Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Pterostilbene & Resveratrol 50 mg / 250 mg Ingredients & Drug Interactions

by Protocol For Life Balance

Pterostilbene & Resveratrol 50 mg / 250 mg label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pterostilbene & Resveratrol 50 mg / 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pterostilbene & Resveratrol 50 mg / 250 mg is a dietary supplement by Protocol For Life Balance with 2 active ingredients. Its ingredients are commonly taken for source of resveratrol, heart and circulation support, inflammation.Based on those ingredients, 826 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Polygonum cuspidatum Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pterostilbene & Resveratrol 50 mg / 250 mg by Protocol For Life Balance

Ask about any prescription or over-the-counter medication and we check it for interactions with Pterostilbene & Resveratrol 50 mg / 250 mg by Protocol For Life Balance — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pterostilbene & Resveratrol 50 mg / 250 mg by Protocol For Life Balance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: 50 mg of trans-pterostilbene and 250 mg of Polygonum cuspidatum extract (hu zhang). Hu zhang is a plant extract used in traditional medicine; it's a natural source of resveratrol, a polyphenol compound.

The capsule also contains inactive ingredients—cellulose, cellulose powder, stearic acid, and silica—which are fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Hu Zhang's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports healthy cardiovascular system and anti-aging.
  • We looked for evidence on: Unstable angina, cardiovascular health, aging, inflammation.
  • The closest evidence on file: Hu Zhang is rated "Insufficient Reliable Evidence To Rate" for Unstable angina (Natural Medicines).

The evidence we hold on hu zhang for treating hepatitis, rheumatoid arthritis, wound healing, gout, osteoarthritis, or unstable angina is insufficient to rate—meaning human studies haven't established it works for those uses. We have no effectiveness data on file for trans-pterostilbene.

If you're considering this product for a specific health goal, talk with your doctor or pharmacist about whether the science supports it.

The evidence, ingredient by ingredient Hu Zhang

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hu zhang is traditionally used in herbal medicine, but human safety data for supplements are limited. The extract contains emodin, a compound that may upset your digestion.

The safety information is insufficient, and some compounds in hu zhang may affect the uterus, so it's best avoided during pregnancy. There's also not enough safety data to recommend use while breastfeeding—talk with your doctor or pharmacist for personalized advice if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Hu Zhang

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hu Zhang.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 827 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check before starting if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel)—there's a Moderate-severity risk of increased bleeding. Also flag any drug metabolized by CYP3A4, CYP2C19, CYP1A2, or CYP2E1 enzymes, estrogen replacement therapy, or carbamazepine (Tegretol), since the hu zhang in this product may theoretically alter how your liver processes them.

Use the medication checker on this page to search your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

This product combines two compounds from plant sources, but human evidence that either one works for common health conditions is lacking. The main safety concern is its potential to thin your blood or interact with your liver's ability to clear certain medications.

If you take a blood thinner, hormone therapy, seizure medication, or any drug metabolized by your liver, check with your doctor or pharmacist before adding this to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pterostilbene & Resveratrol 50 mg / 250 mg, straight from the product label.

Brand Protocol For Life Balance
Barcode (UPC) 707359133570
Net contents 60 Veg Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2013
DSLD ID 23787
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pterostilbene & Resveratrol 50 mg / 250 mg by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
UPC/BARCODE
707359133570
IngredientAmount% DV
Trans-Pterostilbene50 mg--
Polygonum cuspidatum Extract500 mg--

Other ingredients: Cellulose, Cellulose powder, Stearic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

SUGGESTED USAGE: As a dietary supplement, take 1 capsule 1-2 times daily, or as directed by your healthcare practitioner.

General Statements

• Supports a Healthy Cardiovascular System* • Anti-Aging*

Formulated by doctors and clinical scientists exclusively for licensed healthcare practitioners.

Please Recycle.

HOW IT WORKS: Like Resveratrol, Pterostilbene belongs to a class of polyphenols called stilbenes that are naturally produced by plants in response to stress. Although these two stilbenes have similar properties, Pterostilbene's methyoxylated structure allows for enhanced absorption and metabolic stability.* Emerging research suggests that Pterostilbene may support cardiovascular health, may help to maintain proper cell cycle regulation, and can promote a healthy response to cellular stress.*

FDA Statement of Identity

A Dietary Supplement

Precautions

CAUTIONS/INTERACTIONS: If you are taking carmabazepine or other anticonvulsant medications, consult your healthcare practitioner before taking this product.

This product may cause digestive upset in some sensitive individuals.

Do Not Eat Freshness Packet. Keep in Bottle.

Produced in a GMP facility that processes other ingredients containing these allergens.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

pTeroPure(R)

GMP

General

CODE P3357 V1

Brand IP Statement(s)

This formula combines pTeroPure(R) trans-Pterostilbene with trans-Resveratrol, creating a powerful, more comprehensive, free radical scavenging, anti-aging combination.*

pTeroPure(R) is a registered trademark of ChromaDex, Inc.

Formulation

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Vegetarian/Vegan

Storage

Store in a cool, dry place after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pterostilbene & Resveratrol 50 mg / 250 mg by Protocol For Life Balance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pterostilbene & Resveratrol 50 mg / 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pterostilbene & Resveratrol 50 mg / 250 mg by Protocol For Life Balance

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Trans-Pterostilbene

50 mg per serving

Polygonum cuspidatum Extract

Interacts with
826 drugs
500 mg per serving Form: natural Trans-Resveratrol

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and ear...

Polygonum cuspidatum Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Cellulose powder, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pterostilbene & Resveratrol 50 mg / 250 mg by Protocol For Life Balance Drug Interactions

Want to check YOUR meds against Pterostilbene & Resveratrol 50 mg / 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
826Drugs
826 Moderate

Ingredients driving the most interactions

Polygonum cuspidatum Extract 826

Individual Drug Interactions

The ingredients in Pterostilbene & Resveratrol 50 mg / 250 mg interact with 826 drugs. Click any drug to see the details.

1 of the 2 ingredients in Pterostilbene & Resveratrol 50 mg / 250 mg interact with drugs. Each result below shows which ingredient is responsible. Polygonum cuspidatum Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pterostilbene & Resveratrol 50 mg / 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Polygonum cuspidatum Extract7 drug types · 826 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Hu zhang contains the constituent resveratrol. Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP1A2 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2C19 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2E1 enzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP3A4 enzyme. However, a clinical study in adults with NAFLD found that adding resveratrol 3000 mg daily for 8 weeks did not necessitate dose adjustments to any established medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Estrogens

Theoretically, hu zhang might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that hu zhang might have estrogenic activity.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, hu zhang might increase the effects and adverse effects of carbamazepine.
In animals, blood and tissue levels of carbamazepine were increased when given in combination with hu zhang. It is thought that increased levels of carbamazepine are due to cytochrome P450 3A4 (CYP3A4) inhibition. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Polygonum cuspidatum Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pterostilbene & Resveratrol 50 mg / 250 mg, from the product label.

Protocol For Life Balance

See all Protocol For Life Balance products
Name
Protocol For Life Balance(R)
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Pharmacist Counseling Corner

Pterostilbene & Resveratrol 50 mg / 250 mg by Protocol For Life Balance: Common Questions

Does Pterostilbene & Resveratrol 50 mg / 250 mg by Protocol For Life Balance interact with any medications?
Yes. Based on its ingredients, Pterostilbene & Resveratrol 50 mg / 250 mg has a known interaction with 826 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pterostilbene & Resveratrol 50 mg / 250 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the difference between pterostilbene and resveratrol?
Both are polyphenols—natural compounds found in plants. This product contains 50 mg of trans-pterostilbene (a direct ingredient) and 250 mg of hu zhang extract, which is a source of resveratrol. We have no human evidence on file for how well either works on its own.
Can I take this if I'm on a blood thinner like warfarin?
There's a documented Moderate-severity concern: resveratrol in hu zhang may increase bleeding risk when combined with blood thinners or antiplatelet drugs. Don't start without talking to your doctor or pharmacist first—they can assess your individual situation.
Is this safe during pregnancy or while breastfeeding?
No. The safety data advises against use during pregnancy because some compounds in hu zhang may affect the uterus. There isn't enough safety information to recommend it while breastfeeding either—talk with your doctor or pharmacist for personalized guidance.
What are the side effects?
Adverse effects haven't been formally documented in our data, but hu zhang's emodin content may cause digestive upset in some people. Human safety data for this supplement are limited overall.
Does this product help with arthritis or wound healing?
The evidence we hold is insufficient to rate hu zhang for osteoarthritis, rheumatoid arthritis, or wound healing. That means human studies haven't established it works for those uses—talk with your doctor about what's proven for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pterostilbene & Resveratrol 50 mg / 250 mg label
Go deeper

The Full Monographs Behind Pterostilbene & Resveratrol 50 mg / 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hu Zhang

Interacts with 826 drugs

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and early human research looks interesting for...

Read the full Hu Zhang monograph →
Sources

Sources & How We Checked

Pterostilbene & Resveratrol 50 mg / 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hu Zhang 19 references
  1. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  2. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  3. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
  4. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
  5. Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
  6. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  7. Matsuda H, Shimoda H, Morikawa T, Yoshikawa M. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg Med Chem Lett 2001;11:1839-42. PubMed
  8. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  9. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
  10. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
  11. Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
  12. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
  13. Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
  14. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  15. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
  16. Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. PubMed
  17. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
  18. Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. PubMed
  19. Chi YC, Lin SP, Hou YC. A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats. Toxicol Appl Pharmacol 2012;263(3):315-22. PubMed

See these in context on the Hu Zhang monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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