Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

PumpSurge Watermelon Ingredients & Drug Interactions

by Jacked Factory

PumpSurge Watermelon label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PumpSurge Watermelon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PumpSurge Watermelon is a dietary supplement by Jacked Factory with 6 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 398 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Huperzine A, L-Citrulline, Taurine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against PumpSurge Watermelon by Jacked Factory

Ask about any prescription or over-the-counter medication and we check it for interactions with PumpSurge Watermelon by Jacked Factory — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of PumpSurge Watermelon by Jacked Factory

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

PumpSurge Watermelon contains six active ingredients. L-citrulline is an amino acid your body converts to arginine, which helps relax blood vessels and improve blood flow — key for workout performance.

Taurine is another amino acid that supports heart health and muscle function. Alpha-glycerylphosphorylcholine (alpha-GPC) supports brain function and mental sharpness.

Betaine anhydrous helps your body produce energy and supports muscle development. Huperzine A is a plant-derived compound that may enhance focus and memory.

AstraGin is included to aid ingredient absorption. The powder also contains inactive ingredients like citric acid, natural and artificial flavors, and sweeteners (sucralose and acesulfame potassium), plus silicon dioxide and calcium silicate for texture.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: blood flow and muscle performance during exercise.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle soreness, Physical performance, Muscle strength, Erectile dysfunction (ED), nitric oxide production — and 3 related terms.
  • The strongest evidence on file: L-citrulline is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Huperzine A is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.
  • Also on file: Betaine Anhydrous is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

L-citrulline is possibly effective for athletic performance — the science supports it helps during workouts. For cardiovascular health and heart function, the evidence isn't established enough in our data to rate it either way.

Taurine is possibly effective for congestive heart failure and hepatitis. Huperzine A is possibly effective for Alzheimer disease but has insufficient evidence for memory or athletic performance specifically.

Betaine anhydrous is effective for homocystinuria and possibly effective for high homocysteine levels, but evidence is unclear for other uses like muscle building or fat loss. Alpha-glycerylphosphorylcholine is possibly effective for Alzheimer disease; evidence is insufficient for general cognitive function.

The evidence, ingredient by ingredient L-citrulline Taurine Alpha-gpc Betaine Anhydrous Huperzine A

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-citrulline is generally well tolerated in healthy adults, though long-term safety isn't fully studied. Side effects are usually mild — gastrointestinal discomfort and heartburn are the most common.

During pregnancy, there isn't enough safety data, so it's best to avoid it. Safety while breastfeeding is unknown; avoid supplemental use.

Taurine is generally well tolerated short-term in healthy adults. Constipation, diarrhea, and indigestion are typical.

Long-term safety is less certain, and there's not enough data for supplement doses without medical guidance. Taurine occurs naturally in breast milk, but supplement safety isn't well studied.

Huperzine A is a pharmacologically active compound — it can cause real side effects and needs careful use with medical guidance. It should be avoided during pregnancy and breastfeeding.

Alpha-GPC is generally well tolerated, though long-term safety isn't established; avoid unless your doctor directs it during pregnancy or breastfeeding. Betaine anhydrous is generally well tolerated; side effects include body odor, nausea, vomiting, and gastrointestinal distress.

Avoid during pregnancy unless advised by a doctor; safety while breastfeeding isn't well established.

Side effects, ingredient by ingredient L-citrulline Taurine Alpha-gpc Betaine Anhydrous Huperzine A

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Huperzine A, Taurine, Alpha-gpc, L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 398 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking PumpSurge Watermelon, double-check if you're on blood pressure medications (antihypertensives) — L-citrulline and taurine can lower blood pressure further. If you take lithium for mood, taurine may raise its level in your blood.

Anticholinergic drugs (like scopolamine patches or bladder medications) and cholinergic drugs (which boost nerve signals) may not work as intended or could have stronger effects with huperzine A. Erectile dysfunction medications (PDE-5 inhibitors) may interact with L-citrulline.

Use the medication checker on this page with your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

PumpSurge Watermelon is designed for workout performance, especially if you're looking for better blood flow and endurance. If you take blood pressure medications, lithium, anticholinergic drugs, cholinergic drugs, or erectile dysfunction medications, check with your pharmacist first — this product has documented interactions with those drug types.

Pregnant or breastfeeding? Talk to your doctor or pharmacist; several ingredients lack safety data for those situations.

Otherwise, it's generally well tolerated in healthy adults.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PumpSurge Watermelon, straight from the product label.

Brand Jacked Factory
Barcode (UPC) 628250670332
Net contents 8.82 Ounce(s); 250 Gram(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 326685
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PumpSurge Watermelon by Jacked Factory, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
12.5 Gram(s)
Maximum serving Sizes:
12.5 Gram(s)
Servings per container
20
UPC/BARCODE
628250670332
IngredientAmount% DV
L-Citrulline5 Gram(s)--
Taurine2 Gram(s)--
Alpha-Glycerylphosphorylcholine150 mg--
Betaine Anhydrous2.5 Gram(s)--
AstraGin25 mg--
Huperzine A50 mcg--

Other ingredients: Citric Acid, Natural & Artificial Flavors, Silicon Dioxide, Calcium Silicate, Acesulfame Potassium, Sucralose, Beet, Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Ready to get your swole on? PumpSurge is a stimulant-free formula that gets your blood flowing while augmenting the mind-muscle connection. Feel the difference starting from the very first scoop with clinical doses of proven nitric oxide boosters and focus-enhancers that amplify "the pump" as you crank out rep after rep in the gym.

PumpSurge is a stimulant-free formula that gets your blood flowing while augmenting the mind-muscle connection.

Laser focus Increase strength Powerful pumps Enhanced endurance

Suggested/Recommended/Usage/Directions

Directions: Mix one serving (1 scoop) with 8-12 oz. of water 30-40 minutes before your workout. 1 scoop | 8-12 oz. water | 1x daily

Precautions

Warning: This product is only intended for use in healthy adults, 18 years of age or older. Keep out of reach of children.

Pregnant or nursing women should consult a physician before using this product.

Do not use if safety seal is broken or missing.

Storage

Store in a cool, dry place.

General Statements

Get Connected Facebook @JACKEDFACTORY Instagram @JACKED_FACTORY

Please recycle container

Formula

5 g L-citrulline 150 mg Alpha GPC 50 mcg Huperzine-A per serving

Watermelon Naturally & artificially flavored

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

AstraGin is a trademark of NuLive Science USA, Inc.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PumpSurge Watermelon by Jacked Factory label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PumpSurge Watermelon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PumpSurge Watermelon by Jacked Factory

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size12.5 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Citrulline

Interacts with
178 drugs
5 Gram(s) per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Taurine

Interacts with
173 drugs
2 Gram(s) per serving

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements,...

Taurine monograph & interactions

Alpha-Glycerylphosphorylcholine

Interacts with
16 drugs
150 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha-Glycerylphosphorylcholine monograph & interactions

Betaine Anhydrous

No known
interactions
2.5 Gram(s) per serving

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

AstraGin

25 mg per serving Form: Astragalus membranaceus root extract, Panax notoginseng root extract

Huperzine A

Interacts with
219 drugs
50 mcg per serving Form: Toothed Clubmoss aerial part extract

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription A...

Huperzine A monograph & interactions

Other (inactive) ingredients: Citric Acid, Natural & Artificial Flavors, Silicon Dioxide, Calcium Silicate, Acesulfame Potassium, Sucralose, Beet, Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

PumpSurge Watermelon by Jacked Factory Drug Interactions

Want to check YOUR meds against PumpSurge Watermelon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
398Drugs
398 Moderate

Ingredients driving the most interactions

Huperzine A 219
L-Citrulline 178
Taurine 173
Alpha-Glycerylphosphorylcholine 16

Individual Drug Interactions

The ingredients in PumpSurge Watermelon interact with 398 drugs. Click any drug to see the details.

4 of the 6 ingredients in PumpSurge Watermelon interact with drugs. Each result below shows which ingredient is responsible. Huperzine A L-Citrulline Taurine Alpha-Glycerylphosphorylcholine

Each ingredient & the kinds of drugs it affects

For each ingredient in PumpSurge Watermelon with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Huperzine A2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B
Huperzine A full monograph & interactions

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D
Taurine full monograph & interactions

Alpha-Glycerylphosphorylcholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha-Glycerylphosphorylcholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PumpSurge Watermelon, from the product label.

Jacked Factory

See all Jacked Factory products
Name
Jacked Factory
City
St. John's
ZipCode
A1A 5A1
Phone Number
1-877-250-5237
Web Address
Jackedfactory.com
Pharmacist Counseling Corner

PumpSurge Watermelon by Jacked Factory: Common Questions

Does PumpSurge Watermelon by Jacked Factory interact with any medications?
Yes. Based on its ingredients, PumpSurge Watermelon has a known interaction with 398 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PumpSurge Watermelon contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this hurt my blood pressure or my heart medications?
L-citrulline and taurine in this product can lower blood pressure, so if you take blood pressure medication, they might work together too well and drop your pressure too far. Talk to your pharmacist or doctor before starting — you may need a dose adjustment. If you take an erectile dysfunction drug like sildenafil, L-citrulline also pairs with that in the same way.
Can I take this while pregnant or breastfeeding?
Most of the ingredients in this product don't have enough safety data during pregnancy, so it's best to avoid it unless your doctor says otherwise. While breastfeeding, L-citrulline, huperzine A, and alpha-GPC lack sufficient safety data — avoid those. Taurine is likely safe during breastfeeding since it occurs naturally in breast milk, but supplement safety isn't well studied. Ask your doctor or pharmacist.
What's the most common side effect I might notice?
Stomach upset is the most likely — gastrointestinal discomfort, heartburn, nausea, and diarrhea show up most often with these ingredients. Some people also report body odor from betaine anhydrous. These tend to be mild and often improve as your body adjusts.
Does this actually boost workout performance?
L-citrulline, the main ingredient for that goal, is possibly effective for athletic performance — the evidence supports it. The others have less clear evidence for workouts specifically, though taurine and betaine do support muscle and energy function.
Is there anything in here that could cause problems if I take it long-term?
Long-term safety for most of these ingredients isn't fully studied. L-citrulline and taurine are generally well tolerated in the short run, but we don't have complete long-term data. Huperzine A is a pharmacologically active compound, so it needs careful, guided use. Chat with your pharmacist about your plans.
What does huperzine A actually do?
Huperzine A is a plant-derived compound that may boost focus and memory by increasing a neurotransmitter called acetylcholine. It's possibly effective for Alzheimer disease, but evidence for general memory in healthy people isn't established. It does come with cholinergic side effects like nausea, diarrhea, and dry mouth, especially at higher doses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PumpSurge Watermelon is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PumpSurge Watermelon label
Go deeper

The Full Monographs Behind PumpSurge Watermelon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph → Herb & supplement monograph

Huperzine A

Interacts with 219 drugs

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...

Read the full Huperzine A monograph →
Sources

Sources & How We Checked

PumpSurge Watermelon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 57 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Taurine 21 references
  1. Ahmad S, Robertson HT, Golper TA, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int 1990;38:912-8. PubMed
  2. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
  3. Obermann M, Schorn CF, Mummel P, et al. Taurine induced toxic encephalopathy? Clin Neurol Neurosurg 2006;108:812-3. PubMed
  4. Bichler, A., Swenson, A., and Harris, M. A. A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure. Amino Acids 2006;31(4):471-476. PubMed
  5. Iyadurai, S. J. and Chung, S. S. New-onset seizures in adults: possible association with consumption of popular energy drinks. Epilepsy Behav 2007;10(3):504-508. PubMed
  6. Berger, A. J. and Alford, K. Cardiac arrest in a young man following excess consumption of caffeinated "energy drinks". Med J Aust. 1-5-2009;190(1):41-43. PubMed
  7. Worthley, M. I., Prabhu, A., De, Sciscio P., Schultz, C., Sanders, P., and Willoughby, S. R. Detrimental effects of energy drink consumption on platelet and endothelial function. Am J Med 2010;123(2):184-187. PubMed
  8. Morchon, Simon D. and Perez Castrillon, J. L. [Hypoglycemia by intake of taurine]. Rev.Clin Esp. 2010;210(1):49.
  9. Livshits, Z., Hoffman, R. S., Hymes, K. B., and Nelson, L. S. If vitamins could kill: massive hemolysis following naturopathic vitamin infusion. J Med Toxicol. 2011;7(3):224-226. PubMed
  10. Schoffl, I., Kothmann, J. F., Schoffl, V., Rupprecht, H. D., and Rupprecht, T. "Vodka energy": too much for the adolescent nephron? Pediatrics 2011;128(1):e227-e231. PubMed
  11. Calabro, R. S., Italiano, D., Gervasi, G., and Bramanti, P. Single tonic-clonic seizure after energy drink abuse. Epilepsy Behav 2012;23(3):384-385. PubMed
  12. Fujita, T., Ando, K., Noda, H., Ito, Y., and Sato, Y. Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 1987;75(3):525-532. PubMed
  13. Darling, P. B., Lepage, G., Leroy, C., Masson, P., and Roy, C. C. Effect of taurine supplements on fat absorption in cystic fibrosis. Pediatr Res 1985;19(6):578-582. PubMed
  14. Fukuyama, Y. and Ochiai, Y. Therapeutic trial by taurine for intractable childhood epilepsies. Brain Dev. 1982;4(1):63-69. PubMed
  15. Franconi, F., Bennardini, F., Mattana, A., Miceli, M., Ciuti, M., Mian, M., Gironi, A., Anichini, R., and Seghieri, G. Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am.J. DOI
  16. Stohs SJ, Miller M. A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides. Food Chem Toxicol. 2014 Jan;63:240-3. PubMed
  17. Sun Q, Wang B, Li Y, Sun F, et al. Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized, double-blind, placebo-controlled study. Hypertension 2016 Mar;67(3):541-9. PubMed
  18. Jang ES, Hwang SH, Kim JW, Jeong SH. Effectiveness of 4-week oral taurine treatment for muscle cramps in patients with liver cirrhosis: a single-arm pilot study. Yonsei Med J 2021;62(1):21-8. PubMed
  19. Guan L, Miao P. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials. Eur J Pharmacol 2020;885:173533. PubMed
  20. Higgins JP, Liras GN, Liras IN, et al. Energy Drink Effects on Hemodynamics and Endothelial Function in Young Adults. Cardiology. 2021;146(2):258-262. PubMed
  21. Pallangyo P, Bhalia SV, Komba M, et al. Acute Myocardial Infarction Following the Consumption of Energy Drink in a 28-Year-Old Male: A Case Report. J Investig Med High Impact Case Rep. 2023 Jan-Dec;11:23247096231168811. PubMed

See these in context on the Taurine monograph →

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
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See these in context on the Alpha-gpc monograph →

Betaine Anhydrous 11 references
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  2. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
  3. Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
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  5. Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PloS Med 2005;2:e135. PubMed
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  7. Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
  8. Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
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  11. Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed

See these in context on the Betaine Anhydrous monograph →

Huperzine A 13 references
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  2. Ye JW, Cai JX, Wang LM, Tang XC. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther 1999;288:814-9.. DOI
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  9. Cheng, D. H., Ren, H., and Tang, X. C. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport 12-20-1996;8(1):97-101. PubMed
  10. Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. J Neural Transm (Vienna) 2009;116(4):457-65. PubMed
  11. Xu ZQ, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ. Treatment with Huperzine A improves cognition in vascular dementia patients. Cell Biochem Biophys 2012;62(1):55-8. PubMed
  12. Yang G, Wang Y, Tian J, Liu JP. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One 2013;8(9):e74916. PubMed
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See these in context on the Huperzine A monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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