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Dietary supplement

Pure Choline Bitartrate Powder Ingredients & Drug Interactions

by Hard Rhino

Pure Choline Bitartrate Powder label
See full label image
Powder Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure Choline Bitartrate Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Pure Choline Bitartrate Powder is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline Bitartrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure Choline Bitartrate Powder by Hard Rhino

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure Choline Bitartrate Powder by Hard Rhino — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pure Choline Bitartrate Powder by Hard Rhino

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: choline bitartrate, a form of choline, an essential nutrient your body uses to make acetylcholine (a neurotransmitter involved in muscle and nerve function) and phosphatidylcholine (a building block for cell membranes and the brain).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Choline product and its label doesn't state a use — see Choline's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for choline bitartrate is mixed. For athletic performance, the data suggests it's possibly ineffective.

For age-related cognitive decline, Alzheimer disease, bronchitis, hay fever, and liver conditions (TPN-associated hepatic steatosis), we don't have enough reliable evidence to know whether it works. If you're considering it for a specific health goal, talk it over with your doctor to see whether the science supports its use for your situation.

The evidence, ingredient by ingredient Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Choline is generally well tolerated at food-level amounts and doses taken appropriately—but high-dose supplements can cause side effects. The tolerable upper intake level is 3.5 grams daily; doses exceeding this may cause fishy body odor, diarrhea, nausea, sweating, salivation, and vomiting.

Very high doses (9 grams and above) carry greater risk of gastrointestinal upset. Choline is important during pregnancy and breastfeeding, but doses should follow your doctor's advice rather than arbitrary supplementation.

If you're pregnant, nursing, or planning to become pregnant, discuss choline supplementation with your healthcare provider before starting.

Side effects, ingredient by ingredient Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take atropine or any anticholinergic medication (used for conditions ranging from overactive bladder to certain types of poisoning), double-check with your pharmacist or doctor before adding this choline supplement—it may theoretically reduce the medication's effectiveness, especially if taken close together.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Pure Choline Bitartrate Powder may be worth considering if your doctor recommends choline supplementation for a specific reason—but the evidence for most common uses is limited or unclear. It interacts with atropine and related anticholinergic medications, so check your exact prescriptions before starting.

Talk with your doctor or pharmacist about whether this product is right for you and at what dose.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure Choline Bitartrate Powder, straight from the product label.

Brand Hard Rhino
Net contents 500 Gram(s); 1.1 lb
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 34287
Product type Vitamin
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure Choline Bitartrate Powder by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
550 mg
Maximum serving Sizes:
550 mg
Servings per container
909
IngredientAmount% DV
Choline Bitartrate550 mg--

Other ingredients: Choline Bitartrate, Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

No added fillers No flow agents No driers No other ingredients

Allergens: This product contains NO Soy, Milk & Byproducts, Eggs, Fish, Shellfish, Wheat, Gluten, Tree Nuts, or Sesame Seeds.

Suggested/Recommended/Usage/Directions

Suggested Use: A dosage of 500 mg is considered adequate for most individuals. As with all of our powders, a micro scale is strongly recommended for proper dosage.

Suggested Use: As a dietary supplement 500 mg is considered adequate for most individuals.

Storage

Storage: Store in a cool & dry place. Keep away from strong light & heat.

FDA Disclaimer Statement

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

WARNING: A scale is required for accurate measurements.

Keep away from children.

Do not take this or any other supplement if you are pregnant or nursing.

Do not take if you have high blood pressure or any medical complications.

Do not take this or any other supplement if you are pregnant or nursing, have high blood pressure or taking other prescription drugs.

WARNING: A micro scale is required for accurate measurements.

General Statements

Always consult with your physician before taking any new dietary supplements.

Expiration date on back of pouch.

USP-FCC

This is a NON-GMO ingredient produced with organic material.

Quality Healthcare Worldwide

Always consult with a physician before taking any new dietary supplement.

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure Choline Bitartrate Powder by Hard Rhino label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure Choline Bitartrate Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure Choline Bitartrate Powder by Hard Rhino

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size550 mg Dosage formPowder Servings per container909 Amounts shown are per serving.

Choline Bitartrate

Interacts with
16 drugs
550 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline Bitartrate monograph & interactions

Other (inactive) ingredients: Choline Bitartrate, Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure Choline Bitartrate Powder by Hard Rhino Drug Interactions

Want to check YOUR meds against Pure Choline Bitartrate Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline Bitartrate 16

Individual Drug Interactions

The ingredients in Pure Choline Bitartrate Powder interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pure Choline Bitartrate Powder interact with drugs. Each result below shows which ingredient is responsible. Choline Bitartrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure Choline Bitartrate Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline Bitartrate1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline Bitartrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure Choline Bitartrate Powder, from the product label.

Hard Rhino

See all Hard Rhino products
Name
GUARDIAN Biosciences
City
Phoenix
State
Arizona
Pharmacist Counseling Corner

Pure Choline Bitartrate Powder by Hard Rhino: Common Questions

Does Pure Choline Bitartrate Powder by Hard Rhino interact with any medications?
Yes. Based on its ingredients, Pure Choline Bitartrate Powder has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure Choline Bitartrate Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is choline bitartrate safe during pregnancy?
Choline is important during pregnancy, and this form is rated likely safe—but supplement doses should be taken only under your doctor's guidance rather than on your own. Talk with your healthcare provider about whether and how much you need.
Can I take this while breastfeeding?
Your choline needs are higher while breastfeeding. This supplement is rated likely safe, but use it only under professional guidance to make sure the dose is right for you and your baby.
What does choline do in the body?
Choline is an essential nutrient your body uses to make acetylcholine, a chemical messenger for muscles and nerves, and phosphatidylcholine, which helps build cell membranes and supports brain function.
What side effects can high-dose choline cause?
At doses above the tolerable upper limit of 3.5 grams daily, choline can cause fishy body odor, nausea, diarrhea, sweating, salivation, and vomiting. Very high doses (9 grams and above) carry greater risk of gastrointestinal upset.
Does this supplement really work for athletic performance?
The evidence suggests choline bitartrate is possibly ineffective for athletic performance. If you're considering it for sports or fitness, your doctor or coach can help you decide whether it's worth trying.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure Choline Bitartrate Powder label
Go deeper

The Full Monographs Behind Pure Choline Bitartrate Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Pure Choline Bitartrate Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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