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Dietary supplement

Pure Forskolin Ingredients & Drug Interactions

by TruDerma

Pure Forskolin label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure Forskolin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Pure Forskolin is a dietary supplement by TruDerma with 1 active ingredient. Its ingredients are commonly taken for weight management, asthma and breathing, high blood pressure.Based on those ingredients, 915 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Forskolin Proprietar Formula. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure Forskolin by TruDerma

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure Forskolin by TruDerma — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pure Forskolin by TruDerma

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Forskolin Proprietar Formula” is a proprietary blend — the label gives one combined amount (250 mg) without saying how much of each component you get.

Pure Forskolin contains two active ingredients: coleus forskohlii root extract and coleus forskohlii itself. Forskolin is the key compound in coleus that's believed to work on cells throughout your body.

The product also includes several inactive ingredients — vegetable cellulose (capsule), di-calcium phosphate, vegetable stearate, silica, chlorophyll, and titanium dioxide — that help hold the capsule together and maintain stability.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Coleus product and its label doesn't state a use — see Coleus's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence on coleus forskohlii and pure forskolin isn't established in our data. We hold insufficient reliable evidence to rate its use for angina, asthma, cancer, congestive heart failure, atopic dermatitis (eczema), or dry eye.

That doesn't mean it won't work — it means the studies aren't strong enough yet to say one way or the other. If you're considering it for any of these reasons, talk it over with your doctor.

The evidence, ingredient by ingredient Coleus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Coleus is generally well tolerated when taken by mouth, but a small number of users report gastrointestinal side effects — mainly dose-related diarrhea, along with occasional nausea, vomiting, or constipation. One clinical trial participant out of 15 experienced increased bowel movements and loose stools.

Because coleus may lower blood pressure and isn't well studied long-term, use it with care and under professional guidance. The safety data advises against use during pregnancy and while breastfeeding; there isn't enough information to know the risks, so talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Coleus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Coleus.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 916 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you use nitrates or calcium channel blockers (heart and blood pressure medications) — these carry the highest risk. Also double-check any antihypertensive drugs (blood pressure medications), blood thinners (anticoagulants or antiplatelets), warfarin, or medications processed by your liver's CYP2C9 or CYP3A4 pathways — most common heart, blood pressure, and anti-inflammatory drugs fall into these categories.

Run your exact medications through our search tool or ask your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Pure Forskolin is generally well tolerated for short-term use, but it's not right for everyone — particularly anyone taking heart medications, blood pressure drugs, or blood thinners. Because it can affect how your liver processes many medications and lower blood pressure on its own, you'll want to check your exact prescription list with your doctor or pharmacist before starting.

Its effectiveness for the conditions it's marketed for isn't established in our data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure Forskolin, straight from the product label.

Brand TruDerma
Barcode (UPC) 700064800980
Net contents 60 Veggie Cap(s)
Market status On market
Date entered into DSLD Feb 24, 2017
DSLD ID 71076
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure Forskolin by TruDerma, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
60
UPC/BARCODE
700064800980
IngredientAmount% DV
Coleus forskohlii root extract0 NP--
Coleus forskohlii0 NP--
Forskolin Proprietar Formula250 mg--

Other ingredients: Vegetable Cellulose, Di-Calcium Phosphate, Vegetable Stearate, Silica, Chlorophyll, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Stimulant free

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one (1) veggie capsule daily, or as directed by your health care professional.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical conditions, including heart disease and blood pressure disorders, should consult a physician before using this or any dietary supplement.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical conditions, including heart disease and blood pressure disorders, should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical conditions, including heart disease and blood pressure disorders, should consult a physician before using this or any dietary supplement.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

1020

General Statements

Metabolic support

100% pure

Formula

250 mg Forskolin

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure Forskolin by TruDerma label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure Forskolin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure Forskolin by TruDerma

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Forskolin Proprietar Formula

Interacts with
915 drugs
250 mg per serving

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. Whil...

Forskolin Proprietar Formula monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Di-Calcium Phosphate, Vegetable Stearate, Silica, Chlorophyll, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure Forskolin by TruDerma Drug Interactions

Want to check YOUR meds against Pure Forskolin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
915Drugs
29 Major 886 Moderate

Ingredients driving the most interactions

Forskolin Proprietar Formula 915

Individual Drug Interactions

The ingredients in Pure Forskolin interact with 915 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pure Forskolin interact with drugs. Each result below shows which ingredient is responsible. Forskolin Proprietar Formula

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure Forskolin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Forskolin Proprietar Formula7 drug types · 915 drugs

Calcium Channel Blockers

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and calcium channel blockers both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Nitrates

Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and nitrates both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of coleus and anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro and animal research shows that forskolin, a constituent of coleus, can inhibit platelet aggregation and adhesion.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Animal research shows that forskolin, a constituent of coleus, may lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, taking coleus may affect drugs metabolized by CYP2C9 and increase the risk of adverse effects or reduce the effectiveness.
Research on the effect of coleus on CYP2C9 is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking coleus may affect the metabolism of warfarin and increase the risk of adverse effects or reduce the effectiveness.
Some animal research shows that coleus extract can induce cytochrome P450 2C9 (CYP2C9), an enzyme that metabolizes warfarin. However, other in vitro research shows that coleus can inhibit CYP2C9. Theoretically, taking coleus with drugs metabolized by CYP2C9 might affect drug levels and the risk of adverse effects. Until more is known, advise patients that taking coleus might increase or decrease levels of warfarin.

Likelihood Possible Evidence D
Forskolin Proprietar Formula full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure Forskolin, from the product label.

TruDerma

See all TruDerma products
Name
truDERMA
Street Address
8840 W. Russell Rd. #245
City
Las Vegas
State
NV
ZipCode
89148
Phone Number
1-855-479-2700
Pharmacist Counseling Corner

Pure Forskolin by TruDerma: Common Questions

Does Pure Forskolin by TruDerma interact with any medications?
Yes. Based on its ingredients, Pure Forskolin has a known interaction with 915 medications, including 29 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure Forskolin contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the difference between the two coleus ingredients listed?
Both are coleus forskohlii — the first is the root extract, the second is the whole plant form. They contain the same active compound (forskolin) and carry the same interactions and safety profile.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advises against use during pregnancy, and there isn't enough information about breastfeeding. Talk with your doctor or pharmacist for personalized advice, especially if you're considering it for a specific health reason.
What side effects should I watch for?
The most common are gastrointestinal — diarrhea, nausea, vomiting, or constipation — typically dose-related. Because it may lower blood pressure, watch for dizziness or lightheadedness, especially if you're already on blood pressure medication.
Will this help with angina, asthma, or eczema?
We don't have enough reliable evidence to say whether it works for these conditions. The studies aren't strong enough yet. If you're considering it for a specific health issue, ask your doctor whether it's right for you.
Is this safe to use long-term?
Coleus isn't well studied for long-term use, so the data we have doesn't support it. Use it short-term and under professional guidance. Talk with your pharmacist or doctor about how long it's safe for you personally.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure Forskolin label
Go deeper

The Full Monographs Behind Pure Forskolin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Coleus

Interacts with 915 drugs

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. While early lab and small human studies are...

Read the full Coleus monograph →
Sources

Sources & How We Checked

Pure Forskolin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coleus 16 references
  1. Baumann G, Felix S, Sattelberger U, Klein G. Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy. A comparative study with dobutamine and sodium nitroprusside. J Cardiovasc Pharmacol 1990;16:93-100.
  2. Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. Arzneimittelforschung 1987;37:364-7.
  3. Bauer K, Dietersdorfer F, Kaspar S, et al. Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Clin Pharmacol Ther 1993;53:76-83. PubMed
  4. Christenson JT, Thulesius O, Nazzal MM. The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release. Vasa 1995;24:56-61.
  5. Agarwal KC, Zielinski BA, Maitra RS. Significance of plasma adenosine in the antiplatelet activity of forskolin: potentiation by dipyridamole and dilazep. Thromb Haemost 1989;61:106-10. DOI
  6. Agarwal KC, Parks RE. Forskolin: a potential antimetastatic agent. Int J Cancer 1983;32:801-4. PubMed
  7. Almeida, F. C. and Lemonica, I. P. The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats. J Ethnopharmacol 2000;73(1-2):53-60. PubMed
  8. Ding, X. and Staudinger, J. L. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway. J Pharmacol Exp Ther 2005;312(2):849-856. PubMed
  9. Staudinger, J. L., Ding, X., and Lichti, K. Pregnane X receptor and natural products: beyond drug-drug interactions. Expert.Opin Drug Metab Toxicol 2006;2(6):847-857. PubMed
  10. van Hecke, E., Hindryckx, P., Geuns, J. M., and Devriese, E. Airborne contact dermatitis from coleus in a housewife. Contact Dermatitis 1991;25(2):128-129. PubMed
  11. Schlepper, M., Thormann, J., and Mitrovic, V. Cardiovascular effects of forskolin and phosphodiesterase-III inhibitors. Basic Res Cardiol 1989;84 Suppl 1:197-212. PubMed
  12. Dooms-Goossens, A., Borghijs, A., Degreef, H., Devriese, E. G., and Geuns, J. M. Airborne contact dermatitis to Coleus. Contact Dermatitis 1987;17(2):109-110. PubMed
  13. Lindner, E., Dohadwalla, A. N., and Bhattacharya, B. K. Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin. Arzneimittelforschung 1978;28(2):284-289.
  14. Loftus HL, Astell KJ, Mathai ML, et al. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. Nutrients. 2015;7(11): PubMed
  15. Yokotani K, Chiba T, Sato Y, et al. Hepatic cytochrome P450 mediates interaction between warfarin and Coleus forskohlii extract in vivo and in vitro. J Pharm Pharmacol. 2012;64(12):1793-801.
  16. Nishijima C, Chiba T, Sato Y, Umegaki K. Nationwide Online Survey Enables the Reevaluation of the Safety of Coleus forskohlii Extract Intake Based on the Adverse Event Frequencies. Nutrients. 2019;11(4). pii: E866. PubMed

See these in context on the Coleus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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