Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Pterostilbene & Resveratrol 50 mg/250 mg Ingredients & Drug Interactions

by NOW

Pterostilbene & Resveratrol 50 mg/250 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pterostilbene & Resveratrol 50 mg/250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pterostilbene & Resveratrol 50 mg/250 mg is a dietary supplement by NOW with 2 active ingredients. Its ingredients are commonly taken for source of resveratrol, heart and circulation support, inflammation.Based on those ingredients, 826 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Polygonum cuspidatum extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pterostilbene & Resveratrol 50 mg/250 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Pterostilbene & Resveratrol 50 mg/250 mg by NOW — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Pterostilbene & Resveratrol 50 mg/250 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: trans-pterostilbene (50 mg per capsule) and polygonum cuspidatum extract (250 mg per capsule). The extract, also called hu zhang, is a plant source of resveratrol and other compounds traditionally used for various conditions.

The capsule itself contains inactive ingredients — cellulose, silica, and stearic acid — which are fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Hu Zhang's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support healthy vascular function.
  • We looked for evidence on: Unstable angina, Cardiovascular health, Endothelial function, Blood flow.
  • The closest evidence on file: Hu Zhang is rated "Insufficient Reliable Evidence To Rate" for Unstable angina (Natural Medicines).

The evidence we have for hu zhang is not established. The data shows insufficient reliable evidence to rate its use for hepatitis, rheumatoid arthritis, wound healing, gout, osteoarthritis, and unstable angina.

There's no effectiveness information on file for trans-pterostilbene. If you're considering this for a specific condition, talk with your doctor or pharmacist about what the current evidence shows.

The evidence, ingredient by ingredient Hu Zhang

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Safety data for hu zhang in humans is limited. It's used in traditional medicine, but it contains emodin, a compound that may cause digestive upset in some people.

The safety notes advise caution with general use. For pregnancy, there isn't enough safety information — some compounds in hu zhang may affect the uterus — so it's best to avoid it if you're pregnant.

It's also best avoided while breastfeeding because there isn't enough safety data. If you're pregnant, breastfeeding, or planning either, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Hu Zhang

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hu Zhang.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 827 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use blood thinners or antiplatelet drugs (moderate risk of increased bleeding), drugs broken down by your liver through CYP1A2, CYP2C19, CYP3A4, or CYP2E1 pathways (moderate risk of raised drug levels), estrogen replacement therapy (moderate risk of interference), or carbamazepine/Tegretol (minor risk of increased effects).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

This product pairs pterostilbene with resveratrol from hu zhang, but effectiveness for most common uses isn't well established in the data we hold. The main concern is its potential to interact with blood thinners, certain liver-metabolized medications, seizure drugs, and hormone therapy.

If you take any prescription medications — especially blood thinners, antiplatelet drugs, seizure medications, or hormone therapy — check them against the interaction tool before starting. Talk with your doctor or pharmacist to see if this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pterostilbene & Resveratrol 50 mg/250 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739033574
Net contents 60 Veg Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2018
DSLD ID 77823
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pterostilbene & Resveratrol 50 mg/250 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
UPC/BARCODE
733739033574
IngredientAmount% DV
Trans-Pterostilbene50 mg--
Polygonum cuspidatum extract500 mg--

Other ingredients: Cellulose, Cellulose powder, Silica, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 capsule 1 to 2 times daily.

General Statements

Pterostilbene is a naturally occurring polyphenol closely related to Resveratrol. It is, however, more readily absorbed and utilized by the body. Emerging research suggests that Pterostilbene may help to support healthy vascular function, maintain proper cell cycle regulation, and can promote a healthy response to normal cellular stress.

Cardiovascular support ~ Free radical scavengers ~ Cellular protection

General Health Family owned since 1968.

Natural color variation may occur in this product.

Formula

NOW uses all-trans-Pterostilbene, which has been clinically evaluated for its superior bioavailability. Trans-Resveratrol is added as a natural complement to Pterostilbene's metabolic activities.

pTeroPure

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Resveratrol may interact with many pharmaceutical medications (especially anticonvulsants and NSAIDs, including diclofenac). Consult physician if pregnant/nursing, taking medication, or have a medical condition before using this product.

This product may cause digestive upset in some sensitive individuals. If you experience any gastrointestinal discomfort after using this product, discontinue use.

Keep out of reach of children.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in GMP facility that processes other ingredients containing these allergens.

General

CODE 3357 V4

FDA Statement of Identity

A Dietary Supplement

Formulation

Vegetarian/Vegan

Non-GMO

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Seals/Symbols

Non-GMO

GMP Quality Assured

Brand IP Statement(s)

pTeroPure is a registered trademark of ChromaDex, Inc. Protected by U.S. patent numbers 8,524,782, 8,133,917, 8,252,845, 8,841,350 and international patents.

Storage

Store in a cool, dry place after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pterostilbene & Resveratrol 50 mg/250 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pterostilbene & Resveratrol 50 mg/250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pterostilbene & Resveratrol 50 mg/250 mg by NOW

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Trans-Pterostilbene

50 mg per serving

Polygonum cuspidatum extract

Interacts with
826 drugs
500 mg per serving Form: Natural Trans-Resveratrol

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and ear...

Polygonum cuspidatum extract monograph & interactions

Other (inactive) ingredients: Cellulose, Cellulose powder, Silica, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pterostilbene & Resveratrol 50 mg/250 mg by NOW Drug Interactions

Want to check YOUR meds against Pterostilbene & Resveratrol 50 mg/250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
826Drugs
826 Moderate

Ingredients driving the most interactions

Polygonum cuspidatum extract 826

Individual Drug Interactions

The ingredients in Pterostilbene & Resveratrol 50 mg/250 mg interact with 826 drugs. Click any drug to see the details.

1 of the 2 ingredients in Pterostilbene & Resveratrol 50 mg/250 mg interact with drugs. Each result below shows which ingredient is responsible. Polygonum cuspidatum extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pterostilbene & Resveratrol 50 mg/250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Polygonum cuspidatum extract7 drug types · 826 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Hu zhang contains the constituent resveratrol. Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP1A2 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2C19 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2E1 enzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP3A4 enzyme. However, a clinical study in adults with NAFLD found that adding resveratrol 3000 mg daily for 8 weeks did not necessitate dose adjustments to any established medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Estrogens

Theoretically, hu zhang might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that hu zhang might have estrogenic activity.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, hu zhang might increase the effects and adverse effects of carbamazepine.
In animals, blood and tissue levels of carbamazepine were increased when given in combination with hu zhang. It is thought that increased levels of carbamazepine are due to cytochrome P450 3A4 (CYP3A4) inhibition. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Polygonum cuspidatum extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pterostilbene & Resveratrol 50 mg/250 mg, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
www.nowfoods.com
Pharmacist Counseling Corner

Pterostilbene & Resveratrol 50 mg/250 mg by NOW: Common Questions

Does Pterostilbene & Resveratrol 50 mg/250 mg by NOW interact with any medications?
Yes. Based on its ingredients, Pterostilbene & Resveratrol 50 mg/250 mg has a known interaction with 826 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pterostilbene & Resveratrol 50 mg/250 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is hu zhang, and why is it in this product?
Hu zhang is polygonum cuspidatum extract, a plant source of resveratrol and related compounds. It's been used in traditional medicine for various conditions. This product pairs it with pterostilbene, another related compound, in one capsule.
Does this product actually work for anything?
The data we have shows insufficient reliable evidence to rate hu zhang for hepatitis, rheumatoid arthritis, wound healing, gout, osteoarthritis, and unstable angina. We don't have effectiveness information for pterostilbene. Talk with your doctor about whether it's right for what you're hoping to use it for.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against it. There isn't enough safety information, and some compounds in hu zhang may affect the uterus or bowel. If you're pregnant, breastfeeding, or planning either, talk with your doctor or pharmacist first.
What are the side effects?
Adverse effects aren't well documented in the data we hold. However, hu zhang contains emodin, which may cause digestive upset in some people. If you notice new GI symptoms after starting, stop and talk with your pharmacist.
Is this safe to take with my medications?
That depends entirely on what you take. Hu zhang has documented interactions with blood thinners, certain liver-metabolized drugs, seizure medications, and hormone therapy. Use the interaction checker on this page to look up your exact prescriptions, then talk with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pterostilbene & Resveratrol 50 mg/250 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pterostilbene & Resveratrol 50 mg/250 mg label
Go deeper

The Full Monographs Behind Pterostilbene & Resveratrol 50 mg/250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hu Zhang

Interacts with 826 drugs

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and early human research looks interesting for...

Read the full Hu Zhang monograph →
Sources

Sources & How We Checked

Pterostilbene & Resveratrol 50 mg/250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hu Zhang 19 references
  1. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  2. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  3. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
  4. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
  5. Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
  6. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  7. Matsuda H, Shimoda H, Morikawa T, Yoshikawa M. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg Med Chem Lett 2001;11:1839-42. PubMed
  8. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  9. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
  10. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
  11. Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
  12. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
  13. Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
  14. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  15. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
  16. Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. PubMed
  17. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
  18. Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. PubMed
  19. Chi YC, Lin SP, Hou YC. A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats. Toxicol Appl Pharmacol 2012;263(3):315-22. PubMed

See these in context on the Hu Zhang monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team