Interactions on record — worth a quick check against your medications. Based on 4 of 8 ingredients. Check your meds →
Dietary supplement

Pro-Series Build Grape Ingredients & Drug Interactions

by Jacked Factory

Pro-Series Build Grape label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pro-Series Build Grape against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pro-Series Build Grape is a dietary supplement by Jacked Factory with 8 active ingredients. Its ingredients are commonly taken for fatigue and low energy, athletic performance and stamina, respiratory and lung support.Based on those ingredients, 662 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi, Lion's Mane, Shiitake. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pro-Series Build Grape by Jacked Factory

Ask about any prescription or over-the-counter medication and we check it for interactions with Pro-Series Build Grape by Jacked Factory — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pro-Series Build Grape by Jacked Factory

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 8 active ingredients.
  • “Peak02” is listed as a grouped ingredient — the label gives one combined amount (2,000 mg) without saying how much of each component you get.

Pro-Series Build Grape is a powder with 8 active ingredients. The main components are four medicinal mushrooms—cordyceps, lion's mane, shiitake, and reishi—plus hydroxyisocaproic acid (an amino acid metabolite), Peak02 (a mushroom blend), Turkey Tail mushroom, and elevATP (a plant-derived compound).

The product also contains several inactive ingredients: malic acid, tartaric acid, natural flavors, calcium silicate, silicon dioxide, sucralose, and grape powder.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: muscle building, strength, endurance, athletic performance.
  • We looked for evidence on: Athletic performance, Fatigue, Muscle strength, Exercise capacity, Oxygen utilization, Power output.
  • The closest evidence on file: Cordyceps is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Cordyceps is rated "Insufficient Reliable Evidence To Rate" for Fatigue.
  • Also on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Chronic fatigue syndrome (CFS), Cancer-related fatigue.

The evidence for these ingredients is largely insufficient or mixed. Cordyceps is rated possibly ineffective for athletic performance and has insufficient evidence for sexual dysfunction, arrhythmia, asthma, lung cancer, and COPD.

Lion's mane, shiitake, and reishi all lack sufficient reliable evidence to rate their effectiveness for the conditions they're studied in—which include cognitive function, cancer, dental plaque, and altitude sickness, among others. Reishi is rated possibly ineffective for high cholesterol.

The facts we hold don't establish what this product is designed to do, so you may want to check the label or ask the maker what results they claim.

The evidence, ingredient by ingredient Cordyceps Lion's Mane Mushroom Shiitake Mushroom Reishi Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cordyceps and lion's mane are generally well tolerated short-term, though evidence is limited. The most common side effects of cordyceps are abdominal discomfort, constipation, and diarrhea—usually uncommon and sometimes eased by taking it after food.

Lion's mane may cause gastrointestinal discomfort, nausea, or skin rash. Shiitake mushroom is safe as a cooked food but concentrated supplements lack long-term safety data; it can cause abdominal discomfort, bloating, diarrhea, nausea, and vomiting.

Raw shiitake can cause a distinctive skin eruption, and occupational exposure to shiitake spores has caused respiratory problems. Reishi is generally well tolerated short-term but long-term safety is not well studied; common side effects are dizziness, dry mouth, itching, nausea, rash, and stomach upset.

There is one case report of liver inflammation possibly linked to a cordyceps-containing product, though the cordyceps itself may not have been the culprit. During pregnancy, the safety data advises against cordyceps, lion's mane, shiitake, and reishi because there isn't enough information.

The same applies to breastfeeding. Talk with your doctor or pharmacist about whether this product is appropriate for you if you're pregnant or nursing.

Side effects, ingredient by ingredient Cordyceps Lion's Mane Mushroom Shiitake Mushroom Reishi Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Cordyceps, Shiitake Mushroom, Reishi Mushroom, Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 662 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any of these medication types. Worst-risk first: blood thinners or antiplatelet drugs (cordyceps and lion's mane may increase bleeding risk), drugs processed by the liver enzyme CYP2D6 (shiitake may lower their levels), blood pressure medications (reishi may lower your pressure further), diabetes medications (lion's mane and reishi may lower blood sugar more), immunosuppressants (cordyceps, lion's mane, and shiitake may interfere), or testosterone therapy (cordyceps may add to its effects).

We could not check King Trumpet, Hydroxyisocaproic Acid, Peak02's full composition, Turkey Tail, or elevATP for interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a mushroom-based sports supplement with four active fungi and several compounds whose effectiveness for athletic performance or any other specific benefit isn't well established in our data. If you take blood thinners, diabetes medications, immunosuppressants, blood pressure drugs, or medications processed by your liver, check your exact drugs with the tool on this page before starting.

Pregnant or nursing people should avoid it. Discuss this product with your doctor or pharmacist before adding it to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pro-Series Build Grape, straight from the product label.

Brand Jacked Factory
Barcode (UPC) X002LJJ1UT
Net contents 12.7 Ounce(s); 360 Gram(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 257844
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pro-Series Build Grape by Jacked Factory, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Gram(s)
Maximum serving Sizes:
12 Gram(s)
Servings per container
60
UPC/BARCODE
X002LJJ1UT
IngredientAmount% DV
King Trumpet0 NP--
Cordyceps0 NP--
Lion's Mane0 NP--
Calories10 Calorie(s)--
Shiitake0 NP--
Hydroxyisocaproic Acid750 mg--
Reishi0 NP--
Total Carbohydrates2 Gram(s)1%
Peak022000 mg--
Turkey Tail0 NP--
elevATP150 mg--

Other ingredients: Malic Acid, Tartaric Acid, Natural Flavors, Calcium Silicate, Silicon Dioxide, Sucralose, Grape powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Pro-Series Build is an elite muscle-building formula designed to optimize your athletic performance, strength, endurance, and recovery.

These ingredients have been shown in clinical research to significantly improve strength, power, endurance, blood flow, and oxygen uptake in as little as one week.

Pro-Series Build allows you to break limits in the trenches and perform at peak capacity every single training session. Best of all, Pro-Series Build is a stimulant-free formula that you can stack with your favorite pre-workout, intra-workout, and post-workout supplements for even greater results.

Best of all, Pro-Series Build is a stimulant-free formula that you can stack with your favorite pre-workout, intra-workout, and post-workout supplements for even greater results.

Lean muscle builder Optimize athletic performance Rapid ATP booster Increase strength Elite muscle-building formula

Formula

Featuring clinical doses of PeakO2, ElevATP, and Hydroxy-Isocaproic Acid (HICA), Pro-Series Build is revolutionizing performance supplementation for athletes, bodybuilders, and gym-goers alike.

150 mg ElevATP 750 mg Hydroxy-Isocaproic acid 2000 mg PeakO2

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, mix 1-2 scoops with 8-10 oz of water 30-40 minutes before your workout. Do not exceed 2 scoops in a 24 hour period. 1 Scoop I 2 Scoops - 8-10 oz water - 30-40 mins

Precautions

Warning: Consult your physician prior to using this product if you are pregnant, nursing, under 18 years of age, taking medication or have a medical condition.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, under 18 years of age, taking medication or have a medical condition.

Immediately discontinue use and contact your physician if any adverse reactions occur.

Keep out of reach of children.

Storage

Store in a cool, dry place away from excessive heat.

General Statements

Get connected Facebook @JackedFactory Instagram @Jacked_Factory

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

ElevATP is a registered trademark material of Futureceuticals PeakO2 is protected by patents pending owned by Disruptive Nutrition, LLC and under exclusive global distribution by Compound Solutions, Inc.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pro-Series Build Grape by Jacked Factory label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pro-Series Build Grape label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pro-Series Build Grape by Jacked Factory

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Gram(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Hydroxyisocaproic Acid

750 mg per serving

Peak02

2000 mg per serving

ElevATP

150 mg per serving Form: Ancient Peat, Apple Extract

Other (inactive) ingredients: Malic Acid, Tartaric Acid, Natural Flavors, Calcium Silicate, Silicon Dioxide, Sucralose, Grape powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pro-Series Build Grape by Jacked Factory Drug Interactions

Want to check YOUR meds against Pro-Series Build Grape?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
662Drugs
654 Moderate 8 Minor

Ingredients driving the most interactions

Reishi 375
Lion's Mane 327
Shiitake 312
Cordyceps 249

Individual Drug Interactions

The ingredients in Pro-Series Build Grape interact with 662 drugs. Click any drug to see the details.

4 of the 8 ingredients in Pro-Series Build Grape interact with drugs. Each result below shows which ingredient is responsible. Reishi Lion's Mane Shiitake Cordyceps

Each ingredient & the kinds of drugs it affects

For each ingredient in Pro-Series Build Grape with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi full monograph & interactions

Lion's Mane3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane full monograph & interactions

Shiitake2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Shiitake full monograph & interactions

Cordyceps3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pro-Series Build Grape, from the product label.

Jacked Factory

See all Jacked Factory products
Name
Jacked Factory
City
St. John's
ZipCode
A1A 5A1
Phone Number
1-877-250-5237
Web Address
Jackedfactory.com
Pharmacist Counseling Corner

Pro-Series Build Grape by Jacked Factory: Common Questions

Does Pro-Series Build Grape by Jacked Factory interact with any medications?
Yes. Based on its ingredients, Pro-Series Build Grape has a known interaction with 662 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pro-Series Build Grape contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have any side effects?
Most side effects are mild. Cordyceps and lion's mane may cause gastrointestinal discomfort, nausea, constipation, or diarrhea. Shiitake can cause abdominal discomfort, bloating, diarrhea, nausea, and vomiting. Reishi may cause dizziness, dry mouth, itching, nausea, rash, or stomach upset. These are usually uncommon, and some ease if you take cordyceps after food.
Can I take this while pregnant or breastfeeding?
No. The safety data advises against cordyceps, lion's mane, shiitake, and reishi during pregnancy and breastfeeding because there isn't enough information. Talk with your doctor or pharmacist about your options.
What are the mushrooms in this for?
The label or product description from the maker should tell you what they're claiming this product does. Our data shows most of these mushrooms lack sufficient evidence to rate their effectiveness for any specific purpose, so results aren't established.
Is cordyceps safe to use long-term?
Cordyceps seems generally well tolerated when used for up to a year, though the evidence is limited and supplement quality varies widely. Long-term safety beyond that isn't well studied.
What's Peak02 in this product?
Peak02 is listed as a blend or group of component ingredients, which are included separately in the ingredient list. We couldn't check it for interactions as a group product.
Can I take this if I'm on blood thinners?
Not without checking first. Cordyceps and lion's mane may theoretically increase bleeding risk with anticoagulants or antiplatelet drugs like warfarin or aspirin, and reishi at higher doses may as well. Use the medication checker on this page with your exact drug, then confirm with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pro-Series Build Grape is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pro-Series Build Grape label
Go deeper

The Full Monographs Behind Pro-Series Build Grape’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph →
Sources

Sources & How We Checked

Pro-Series Build Grape's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 104 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cordyceps 14 references
  1. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 1998;4:289-303.
  2. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med 1998;4:429-57.
  3. Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997;60:2349-59. PubMed
  4. Zhao Y. [Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:612-5, 42.
  5. Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
  6. Zhu XY, Yu HY. [Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response]. Chung Hsi I Chieh Ho Tsa Chih 1990;10:485-7, 454.
  7. Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 9-5-2003;73(16):2127-2136. PubMed
  8. Ikumoto, T., Sasaki, S., Namba, H., Toyama, R., Moritoki, H., and Mouri, T. [Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria]. Yakugaku Zasshi 1991;111(9):504-509. PubMed
  9. Wu, T. N., Yang, K. C., Wang, C. M., Lai, J. S., Ko, K. N., Chang, P. Y., and Liou, S. H. Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. Sci.Total Environ. 4-5-1996;182(1-3):193-195. PubMed
  10. Hong T, Zhang M, Fan J. Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients (Review). Cochrane Database Syst Rev. 2015;(10):CD009698. doi: 10.1002/14651858.CD009698.pub2.
  11. Zhang HW, Lin ZX, Tung YS, Kwan TH, Mok CK, Leung C, Chan LS. Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease (Review). Cochrane Database Syst Rev. 2014;(12):CD008353. doi: 10.1002/14651858.CD008353.pub2. PubMed
  12. Bee Yean O, Zoriah A. Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysis. J Tradit Chin Med. 2019;39(1):1-14.
  13. Thurian D, Montani M, Stickel F. Drug-induced, mixed-type hepatitis following ingestion of Cordyceps sinensis. Int J Clin Pharmacol Ther 2022;60(2):115-120. PubMed
  14. Yu X, Mao Y, Shergis JL, et al. Effectiveness and safety of oral Cordyceps sinensis on stable COPD of GOLD stages 2-3: Systematic review and meta-analysis. Evid Based Complement Alternat Med. 2019;2019:4903671.

See these in context on the Cordyceps monograph →

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Shiitake Mushroom 67 references
  1. Hitosugi M, Kitamura O, Takatsu A, Yoshino Y. Autopsy case of duodenal obstruction from impacted mushroom. J Gastroenterol 1998;33:562-5. PubMed
  2. Hanada K, Hashimoto I. Flagellate mushroom (Shiitake) dermatitis and photosensitivity. Dermatol 1998;197:255-7. PubMed
  3. Levy AM, Kita H, Phillips SF, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol 1998;101:613-20. PubMed
  4. Murakami M, Kawabe K, Hosoi Y, et al. Decreased pulmonary perfusion in hypersensitivity pneumonitis caused by Shiitake mushroom spores. J Intern Med 1997;241:85-8. PubMed
  5. Matsui S, Nakazawa T, Umegae Y, Mori M. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. Intern Med 1992;31:1204-6.
  6. Nakamura T. Shiitake (Lentinus edodes) dermatitis. Contact Dermatitis 1992;27:65-70.
  7. Ueda A, Obama K, Aoyama K, et al. Allergic contact dermatitis in shiitake (Lentinus edodes (Berk) Sing) growers. Contact Dermatitis 1992;26:228-33.
  8. Burikhanov, R. B., Wakame, K., Igarashi, Y., Wang, S., and Matsuzaki, S. Suppressive effect of active hexose correlated compound (AHCC) on thymic apoptosis induced by dexamethasone in the rat. Endocr.Regul. 2000;34(4):181-188.
  9. Gao, Y., Zhang, D., Sun, B., Fujii, H., Kosuna, K., and Yin, Z. Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses. Cancer Immunol.Immunother. 2006;55(10):1258-1266. PubMed
  10. Ritz, B. W., Nogusa, S., Ackerman, E. A., and Gardner, E. M. Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection. J Nutr. 2006;136(11):2868-2873. PubMed
  11. Aviles, H., O'Donnell, P., Sun, B., and Sonnenfeld, G. Active hexose correlated compound (AHCC) enhances resistance to infection in a mouse model of surgical wound infection. Surg.Infect.(Larchmt.) 2006;7(6):527-535. PubMed
  12. Spierings, E. L., Fujii, H., Sun, B., and Walshe, T. A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers. J Nutr Sci Vitaminol.(Tokyo) 2007;53(6):536-539. PubMed
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