnancy and breastfeeding. The recommendation is to avoid use. Talk with your doctor or pharmacist about whether it's right for you in your situation.
What is propolis actually used for in this product?
Bee propolis in this product is included for its possibly effective use in mouth sores (oral mucositis) and cold sores, and for possibly effective use in diabetes — though the evidence for diabetes is limited.
What side effects should I watch for?
Headache is the most common side effect, reported in a small number of trial participants taking propolis at higher doses. Serious but rare reactions include severe allergic swelling, breathing trouble, and anaphylaxis, especially in people with a history of asthma or allergies. Stop and seek medical help if you notice swelling, shortness of breath, or difficulty swallowing.
Does royal jelly actually boost energy or athletic performance?
The evidence doesn't support that. Royal jelly is rated possibly ineffective for athletic performance and physical performance in the data we hold.
I'm on blood pressure medicine — can I take this?
Royal jelly in this product carries a moderate interaction concern with blood-pressure-lowering drugs because animal research suggests it may lower blood pressure further. Check with your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Premium Bee Pollen 1000 Plus Complex is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Premium Bee Pollen 1000 Plus Complex label
Go deeper

The Full Monographs Behind Premium Bee Pollen 1000 Plus Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Propolis

Interacts with 921 drugs

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research suggests it may help with cold sores, mouth so...

Read the full Propolis monograph → Herb & supplement monograph

Bee Pollen

Interacts with 2 drugs

Bee pollen is a nutrient-rich product collected by bees and marketed as a 'superfood' for energy and immune support, but solid human evidence for most of these claims is lacking. It can caus...

Read the full Bee Pollen monograph → Herb & supplement monograph

Royal Jelly

Interacts with 174 drugs

Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune support, but solid human evidence is limit...

Read the full Royal Jelly monograph →
Sources

Sources & How We Checked

Premium Bee Pollen 1000 Plus Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 50 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Propolis 21 references
  1. Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
  2. Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
  3. Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
  4. Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
  5. Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
  6. Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
  7. Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
  8. Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
  9. Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
  10. Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
  11. Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
  12. Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
  13. Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
  14. Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
  15. Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
  16. Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
  17. Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
  18. D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
  19. Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
  20. Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
  21. Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed

See these in context on the Propolis monograph →

Bee Pollen 15 references
  1. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  4. Shad JA, Chinn CG, Brann OS. Acute hepatitis after ingestion of herbs. South Med J 1999;92:1095-7. PubMed
  5. Puente S, Iniguez A, Subirats M, et al. [Eosinophilic gastroenteritis caused by bee pollen sensitization]. Med Clin (Barc) 1997;108:698-700.
  6. Winther K, Hedman C. Assessment of the Effects of the Herbal Remedy Femal on the Symptoms of Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study. Curr Ther Res Clin Exp 2002;63:344-53. DOI
  7. Cohen SH, Yunginger JW, Rosenberg N, Fink JN. Acute allergic reaction after composite pollen ingestion. J Allergy Clin Immunol 1979;64:270-4. PubMed
  8. Hurren KM, Lewis CL. Probable interaction between warfarin and bee pollen. Am J Health Syst Pharm 2010;67:2034-7. PubMed
  9. Akiyasu T, Paudyal B, Paudyal P, et al. A case report of acute renal failure associated with bee pollen contained in nutritional supplements. Ther Apher Dial 2010;14:93-7. PubMed
  10. Greenberger, P. A. and Flais, M. J. Bee pollen-induced anaphylactic reaction in an unknowingly sensitized subject. Ann.Allergy Asthma Immunol 2001;86(2):239-242. PubMed
  11. Lin FL, Vaughan TR, Vandewalker ML, et al. Hypereosinophilia, neurologic, and gastrointestinal symptoms after bee-pollen ingestion. J Allergy Clin Immunol 1989;83(4):793-796. PubMed
  12. Mansfield LE, Goldstein GB. Anaphylactic reaction after ingestion of local bee pollen. Ann Allergy 1981;47(3):154-156.
  13. Choi JH, Jang YS, Oh JW, Kim CH, Hyun IG. Bee pollen-induced anaphylaxis: a case report and literature review. Allergy Asthma Immunol Res 2015 Sep;7(5):513-7. PubMed
  14. Nonotte-Varly C. Allergenicity of Artemisia contained in bee pollen is proportional to its mass. Eur Ann Allergy Clin Immunol 2015;47(6):218-24.
  15. Leang ZX, Thalayasingam M, O'Sullivan M. A paediatric case of exercise-augmented anaphylaxis following bee pollen ingestion in Western Australia. Asia Pac Allergy. 2022 Jul 12;12(3):e23. PubMed

See these in context on the Bee Pollen monograph →

Royal Jelly 14 references
  1. Takahashi M, Matsuo I, Ohkido M. Contact dermatitis due to honeybee royal jelly. Contact Dermatitis 1983;9:452-5.
  2. Bullock RJ, et al. Fatal royal jelly-induced asthma. Med J Aust 1994;160:44. DOI
  3. Thien FC, Leung R, Baldo BA, et al. Asthma and anaphylaxis induced by royal jelly. Clin Exp Allergy 1996;26:216-22. PubMed
  4. Yonei Y, Shibagaki K, Tsukada N, et al. Case report: haemorrhagic colitis associated with royal jelly intake. J Gastroenterol Hepatol 1997;12:495-9.
  5. Harwood M, Harding S, Beasley R, Frankish PD. Asthma following royal jelly. N Z Med J 1996;109:325.
  6. Laporte JR, Ibaanez L, Vendrell L, Ballarin E. Bronchospasm induced by royal jelly. Allergy 1996;51:440. DOI
  7. Leung R, Thien FC, Baldo B, et al. Royal jelly-induced asthma and anaphylaxis: clinical characteristics and immunologic correlations. J Allergy Clin Immunol 1995;96:1004-7. PubMed
  8. Peacock S, Murray V, Turton C. Respiratory distress and royal jelly. BMJ 1995;311:1472. DOI
  9. Winther K, Hedman C. Assessment of the Effects of the Herbal Remedy Femal on the Symptoms of Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study. Curr Ther Res Clin Exp 2002;63:344-53. DOI
  10. Lee NJ, Fermo JD. Warfarin and royal jelly interaction. Pharmacotherapy 2006;26:583-6. PubMed
  11. Tokunaga, K. H., Yoshida, C., Suzuki, K. M., Maruyama, H., Futamura, Y., Araki, Y., and Mishima, S. Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats. Biol.Pharm.Bull. 2004;27(2):189-192. PubMed
  12. Sultana, A., Nabi, A. H., Nasir, U. M., Maruyama, H., Suzuki, K. M., Mishima, S., and Suzuki, F. A dipeptide YY derived from royal jelly proteins inhibits renin activity. Int.J.Mol.Med. 2008;21(6):677-681. DOI
  13. Gómez Torrijos E, Méndez Diaz Y, Borja Segade JM, et al. Occupational allergic respiratory disease due to royal jelly. Ann Allergy Asthma Immunol. 2016;117(1):102-3. PubMed
  14. Li JD, Cui L, Xu YY, Guan K. A case of anaphylaxis caused by major royal jelly protein 3 of royal jelly and its cross-reactivity with honeycomb. J Asthma Allergy 2021;14:1555-7. PubMed

See these in context on the Royal Jelly monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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