Major interaction on record — check this product against your medications before combining. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Purple Capsule Ingredients & Drug Interactions

by Cutler Nutrition

Purple Capsule label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Purple Capsule against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Purple Capsule is a dietary supplement by Cutler Nutrition with 4 active ingredients. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 901 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are White Peony (root) extract, Glucosamine Sulfate 2KCl, Cissus quadrangularis. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Purple Capsule by Cutler Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Purple Capsule by Cutler Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Purple Capsule by Cutler Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Purple Capsule contains four active ingredients. Methylsulfonylmethane (MSM) and Cissus quadrangularis are plant-derived compounds; glucosamine sulfate 2KCl comes from shellfish or is lab-made and is used for joint cartilage support; and white peony root extract is a traditional herbal component.

The capsule itself is made from gelatin, and the product also contains several inactive ingredients including microcrystalline cellulose, magnesium stearate, silica, titanium dioxide, and colorants (FD&C Red No. 3 and FD&C Blue No.

1).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: muscle building, performance, recovery and bone joint health.
  • We looked for evidence on: Fractures, Joint pain, Knee pain, Muscle cramps, Muscle strength, Osteoarthritis — and 4 related terms.
  • The strongest evidence on file: Glucosamine is rated "Likely Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Peony is rated "Insufficient Reliable Evidence To Rate" for Muscle cramps, Osteoarthritis.
  • Also on file: Glucosamine is rated "Insufficient Reliable Evidence To Rate" for Joint pain, Postoperative recovery, Knee pain.

Glucosamine sulfate is likely effective for osteoarthritis, the most established benefit among these ingredients. Cissus quadrangularis is possibly effective for weight loss and obesity-related concerns.

The evidence is insufficient to rate white peony root for the conditions we hold data on—aging skin, anal fissures, atherosclerosis, chronic fatigue, cirrhosis, and migraine headache. We hold no effectiveness ratings for methylsulfonylmethane in our data.

The evidence, ingredient by ingredient Cissus Quadrangularis Glucosamine Peony

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glucosamine and white peony are both generally well tolerated for short-term use, though long-term safety data are limited. The most common side effects from glucosamine are bloating, constipation, diarrhea, heartburn, and nausea.

Peony may cause abdominal distension, loss of appetite, diarrhea, and nausea; in one study, about 5% of people taking high-dose peony experienced diarrhea. Rarely, glucosamine can trigger allergic reactions ranging from mild (itching, hives) to severe, and a small number of cases of asthma flare-ups have been reported.

During pregnancy, the safety data advise against both glucosamine and cissus quadrangularis—avoid them. White peony also lacks sufficient data, so it's best avoided in pregnancy.

For breastfeeding, glucosamine, cissus, and peony all have insufficient data; talk with your doctor or pharmacist before use. We have no pregnancy or breastfeeding data on file for methylsulfonylmethane.

Side effects, ingredient by ingredient Cissus Quadrangularis Glucosamine Peony

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Peony, Glucosamine, Cissus Quadrangularis.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 902 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check if you use warfarin or other blood thinners, antidiabetes medications, drugs broken down by your liver's CYP1A2 or CYP3A4 enzymes (ask your pharmacist if unsure), estrogens or hormone replacement therapy, birth control pills, the antipsychotic clozapine, or the seizure drug phenytoin. These are the medication types documented to interact with ingredients in this capsule.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Purple Capsule may suit someone interested in joint support or weight-loss support who isn't taking warfarin, diabetes medications, hormone therapy, birth control, blood thinners, or seizure medications. If you take any prescription drug—especially for heart, brain, or hormone health—check it against the medication interactions tool below before you start.

Pregnant or breastfeeding? Talk to your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Purple Capsule, straight from the product label.

Brand Cutler Nutrition
Barcode (UPC) 810150021059
Net contents 30 Pack(s)
Market status On market
Date entered into DSLD Apr 24, 2015
DSLD ID 44935
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Purple Capsule by Cutler Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Purple Capsule(s)
Maximum serving Sizes:
1 Purple Capsule(s)
UPC/BARCODE
810150021059
IngredientAmount% DV
Methylsulfonylmethane400 mg--
Cissus quadrangularis100 mg--
Glucosamine Sulfate 2KCl200 mg--
White Peony (root) extract100 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silica, Titanium Dioxide, FD&C Red No. 3, FD&C Blue No. 1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

LEGENDARY JAY PERFORMANCE & RECOVERY PACK IMMUNE SYSTEM SUPPORT ENERGY ANTIOXIDANTS BONE & JOINT HEALTH

DAILY VITAMINS & MINERALS

PRO MULTI-VITAMIN & MINERAL TRAINING PACK WITH ENERGY

MAY HELP TO SUPPORT: MUSCLE BUILDING & PERFORMANCE BONE & JOINT HEALTH OVERALL HEALTH & WELLNESS

{Capsule} NOT ACTUAL SIZE

When combined with a proper exercise and nutrition regimen. Statements based on early-stage independent 3rd party in vivo and / or in vitro model scientific research data findings for individual ingredients.

Formula

GREEN FOOD COMPLEX

Contains crustacean shellfish (shrimp, crab).

CAFFEINE WARNING: The recommended serving of this product contains approximately as much caffeine as one cup of coffee.

Formulation

100% TRANSPARENT / NO PROPRIETARY BLENDS

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

Contains crustacean shellfish (shrimp, crab).

WARNINGS: Not intended for use by persons under age 18.

Do not exceed recommended dose.

Get the consent of a licensed physician before using this product, especially if you are taking medication, have a medical condition, you are pregnant, nursing or thinking about becoming pregnant.

KEEP THIS PRODUCT AND ALL SUPPLEMENTS OUT OF THE REACH OF CHILDREN.

CAFFEINE WARNING: The recommended serving of this product contains approximately as much caffeine as one cup of coffee.

Do not consume caffeine, or combine with synephrine, including but not limited to coffee, tea, soda and other dietary supplements or medications containing phenylephrine or caffeine.

Too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally rapid heartbeat. Discontinue use if you experience dizziness, severe headache, rapid heartbeat or shortness of breath.

Suggested/Recommended/Usage/Directions

Please read entire label before use.

SUGGESTED USE: Take one (1) pack daily with breakfast or any other meal, with plenty of water, or as directed by a qualified healthcare practitioner. For better results, take two (2) packs daily, separated by 4-12 hours.

General

Rev. 01-001-PPK003 10/14

FDA Disclaimer Statement

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Purple Capsule by Cutler Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Purple Capsule label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Purple Capsule by Cutler Nutrition

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Purple Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Methylsulfonylmethane

400 mg per serving

Cissus quadrangularis

Interacts with
86 drugs
100 mg per serving

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis monograph & interactions

Glucosamine Sulfate 2KCl

Interacts with
170 drugs
200 mg per serving

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

Glucosamine Sulfate 2KCl monograph & interactions

White Peony (root) extract

Interacts with
811 drugs
100 mg per serving

Peony root is a traditional Chinese medicine herb often used for menstrual problems, cramps, and inflammation, frequently as part of combination formu...

White Peony (root) extract monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silica, Titanium Dioxide, FD&C Red No. 3, FD&C Blue No. 1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Purple Capsule by Cutler Nutrition Drug Interactions

Want to check YOUR meds against Purple Capsule?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
901Drugs
2 Major 898 Moderate 1 Minor

Ingredients driving the most interactions

White Peony (root) extract 811
Glucosamine Sulfate 2KCl 170
Cissus quadrangularis 86

Individual Drug Interactions

The ingredients in Purple Capsule interact with 901 drugs. Click any drug to see the details.

3 of the 4 ingredients in Purple Capsule interact with drugs. Each result below shows which ingredient is responsible. White Peony (root) extract Glucosamine Sulfate 2KCl Cissus quadrangularis

Each ingredient & the kinds of drugs it affects

For each ingredient in Purple Capsule with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

White Peony (root) extract7 drug types · 811 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, combining peony with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research suggests that peony might have antiplatelet, anticoagulant, and antithrombotic effects.

Likelihood Possible Evidence D
Clozapine (Clozaril)

Theoretically, peony might increase the levels and clinical effects of clozapine.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on cytochromes P450 (CYP) 1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, peony might interfere with contraceptive drugs due to competition for estrogen receptors.
In vitro and animal research shows that peony extract has estrogenic activity. Concomitant use might also increase the risk for estrogen-related adverse effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on CYP1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on CYP1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of peony might interfere with hormone replacement therapy and/or increase the risk for estrogen-related adverse effects.
In vitro and animal research shows that peony extract has estrogenic activity. Theoretically, peony might compete for estrogen receptors and/or cause additive estrogenic effects.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, peony might reduce the levels and clinical effects of phenytoin.
Animal research shows that taking peony root reduces levels of phenytoin. Some researchers suggest that peony root might affect cytochrome P450 (CYP) 2C9, which metabolizes phenytoin. However, preliminary research in humans shows that peony root does not alter levels of losartan (Cozaar), which is also metabolized by CYP2C9.

Likelihood Probable Evidence D
White Peony (root) extract full monograph & interactions

Glucosamine Sulfate 2KCl4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
Glucosamine Sulfate 2KCl full monograph & interactions

Cissus quadrangularis1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Purple Capsule, from the product label.

Cutler Nutrition

See all Cutler Nutrition products
Name
CUTLER NUTRITION
City
Hollywood
State
FL
ZipCode
33312
Pharmacist Counseling Corner

Purple Capsule by Cutler Nutrition: Common Questions

Does Purple Capsule by Cutler Nutrition interact with any medications?
Yes. Based on its ingredients, Purple Capsule has a known interaction with 901 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Purple Capsule contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my joint pain or arthritis?
Glucosamine sulfate in this product is likely effective for osteoarthritis. Cissus quadrangularis is possibly effective for weight loss, which may indirectly ease joint stress. The other ingredients don't have established effectiveness data for joint or pain conditions in our records.
Can I take this if I'm on blood thinners like warfarin?
No—glucosamine can increase warfarin's blood-thinning effect and raise your risk of bleeding. White peony also theoretically increases bleeding risk. Talk to your doctor or pharmacist before using this product if you take any blood thinner or antiplatelet drug.
What are the side effects?
The most common ones are digestive: bloating, constipation, diarrhea, heartburn, and nausea from glucosamine; diarrhea and stomach upset from peony. Headache and insomnia have been reported with cissus, though rates were similar to placebo. Rarely, glucosamine can cause allergic reactions including asthma flare-ups.
Is this safe during pregnancy or breastfeeding?
No. The safety data advise against glucosamine, cissus, and white peony during pregnancy. For breastfeeding, none of these three have enough data to confirm safety—talk with your doctor before use. We have no pregnancy or breastfeeding information for methylsulfonylmethane.
Can I take this with my diabetes medication?
Cissus quadrangularis might lower your blood sugar further and raise the risk of low blood sugar (hypoglycemia). If you take diabetes medications, check with your pharmacist before adding this product.
What is methylsulfonylmethane (MSM)?
It's one of the four active ingredients in this capsule, but we don't have interaction or effectiveness data on file for it. Your pharmacist can give you more details about this ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Purple Capsule is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Purple Capsule label
Go deeper

The Full Monographs Behind Purple Capsule’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph → Herb & supplement monograph

Peony

Interacts with 811 drugs

Peony root is a traditional Chinese medicine herb often used for menstrual problems, cramps, and inflammation, frequently as part of combination formulas. Human evidence for most uses is lim...

Read the full Peony monograph →
Sources

Sources & How We Checked

Purple Capsule's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 78 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Glucosamine 58 references
  1. Adams ME. Hype about glucosamine. Lancet 1999;354:353-4. PubMed
  2. Balkan B, Dunning BE. Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes 1994;43:1173-9. PubMed
  3. Giaccari A, Morviducci L, Zorretta D, et al. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia. Diabetologia 1995;38:518-24. PubMed
  4. Holmang A, Nilsson C, Niklasson M, et al. Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin. Diabetes 1999;48:106-11. PubMed
  5. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.
  6. Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother 1998;32:574-9.
  7. Shankar RR, Zhu JS, Baron AD. Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus. Metabolism 1998;47:573-7.
  8. Almada A, Harvey P, Platt K. Effects of chronic oral glucosamine sulfate on fasting insulin resistance index (FIRI) in non-diabetic individuals. FASEB J 2000;14:A750.
  9. Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomised, placebo-controlled trial. Lancet 2001;357:251-6.
  10. Does glucosamine increase serum lipid levels and blood pressure? Pharmacist's Letter/Prescriber's Letter 2001;17(11):171115.
  11. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  12. Monauni T, Zenti MG, Cretti A, et al. Effects of glucosamine infusion on insulin secretion and insulin action in humans. Diabetes 2000;49:926-35. PubMed
  13. Pouwels MJ, Jacobs JR, Span PN, et al. Short-term glucosamine infusion does not affect insulin sensitivity in humans. J Clin Endocrinol Metab 2001;86:2099-103. DOI
  14. Yun J, Tomida A, Nagata K, Tsuruo T. Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II. Oncol Res 1995;7:583-90.
  15. Pavelka K, Gatterova J, Olejarova M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: A 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002;162:2113-23. PubMed
  16. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  17. Scroggie DA, Albright A, Harris MD. The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Arch Intern Med 2003; PubMed
  18. Hoffer LJ, Kaplan LN, Hamadeh MJ, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 2001;50:767-70.. PubMed
  19. Yu JG, Boies SM, Olefsky JM. The effect of oral glucosamine sulfate on insulin sensitivity in human subjects. Diabetes Care 2003;26:1941-2. PubMed
  20. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
  21. Guillaume MP, Peretz A. Possible association between glucosamine treatment and renal toxicity: comment on the letter by Danao-Camara. Arthritis Rheum 2001;44:2943-4. PubMed
  22. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
  23. Tannis AJ, Barban J, Conquer JA. Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals. Osteoarthritis Cartilage 2004;12:506-11. PubMed
  24. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  25. Stumpf JL, Lin SW. Effect of glucosamine on glucose control. Ann Pharmacother 2006;40:694-8. PubMed
  26. Pham T, Cornea A, Blick KE, et al. Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance. Am J Med Sci 2007;333:333-9. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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