Major interaction on record — check this product against your medications before combining. Based on 4 of 8 ingredients. Check your meds →
Dietary supplement

Re-Bld Watermelon Ingredients & Drug Interactions

by Evlution Nutrition

Re-Bld Watermelon label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Re-Bld Watermelon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Re-Bld Watermelon is a dietary supplement by Evlution Nutrition with 8 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 528 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Russian Tarragon, Magnesium Creatine Chelate, L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Re-Bld Watermelon by Evlution Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Re-Bld Watermelon by Evlution Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Re-Bld Watermelon by Evlution Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 8 active ingredients.
  • “RE-BLD(TM) BCAA Fusion Proprietary Blend” is a proprietary blend — the label gives one combined amount (2,010 mg) without saying how much of each component you get.

Re-Bld Watermelon contains 8 active ingredients. The core are three branched-chain amino acids — L-leucine, L-isoleucine, and L-valine — which your muscles use for repair and recovery.

It also includes L-glutamine, an amino acid that supports muscle and immune function; creatine monohydrate, which helps muscle cells produce energy during intense effort; magnesium in two forms (magnesium creatine chelate and magnesium); and Russian tarragon, an herb added for flavor and potential digestive support. The product also contains inactive ingredients — natural and artificial flavor, malic acid, silica, citric acid, sucralose, acesulfame potassium, and FD&C Red #40 — which are fillers and binders used to form the powder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle growth, strength, recovery and performance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Muscle breakdown, Muscle cramps, Muscle strength — and 3 related terms.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Muscle strength.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.

The evidence for this product's ingredients is mixed. L-glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting and recovery after surgery or critical illness.

Creatine monohydrate is possibly effective for muscle strength and athletic performance, though it's possibly ineffective for Huntington disease and bone density. Magnesium is effective for indigestion and constipation.

The branched-chain amino acids L-leucine, L-isoleucine, and L-valine aren't rated in our data. Russian tarragon for postoperative nausea and vomiting has insufficient reliable evidence to rate.

The evidence, ingredient by ingredient Glutamine Creatine Magnesium Tarragon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glutamine and creatine are generally well tolerated in healthy adults. Common side effects from glutamine include belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting — especially at high doses.

Creatine's most common effects are dehydration, diarrhea, gastrointestinal upset, muscle cramps, and water retention; rare serious cases have involved kidney or muscle damage, so people with kidney problems should be careful. Magnesium commonly causes diarrhea, nausea, vomiting, and gastrointestinal irritation.

Russian tarragon from food is generally safe, but concentrated extracts carry concern from estragole, a compound that's raised cancer risk in animal studies. Pregnancy and lactation: glutamine is likely safe; magnesium is needed but supplements should be guided by your doctor; creatine should be avoided in pregnancy (safety not established) and during breastfeeding; Russian tarragon is likely unsafe in concentrated medicinal amounts during pregnancy, though food amounts are probably fine — check with your doctor or midwife.

Data on L-leucine, L-isoleucine, and L-valine during pregnancy or breastfeeding isn't on file.

Side effects, ingredient by ingredient Glutamine Creatine Magnesium Tarragon

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Tarragon, Glutamine, Magnesium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; heart-rhythm medications; Parkinson's medications.
  • For scale: 528 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on any of these: Parkinson's medications (especially levodopa/carbidopa), skeletal muscle relaxants, potassium-sparing diuretics, calcium channel blockers for high blood pressure, acid-reducing drugs or antacids, diabetes medications (sulfonylureas), quinolone antibiotics, bisphosphonates for bone health, anticonvulsants, blood thinners or aspirin, CNS depressants like benzodiazepines or certain antidepressants, or monoamine oxidase inhibitors (older-class antidepressants).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is aimed at athletes and people recovering from illness who want to build or preserve muscle. It's generally well tolerated if you're healthy and don't have kidney disease, but several ingredients — especially magnesium and tarragon — interact with common medications.

If you take a Parkinson's drug, a muscle relaxant, a blood thinner, an antibiotic, a diabetes medication, or an antidepressant, talk with your doctor or pharmacist before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Re-Bld Watermelon, straight from the product label.

Brand Evlution Nutrition
Net contents 11.4 oz.; 324 Gram(s)
Market status On market
Date entered into DSLD May 23, 2014
DSLD ID 33363
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Re-Bld Watermelon by Evlution Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Children less than 4 years of age
Minimum serving Sizes:
10.8 Gram(s)
Maximum serving Sizes:
10.8 Gram(s)
Servings per container
30
IngredientAmount% DV
L-Glutamine3000 mg--
L-Leucine0 NP--
L-Isoleucine0 NP--
Creatine Monohydrate3000 mg--
L-Valine0 NP--
Magnesium Creatine Chelate1000 mg--
Magnesium80 mg20%
Russian Tarragon0 NP--
RE-BLD(TM) BCAA Fusion Proprietary Blend2010 mg--

Other ingredients: Natural and Artificial flavor, Malic Acid, Silica, Citric Acid, Sucralose, Acesulfame Potassium, FD&C Red #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

SUGGESTED USE: As a dietary supplement mix 1 scoop of RE-BLD(TM) with (12-24oz) of Cold water (vary amount of water by taste preference) Immediately Post training.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

FACEBOOK.com/EVLsports YOUTUBE.com/EVLsports INSTAGRAM.com/EVLsports TWITTER.com/EVLsports # We want to see your EVL side: # EVL

This product is manufactured in a GMP compliant facility.

{Chart} PEAK PERFORMANCE STACK PRODUCTS PRE-WORKOUT DURING WORKOUT POST-WORKOUT ENGN(TM) 1-2 servings 15-30 minutes A-10(TM) AMINO MATRIX 1 serving 1 serving RE-BLD(TM) 1 serving immediately GLU+(TM) L-GLUTAMINE ANTIOXIDANTS 1 serving

- RAPID REBUILD

NATURALLY AND ARTIFICIALLY FLAVORED

- REBUILD MUSCLE - RAPID RECOVERY - ENHANCE STRENGTH - INCREASE ENDURANCE 30 servings

Seals/Symbols

EVL(R)

MADE IN THE USA

Brand IP Statement(s)

THE EVLUTION OF MUSCLE BUILDING. WHEN COMBINED WITH REGULAR TRAINING, RE-BLD(TM) IS ENGINEERED TO SUPPORT: - STRENGTH - MUSCLE GROWTH - RECOVERY - PROTEIN SYNTHESIS - ENDURANCE - PERFORMANCE

Creatine MagnaPower is a registered trademark of Albion Laboratories, Inc. Chelate covered by U.S. Patent 6,114,379.

POST-ORKOUT REBUILD(TM)

Precautions

Warnings: Not for use by those with pre-existing medical conditions or taking any medications, those under the age of 18, or women that are contemplating pregnancy, pregnant or nursing.

Warnings: Not for use by those with pre-existing medical conditions or taking any medications, those under the age of 18, or women that are contemplating pregnancy, pregnant or nursing. Keep out of reach of children and pets.

Formula

- CREATINE + GLUTAMINE + AMINOS

Storage

Store in a dry place away from direct sunlight.

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Re-Bld Watermelon by Evlution Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Re-Bld Watermelon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Re-Bld Watermelon by Evlution Nutrition

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size10.8 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
3000 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Creatine Monohydrate

No known
interactions
3000 mg per serving

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Creatine Monohydrate monograph & interactions

Magnesium Creatine Chelate

Interacts with
295 drugs
1000 mg per serving

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magnesium Creatine Chelate monograph & interactions

Magnesium

Interacts with
295 drugs
80 mg per serving Form: Creatine MagnaPower(R) magnesium creatine chelate

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magnesium monograph & interactions

RE-BLD(TM) BCAA Fusion Proprietary Blend

2010 mg per serving

Other (inactive) ingredients: Natural and Artificial flavor, Malic Acid, Silica, Citric Acid, Sucralose, Acesulfame Potassium, FD&C Red #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Re-Bld Watermelon by Evlution Nutrition Drug Interactions

Want to check YOUR meds against Re-Bld Watermelon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
528Drugs
6 Major 521 Moderate 1 Minor

Ingredients driving the most interactions

Russian Tarragon 359
Magnesium Creatine Chelate 295
L-Glutamine 50

Individual Drug Interactions

The ingredients in Re-Bld Watermelon interact with 528 drugs. Click any drug to see the details.

3 of the 8 ingredients in Re-Bld Watermelon interact with drugs. Each result below shows which ingredient is responsible. Russian Tarragon Magnesium Creatine Chelate L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Re-Bld Watermelon with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Russian Tarragon3 drug types · 359 drugs

Anticoagulant/Antiplatelet Drugs

Evidence from in vitro research suggests that tarragon extract inhibits platelet aggregation and adhesion. Theoretically, tarragon might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Cns Depressants

Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneally at a dose of 1 mL/kg. Theoretically, concomitant use of tarragon with CNS depressants, including antihistamines, barbiturates, benzodiazepines, and tricyclic antidepressants, may increase sedative and other adverse effects.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

In vitro research suggests that tarragon extract inhibits monoamine oxidase (MAO)-A and MAO-B enzymes. Theoretically, concomitant use with MAOIs might increase the effects and adverse effects associated with MAOIs.

Likelihood Possible Evidence D
Russian Tarragon full monograph & interactions

Magnesium Creatine Chelate15 drug types · 295 drugs

Levodopa/Carbidopa (Sinemet)

Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.

Likelihood Probable Evidence B
Aminoglycoside Antibiotics

Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.

Likelihood Possible Evidence D
Antacids

Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.

Likelihood Possible Evidence D
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.

Likelihood Probable Evidence B
Calcium Channel Blockers

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.

Likelihood Possible Evidence D
Digoxin

Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.

Likelihood Possible Evidence B
Potassium-Sparing Diuretics

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.

Likelihood Probable Evidence D
Quinolone Antibiotics

Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.

Likelihood Probable Evidence A
Sulfonylureas

Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.

Likelihood Unlikely Evidence B
Gabapentin (Neurontin)

Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Unlikely Evidence B
Sevelamer (Renagel, Renvela)

Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.

Likelihood Possible Evidence B
Magnesium Creatine Chelate full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Re-Bld Watermelon, from the product label.

Evlution Nutrition

See all Evlution Nutrition products
Name
EVLUTION NUTRITION
Street Address
1560 Sawgrass Corporate Parkway, 4th Floor
City
Sunrise
State
Florida
ZipCode
33323
Phone Number
1(855)385-2300
Pharmacist Counseling Corner

Re-Bld Watermelon by Evlution Nutrition: Common Questions

Does Re-Bld Watermelon by Evlution Nutrition interact with any medications?
Yes. Based on its ingredients, Re-Bld Watermelon has a known interaction with 528 medications, including 6 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Re-Bld Watermelon contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe for me to take if I have kidney problems?
No. Both glutamine and creatine should be used only under medical supervision if you have kidney or liver disease. Talk with your doctor before starting it.
Can I take this while pregnant or breastfeeding?
Glutamine is likely safe during pregnancy and breastfeeding, but magnesium supplements in pregnancy need your doctor's guidance even though magnesium is essential. Creatine should be avoided in both pregnancy and breastfeeding — safety hasn't been established. We don't have pregnancy or breastfeeding data for the branch-chain amino acids. Talk this over with your doctor or midwife before using it.
What are the most common side effects?
Digestive issues are most common: belching, bloating, constipation, diarrhea, nausea, and vomiting — especially if you take a large dose. You may also notice muscle cramps or water retention from the creatine.
Does this actually help build muscle?
Creatine is possibly effective for muscle strength and athletic performance, and glutamine is possibly effective for recovery after surgery or critical illness. The branched-chain amino acids are included for muscle repair, but we don't have effectiveness ratings for them individually. Results vary by person and depend on your training and diet.
What's Russian tarragon in here for?
It's an herb included mainly for flavor. There's insufficient evidence in our data to rate whether it actually helps with postoperative nausea, which is what it's sometimes used for.
Can I take this with my blood thinner or diabetes medication?
Not without checking first. Russian tarragon may increase bleeding risk with blood thinners, and magnesium can increase the effect of diabetes medications, raising your risk of low blood sugar. Talk with your doctor or pharmacist about your specific drugs and whether this product is safe to combine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Re-Bld Watermelon label
Go deeper

The Full Monographs Behind Re-Bld Watermelon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph → Herb & supplement monograph

Tarragon

Interacts with 359 drugs

Tarragon is a flavorful culinary herb that has been used in traditional medicine for digestion, sleep, and other complaints, but solid human evidence for any health benefit is lacking. Amoun...

Read the full Tarragon monograph →
Sources

Sources & How We Checked

Re-Bld Watermelon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 188 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Creatine 86 references
  1. Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999;340:814-5. PubMed
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See these in context on the Creatine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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