Pycnogenol-50 50 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Pycnogenol-50 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pycnogenol-50 50 mg is a dietary supplement by DaVinci Laboratories with 1 active ingredient. Its ingredients are commonly taken for circulation and vein health, antioxidant support, skin health and aging.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pycnogenol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pycnogenol-50 50 mg by DaVinci Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with Pycnogenol-50 50 mg by DaVinci Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pycnogenol-50 50 mg by DaVinci Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Pycnogenol, a standardized extract of maritime pine bark, at 50 mg per capsule. The capsule itself is made up of inactive ingredients — cellulose, microcrystalline cellulose, leucine, and silica — which are fillers and binders that hold the dose together.
Does it work?
Moderate evidence
Maritime pine bark extract (Pycnogenol) is rated possibly effective for two conditions: osteoarthritis and chronic venous insufficiency — a condition where blood pools in the veins, usually in the legs. It's also rated possibly effective for asthma.
For high cholesterol (hyperlipidemia), the evidence suggests it's possibly ineffective — so it's not a reliable choice if that's your reason for taking it.
How safe is it?
Well-documented data
Pycnogenol is generally well tolerated in the studies we have, but long-term safety hasn't been fully worked out yet. The most common side effects when taken by mouth are stomach complaints, dizziness, and vertigo.
A few reports mention headache and, in rare cases, chest pain or heart failure worsening — though those cases involved people with existing heart disease, so it's unclear whether the supplement caused them. Because there isn't enough safety data, it's best avoided during pregnancy and while breastfeeding; talk with your doctor or pharmacist if you're in either situation and considering this product.
Meds to double-check
Moderate interaction found
Before taking Pycnogenol-50, check your medications if you're on blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel) — there's a moderate risk of increased bleeding. Also verify any diabetes medications, since maritime pine bark extract may lower blood sugar and require dose adjustments.
If you take immunosuppressants, flag those too, as the extract may interfere with their effect.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Pycnogenol may help with osteoarthritis, poor circulation in the legs, or asthma symptoms, though the evidence is solid enough to call it 'possibly effective' rather than proven. It's not right for you if you're on blood thinners, diabetes medications, or immunosuppressants without checking first — these interactions matter.
Before starting, check your exact medications with the tool on this page and loop in your pharmacist or doctor.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pycnogenol-50 50 mg, straight from the product label.
| Brand | DaVinci Laboratories |
|---|---|
| Barcode (UPC) | 026664277961 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 20, 2024 |
| DSLD ID | 313233 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pycnogenol-50 50 mg by DaVinci Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pycnogenol | 100 mg | -- |
Other ingredients: Cellulose, Microcrystalline Cellulose, Leucine, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Truth We pledge total truth in labeling. Our family of products contains only the purest and most potent ingredients. Guaranteed.
Formulation
Color of this product may vary due to color variations of the natural ingredients.
Vegetarian
Gluten free
Precautions
Warning: If pregnant or nursing, consult your healthcare practitioner before taking this product.
Keep out of reach of children.
To obtain product information or report a serious adverse event, call 1-800-325-1776. Not labeled for sale in California
Storage
Store in a cool, dry place.
Brand IP Statement(s)
Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
A Dietary Supplement to support vascular function and skin health
A Dietary Supplement to support vascular function and skin health
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 2 capsules with breakfast and 2 capsules with lunch for two weeks. Then take 2 capsules with daily breakfast, or as directed by your healthcare practitioner.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pycnogenol-50 50 mg by DaVinci Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pycnogenol-50 50 mg by DaVinci Laboratories
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Pycnogenol
Interacts with327 drugs
Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...
Pycnogenol monograph & interactionsOther (inactive) ingredients: Cellulose, Microcrystalline Cellulose, Leucine, Silica. These complete the product’s ingredient list but are not active constituents.
Pycnogenol-50 50 mg by DaVinci Laboratories Drug Interactions
HelloPharmacist Interaction Report
Pycnogenol-50 by DaVinci Laboratories contains maritime pine bark extract, which does interact with several medication types.
The most serious concern is with blood thinners and antiplatelet drugs (like warfarin, aspirin, and clopidogrel). Maritime pine bark extract may increase bleeding risk because it can slow platelet clumping.
The effect hasn't caused documented bleeding in humans, but it's a real theoretical concern worth checking.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to verify any diabetes medications you're on. One clinical study found that maritime pine bark extract can lower blood sugar, which means your dose might need adjusting.
Additionally, if you take immunosuppressants (drugs that calm your immune system), maritime pine bark extract might work against them — though this hasn't been reported in actual patients yet, only in lab and animal studies.
Altogether, these interactions span 322 individual medications. Before you start Pycnogenol-50, run your exact medications through the checker below — especially if you're on blood thinners, diabetes drugs, or immune-suppressing medication.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pycnogenol-50 50 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pycnogenol-50 50 mg interact with 327 drugs. Click any drug to see the details.
1 of the 1 ingredient in Pycnogenol-50 50 mg interact with drugs. Each result below shows which ingredient is responsible. Pycnogenol
EculizumabSoliris
How Eculizumab interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Eculizumab interactionEdoxabanSavaysa
How Edoxaban interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Edoxaban interactionEfalizumabRaptiva
How Efalizumab interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Efalizumab interactionEffientPrasugrel
How Effient interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Effient interactionEfgartigimod Alfa-fcabVyvgart
How Efgartigimod Alfa-fcab interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Efgartigimod Alfa-fcab interactionElranatamabElrexfio
How Elranatamab interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Elranatamab interactionEmapalumab-lzsgGamifant
How Emapalumab-lzsg interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Emapalumab-lzsg interactionEmpagliflozinJardiance
How Empagliflozin interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Empagliflozin, Metformin Hydrochloride interactionEnoxaparinLovenox
How Enoxaparin interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Enoxaparin interactionEpcoritamab-byspEpkinly
How Epcoritamab-bysp interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Epcoritamab-bysp interactionEptifibatideIntegrilin
How Eptifibatide interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Eptifibatide interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Ertugliflozin, Metformin Hydrochloride interactionEsomeprazole, NaproxenVimovo
How Esomeprazole, Naproxen interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Esomeprazole, Naproxen interactionEtanercept-szzsErelzi
How Etanercept-szzs interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Etanercept-szzs interactionEtanercept-ykroEticovo
How Etanercept-ykro interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Etanercept-ykro interactionEtrasimodVelsipity
How Etrasimod interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Etrasimod interactionExenatideBydureon, Byetta
How Exenatide interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Exenatide Synthetic interactionFamotidine, IbuprofenDuexis
How Famotidine, Ibuprofen interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Famotidine, Ibuprofen interactionFingolimodGilenya, Tascenso ODT
How Fingolimod interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Fingolimod interactionFish Oil TriglyceridesOmegaven
How Fish Oil Triglycerides interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Fish Oil Triglycerides interactionFludrocortisoneFlorinef Acetate
How Fludrocortisone interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Fludrocortisone interactionFluorouracil (iv)Fluorouracil
How Fluorouracil (iv) interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Fluorouracil (iv) interactionFlupenthixolFluanxol
How Flupenthixol interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Flupenthixol interactionFondaparinuxArixtra
How Fondaparinux interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Fondaparinux interactionFostamatinibTavalisse
How Fostamatinib interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Fostamatinib interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pycnogenol-50 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Pycnogenol
Anticoagulant/Antiplatelet Drugs
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.
Antidiabetes Drugs
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Immunosuppressants
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Pycnogenol-50 50 mg, from the product label.
DaVinci Laboratories
See all DaVinci Laboratories products- Name
- DaVinci Laboratories a division of FoodScience LLC
- Street Address
- 929 Harvest Lane
- City
- Williston
- State
- VT
- ZipCode
- 05495
- Phone Number
- 1-800-325-1776
- Web Address
- www.davincilabs.com
Pycnogenol-50 50 mg by DaVinci Laboratories: Common Questions
Does Pycnogenol-50 50 mg by DaVinci Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is Pycnogenol and where does it come from?
Can I take this if I'm on aspirin or another blood thinner?
Will this help my cholesterol?
What are the side effects?
Is it safe to take if I'm pregnant or breastfeeding?
Can I take this if I have diabetes and I'm on diabetes medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pycnogenol-50 50 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pycnogenol-50 50 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Pycnogenol-50 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Maritime Pine 14 references
- Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
- Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
- Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
- Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
- Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
- Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
- Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
- Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
- Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
- Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
- Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
- Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
- Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
- Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC