Protease 375K Ingredients & Drug Interactions
by TransFormation Professional Protocol
What is this page for?
First and foremost: checking Protease 375K against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Protease 375K is a dietary supplement by TransFormation Professional Protocol with 1 active ingredient. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Protease 375K by TransFormation Professional Protocol
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Protease 375K contains one active ingredient: protease, a digestive enzyme that breaks down protein. The capsule also holds two inactive ingredients—hypromellose and water—that serve as the capsule shell and base.
Does it work?
Couldn't assess
We don't hold effectiveness data for protease in our records, so we can't tell you whether this product works for its intended use. If you're considering it for a specific health goal, that's a good question to ask your pharmacist or doctor.
How safe is it?
Well-documented data
Protease is generally well tolerated for most adults, though some people experience digestive upset or allergic reactions. During pregnancy, safety hasn't been established—the data advises against use unless a doctor prescribes it.
During breastfeeding, there's very little safety information available, so medical advice is recommended before using it. Rarely, people with occupational exposure to airborne proteolytic enzymes have developed allergic rhinitis (nasal inflammation and congestion) or asthma.
If you have a history of enzyme sensitivities or respiratory allergies, mention that to your pharmacist.
Meds to double-check
No known interactions
No interactions are documented in our data for protease. Still, run your specific medications through the checker on this page before you start, especially if you take multiple drugs.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Protease 375K has no known drug interactions, making it potentially safe to combine with most medications—though you should always double-check your exact prescriptions. If you're pregnant, planning pregnancy, or breastfeeding, talk with your pharmacist or doctor before starting it.
For healthy adults without enzyme sensitivities, it's generally well tolerated.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Protease 375K, straight from the product label.
| Brand | TransFormation Professional Protocol |
|---|---|
| Barcode (UPC) | 632889400956 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 18, 2023 |
| DSLD ID | 293776 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Protease 375K by TransFormation Professional Protocol, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
TPP Protease 375K is uniquely formulated to promote systemic balance. This highly purified enzyme is concentrated from mycological sources specifically cultivated for optimum activity in the human body. All Transformation Enzyme formulas are carefully prepared to assure maximum quality and nutritional effectiveness.
Formulation
No unnecessary ingredients
Suggested/Recommended/Usage/Directions
Recommended usage: One (1) capsule two times a day on an empty stomach with 8 oz. of water or as directed by a health care practitioner. Contents may be removed from capsule and taken by spoon immediately after mixing with a small amount of tepid water. One (1) capsule may be taken with meals to enhance the digestion of proteins.
Storage
Store tightly sealed in a cool, dry place.
Precautions
Keep out of reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Enzyme Supplement
Brand IP Statement(s)
Transformation Enzyme is a registered trademark of Transformation Enzyme Corporation. Professional Protocol is a trademark of Transformation Enzyme Corporation.
General Statements
Enzyme activity is measured in Food Chemicals Codex (FCC) units.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Protease 375K by TransFormation Professional Protocol label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Protease 375K by TransFormation Professional Protocol
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.
Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsOther (inactive) ingredients: Hypromellose, Water. These complete the product’s ingredient list but are not active constituents.
Protease 375K by TransFormation Professional Protocol Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Protease 375K. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Protease 375K, from the product label.
TransFormation Professional Protocol
See all TransFormation Professional Protocol products- Name
- Transformation Enzyme Corporation
- Street Address
- 2900 Wilcrest Dr. Suite 220
- City
- Houston
- State
- TX
- ZipCode
- 77042
Protease 375K by TransFormation Professional Protocol: Common Questions
Does Protease 375K by TransFormation Professional Protocol interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Protease 375K while I'm pregnant?
Is it safe to use while breastfeeding?
What side effects should I watch for?
Does protease interact with my medications?
What does protease do?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Protease 375K is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Protease 375K’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Protease 375K's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC