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Dietary supplement

Prodentis Probiotic Drops Ingredients & Drug Interactions

by BioGaia

Prodentis Probiotic Drops label
See full label image
Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Prodentis Probiotic Drops against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Prodentis Probiotic Drops is a dietary supplement by BioGaia with 2 active ingredients. Its ingredients are commonly taken for infant colic, diarrhea (including antibiotic-associated), digestive health.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Limosilactobacillus reuteri ATCC PTA 5289. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Prodentis Probiotic Drops by BioGaia

Ask about any prescription or over-the-counter medication and we check it for interactions with Prodentis Probiotic Drops by BioGaia — and tell you which ingredient is responsible.

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Computed from our clinical databases

HelloPharmacist Scorecard of Prodentis Probiotic Drops by BioGaia

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The stated purpose hasn't been mapped to our evidence data yet.

Why this rating?
  • We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Ingredient Transparency
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “L. reuteri Prodentis Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
Known Interaction Concern
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Limosilactobacillus Reuteri.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Safety Information
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

HelloPharmacist summaryFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Prodentis Probiotic Drops, straight from the product label.

Brand BioGaia
Barcode (UPC) 602359460438
Net contents 5 mL; 0.17 Fluid Ounce(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 311011
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Prodentis Probiotic Drops by BioGaia, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Infants
Minimum serving Sizes:
5 Drop(s)
Maximum serving Sizes:
5 Drop(s)
Servings per container
25
UPC/BARCODE
602359460438
IngredientAmount% DV
L. reuteri Prodentis Blend0 NP--
Limosilactobacillus reuteri ATCC PTA 52890 NP--
Limosilactobacillus reuteri DSM 179380 NP--

Other ingredients: Sunflower Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Probiotics drops BioGaia Prodentis is a dietary supplement containing the patented probiotic blend Limosilactobacillus reuteri Prodentis (L. reuteri DSM 17938 and L. reuteri ATCC PTA 5289) that helps keep a natural balance in the mouth. L. reuteri Prodentis has been tested in more than 60 clinical studies and proven effective and safe.

Probiotic drops

Brand IP Statement(s)

BioGaia Prodentis is a dietary supplement containing the patented probiotic blend Limosilactobacillus reuteri Prodentis (L. reuteri DSM 17938 and L. reuteri ATCC PTA 5289) that helps keep a natural balance in the mouth. BioGaia Groundbreaking probiotics Driven by science

Registered trademarks belong to BioGaia AB. Protected by corresponding patents of US7,374,924, US8,785,183 and other issued and pending patent applications.

Suggested/Recommended/Usage/Directions

Shake well

How to use: Shake well for 10 seconds before each use to mix the probiotic with the oil. Use 5 drops daily. Use: 5 drops.

Formulation

For gums and teeth Clinically proven

Non-GMO ingredients, no artificial colors, flavors, dairy, soy or gluten.

Country of origin: Sweden

Milk free Lactose free Gluten free

Probiotic oral health

FDA Statement of Identity

Probiotic Supplement

Storage

Storage: Store in a dry place, at room temperature. Opened bottle should be used within 2 months.

The package includes a white desiccant device for prolongation of shelf-life.

Precautions

Keep out of reach of children.

Do not give directly from the bottle into the mouth as this may reduce the quality of the product. The package includes a white desiccant device for prolongation of shelf-life. It is approved for use in direct contact with food and should not be consumed.

To report an adverse event, call (888) 485-2135.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Prodentis Probiotic Drops by BioGaia label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Prodentis Probiotic Drops label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Prodentis Probiotic Drops by BioGaia

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 Drop(s) Dosage formLiquid Servings per container25 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L. reuteri Prodentis Blend

0 NP per serving

Other (inactive) ingredients: Sunflower Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Prodentis Probiotic Drops by BioGaia Drug Interactions

Prodentis Probiotic Drops contains 2 ingredients, and 1 of them has known drug interactions. Altogether it interacts with 182 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Prodentis Probiotic Drops?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Limosilactobacillus reuteri ATCC PTA 5289 182

Individual Drug Interactions

The ingredients in Prodentis Probiotic Drops interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Prodentis Probiotic Drops interact with drugs. Each result below shows which ingredient is responsible. Limosilactobacillus reuteri ATCC PTA 5289

Each ingredient & the kinds of drugs it affects

For each ingredient in Prodentis Probiotic Drops with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Limosilactobacillus reuteri ATCC PTA 52891 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Limosilactobacillus reuteri with antibiotic drugs might decrease the effectiveness of L. reuteri.
L. reuteri preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. reuteri preparations by at least two hours.

Likelihood Probable Evidence D
Limosilactobacillus reuteri ATCC PTA 5289 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Prodentis Probiotic Drops, from the product label.

BioGaia

See all BioGaia products
Name
BioGaia USA
City
St. Louis
State
MO
ZipCode
63139
Phone Number
(877)776-0101
Web Address
BioGaiaUSA.com
Pharmacist Counseling Corner

Prodentis Probiotic Drops by BioGaia: Common Questions

Does Prodentis Probiotic Drops by BioGaia interact with any medications?
Yes. Based on its ingredients, Prodentis Probiotic Drops has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Prodentis Probiotic Drops contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Prodentis Probiotic Drops is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Prodentis Probiotic Drops label
Go deeper

The Full Monographs Behind Prodentis Probiotic Drops’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Limosilactobacillus Reuteri

Interacts with 182 drugs

Limosilactobacillus reuteri (formerly Lactobacillus reuteri) is a probiotic bacterium found in the human gut and certain fermented foods. It has the most supportive evidence for reducing cry...

Read the full Limosilactobacillus Reuteri monograph →
Sources

Sources & How We Checked

Prodentis Probiotic Drops's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Limosilactobacillus Reuteri 14 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Savino F, Cordisco L, Tarasco V, et al. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics 2010;126:e526-33.
  3. Savino F, Pelle E, Palumeri E, et al. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics 2007;119:e124-30.
  4. Beerepoot MA, ter Riet G, Nys S, van der Wal WM, de Borgie CA, de Reijke TM,Prins JM, Koeijers J, Verbon A, Stobberingh E, Geerlings SE. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in p DOI
  5. Chau K, Lau E, Greenberg S, Jacobson S, Yazdani-Brojeni P, Verma N, Koren G.Probiotics for infantile colic: a randomized, double-blind, placebo-controlled trial investigating Lactobacillus reuteri DSM 17938. J Pediatr 2015;166(1):74-8. PubMed
  6. Indrio F, Di Mauro A, Riezzo G, Civardi E, Intini C, Corvaglia L, Ballardini E, Bisceglia M, Cinquetti M, Brazzoduro E, Del Vecchio A, Tafuri S, Francavilla R. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional const
  7. Oncel MY, Sari FN, Arayici S, Guzoglu N, Erdeve O, Uras N, Oguz SS, Dilmen U. Lactobacillus Reuteri for the prevention of necrotising enterocolitis in very low birthweight infants: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2014;99(2
  8. Sung V, Hiscock H, Tang ML, Mensah FK, Nation ML, Satzke C, Heine RG, Stock A,Barr RG, Wake M. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ. 2014 1;348:g2107. PubMed
  9. Szajewska H, Gyrczuk E, Horvath A. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind,placebo-controlled trial. J Pediatr. 2013;162(2):257-62. PubMed
  10. Husain S, Allotey J, Drymoussi Z, et al. Effects of oral probiotic supplements on vaginal microbiota during pregnancy: a randomised, double-blind, placebo-controlled trial with microbiome analysis. BJOG. 2020;127(2):275-284. PubMed
  11. Ojetti V, Gigante G, Gabrielli M, et al. The effect of oral supplementation with Lactobacillus reuteri or tilactase in lactose intolerant patients: randomized trial. Eur Rev Med Pharmacol Sci. 2010;14(3):163-70.
  12. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  13. Sheyholislami H, Connor KL. Are probiotics and prebiotics safe for use during pregnancy and lactation? A systematic review and meta-analysis. Nutrients. 2021;13(7):2382. PubMed
  14. Yefet E, Colodner R, Strauss M, Gam Ze Letova Y, Nachum Z. A randomized controlled open label crossover trial to study vaginal colonization of orally administered Lactobacillus reuteri RC-14 and rhamnosus GR-1 in pregnant women at high risk for preterm la

See these in context on the Limosilactobacillus Reuteri monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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