Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Primal Probiotics Ingredients & Drug Interactions

by Primal Blueprint

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Primal Probiotics is a dietary supplement by Primal Blueprint with 4 active ingredients. Its ingredients are commonly taken for digestive and gut health, source of soluble fiber, constipation or bowel regularity.Based on those ingredients, 2,080 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Acacia Gum, Probiotic Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Primal Probiotics by Primal Blueprint

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Prebiotic Blend” is a proprietary blend — the label gives one combined amount (200 mg) without saying how much of each component you get.
  • “Probiotic Blend” is a proprietary blend — the label gives one combined amount (27 mg) without saying how much of each component you get.
  • “Total Probiotic Culture” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This product contains 7 active ingredients: acacia gum, a prebiotic blend, a probiotic blend, fructooligosaccharides (FOS), soluble tapioca fiber, and four specific probiotic strains — Bifidobacterium lactis (Bl-04), Lactobacillus paracasei (LPC-37), Lactobacillus acidophilus (NCFM), and Bifidobacterium animalis lactis (Bl-07). The prebiotics (acacia gum, FOS, and soluble tapioca fiber) feed your existing beneficial bacteria, while the probiotics add live beneficial microorganisms to your gut.

The inactive ingredients — microcrystalline cellulose, gelatin capsule, magnesium stearate, and silicon dioxide — are fillers and the capsule itself.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Common cold, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Gum Arabic is rated "Insufficient Reliable Evidence To Rate" for Irritable bowel syndrome (IBS).

The evidence for this product's individual ingredients is mixed. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), antibiotic-associated diarrhea, Helicobacter pylori infection, and bacterial vaginosis.

For acacia gum and fructooligosaccharides (FOS), the evidence for their intended uses — metabolic syndrome, kidney failure, obesity, and others — is insufficient to rate reliably based on the data we hold. We don't have effectiveness ratings on file for the other probiotic strains, soluble tapioca fiber, or the prebiotic and probiotic blends as whole ingredients.

The evidence, ingredient by ingredient Gum Arabic Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children, though you should check with your doctor before starting it. Acacia gum is recognized as safe as a food additive but can cause digestive upset at higher doses.

The most common side effects are abdominal bloating, flatulence, and mild diarrhea — these occurred in a notable number of trial participants but may subside within 2 weeks of continued use. Fructooligosaccharides (FOS) are generally well tolerated but commonly cause gas and bloating, especially at higher doses.

Rare but serious infections have been reported with L. acidophilus in immunocompromised patients, though this is uncommon. For pregnancy and lactation, the safety data for acacia gum and FOS at supplement doses is limited — talk with your doctor about whether this product is right for you during those periods.

Side effects, ingredient by ingredient Gum Arabic Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Gum Arabic, Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 2,081 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on antibiotics (including amoxicillin) — they can reduce how well this probiotic works and may affect how your antibiotic is absorbed. You should also review any other oral medications you're taking, since the acacia gum fiber may alter their absorption.

Altogether, these interactions span 2,081 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with specific gut issues like irritable bowel syndrome or antibiotic-associated diarrhea, especially for the L. acidophilus component. If you take antibiotics or amoxicillin, you'll need to time this product carefully to avoid reducing its effects or interfering with your medication absorption.

Gas, bloating, and mild digestive upset are common starting effects but often improve within a couple of weeks. Check with your own doctor or pharmacist before starting, especially if you're on any medications or have a weakened immune system.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Primal Probiotics, straight from the product label.

Brand Primal Blueprint
Barcode (UPC) 855232007798
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 249674
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Primal Probiotics by Primal Blueprint, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
855232007798
IngredientAmount% DV
Acacia Gum0 NP--
Prebiotic Blend200 mg--
Probiotic Blend27 mg--
Fructooligosaccharides0 NP--
soluble Tapioca Fiber0 NP--
Bifidobacterium lactis (Bl-04)0 NP--
Lactobacillus paracasei (LPC-37)0 NP--
Lactobacillus acidophilus (NCFM)0 NP--
Bifidobacterium animalis lactis (Bl-07)0 NP--
Total Probiotic Culture0 NP--

Other ingredients: Microcrystalline Cellulose, Gelatin Capsule, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Digestive & immune support

Primal Probiotics provide a unique blend of four research-proven probiotics that support the digestive and immune systems.

FDA Statement of Identity

Dietary Supplement

Formula

4 Probiotic strains 10 Billion CFU per capsule 200 mg Prebiotics

Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule per day before or during meals.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place away from direct sunlight

See for yourself

Primal Probiotics by Primal Blueprint label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Primal Probiotics by Primal Blueprint

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Prebiotic Blend

200 mg per serving

Probiotic Blend

Interacts with
182 drugs
27 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Blend monograph & interactions
  • › Total Probiotic Culture

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin Capsule, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Primal Probiotics by Primal Blueprint Drug Interactions

Want to check YOUR meds against Primal Probiotics?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
2,080Drugs
2,080 Moderate

Ingredients driving the most interactions

Acacia Gum 2,022

Each ingredient & the kinds of drugs it affects

For each ingredient in Primal Probiotics with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Acacia Gum2 drug types · 2,022 drugs

Amoxicillin (Amoxil, Trimox)

Gum arabic can reduce the absorption of amoxicillin.
A small study in healthy volunteers shows that taking amoxicillin and gum arabic concurrently significantly reduces the absorption of amoxicillin. Separate doses of amoxicillin from gum arabic by at least 2 hours.

Likelihood Probable Evidence B
Oral Drugs

Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Gum arabic has been used as a suspending osmotic agent in drug formulations. It might improve bioavailability of water-insoluble drugs like naproxen, but reduce absorption of polar drugs like amoxicillin. To avoid changes in absorption, take gum arabic 30-60 minutes after oral medications.

Likelihood Possible Evidence B

Probiotic Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Primal Probiotics, from the product label.

Primal Blueprint

See all Primal Blueprint products
Name
Primal Nutrition, LLC
City
Oxnard
State
CA
ZipCode
93033
Phone Number
1-888-774-6259
Web Address
primalblueprint.com
Pharmacist Counseling Corner

Primal Probiotics by Primal Blueprint: Common Questions

Does Primal Probiotics by Primal Blueprint interact with any medications?
Yes. Based on its ingredients, Primal Probiotics has a known interaction with 2,080 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Primal Probiotics contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm taking antibiotics?
Not as well as it should. Antibiotics kill the live beneficial bacteria in probiotics, which reduces their effectiveness. Separate your doses by a few hours if possible, and ask your doctor or pharmacist how to time them best for your specific medications.
What side effects should I expect?
Gas, bloating, abdominal discomfort, and mild diarrhea are common, especially when you first start taking it. These usually improve within 2 weeks as your gut adjusts. If symptoms persist or worsen, talk with your pharmacist.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data on the acacia gum and fructooligosaccharides at supplement doses during pregnancy and lactation. Talk with your doctor about whether this product is right for you during those times.
What do the prebiotic ingredients do?
The acacia gum, fructooligosaccharides, and soluble tapioca fiber feed your existing beneficial gut bacteria so they can grow and thrive. They work alongside the live probiotic strains to support your digestive health.
Does this help with IBS or diarrhea?
The Lactobacillus acidophilus in this product is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, and some other digestive issues. The evidence for the other ingredients is less established, so results vary by person — your doctor can help you figure out if it's likely to help your specific condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Primal Probiotics is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Primal Probiotics label
Sources

Sources & How We Checked

Primal Probiotics's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gum Arabic 8 references
  1. Jensen CD, Spiller GA, Gates JE, et al. The effect of acacia gum and a water-soluble dietary fiber mixture on blood lipids in humans. J Am Coll Nutr 1993;12:147-54. PubMed
  2. Eltayeb IB, Awad AI, Elderbi MA, Shadad SA. Effect of gum arabic on the absorption of a single oral dose of amoxicillin in healthy Sudanese volunteers. J Antimicrob Chemother 2004;54:577-8. PubMed
  3. Babiker R, Merghani TH, Elmusharaf K, et al. Effects of gum Arabic ingestion on body mass index and body fat percentage in healthy adult females: two-arm randomized, placebo controlled, double-blind trial. Nutr J 2012;11:111. PubMed
  4. Babiker R, Elmusharaf K, Keogh MB, Banaga AS, Saeed AM. Metabolic effect of gum Arabic (Acacia senegal) in patients with type 2 diabetes mellitus (T2DM): randomized, placebo controlled double blind trial. Functional Foods in Health and Disease. 2017;7(3): DOI
  5. Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules. 2009;14(7):2602-20. PubMed
  6. Ali NE, Kaddam LA, Alkarib SY, et al. Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial. Int J Nephrol. 2020;2020:7214673.
  7. Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of acacia gum (E 414) as a food additive. EFSA J. 2017;15(4):e04741. PubMed
  8. Larson R, Nelson C, Korczak R, et al. Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects. Nutrients 2021;13(2):618. PubMed

See these in context on the Gum Arabic monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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