Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Prodentis Apple Flavor Ingredients & Drug Interactions

by BioGaia

Prodentis Apple Flavor label
See full label image
Lozenge Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Prodentis Apple Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Prodentis Apple Flavor is a dietary supplement by BioGaia with 2 active ingredients. Its ingredients are commonly taken for infant colic, diarrhea (including antibiotic-associated), digestive health.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Limosilactobacillus reuteri ATCC PTA 5289. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Prodentis Apple Flavor by BioGaia

Ask about any prescription or over-the-counter medication and we check it for interactions with Prodentis Apple Flavor by BioGaia — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.
Computed from our clinical databases

HelloPharmacist Scorecard of Prodentis Apple Flavor by BioGaia

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The stated purpose hasn't been mapped to our evidence data yet.

Why this rating?
  • We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Ingredient Transparency
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “L. reuteri Prodentis Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
Known Interaction Concern
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Limosilactobacillus Reuteri.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Safety Information
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

HelloPharmacist summaryFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Prodentis Apple Flavor, straight from the product label.

Brand BioGaia
Barcode (UPC) 602359460483
Net contents 30 Apple Flavored Probiotic Lozenge(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 311010
Product type Non-nutrient/non-botanical
Supplement form Lozenge
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Prodentis Apple Flavor by BioGaia, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Lozenge(s)
Maximum serving Sizes:
1 Lozenge(s)
Servings per container
30
UPC/BARCODE
602359460483
IngredientAmount% DV
L. reuteri Prodentis Blend0 NP--
Limosilactobacillus reuteri ATCC PTA 52890 NP--
Limosilactobacillus reuteri DSM 179380 NP--

Other ingredients: Isomalt, Xylitol, Apple Flavor, Citric Acid, Mint Flavor, Fresh Fruity Flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

BioGaia Prodentis lozenges contain the patented probiotic blend Limosilactobacillus reuteri Prodentis (l. reuteri DSM 17938 and L. reuteri ATCC PTA 5289) that helps keep a natural balance in the mouth.

Formulation

Because L. reuteri Prodentis naturally colonizes humans it has a strong adaption to persist and interact with humans, L. reuteri Prodentis has been tested in more than 50 clinical studies and proven effective and safe for children & adults.

Probiotic oral health For gums and teeth

Country of origin: Sweden.

Clinically Proven

Non-GMO ingredients, no artificial colors, dairy, soy or gluten. Milk Free Lactose Free Gluten Free

FDA Disclaimer Statement

These statements haven not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Use: One (1) lozenge per day. Use regularly for oral health. Directions: Let the lozenge melt in your mouth, preferably after brushing your teeth.

Storage

Storage: Store in a dry place, at room temperature.

Precautions

Keep out of reach of children.

To report a serious adverse event, call (888) 485-2135.

Brand IP Statement(s)

BioGaia Groundbreaking probiotics driven by science

Registered trademarks belong to BioGaia AB. Protected by corresponding patents of US7,374,924 and other issued and pending patent applications.

FDA Statement of Identity

Probiotic Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Prodentis Apple Flavor by BioGaia label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Prodentis Apple Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Prodentis Apple Flavor by BioGaia

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Lozenge(s) Dosage formLozenge Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L. reuteri Prodentis Blend

0 NP per serving

Other (inactive) ingredients: Isomalt, Xylitol, Apple Flavor, Citric Acid, Mint Flavor, Fresh Fruity Flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Prodentis Apple Flavor by BioGaia Drug Interactions

Prodentis Apple Flavor contains 2 ingredients, and 1 of them has known drug interactions. Altogether it interacts with 182 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Prodentis Apple Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Limosilactobacillus reuteri ATCC PTA 5289 182

Individual Drug Interactions

The ingredients in Prodentis Apple Flavor interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Prodentis Apple Flavor interact with drugs. Each result below shows which ingredient is responsible. Limosilactobacillus reuteri ATCC PTA 5289

Each ingredient & the kinds of drugs it affects

For each ingredient in Prodentis Apple Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Limosilactobacillus reuteri ATCC PTA 52891 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Limosilactobacillus reuteri with antibiotic drugs might decrease the effectiveness of L. reuteri.
L. reuteri preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. reuteri preparations by at least two hours.

Likelihood Probable Evidence D
Limosilactobacillus reuteri ATCC PTA 5289 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Prodentis Apple Flavor, from the product label.

BioGaia

See all BioGaia products
Name
BioGaia USA
City
St. Louis
State
MO
ZipCode
63139
Phone Number
(877)776-0101
Web Address
BioGaiaUSA.com
Pharmacist Counseling Corner

Prodentis Apple Flavor by BioGaia: Common Questions

Does Prodentis Apple Flavor by BioGaia interact with any medications?
Yes. Based on its ingredients, Prodentis Apple Flavor has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Prodentis Apple Flavor contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Prodentis Apple Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Prodentis Apple Flavor label
Go deeper

The Full Monographs Behind Prodentis Apple Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Limosilactobacillus Reuteri

Interacts with 182 drugs

Limosilactobacillus reuteri (formerly Lactobacillus reuteri) is a probiotic bacterium found in the human gut and certain fermented foods. It has the most supportive evidence for reducing cry...

Read the full Limosilactobacillus Reuteri monograph →
Sources

Sources & How We Checked

Prodentis Apple Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Limosilactobacillus Reuteri 14 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Savino F, Cordisco L, Tarasco V, et al. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics 2010;126:e526-33.
  3. Savino F, Pelle E, Palumeri E, et al. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics 2007;119:e124-30.
  4. Beerepoot MA, ter Riet G, Nys S, van der Wal WM, de Borgie CA, de Reijke TM,Prins JM, Koeijers J, Verbon A, Stobberingh E, Geerlings SE. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in p DOI
  5. Chau K, Lau E, Greenberg S, Jacobson S, Yazdani-Brojeni P, Verma N, Koren G.Probiotics for infantile colic: a randomized, double-blind, placebo-controlled trial investigating Lactobacillus reuteri DSM 17938. J Pediatr 2015;166(1):74-8. PubMed
  6. Indrio F, Di Mauro A, Riezzo G, Civardi E, Intini C, Corvaglia L, Ballardini E, Bisceglia M, Cinquetti M, Brazzoduro E, Del Vecchio A, Tafuri S, Francavilla R. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional const
  7. Oncel MY, Sari FN, Arayici S, Guzoglu N, Erdeve O, Uras N, Oguz SS, Dilmen U. Lactobacillus Reuteri for the prevention of necrotising enterocolitis in very low birthweight infants: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2014;99(2
  8. Sung V, Hiscock H, Tang ML, Mensah FK, Nation ML, Satzke C, Heine RG, Stock A,Barr RG, Wake M. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ. 2014 1;348:g2107. PubMed
  9. Szajewska H, Gyrczuk E, Horvath A. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind,placebo-controlled trial. J Pediatr. 2013;162(2):257-62. PubMed
  10. Husain S, Allotey J, Drymoussi Z, et al. Effects of oral probiotic supplements on vaginal microbiota during pregnancy: a randomised, double-blind, placebo-controlled trial with microbiome analysis. BJOG. 2020;127(2):275-284. PubMed
  11. Ojetti V, Gigante G, Gabrielli M, et al. The effect of oral supplementation with Lactobacillus reuteri or tilactase in lactose intolerant patients: randomized trial. Eur Rev Med Pharmacol Sci. 2010;14(3):163-70.
  12. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  13. Sheyholislami H, Connor KL. Are probiotics and prebiotics safe for use during pregnancy and lactation? A systematic review and meta-analysis. Nutrients. 2021;13(7):2382. PubMed
  14. Yefet E, Colodner R, Strauss M, Gam Ze Letova Y, Nachum Z. A randomized controlled open label crossover trial to study vaginal colonization of orally administered Lactobacillus reuteri RC-14 and rhamnosus GR-1 in pregnant women at high risk for preterm la

See these in context on the Limosilactobacillus Reuteri monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team