Drug & supplement interaction

Coleus + Amlodipine, Celecoxib

Amlodipine, Celecoxib brand name: Consensi.

Major Interaction
Medically reviewed by · Updated September 2026
The bottom line Major

Amlodipine, Celecoxib falls into 4 drug categories that Coleus can interact with; the most serious is rated major. Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.

Read the full interaction report
SeverityMajor
LikelihoodProbable
Interactions4
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Coleus and Amlodipine, Celecoxib

These two interact in 4 distinct ways. Each one is explained separately below.

Why Are There 4 Interactions?

Coleus interacts with whole categories of medication. Amlodipine, Celecoxib falls into 4 of those categories, so it can interact with Coleus in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Major).

Major

CALCIUM CHANNEL BLOCKERS

1 of 4

Why this applies to Amlodipine, Celecoxib

Amlodipine, Celecoxib falls under CALCIUM CHANNEL BLOCKERS — the group Coleus interacts with.

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and calcium channel blockers both cause coronary vasodilatory effects.
Severity Major Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Consensi (which combines amlodipine, a calcium channel blocker, with celecoxib for pain). Amlodipine works by relaxing and widening your blood vessels to lower blood pressure. The forskolin in Coleus seems to do something similar through a different pathway, so stacking the two could add up and push your blood pressure too low.

What that might feel like: dizziness, lightheadedness when you stand, flushing, swelling in your ankles, or a faster heartbeat. Honestly, this is mostly a theoretical concern based on how each works, not strong human studies. Still, since both can relax blood vessels, I'd run it by your pharmacist or doctor before adding a Coleus supplement, especially if your blood pressure already runs low.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Baumann G, Felix S, Sattelberger U, Klein G. Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy. A comparative study with dobutamine and sodium nitroprusside. J Cardiovasc Pharmacol 1990;16:93-100.
  2. Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. Arzneimittelforschung 1987;37:364-7.
Moderate

ANTIHYPERTENSIVE DRUGS

2 of 4

Amlodipine, Celecoxib also falls under ANTIHYPERTENSIVE DRUGS.

Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Animal research shows that forskolin, a constituent of coleus, may lower blood pressure.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Consensi is a combo pill that pairs amlodipine, a calcium channel blocker that lowers blood pressure, with celecoxib, an anti-inflammatory for pain. The piece that matters here is the amlodipine. Coleus and its active compound forskolin may relax blood vessels and gently nudge blood pressure down on their own.

So if you take them together, the worry is simply additive: the two pulling in the same direction could lower your pressure more than expected. That might leave you feeling dizzy, lightheaded, or faint, especially when you stand up. Keep in mind this is theoretical, based mostly on animal data, so it's a caution and not a sure thing. Before adding Coleus, check with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Baumann G, Felix S, Sattelberger U, Klein G. Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy. A comparative study with dobutamine and sodium nitroprusside. J Cardiovasc Pharmacol 1990;16:93-100.
  2. Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. Arzneimittelforschung 1987;37:364-7.
  3. Schlepper, M., Thormann, J., and Mitrovic, V. Cardiovascular effects of forskolin and phosphodiesterase-III inhibitors. Basic Res Cardiol 1989;84 Suppl 1:197-212. PubMed
  4. Lindner, E., Dohadwalla, A. N., and Bhattacharya, B. K. Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin. Arzneimittelforschung 1978;28(2):284-289.
Moderate

CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES

3 of 4

Amlodipine, Celecoxib also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.

Theoretically, taking coleus may affect drugs metabolized by CYP2C9 and increase the risk of adverse effects or reduce the effectiveness.
Research on the effect of coleus on CYP2C9 is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Consensi combines two medicines, and the part that matters here is celecoxib, which your liver clears using an enzyme called CYP2C9. Coleus (forskolin) may bump into that same enzyme, but the lab and animal data point in opposite directions. Some research suggests it speeds CYP2C9 up, which could lower celecoxib levels and ease its pain relief. Other research suggests it slows the enzyme down, which could let celecoxib build up and raise the odds of stomach upset, fluid retention, or higher blood pressure.

Honestly, this is theoretical and based only on test-tube and animal work, so it isn't a sure thing. Since amlodipine and Coleus can both nudge blood pressure too, please run this past your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Yokotani K, Chiba T, Sato Y, et al. Hepatic cytochrome P450 mediates interaction between warfarin and Coleus forskohlii extract in vivo and in vitro. J Pharm Pharmacol. 2012;64(12):1793-801.
Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

4 of 4

Amlodipine, Celecoxib also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.

Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Consensi combines two active drugs, amlodipine (for blood pressure) and celecoxib (an anti-inflammatory). Both are cleared partly by a liver enzyme called CYP3A4. The concern here is that Coleus might gently rev up that enzyme, which could clear these medicines a little faster and make them work less well. In plain terms, your blood pressure might not stay as controlled, and the celecoxib might give you less pain relief.

I'll be honest with you though: this is based only on lab and test-tube research, not real people, so we truly don't know if it matters in everyday life. It's a theoretical worry, not a proven problem. Still, since both drugs matter, please run it by your pharmacist or doctor before adding Coleus rather than changing anything yourself.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Ding, X. and Staudinger, J. L. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway. J Pharmacol Exp Ther 2005;312(2):849-856. PubMed
  2. Staudinger, J. L., Ding, X., and Lichti, K. Pregnane X receptor and natural products: beyond drug-drug interactions. Expert.Opin Drug Metab Toxicol 2006;2(6):847-857. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Coleus Also Interacts With Other Medications

Coleus has 28 major, 886 moderate known drug interactions in our database — the Amlodipine, Celecoxib one above is among them. If you take anything else, check it against the full list below.

Major 28 Moderate 886 No known interaction 1,916 (incl. Amlodipine, Celecoxib)
Taking anything else?

Check Another of Your Medications Against Coleus

Covers the 2,830 medications we’ve checked against Coleus. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Amlodipine, Celecoxib

This page covers Coleus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amlodipine, Celecoxib page lists 266 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Beer (major).

By severity: 11 major · 211 moderate · 44 minor.

From our pharmacist’s overview on the Amlodipine, Celecoxib page

“Grapefruit is the risk I would want a Consensi patient to grasp first. Consensi pairs amlodipine and celecoxib to treat high blood pressure and arthritis pain, and grapefruit blocks the enzyme that clears amlodipine, raising its levels.”

Reviewed by 2 · Jul 18, 2026

Open the Amlodipine, Celecoxib interaction page

One more smart check

Taking Coleus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 803 real supplement products containing Coleus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coleus. Your product may carry other ingredients that interact with Amlodipine, Celecoxib too, on top of Coleus — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coleus and Amlodipine, Celecoxib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coleus
Top 25%

#232 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amlodipine, Celecoxib
Top half

#1,116 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Coleus

What is Coleus?

Coleus
  • Weight management
  • Asthma and breathing
  • High blood pressure
  • Heart conditions
  • Glaucoma (eye pressure)
  • Exercise and body composition

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. While early lab and small human studies are interesting, solid proof that Coleus supplements help any of these conditions is limited. Talk to your pharmacist or doctor before using it, especially if you have heart problems or low blood pressure.

Read the full Coleus monograph & all interactions
Keep checking

Other Drugs & Coleus

Browse every other medication we’ve checked against Coleus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

28Major
886Moderate
0Minor
1,915No known interaction
28 Major 886 Moderate 1,915 No interaction
Major

28 interactions

Moderate

886 interactions

Showing 60 of 886 moderate interactions — see all 886 on the Coleus page.

No interaction 1,915 drugs checked — show the list

We also checked Coleus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,915 medications checked with no known interaction — see the full Coleus list.

See the full Coleus interactions page
See every supplement checked against Amlodipine, Celecoxib, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Coleus monograph › Uses, safety, and every drug interaction in one place Amlodipine, Celecoxib supplement interactions › Every supplement checked against Amlodipine, Celecoxib, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Coleus and Amlodipine, Celecoxib Together: Common Questions

Can you take Coleus with Amlodipine, Celecoxib?
This is rated a major interaction, so the combination is best avoided unless your doctor or pharmacist has specifically told you otherwise. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 4 interactions listed for Coleus and Amlodipine, Celecoxib?
Amlodipine, Celecoxib belongs to more than one drug category, and Coleus interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Coleus and Amlodipine, Celecoxib interaction?
We rate it Major. This is a clinically significant combination that is generally best avoided, or used only under the direct supervision of your physician or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.