Major interaction on record — check this product against your medications before combining. Based on 6 of 15 ingredients. Check your meds →
Dietary supplement

Amplified Wheybolic Extreme 60 Power Strawberry Ingredients & Drug Interactions

by GNC Pro Performance AMP

Amplified Wheybolic Extreme 60 Power Strawberry label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Amplified Wheybolic Extreme 60 Power Strawberry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Amplified Wheybolic Extreme 60 Power Strawberry is a dietary supplement by GNC Pro Performance AMP with 15 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 565 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Testofen(R) Fenugreek extract, Sodium, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Amplified Wheybolic Extreme 60 Power Strawberry by GNC Pro Performance AMP

Ask about any prescription or over-the-counter medication and we check it for interactions with Amplified Wheybolic Extreme 60 Power Strawberry by GNC Pro Performance AMP — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Amplified Wheybolic Extreme 60 Power Strawberry by GNC Pro Performance AMP

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 10 of its 25 active ingredients.
  • “Amino Acid Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Amino Acceleration System” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Enzyme Matrix Blend” is a proprietary blend — the label gives one combined amount (239 mg) without saying how much of each component you get.

This powder contains 25 ingredients, with key actives being sodium, potassium, and calcium—minerals that support muscle and nerve function. It also includes digestive enzymes (bromelain, protease, lipase, lactase, and others) to help break down and absorb nutrients, plus creatine to support muscle strength and athletic performance, and fenugreek extract (Testofen) traditionally used for sexual function and blood sugar support.

The blend is rounded out with amino acids and an amino acid acceleration system designed to aid protein utilization. The remaining ingredients are inactive (fillers, binders, and flavorings like dicalcium phosphate, lecithin, citric acid, and sucralose).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle strength, size and recovery support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Muscle protein synthesis, Anabolic factors, Post-workout recovery.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Fenugreek is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

Evidence exists for a few of this product's ingredients. Calcium is effective for treating low blood calcium levels and likely effective for osteoporosis.

Creatine is possibly effective for building muscle strength and athletic performance. Fenugreek extract has possibly effective evidence for sexual function and possibly effective for type 2 diabetes.

Lactase is effective for lactose intolerance. For the other ingredients—sodium, potassium, bromelain, the various proteases, lipase, and several others—we don't have established effectiveness ratings in our data.

The product's overall effectiveness for muscle building or athletic performance depends largely on its amino acid and creatine content, but we hold no effectiveness ratings for the amino acid blend itself.

The evidence, ingredient by ingredient Sodium Potassium Calcium Glutamine Creatine Fenugreek

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 10 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is well tolerated at normal dietary amounts, but too much is linked to high blood pressure and heart strain. Potassium from food is fine, but supplements can cause dangerously high blood levels in people with kidney disease.

Calcium is generally safe at recommended doses. Bromelain is generally well tolerated short-term, though long-term data is limited.

Proteolytic enzymes (the various proteases) can sometimes trigger allergic reactions or digestive upset. Creatine is generally well tolerated in healthy adults but may cause water retention, muscle cramps, and digestive upset.

Fenugreek is generally well tolerated at food doses, though supplement amounts may cause abdominal pain, bloating, diarrhea, or allergic reactions including severe ones.

Side effects, ingredient by ingredient Sodium Potassium Calcium Glutamine Creatine Fenugreek

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 10 matched ingredients can interact with medications — Fenugreek, Calcium, Potassium, Glutamine, Bromelain, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 565 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check your medications in our tool if you take: HIV drugs (dolutegravir, elvitegravir), antibiotics (ceftriaxone), blood pressure medications (ACE inhibitors, ARBs, antihypertensives), blood thinners or antiplatelet drugs (warfarin, clopidogrel, aspirin), lithium, potassium-sparing diuretics, diabetes medications, corticosteroids, thyroid hormone (levothyroxine), or theophylline. These interactions range from moderate to major in severity.

If we couldn't check an ingredient with you, that's because we hold no data for it—not because it's safe.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product's high sodium and mineral content makes it important to check with your doctor or pharmacist before starting if you take blood pressure medications, lithium, or potassium-sparing diuretics. If you're HIV-positive on dolutegravir or elvitegravir, or if you take warfarin or other blood thinners, run your medications through the interaction checker below.

It's a workout supplement aimed at muscle building and recovery, so it's best suited for active adults without kidney disease or blood pressure conditions—but always confirm it's right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 13 of 25 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Amplified Wheybolic Extreme 60 Power Strawberry, straight from the product label.

Brand GNC Pro Performance AMP
Barcode (UPC) 048107137335
Net contents 46.5 oz.; 2.9 lbs; 1320 Gram(s)
Market status On market
Date entered into DSLD Aug 25, 2015
DSLD ID 49634
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Amplified Wheybolic Extreme 60 Power Strawberry by GNC Pro Performance AMP, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
29.3 Gram(s)
Maximum serving Sizes:
88 Gram(s)
Servings per container
15
UPC/BARCODE
048107137335
IngredientAmount% DV
Calories300 {Calories}, 200 {Calories}, 100 {Calories}--
Total Carbohydrates11 Gram(s), 7 Gram(s), 4 Gram(s)4%, 2%, 1%
Sugar4 Gram(s), 3 Gram(s), 1 Gram(s)--
Calories from Fat20 {Calories}, 15 {Calories}, 5 {Calories}--
Protein60 Gram(s), 40 Gram(s), 20 Gram(s)--
Saturated Fat1 Gram(s), 0.5 Gram(s), 0.5 Gram(s)5%, 3%, 2%
Sodium260 mg, 170 mg, 90 mg11%, 7%, 4%
Potassium360 mg, 240 mg, 120 mg10%, 7%, 3%
Cholesterol30 mg, 20 mg, 10 mg10%, 7%, 3%
Calcium650 mg, 430 mg, 220 mg65%, 43%, 22%
Total Fat2 Gram(s), 1.5 Gram(s), 0.5 Gram(s)3%, 2%, 1%
Amylase0 NP, 0 NP, 0 NP--
Bromelain0 NP, 0 NP, 0 NP--
Protease0 NP, 0 NP, 0 NP--
Lipase0 NP, 0 NP, 0 NP--
Lactase0 NP, 0 NP, 0 NP--
Peptidase0 NP, 0 NP, 0 NP--
Invertase0 NP, 0 NP, 0 NP--
Glucoamylase0 NP, 0 NP, 0 NP--
Alpha-Galactosidase0 NP, 0 NP, 0 NP--
Amino Acid Blend0 NP, 0 NP, 0 NP--
Protease 4.50 NP, 0 NP, 0 NP--
Protease 30 NP, 0 NP, 0 NP--
Protease 60 NP, 0 NP, 0 NP--
Carbogen0 NP, 0 NP, 0 NP--
Amino Acceleration System0 NP, 0 NP, 0 NP--
Enzyme Matrix Blend239 mg, 158 mg, 79 mg--
CereCalase0 NP, 0 NP, 0 NP--
Power Complex0 NP, 0 NP, 0 NP--
Creatine3 Gram(s), 2 Gram(s), 1 Gram(s)--
Testofen(R) Fenugreek extract600 mg, 400 mg, 200 mg--
Aminogen0 NP, 0 NP, 0 NP--
Leucine10 Gram(s), 6.66 Gram(s), 3.33 Gram(s)--
Isoleucine4 Gram(s), 2.66 Gram(s), 1.33 Gram(s)--
Valine4 Gram(s), 2.66 Gram(s), 1.33 Gram(s)--
Glutamine10.3 Gram(s), 6.86 Gram(s), 3.43 Gram(s)--
Arginine1.1 Gram(s), 733 mg, 366 mg--

Other ingredients: Protein Blend, Natural and Artificial flavors, Dicalcium Phosphate, Lecithin, nonfat dry Milk powder, Citric Acid, Gum Blend, Malic Acid, Sucralose, Beet powder, Salt, Acesulfame Potassium, Tartaric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

7 products in one AMP - Clinically Proven Ingredients Delivery More Size & Anabolic Power + 30% Increase in Muscle Strength

Clinically Researched Natural + Artificial Flavors

Significant product settling may occur.

In an eight-week randomized double-blind, placebo-controlled study of 30 healthy male volunteers comparing 1 set resistance training + active or carbohydrate placebo to 2 sets resistance training alone with no supplement, the active group showed equal gains in maximal muscle strength and muscle endurance compared to the control group. When used in conjunction with an exercise program. As with any food product, use of this product alone will not lead to increased muscle mass or strength. Per 3 scoop serving. Inclusion of these enzymes resulted in a 12% greater protein breakdown as measured by the release profile of the amino acid tyrosine. These results represent the enzyme activity potential under simulated conditions. Effects in the human body have not been studied.

Daily Power Recovery Strength

Typical Amino Acid Profile Per Serving Alanine 2913 mg Arginine 1223 mg Aspartate 6450 mg Cystine 1440 mg Glutamin & Glutamic Acid 10310 mg Glycine 982 mg Histidine 1095 mg Isoleucine 4007 mg Leucine 10088 mg Lysine 5194 mg Methionine 1218 mg Phenylalanine 1799 mg Proline 4023 mg Serine 2809 mg Threonine 4179 mg Tryptophan 1020 mg Tyrosine 1747 mg Valine 4003 mg Total 64500 mg Indicates Branched Chain Amino Acids (BCAA). Denotes naturally occurring and added free form amino acids.

This breakthrough formula takes protein functionality and performance to new levels so you can break through plateaus and achieve a new level of muscular power.

The full muscle building potential of a GNC product is based on its total nitrogen content - so the more nitrogen a product has, the stronger it will perform. Nitrogen needs increase during training, and if nitrogen levels are low, your body pulls from muscle stores which can result in catabolism, poor performance and longer recovery.

Now you can customize your dosing to meet your specific training goals and nutrient needs. Boost power and anabolism while improving muscle strength, stamina, size and recovery!

Products bearing this logo have been tested for banned substances by HFL Sport Science, a world-class anti-doping lab. Product was tested for over 145 banned substances on the 2014 World Anti-Doping Agency (WADA) Prohibited List via HFL skip lot testing protocol #ICP0307. See gnc.com for more information.

The athletes using this proprietary module of whey protein and leucine demonstrated an increased improvement in muscle strength and muscle size as compared to those performing the same exercise training regimen who did not consume the proprietary module. In a clinical study of participants using a unilateral lower limb resistance training protocol, even the untrained limb demonstrated increases in muscle size.*

{Chart} 30% Increase in muscle strength compared to placebo Whey + Luecine Group 30% Carb Placebo Group An 8-week study of athletes performing an intense resistance exercise training regimen demonstrated that those using this proprietary module if whey protein and leucine had greater increases in muscle strength and size than those on a placebo.

Formula

- 60g Whey Protein Isolate & Hydrolysate Formula + 18g BCAA for Improved Muscle Recovery & Growth - Features 600mg Testofen(R) Fenugreen to Support Testosterone Levels + 3g Creatine Blend to Boost Anabolic Factors in the Body

Contains: Milk and Soybeans.

This product is the only why protein isolate to combine the whey and leucine clinically shown to fuel increased strength and size with additional ingredients proven to amplify power and anabolism.

This formula features a protein blend that has been validated in clinical studies to give you a 30% increase in strength, increased muscle size and a 100% improvement in exercise efficiency. Our GNC scientists have AMPed up the protein with a Power Complex featuring an mTOR-stimulating BCAA blend for protein synthesis and added creatine to increase anabolic muscle growth, making this product a combination of 7 products in 1!

Power Complex In addition to 10 grams of leucine this formula is stacked with 4 grams of both isoleucine and valine to stimulate mTOR activation and give you a powerful boost of all three BCAA to fuel your workout and enhance your recovery. This product has upped the ante and added a 3 gram creatine blend to boost anabolic factors in the body, increase athletic performance and fuel strength + 600mg of Testofen(R) Fenugreek to help support testosterone levels in the body. Highly Effective Whey-Leucine Base The impressive 60 grams of protein is made entirely from two of the highest quality, fast-absorbing forms of whey protein, isolates and hydrolysates, including 10 grams of leucine to create an ideal environment for muscle protein synthesis. This potent blend delivers Arginine, which is involved in creatine synthesis, and over 10 grams of glutamine to provide anabolic effects. In fact, the whey and leucine blend in this product has been shown to increase muscle strength and stamina with half the sets.

Powerful Amino Acid System This product is loaded with arginine and glutamine, two key amino acids necessary for muscle building and recovery. Over 10 grams of glutamine helps to combat catabolism and support function, while arginine helps to support blood vessel tone and blood flow, and is involved in the production of creatine. Digestive Enzyme Blend for 12% Greater Protein Breakdown This digestive enzyme blend with proven bioactivity is designed to accelerate the availability and absorption of amino acids in muscles. This proprietary enzyme blend provides a 12% greater protein breakdown for improved uptake.

Who can benefit from taking Amplified Wheybolic Extreme 60(TM) Power? Whether you're a serious athlete, weekend warrior or training for a competition, you can benefit from this powerful formula.

30% Increase in Muscle Strength The unique protein blend includes an anabolic module of 20 grams of whey protein and 6.2 grams of leucine that was clinically tested in an 8-week study of athletes performing an intense resistance exercise training regimen.

Seals/Symbols

NITRO-FACTOR 71G(TM)

INFORMED-CHOICE {Check}.ORG Trusted by Sport

FDA Statement of Identity

Dietary Supplement

General

CODE 386370 LOG

Suggested/Recommended/Usage/Directions

Directions: Once per day as a dietary supplement, consume 1-3 scoops of GNC Pro Performance(R) AMP Amplified Wheybolic Extreme 60(TM) Power in 6, 8 or 12 oz of cold water respectively 30 minutes after your workout. On non-training days, consume one serving first thing in the morning. For extreme results, take the full 3 scoop serving twice per day, pre- and post-workout.

{Chart} Daily Dose Protein Power Complex Benefit 1 scoop 30 minutes post-workout or in the morning 20 g 7.19 g Helps meet protein needs & fuels metabolism 2 scoops 30 minutes post-workout or in the morning 40 g 14.38 g Fuels muscles, metabolism, supports recovery & muscle protein synthesis 3 scoops 30 minutes post-workout or in the morning 60 g 21.6 g Increase muscle size, anabolic factors, and power & strength by 30%

When Should I Take It? Once per day, consume 1-3 scoops of GNC Pro Performance(R) AMP Amplified Wheybolic Extreme 60(TM) Power 30 minutes after your workout. On non-training days, consume one serving first thing in the morning. For extreme results, take the full 3 scoop serving pre- and post-workout.

Stack with: Pro Performance(R) AMP Amplified Strength, Amplified Push and Amplified Recover PM.

Precautions

Contains: Milk and Soybeans.

Warning: For adults use only. Use only as directed.

Consult your physician prior to using this product if you are pregnant, nursing, under 18 years of age, taking medication, or have a medical condition.

Consult your physician prior to using this product if you are pregnant, nursing, under 18 years of age, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery. Notice: Use this product as a food supplement only. Do not use for weight reduction.

Keep out of reach of children.

Brand IP Statement(s)

Testofen(R) is a trademark of Gencor Nutrients, Inc. Aminogen(R) & Carbogen(R) are registered trademarks of Triarco Industries. Enzyme Matrix(TM) and CereCalase(R) are products of National Enzyme Company.

What is Amplified Wheybolic Extreme 60(TM) Power? GNC's most advanced protein, Amplified Wheybolic Extreme 60(TM), has evolved even further to help meet your specific training goals and develop more strength and power.

Amplified Wheybolic Extreme 60(TM) Power - Break Plateaus, Build Power

Nitro-Factor(TM) - Maximizing Muscle Building

Pro Performance(R) AMP Amplified Wheybolic Extreme 60 (TM) Power with a Nitro-Force(TM) of 71 grams helps fuel performance and anabolism.

Amplified Wheybolic Extreme 60(TM) Power Features 7 Products in 1! 1. Whey Protein Isolate 2. Amino Acid Complex 3. BCAA Complex 4. Leucine 5. Creatine 6. Fenugreek 7. Digestive Enzymes

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Amplified Wheybolic Extreme 60 Power Strawberry by GNC Pro Performance AMP label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Amplified Wheybolic Extreme 60 Power Strawberry label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Amplified Wheybolic Extreme 60 Power Strawberry by GNC Pro Performance AMP

These are the 15 active ingredients this product is made of. Select any to open its full monograph.

Serving size29.3 Gram(s) Dosage formPowder Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

4 Gram(s) per serving

Protein

60 Gram(s) per serving

Sodium

Interacts with
205 drugs
260 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
360 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Calcium

Interacts with
168 drugs
650 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Amino Acid Blend

0 NP per serving

Amino Acceleration System

0 NP per serving
  • › Carbogen
  • › Enzyme Matrix Blend
  • › Aminogen

Power Complex

0 NP per serving

Other (inactive) ingredients: Protein Blend, Natural and Artificial flavors, Dicalcium Phosphate, Lecithin, Nonfat dry Milk powder, Citric Acid, Gum Blend, Malic Acid, Sucralose, Beet powder, Salt, Acesulfame Potassium, Tartaric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Amplified Wheybolic Extreme 60 Power Strawberry by GNC Pro Performance AMP Drug Interactions

Want to check YOUR meds against Amplified Wheybolic Extreme 60 Power Strawberry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
565Drugs
7 Major 556 Moderate 2 Minor

Ingredients driving the most interactions

Testofen(R) Fenugreek extract 389
Sodium 205
Calcium 168
Potassium 62
Glutamine 50

Individual Drug Interactions

The ingredients in Amplified Wheybolic Extreme 60 Power Strawberry interact with 565 drugs. Click any drug to see the details.

5 of the 15 ingredients in Amplified Wheybolic Extreme 60 Power Strawberry interact with drugs. Each result below shows which ingredient is responsible. Testofen(R) Fenugreek extract Sodium Calcium Potassium Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Amplified Wheybolic Extreme 60 Power Strawberry with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Testofen(R) Fenugreek extract9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
Testofen(R) Fenugreek extract full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Amplified Wheybolic Extreme 60 Power Strawberry, from the product label.

GNC Pro Performance AMP

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Pharmacist Counseling Corner

Amplified Wheybolic Extreme 60 Power Strawberry by GNC Pro Performance AMP: Common Questions

Does Amplified Wheybolic Extreme 60 Power Strawberry by GNC Pro Performance AMP interact with any medications?
Yes. Based on its ingredients, Amplified Wheybolic Extreme 60 Power Strawberry has a known interaction with 565 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Amplified Wheybolic Extreme 60 Power Strawberry contains 15 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this have a lot of sodium in it?
Sodium is one of the active ingredients here, so yes—there's a meaningful amount. That's why it's important to check with your doctor if you have high blood pressure or take blood pressure medications, since high sodium can work against those drugs. The data warns against excess sodium intake.
Is this safe during pregnancy?
Safety data varies by ingredient. Calcium and lactase are likely safe in pregnancy at recommended amounts. Creatine and bromelain lack enough pregnancy safety data—the facts advise against them unless prescribed. Fenugreek is rated likely unsafe in pregnancy, especially near delivery. Talk with your doctor before taking any supplement while pregnant.
Can I use this while breastfeeding?
Some ingredients have limited or no breastfeeding data. Potassium and lactase are likely safe. Creatine, bromelain, and the proteases lack enough safety information—the facts recommend checking with your provider first. Fenugreek is possibly safe during lactation and is sometimes used to support milk supply, but discuss it with your doctor or lactation consultant.
Will this help me build muscle?
Creatine in the formula is possibly effective for muscle strength and athletic performance. Calcium is effective for bone health. However, we don't have established effectiveness ratings for the amino acid blend itself or the enzyme blend in our data, so the product's full muscle-building potential isn't fully graded here.
What are all these enzymes for?
They're digestive enzymes designed to help break down protein, carbohydrates, and fats so your body can absorb them better. Bromelain, protease, lipase, lactase, and others work together to aid digestion—especially helpful if you're consuming a high-protein powder.
I have kidney disease—is this safe for me?
You should talk to your doctor. This product is high in sodium, potassium, and creatine—all things that need careful monitoring if your kidneys aren't working well. The facts caution that potassium supplements can be risky for people with kidney disease, and creatine safety in that population isn't guaranteed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Go deeper

The Full Monographs Behind Amplified Wheybolic Extreme 60 Power Strawberry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph →
Sources

Sources & How We Checked

Amplified Wheybolic Extreme 60 Power Strawberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 263 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
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  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
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  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
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  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
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  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
  34. Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Potassium 12 references
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  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Calcium 62 references
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  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
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  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
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  26. Tseng M, Breslow RA, Graubard BI, Ziegler RG. Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort. Am J Clin Nutr 2005;81:1147-54. PubMed
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  30. Rocephin (ceftriaxone) and calcium interaction. Pharmacist's Letter / Prescriber's Letter 2007;23(10):231005.
  31. Bolland MJ, Barber PA, Doughty RN, et al. Vascular events in healthy older women receiving calcium supplementation: randomised control trial. BMJ 2008;336:262-6.
  32. Bolland MJ, Avenell A, Baron JA, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 2010;341:c3691. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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