Pure L-Proline USP Pharma Grade Powder Ingredients & Drug Interactions
by Hard Rhino
What is this page for?
First and foremost: checking Pure L-Proline USP Pharma Grade Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pure L-Proline USP Pharma Grade Powder is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for joint and connective tissue support, skin health and wound healing, collagen production.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Pure L-Proline USP Pharma Grade Powder by Hard Rhino
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product is pure L-proline, a naturally occurring amino acid your body uses to build and repair connective tissue, including collagen in skin, tendons, and bone. L-proline comes from protein-containing foods, but this supplement delivers it as a standalone powder — useful if you're looking to get more than diet alone provides.
There are no inactive ingredients listed, so you're getting proline only.
Does it work?
Couldn't assess
The evidence we hold rates L-proline as having insufficient reliable data to judge its effect on athletic performance, bone density, fractures, wound healing, or osteopenia (low bone mass). That means the research so far hasn't been strong or complete enough to say whether it works for these purposes.
If you're considering it for a specific health goal, talk it over with your doctor to see whether supplementing makes sense for you.
How safe is it?
Some data gaps
L-proline is generally considered low-risk when you get it from food, but how safe supplemental doses are hasn't been well studied. There isn't enough reliable data on larger amounts taken as a supplement, so it's best to avoid extra amounts unless your doctor specifically advises it.
Safety data while breastfeeding isn't established either, so use caution if you're nursing — talk with your doctor or pharmacist about whether this is right for you during that time.
Meds to double-check
No known interactions
No interactions are documented in our data for L-proline. That said, run your medications through the search tool on this page to be sure, and let your doctor or pharmacist know you're adding this supplement.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and some safety-information gaps remain.
Hard Rhino's L-proline is a straightforward single-ingredient amino acid powder with no documented drug interactions in our data. The evidence on whether it actually works for bone health, wound healing, or athletic performance isn't solid yet.
If you're pregnant, breastfeeding, or taking medications regularly, check with your doctor or pharmacist before you start — they can tell you whether this fits your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pure L-Proline USP Pharma Grade Powder, straight from the product label.
| Brand | Hard Rhino |
|---|---|
| Net contents | 500 Gram(s); 1.1 lb |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2014 |
| DSLD ID | 34528 |
| Product type | Amino Acid/protein |
| Supplement form | Powder |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pure L-Proline USP Pharma Grade Powder by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Proline | 500 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
No added fillers No flow agents No driers No other ingredients
Allergens: This product contains NO Soy, Milk & Byproducts, Eggs, Fish, Shellfish, Wheat, Gluten, Tree Nuts, or Sesame Seeds.
Suggested/Recommended/Usage/Directions
Suggested Use: Dosage for L-Proline can vary between 500 mg and 2500 mg once or twice daily. As with all our powders, a micro scale is strongly recommended for proper dosage.
Suggested Use: As a dietary supplement, take 500mg once daily or needed. Dosages can vary from 500mg to 2500mg per day.
Storage
Storage: Store in a cool and dry place. Keep away from strong light and heat.
FDA Disclaimer Statement
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
WARNING: A scale is required for accurate measurements.
Keep away from children.
Do not take this or any other supplement if you are pregnant or nursing.
Do not take if you have high blood pressure or any medical complications.
Do not take this or any other supplement if you are pregnant or nursing, have high blood pressure or taking other prescription drugs.
General Statements
Always consult with your physician before taking any new dietary supplements. Expiration date on back of pouch.
USP-FCC
This is a NON-GMO ingredient produced with organic material.
Always consult with a physician before taking any new dietary supplement.
Quality Healthcare Worldwide
FDA Statement of Identity
DIETARY SUPPLEMENT
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pure L-Proline USP Pharma Grade Powder by Hard Rhino label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pure L-Proline USP Pharma Grade Powder by Hard Rhino
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size500 mg Dosage formPowder Servings per container1000 Amounts shown are per serving.
L-Proline
No knowninteractions
Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of...
L-Proline monograph & interactionsPure L-Proline USP Pharma Grade Powder by Hard Rhino Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Pure L-Proline USP Pharma Grade Powder. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Pure L-Proline USP Pharma Grade Powder, from the product label.
Pure L-Proline USP Pharma Grade Powder by Hard Rhino: Common Questions
Does Pure L-Proline USP Pharma Grade Powder by Hard Rhino interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is L-proline safe if I'm pregnant or breastfeeding?
What does L-proline do in the body?
Does this product actually help with bone health or wound healing?
Does this powder have any fillers or added ingredients?
Are there any side effects from L-proline supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pure L-Proline USP Pharma Grade Powder is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pure L-Proline USP Pharma Grade Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Pure L-Proline USP Pharma Grade Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proline 4 references
- Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res. 2016;31(2):326-35. PubMed
- Gracia-Marco L, Bel-Serrat S, Cuenca-Garcia M, et al. Amino acids intake and physical fitness among adolescents. Amino Acids. 2017;49(6):1041-1052. PubMed
- Jamdar J, Rao B, Netke S, et al. Reduction in tibial shaft fracture healing time with essential nutrient supplementation containing ascorbic acid, lysine, and proline. J Altern Complement Med. 2004;10(6):915-6.
- Mehl AA, Damião AO, Viana SD, Andretta CP. Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair. J Wound Care 2021;30(1):26-31. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC