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Dietary supplement

Pycnogenol (Pine Bark extract) 50 mg Ingredients & Drug Interactions

by Pure Encapsulations

Pycnogenol (Pine Bark extract) 50 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pycnogenol (Pine Bark extract) 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pycnogenol (Pine Bark extract) 50 mg is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for circulation and vein health, antioxidant support, skin health and aging.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are French Maritime Pine Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pycnogenol (Pine Bark extract) 50 mg by Pure Encapsulations

Ask about any prescription or over-the-counter medication and we check it for interactions with Pycnogenol (Pine Bark extract) 50 mg by Pure Encapsulations — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pycnogenol (Pine Bark extract) 50 mg by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: French Maritime Pine Extract, also called Pycnogenol, at 50 mg per capsule. It's a plant-derived compound that may help support joint health and circulation.

The capsule also contains inactive ingredients — plant fiber, cellulose, water, and ascorbyl palmitate — which are binding and stabilizing agents with no active role.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Circulation and vein health support.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Varicose veins, Raynaud syndrome, Atherosclerosis, Hypertension, Hemorrhoids — and 4 related terms.
  • The strongest evidence on file: Maritime Pine is rated "Possibly Effective" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Maritime Pine is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Hemorrhoids, Hypertension, Varicose veins, and more.

Maritime pine bark extract is rated possibly effective for osteoarthritis and for chronic venous insufficiency — a condition where blood doesn't return efficiently from your legs. It's also rated possibly effective for asthma.

For high cholesterol (hyperlipidemia), the evidence suggests it's possibly ineffective, so this isn't the supplement to reach for if that's your goal.

The evidence, ingredient by ingredient Maritime Pine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

In trials, maritime pine bark extract has been generally well tolerated. The most common side effects are stomach upset, dizziness, and vertigo — a spinning sensation.

Headache has been reported in one trial. Rare reports exist of chest pain and worsening heart failure in patients with existing heart disease, but it's unclear whether the supplement caused these or the underlying condition did.

Long-term safety hasn't been fully studied. The safety data advises against use during pregnancy and breastfeeding, so talk to your doctor or pharmacist if either applies to you.

Side effects, ingredient by ingredient Maritime Pine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maritime Pine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take blood thinners or antiplatelet drugs — the supplement may increase bleeding risk. Also double-check if you're on diabetes medications, since maritime pine bark may lower blood sugar further.

If you take immunosuppressants, let your pharmacist know as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have osteoarthritis, chronic leg swelling, or asthma and take no blood thinners or diabetes drugs, maritime pine bark extract is worth discussing with your pharmacist. Anyone on anticoagulants, antiplatelets, diabetes medications, or immunosuppressants should check their exact drugs first — the interaction risk is real.

If you have heart disease, mention it before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pycnogenol (Pine Bark extract) 50 mg, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298002279
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 278339
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pycnogenol (Pine Bark extract) 50 mg by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
766298002279
IngredientAmount% DV
French Maritime Pine Extract50 mg--

Other ingredients: hypoallergenic Plant Fiber, Cellulose, Water, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 1 capsule, 1-3 times daily, between meals.

Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

General Statements

Scan to learn about our hypoallergenic supplements

Contents may not fill package in order to accommodate labeling. Please rely on stated quantity.

Seals/Symbols

GFCO.org Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org

Formulation

Supports cognitive function and cardiovascular health

Gluten-free, Non-GMO & Hypoallergenic

Gluten-free, Non-GMO & Hypoallergenic

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents. Pycnogenol French maritime pine bark extract

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pycnogenol (Pine Bark extract) 50 mg by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pycnogenol (Pine Bark extract) 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pycnogenol (Pine Bark extract) 50 mg by Pure Encapsulations

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

French Maritime Pine Extract

Interacts with
327 drugs
50 mg per serving

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...

French Maritime Pine Extract monograph & interactions

Other (inactive) ingredients: Hypoallergenic Plant Fiber, Cellulose, Water, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pycnogenol (Pine Bark extract) 50 mg by Pure Encapsulations Drug Interactions

Want to check YOUR meds against Pycnogenol (Pine Bark extract) 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

French Maritime Pine Extract 327

Individual Drug Interactions

The ingredients in Pycnogenol (Pine Bark extract) 50 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pycnogenol (Pine Bark extract) 50 mg interact with drugs. Each result below shows which ingredient is responsible. French Maritime Pine Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pycnogenol (Pine Bark extract) 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

French Maritime Pine Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
French Maritime Pine Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pycnogenol (Pine Bark extract) 50 mg, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

Pycnogenol (Pine Bark extract) 50 mg by Pure Encapsulations: Common Questions

Does Pycnogenol (Pine Bark extract) 50 mg by Pure Encapsulations interact with any medications?
Yes. Based on its ingredients, Pycnogenol (Pine Bark extract) 50 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pycnogenol (Pine Bark extract) 50 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on aspirin?
Not without checking first. Maritime pine bark extract may thin your blood and raise bleeding risk when combined with aspirin or other blood thinners. Your pharmacist can tell you whether the combination is right for you or whether you need dose adjustments.
Will this help my osteoarthritis?
Maritime pine bark extract is rated possibly effective for osteoarthritis, meaning some evidence supports it but more research is needed. It's worth trying if you're looking for a plant-based option, but talk to your doctor about how it fits into your full treatment plan.
What are the most common side effects?
Stomach upset, dizziness, and vertigo are the most common. Headache has been reported in at least one study. Most people tolerate it well, but if dizziness is a problem for you, mention it when you start.
Is it safe to take during pregnancy?
No — there isn't enough safety data, so the recommendation is to avoid it during pregnancy. Talk to your obstetrician or pharmacist before taking it if you're pregnant or planning to be.
Can I breastfeed while taking this?
The safety data isn't sufficient, so it's best avoided while breastfeeding. If you're nursing, check with your pharmacist or doctor before starting.
Does this help with high cholesterol?
No — maritime pine bark extract is rated possibly ineffective for high cholesterol. If that's your concern, ask your pharmacist about other options.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pycnogenol (Pine Bark extract) 50 mg label
Go deeper

The Full Monographs Behind Pycnogenol (Pine Bark extract) 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maritime Pine

Interacts with 327 drugs

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research is promising, but many studies are small...

Read the full Maritime Pine monograph →
Sources

Sources & How We Checked

Pycnogenol (Pine Bark extract) 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maritime Pine 14 references
  1. Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
  2. Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
  3. Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
  4. Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
  5. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
  6. Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
  7. Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
  8. Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
  9. Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
  10. Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
  11. Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
  12. Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
  13. Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
  14. Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.

See these in context on the Maritime Pine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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