Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Pumpsurge Cherry Limeade Ingredients & Drug Interactions

by Jacked Factory JF

Pumpsurge Cherry Limeade label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pumpsurge Cherry Limeade against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pumpsurge Cherry Limeade is a dietary supplement by Jacked Factory JF with 6 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 398 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Huperzine-A, L-Citrulline, Taurine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pumpsurge Cherry Limeade by Jacked Factory JF

Ask about any prescription or over-the-counter medication and we check it for interactions with Pumpsurge Cherry Limeade by Jacked Factory JF — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pumpsurge Cherry Limeade by Jacked Factory JF

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Pumpsurge Cherry Limeade is a 6-ingredient powder blend. L-citrulline is an amino acid that widens blood vessels to boost blood flow and oxygen during exercise.

Betaine anhydrous is a compound that helps cells produce energy and maintain proper fluid balance. Taurine is an amino acid that supports heart function and muscle performance.

Alpha-glycerylphosphorylcholine (alpha-GPC) is a compound that supplies choline, which your brain uses to build cell membranes and support cognitive function. Huperzine-A is a plant-derived alkaloid that acts on brain chemistry.

AstraGin is included but we hold no data on its mechanism. The inactive ingredients—citric acid, natural flavors, silicon dioxide, calcium silicate, acesulfame potassium, sucralose, and beet powder—are the excipients that make up the rest of the powder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: pre-workout with pumps focus energy and endurance.
  • We looked for evidence on: Athletic performance, Physical performance, Exercise-induced muscle soreness, Muscle strength, Cognitive function, Memory — and 4 related terms.
  • The strongest evidence on file: L-citrulline is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Huperzine A is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Memory.
  • Also on file: Betaine Anhydrous is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

L-citrulline is possibly effective for athletic performance. Betaine anhydrous is effective for homocystinuria (a rare metabolic disorder) and possibly effective for elevated homocysteine levels in the blood.

Taurine is possibly effective for congestive heart failure and hepatitis. Alpha-glycerylphosphorylcholine is possibly effective for Alzheimer disease.

Huperzine-A is possibly effective for Alzheimer disease. For other conditions listed in the data—cardiovascular disease, diabetes, cognitive function, and several others—the evidence is either insufficient or points toward ineffectiveness.

The facts do not provide effectiveness ratings for AstraGin.

The evidence, ingredient by ingredient L-citrulline Betaine Anhydrous Taurine Alpha-gpc Huperzine A

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-citrulline is generally well tolerated in healthy adults, though long-term safety hasn't been fully studied. The most common side effects are gastrointestinal discomfort and heartburn.

Betaine anhydrous is generally well tolerated, though people report body odor, diarrhea, nausea, and GI distress; rare serious effects include cerebral edema (brain swelling). Taurine is generally well tolerated short-term in healthy people, with constipation, diarrhea, and indigestion as the main side effects.

Alpha-glycerylphosphorylcholine is generally well tolerated, but rarely causes dizziness, insomnia, headache, or heartburn; interestingly, use for 2 months or longer has been associated with an elevated stroke risk compared to shorter use. Huperzine-A can cause dose-dependent cholinergic side effects—blurred vision, constipation, diarrhea, dizziness, dry mouth, nausea, sweating, and vomiting.

Pregnancy safety data is insufficient for L-citrulline, betaine anhydrous, alpha-glycerylphosphorylcholine, and huperzine-A; the safety data advises against use during pregnancy for these four. Taurine is rated Likely Safe in pregnancy and lactation.

For breastfeeding, safety data is unavailable or insufficient for L-citrulline, alpha-glycerylphosphorylcholine, and huperzine-A—discuss with your doctor or pharmacist. Betaine anhydrous has inadequate safety data for breastfeeding, and taurine (which occurs naturally in breast milk) has not been well studied as a supplement during lactation.

Side effects, ingredient by ingredient L-citrulline Betaine Anhydrous Taurine Alpha-gpc Huperzine A

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Huperzine A, Taurine, Alpha-gpc, L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 398 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pumpsurge Cherry Limeade, double-check your medications with your pharmacist if you take: antihypertensive drugs or blood pressure medications (Moderate risk of dangerously low blood pressure); phosphodiesterase-5 inhibitors like sildenafil or tadalafil (Moderate risk); lithium (Moderate risk of lithium buildup); anticholinergic drugs or cholinergic drugs (Moderate risk of reduced or excessive effects); or a scopolamine (Transderm Scop) patch (Minor risk of reduced effectiveness). No interactions are documented for the ingredients we could check against motion-sickness or other over-the-counter products, but discuss the full list of what you take with your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pumpsurge Cherry Limeade is designed for people looking to boost workout performance and blood flow, and its ingredients carry some evidence for athletic benefits and cardiovascular support. However, if you take blood pressure medications, erectile dysfunction drugs, lithium, anticholinergics, cholinergics, or a scopolamine patch, you'll need to check your specific medications with your pharmacist before starting—the interactions documented here are real concerns.

It's not recommended in pregnancy, and breastfeeding safety hasn't been established for most ingredients. Talk it over with your own doctor or pharmacist to see if this product fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pumpsurge Cherry Limeade, straight from the product label.

Brand Jacked Factory JF
Barcode (UPC) X001L5S7H7
Net contents 8.82 Ounce(s); 250 Gram(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 261456
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pumpsurge Cherry Limeade by Jacked Factory JF, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
12.5 Gram(s)
Maximum serving Sizes:
12.5 Gram(s)
Servings per container
20
UPC/BARCODE
X001L5S7H7
IngredientAmount% DV
L-Citrulline5 Gram(s)--
Betaine Anhydrous2.5 Gram(s)--
Taurine2 Gram(s)--
Alpha-Glycerylphosphorylcholine150 mg--
AstraGin25 mg--
Huperzine-A50 mcg--

Other ingredients: Citric Acid, Natural Flavors, Silicon Dioxide, Calcium Silicate, Acesulfame Potassium, Sucralose, Beet, Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

PumpSurge is a cutting-edge pre-workout supplement that contains no stimulants.

Take your training to the next level with unrivaled pumps & focus.

The PumpSurge formulation is scientifically dosed with a synergistic combination of potent ingredients. Experience laser-sharp focus, intense pumps, improved energy, and endless endurance. The PumpSurge formulation was created using ingredient research from studies performed at top universities and labs around the world.

Laser focus Increase strength Powerful pumps Enhance endurance

Suggested/Recommended/Usage/Directions

1 Scoop - 8-12 oz water - 1x Daily Directions: Mix 1 serving (1 scoop) of PumpSurge with 8-12 oz of water 30-40 minutes before your workout.

Precautions

Warning: Check with a qualified healthcare professional before taking this product.

Do not use if you are pregnant or nursing a baby, under 18 years of age, have any known or suspected medical conditions, and/or if you are taking any prescription or OTC medications.

Do not use if you are pregnant or nursing a baby, under 18 years of age, have any known or suspected medical conditions, and/or if you are taking any prescription or OTC medications.

Keep out of reach of children.

Do not use if safety seal is broken or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

5 g L-Citrulline 50 mcg Huperzine-A 150 mg Alpha GPC

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Astragin is a trademark of Nuliv Science USA, Inc.

General Statements

Please recycle container

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pumpsurge Cherry Limeade by Jacked Factory JF label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pumpsurge Cherry Limeade label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pumpsurge Cherry Limeade by Jacked Factory JF

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size12.5 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Citrulline

Interacts with
178 drugs
5 Gram(s) per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Betaine Anhydrous

No known
interactions
2.5 Gram(s) per serving

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

Taurine

Interacts with
173 drugs
2 Gram(s) per serving

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements,...

Taurine monograph & interactions

Alpha-Glycerylphosphorylcholine

Interacts with
16 drugs
150 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha-Glycerylphosphorylcholine monograph & interactions

AstraGin

25 mg per serving Form: Astragalus root extract, Tienchi ginseng root extract

Huperzine-A

Interacts with
219 drugs
50 mcg per serving Form: Toothed Clubmoss aerial part extract

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription A...

Huperzine-A monograph & interactions

Other (inactive) ingredients: Citric Acid, Natural Flavors, Silicon Dioxide, Calcium Silicate, Acesulfame Potassium, Sucralose, Beet, Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pumpsurge Cherry Limeade by Jacked Factory JF Drug Interactions

Want to check YOUR meds against Pumpsurge Cherry Limeade?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
398Drugs
398 Moderate

Ingredients driving the most interactions

Huperzine-A 219
L-Citrulline 178
Taurine 173
Alpha-Glycerylphosphorylcholine 16

Individual Drug Interactions

The ingredients in Pumpsurge Cherry Limeade interact with 398 drugs. Click any drug to see the details.

4 of the 6 ingredients in Pumpsurge Cherry Limeade interact with drugs. Each result below shows which ingredient is responsible. Huperzine-A L-Citrulline Taurine Alpha-Glycerylphosphorylcholine

Each ingredient & the kinds of drugs it affects

For each ingredient in Pumpsurge Cherry Limeade with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Huperzine-A2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B
Huperzine-A full monograph & interactions

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D
Taurine full monograph & interactions

Alpha-Glycerylphosphorylcholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha-Glycerylphosphorylcholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pumpsurge Cherry Limeade, from the product label.

Jacked Factory JF

See all Jacked Factory JF products
Name
Jacked Factory
City
St. John's
State
NL
ZipCode
A1A5G9
Phone Number
1-877-250-5237
Pharmacist Counseling Corner

Pumpsurge Cherry Limeade by Jacked Factory JF: Common Questions

Does Pumpsurge Cherry Limeade by Jacked Factory JF interact with any medications?
Yes. Based on its ingredients, Pumpsurge Cherry Limeade has a known interaction with 398 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pumpsurge Cherry Limeade contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant?
There isn't enough safety data for L-citrulline, betaine anhydrous, alpha-glycerylphosphorylcholine, or huperzine-A during pregnancy, and the data advises against use. Taurine is rated Likely Safe in pregnancy. Talk with your doctor or pharmacist before taking this product if you're pregnant or planning to become pregnant.
Can I take this while breastfeeding?
Safety data is insufficient or unavailable for most of the active ingredients while breastfeeding. Taurine occurs naturally in breast milk and is rated Likely Safe, but the others haven't been well studied. Check with your doctor or pharmacist for personalized advice.
What's L-citrulline in here for?
L-citrulline is an amino acid that widens your blood vessels and boosts blood flow and oxygen to your muscles during exercise. It's possibly effective for athletic performance.
Will this help my athletic performance?
L-citrulline, one of the main ingredients, is possibly effective for athletic performance. The other ingredients have mixed evidence or insufficient data for exercise, so results can vary.
What side effects should I watch for?
Most common are gastrointestinal ones—heartburn, nausea, diarrhea, and stomach discomfort. You might also notice body odor. If you take huperzine-A at high doses, cholinergic side effects like dry mouth, blurred vision, and dizziness can appear. Stop and contact your healthcare provider if you experience unusual symptoms.
Is there anything else in this besides the active ingredients?
Yes—the powder contains inactive ingredients like citric acid, natural flavors, silicon dioxide, calcium silicate, acesulfame potassium, sucralose, and beet powder as fillers and flavor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pumpsurge Cherry Limeade is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pumpsurge Cherry Limeade label
Go deeper

The Full Monographs Behind Pumpsurge Cherry Limeade’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph → Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Huperzine A

Interacts with 219 drugs

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...

Read the full Huperzine A monograph →
Sources

Sources & How We Checked

Pumpsurge Cherry Limeade's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 57 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Betaine Anhydrous 11 references
  1. Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
  2. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
  3. Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
  4. McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
  5. Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PloS Med 2005;2:e135. PubMed
  6. Knopman, D. and Patterson, M. An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis.Assoc.Disord. 2001;15(3):162-165. PubMed
  7. Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
  8. Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
  9. Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021 Mar 25:1-18. PubMed
  10. Zawieja EE, Zawieja B, Chmurzynska A. Betaine supplementation moderately increases total cholesterol levels: a systematic review and meta-analysis. J Diet Suppl. 2021;18(1):105-117. PubMed
  11. Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed

See these in context on the Betaine Anhydrous monograph →

Taurine 21 references
  1. Ahmad S, Robertson HT, Golper TA, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int 1990;38:912-8. PubMed
  2. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
  3. Obermann M, Schorn CF, Mummel P, et al. Taurine induced toxic encephalopathy? Clin Neurol Neurosurg 2006;108:812-3. PubMed
  4. Bichler, A., Swenson, A., and Harris, M. A. A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure. Amino Acids 2006;31(4):471-476. PubMed
  5. Iyadurai, S. J. and Chung, S. S. New-onset seizures in adults: possible association with consumption of popular energy drinks. Epilepsy Behav 2007;10(3):504-508. PubMed
  6. Berger, A. J. and Alford, K. Cardiac arrest in a young man following excess consumption of caffeinated "energy drinks". Med J Aust. 1-5-2009;190(1):41-43. PubMed
  7. Worthley, M. I., Prabhu, A., De, Sciscio P., Schultz, C., Sanders, P., and Willoughby, S. R. Detrimental effects of energy drink consumption on platelet and endothelial function. Am J Med 2010;123(2):184-187. PubMed
  8. Morchon, Simon D. and Perez Castrillon, J. L. [Hypoglycemia by intake of taurine]. Rev.Clin Esp. 2010;210(1):49.
  9. Livshits, Z., Hoffman, R. S., Hymes, K. B., and Nelson, L. S. If vitamins could kill: massive hemolysis following naturopathic vitamin infusion. J Med Toxicol. 2011;7(3):224-226. PubMed
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Alpha-gpc 4 references
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See these in context on the Alpha-gpc monograph →

Huperzine A 13 references
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See these in context on the Huperzine A monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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