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Dietary supplement

Pure Tribulus Terrestris P.E. 40% Saponins Ingredients & Drug Interactions

by Hard Rhino

Pure Tribulus Terrestris P.E. 40% Saponins label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure Tribulus Terrestris P.E. 40% Saponins against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pure Tribulus Terrestris P.E. 40% Saponins is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus Terrestris P.E. 40% Saponins. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure Tribulus Terrestris P.E. 40% Saponins by Hard Rhino

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure Tribulus Terrestris P.E. 40% Saponins by Hard Rhino — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pure Tribulus Terrestris P.E. 40% Saponins by Hard Rhino

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Tribulus Terrestris P.E. 40% Saponins, a plant extract standardized to contain 40% saponins (naturally occurring plant compounds).

The extract comes from the tribulus plant and is delivered as a powder. No other active ingredients are present.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Tribulus product and its label doesn't state a use — see Tribulus's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

Tribulus is rated possibly effective for sexual dysfunction based on available evidence. However, for athletic performance, the evidence suggests it is possibly ineffective.

For benign prostatic hyperplasia (BPH, or enlarged prostate), there isn't enough reliable evidence in our data to rate whether it works or not.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated in the short term by healthy adults, though long-term safety data are limited. The most common side effects reported are mild gastrointestinal complaints—abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation—though in one study these occurred at rates similar to placebo.

Rare serious adverse effects including liver and kidney injury, seizures, and painful erection have been reported. Avoid this product during pregnancy because it may affect hormones and safety is not established.

Also avoid it while breastfeeding due to lack of reliable safety information.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood pressure medications, diabetes medications, or lithium. All three interactions are rated Moderate in severity and could affect how well your medications work or raise the risk of side effects like low blood pressure, low blood sugar, or increased lithium levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may be worth considering if you're interested in support for sexual dysfunction, though the evidence is modest. Do not use it if you take blood pressure medications, diabetes medications, or lithium without checking with your doctor or pharmacist first.

Because long-term safety data are limited and serious effects are rare but possible, this is not a product to take lightly or combine with your current regimen without professional guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure Tribulus Terrestris P.E. 40% Saponins, straight from the product label.

Brand Hard Rhino
Net contents 500 Gram(s); 1.1 lb
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 34545
Product type Botanical
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure Tribulus Terrestris P.E. 40% Saponins by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
600 mg
Maximum serving Sizes:
1000 mg
Servings per container
833
IngredientAmount% DV
Tribulus Terrestris P.E. 40% Saponins600 mg--

Other ingredients: Tribulus Terrestris P.E. 40% Saponins Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Quality Healthcare Worldwide

Always consult with your physician before taking any new dietary supplements. Expiration date on back of pouch.

USP-FCC

This is a NON-GMO ingredient produced with organic material.

Always consult with a physician before taking any new dietary supplement.

Formulation

No added fillers No flow agents No driers No other ingredients

Allergens: This product contains NO Soy, Milk & Byproducts, Eggs, Fish, Shellfish, Wheat, Gluten, Tree Nuts, or Sesame Seeds.

Suggested/Recommended/Usage/Directions

Suggested Use: Dosages range from 600 mg to 1000 mg once or twice daily and taken with meals to avoid an upset stomach. As with all of our powders, a micro scale is strongly recommended for proper dosage.

Suggested Use: Suggested dosage is 600mg once or twice daily, taken with meals.

Storage

Storage: Store in a cool & dry place. Keep away from strong light & heat.

Storage: Store in a cool & dry place. Keep away from direct sunlight and heat.

FDA Disclaimer Statement

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

WARNING: A scale is required for accurate measurements.

Keep away from children.

Do not take this or any other supplement if you are pregnant or nursing.

Do not take if you have high blood pressure or any medical complications.

WARNING: A micro scale is required for accurate measurements.

Do not take this or any other supplement if you are pregnant or nursing, have high blood pressure or taking other prescription drugs.

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure Tribulus Terrestris P.E. 40% Saponins by Hard Rhino label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure Tribulus Terrestris P.E. 40% Saponins label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure Tribulus Terrestris P.E. 40% Saponins by Hard Rhino

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size600 mg Dosage formPowder Servings per container833 Amounts shown are per serving.

Tribulus Terrestris P.E. 40% Saponins

Interacts with
259 drugs
600 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus Terrestris P.E. 40% Saponins monograph & interactions

Other (inactive) ingredients: Tribulus Terrestris P.E. 40% Saponins Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure Tribulus Terrestris P.E. 40% Saponins by Hard Rhino Drug Interactions

Want to check YOUR meds against Pure Tribulus Terrestris P.E. 40% Saponins?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus Terrestris P.E. 40% Saponins 259

Individual Drug Interactions

The ingredients in Pure Tribulus Terrestris P.E. 40% Saponins interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pure Tribulus Terrestris P.E. 40% Saponins interact with drugs. Each result below shows which ingredient is responsible. Tribulus Terrestris P.E. 40% Saponins

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure Tribulus Terrestris P.E. 40% Saponins with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus Terrestris P.E. 40% Saponins3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus Terrestris P.E. 40% Saponins full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure Tribulus Terrestris P.E. 40% Saponins, from the product label.

Hard Rhino

See all Hard Rhino products
Name
GUARDIAN Biosciences
City
Phoenix
State
Arizona
Pharmacist Counseling Corner

Pure Tribulus Terrestris P.E. 40% Saponins by Hard Rhino: Common Questions

Does Pure Tribulus Terrestris P.E. 40% Saponins by Hard Rhino interact with any medications?
Yes. Based on its ingredients, Pure Tribulus Terrestris P.E. 40% Saponins has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure Tribulus Terrestris P.E. 40% Saponins contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does tribulus actually work for sexual dysfunction?
The evidence suggests it's possibly effective for sexual dysfunction, meaning some studies show promise but the data aren't definitive. Results vary by person, and it's not a guaranteed fix.
What are the common side effects?
Most people tolerate it well. The most common complaints are mild stomach issues—nausea, cramping, diarrhea, or constipation—though in studies these happened about as often with placebo. Serious side effects are rare but have been reported.
Can I take this if I'm pregnant or breastfeeding?
No. Tribulus may affect hormones and safety in pregnancy isn't established, so it's considered possibly unsafe. There also isn't enough safety data for breastfeeding, so avoid it during that time too.
Why does tribulus interact with blood pressure and diabetes medications?
Tribulus can lower blood pressure and blood sugar levels on its own. When you add it to medications that already do these things, you raise the risk of your pressure or sugar dropping too low.
What's in this product besides tribulus?
Just the tribulus extract itself—no other active ingredients. The powder form is the extract standardized to 40% saponins.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure Tribulus Terrestris P.E. 40% Saponins is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure Tribulus Terrestris P.E. 40% Saponins label
Go deeper

The Full Monographs Behind Pure Tribulus Terrestris P.E. 40% Saponins’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Pure Tribulus Terrestris P.E. 40% Saponins's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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