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Dietary supplement

Red Yeast Rice Care 1215 mg Ingredients & Drug Interactions

by ForestLeaf

Red Yeast Rice Care 1215 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Red Yeast Rice Care 1215 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Red Yeast Rice Care 1215 mg is a dietary supplement by ForestLeaf with 4 active ingredients. Its ingredients are commonly taken for diabetic nerve pain (neuropathy), blood sugar support in diabetes, antioxidant support.Based on those ingredients, 853 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Red Yeast Rice, organic Flaxseed Oil powder, Alpha Lipoic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Red Yeast Rice Care 1215 mg by ForestLeaf

Ask about any prescription or over-the-counter medication and we check it for interactions with Red Yeast Rice Care 1215 mg by ForestLeaf — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Red Yeast Rice Care 1215 mg by ForestLeaf

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains four active ingredients. Alpha-lipoic acid is an antioxidant that plays a role in energy production in your cells.

CoQ10 (coenzyme Q10) is a compound your body makes naturally and uses in cellular energy. Red yeast rice is a fermented rice product that contains lovastatin, a statin-type compound that lowers cholesterol.

Organic flaxseed oil powder provides alpha-linolenic acid, an omega-3 type fat. The capsules also contain inactive ingredients: vegetable cellulose, microcrystalline cellulose, magnesium stearate, and silicon dioxide — these are binders and fillers that hold the product together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: lower LDL cholesterol and support heart health.
  • We looked for evidence on: Hyperlipidemia, Cardiovascular disease (CVD), Coronary heart disease (CHD), Atherosclerosis, Angina, Atrial fibrillation — and 4 related terms.
  • The strongest evidence on file: Alpha-lipoic Acid is rated "Possibly Effective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Red Yeast Rice is rated "Possibly Effective" for HIV/AIDS-related dyslipidemia.
  • Also on file: Coenzyme Q10 is rated "Possibly Effective" for Congestive heart failure (CHF).

Evidence for these ingredients is mixed. Alpha-lipoic acid is rated possibly effective for diabetic nerve pain (neuropathy) and high cholesterol (hyperlipidemia), and possibly effective for weight management.

CoQ10 is rated likely effective for CoQ10 deficiency itself, and possibly effective for migraine headaches, fibromyalgia, congestive heart failure, and diabetic nerve pain. Red yeast rice is rated possibly effective for high cholesterol related to HIV/AIDS and for heart attack prevention.

Flaxseed oil, however, is rated possibly ineffective for weight management, rheumatoid arthritis, bipolar disorder, and high cholesterol — meaning the evidence doesn't support its use for these purposes.

The evidence, ingredient by ingredient Alpha-lipoic Acid Coenzyme Q10 Red Yeast Rice Flaxseed Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-lipoic acid is generally well tolerated but can lower blood sugar and is best used under medical guidance; avoid it during pregnancy and while breastfeeding because there isn't enough safety data. CoQ10 is generally well tolerated by most adults; avoid it during pregnancy unless your doctor advises otherwise, and use caution while breastfeeding since safety hasn't been well studied.

Red yeast rice works like a statin drug and carries similar risks, plus product quality varies — it is likely unsafe during pregnancy and should be avoided while breastfeeding. Flaxseed oil is generally well tolerated, but not enough safety data exists for pregnancy, so check with your doctor; use only with medical advice while breastfeeding.

Common side effects from oral use include headache, nausea, heartburn, and diarrhea. Red yeast rice specifically may cause muscle pain (myopathy) and in rare cases serious muscle breakdown (rhabdomyolysis) and liver damage, especially at higher doses or when combined with certain other drugs.

Side effects, ingredient by ingredient Alpha-lipoic Acid Coenzyme Q10 Red Yeast Rice Flaxseed Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Alpha-lipoic Acid, Red Yeast Rice, Coenzyme Q10, Flaxseed Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 854 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take statins or other cholesterol drugs (Moderate severity — red yeast rice), warfarin or other blood thinners (Moderate severity — CoQ10 and alpha-lipoic acid, flaxseed oil), thyroid hormone replacement (Moderate severity — alpha-lipoic acid), cyclosporine, gemfibrozil, or high-dose niacin (Moderate severity — red yeast rice). Also clear it if you're on chemotherapy, blood pressure medications, or ezetimibe.

No interactions are documented for the inactive ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines ingredients with a range of evidence levels, but its red yeast rice content means it works like a prescription statin and carries similar risks — particularly dangerous interactions with other cholesterol drugs, blood thinners, and certain other medications. If you take any prescription medications, especially heart or blood pressure drugs, blood thinners, or cholesterol medications, talk with your doctor or pharmacist before starting this supplement.

The ingredients may also lower blood sugar and blood pressure, so medical guidance is important if you're on diabetes or hypertension drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Red Yeast Rice Care 1215 mg, straight from the product label.

Brand ForestLeaf
Barcode (UPC) X00216VI5D
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 229529
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Red Yeast Rice Care 1215 mg by ForestLeaf, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
X00216VI5D
IngredientAmount% DV
Alpha Lipoic Acid225 mg--
CoQ1060 mg--
Red Yeast Rice1215 mg33%
organic Flaxseed Oil powder300 mg--

Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Red Rice Yeast Care helps lower your bad LDL cholesterol levels, and raises your good HDL cholesterol levels, for a healthy heart and better life.

Made with organic flaxseed

Formulation

Helps lower LDL (bad) cholesterol levels Maintains healthy metabolic functions Supports a healthy cardiovascular system

Non GMO

GMP/FDA Approved Facility UL Certified Facility

Dairy, gluten, egg & nut free

Made with organic flaxseed

Tested for absorption

Promotes healthy cholesterol levels Cholesterol complex

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made in the United States

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take 3 capsules daily, preferably with a meal, or as directed by your healthcare professional.

Precautions

Caution: Keep out of reach of children.

If you are pregnant, nursing, or taking any prescription medicine, consult your physician before taking this product.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Red Yeast Rice Care 1215 mg by ForestLeaf label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Red Yeast Rice Care 1215 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Red Yeast Rice Care 1215 mg by ForestLeaf

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Alpha Lipoic Acid

Interacts with
263 drugs
225 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha Lipoic Acid monograph & interactions

CoQ10

Interacts with
198 drugs
60 mg per serving

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

CoQ10 monograph & interactions

Red Yeast Rice

Interacts with
477 drugs
1215 mg per serving

Red yeast rice contains monacolin K, which is chemically identical to the prescription statin lovastatin, and it can lower LDL ('bad') cholesterol. Be...

Red Yeast Rice monograph & interactions

Organic Flaxseed Oil powder

Interacts with
293 drugs
300 mg per serving

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help s...

Organic Flaxseed Oil powder monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Red Yeast Rice Care 1215 mg by ForestLeaf Drug Interactions

Want to check YOUR meds against Red Yeast Rice Care 1215 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
853Drugs
786 Moderate 67 Minor

Ingredients driving the most interactions

Red Yeast Rice 477
organic Flaxseed Oil powder 293
Alpha Lipoic Acid 263
CoQ10 198

Individual Drug Interactions

The ingredients in Red Yeast Rice Care 1215 mg interact with 853 drugs. Click any drug to see the details.

4 of the 4 ingredients in Red Yeast Rice Care 1215 mg interact with drugs. Each result below shows which ingredient is responsible. Red Yeast Rice organic Flaxseed Oil powder Alpha Lipoic Acid CoQ10

Each ingredient & the kinds of drugs it affects

For each ingredient in Red Yeast Rice Care 1215 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Red Yeast Rice6 drug types · 477 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, taking red yeast rice in combination with cyclosporine might increase the risk of myopathy.
Red yeast rice contains varying levels of the statin drug lovastatin. Cyclosporine has been reported to increase plasma levels of lovastatin by 5- to 20-fold, resulting in reports of myopathy and rhabdomyolysis.

Likelihood Probable Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inhibitors

Theoretically, drugs that inhibit the CYP3A4 enzymes might increase levels of lovastatin from red yeast rice.
Red yeast rice contains varying levels of the statin drug lovastatin, which is metabolized by CYP3A4. Combining red yeast rice with CYP3A4 inhibitors might increase serum levels of lovastatin from red yeast rice.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, taking red yeast rice in combination with gemfibrozil might increase the risk of rhabdomyolysis.
Red yeast rice contains varying levels of the statin drug lovastatin. Gemfibrozil has been reported to increase the risk of rhabdomyolysis when used in combination with lovastatin.

Likelihood Probable Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use might increase the risk of liver damage.
Red yeast rice contains varying levels of the drug lovastatin. Lovastatin can cause liver damage in some people. Some clinical research suggests that supplements containing red yeast rice might increase liver enzyme levels in some, but not all, participants. Cases of acute hepatitis have been associated with red yeast rice. Combining it with hepatotoxic drugs might further increase this risk.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, taking red yeast rice with other statins might increase the risk of potential adverse effects.
Red yeast rice contains varying levels of the statin drug lovastatin and might result in supratherapeutic levels when used with other statins. Based on evaluation of data from the US Food and Drug Administration's adverse event reporting system (FAERS), it is recommended that red yeast rice products be avoided in people taking prescription statins.

Likelihood Probable Evidence D
Niacin

Theoretically, taking red yeast rice in combination with high-dose niacin might increase the risk of rhabdomyolysis.
Red yeast rice contains varying levels of the statin drug lovastatin and has been linked to reports of myopathy. Niacin has been reported to increase the risk of rhabdomyolysis when used in combination with lovastatin.

Likelihood Probable Evidence D
Red Yeast Rice full monograph & interactions

organic Flaxseed Oil powder3 drug types · 293 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Small clinical studies show that consuming flaxseed oil might decrease platelet aggregation and increase bleeding time.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Some clinical evidence suggests that long-term consumption of flaxseed oil can modestly lower systolic and diastolic blood pressure, while other clinical research shows no effect.

Likelihood Possible Evidence D
Ezetimibe (Zetia)

Concomitant use of flaxseed oil and ezetimibe reduces the absorption of alpha-linolenic acid from flaxseed oil.
In one clinical study, concomitant consumption of ezetimibe 10 mg daily with flaxseed oil 2 grams providing 1 gram of alpha-linolenic acid daily blocked the absorption of alpha-linolenic acid, resulting in an overall reduction in alpha-linolenic plasma levels from baseline.

Likelihood Probable Evidence B
organic Flaxseed Oil powder full monograph & interactions

Alpha Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha Lipoic Acid full monograph & interactions

CoQ103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
CoQ10 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Red Yeast Rice Care 1215 mg, from the product label.

ForestLeaf

See all ForestLeaf products
Name
Forest Leaf
City
Brooklyn
State
NY
ZipCode
11219
Phone Number
929.810.5089
Web Address
www.ForestLeaf.com
Pharmacist Counseling Corner

Red Yeast Rice Care 1215 mg by ForestLeaf: Common Questions

Does Red Yeast Rice Care 1215 mg by ForestLeaf interact with any medications?
Yes. Based on its ingredients, Red Yeast Rice Care 1215 mg has a known interaction with 853 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Red Yeast Rice Care 1215 mg contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Red yeast rice is likely unsafe in pregnancy because of its statin-like effects; alpha-lipoic acid should be avoided due to insufficient safety data, and flaxseed oil is possibly safe but should be discussed with your doctor. For breastfeeding, there isn't enough data on any of the main ingredients, so talk with your doctor or pharmacist before using this product.
What are the most common side effects?
Headache, nausea, heartburn, and diarrhea are reported most often. A small number of people have reported skin rashes. Red yeast rice specifically may cause muscle pain, and at higher doses or in certain drug combinations, serious muscle breakdown and liver damage are rare but possible risks.
Does this product actually lower cholesterol?
Red yeast rice is rated possibly effective for HIV-related high cholesterol and heart attack prevention. Flaxseed oil, however, is rated possibly ineffective for high cholesterol — meaning the evidence doesn't support its use for this purpose. Alpha-lipoic acid and CoQ10 are rated possibly effective for cholesterol.
Why does this product have so many interactions?
Red yeast rice contains lovastatin, a prescription statin drug that your body metabolizes in a way that overlaps with how many other medications are processed. That's why it interacts with blood thinners, other cholesterol drugs, and dozens of common medications. Alpha-lipoic acid and flaxseed oil can also affect bleeding and blood pressure, adding more overlaps.
Can I take this if I'm on a blood thinner like warfarin?
No, not without checking with your doctor first. CoQ10 may weaken warfarin's effects, and alpha-lipoic acid and flaxseed oil may increase bleeding risk — these are Moderate-severity concerns that need your doctor's evaluation.
Will this lower my blood sugar?
Alpha-lipoic acid theoretically might increase the risk of low blood sugar (hypoglycemia) if you're on diabetes medications, though larger studies haven't shown a strong effect. If you take diabetes drugs, talk with your doctor or pharmacist before starting this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Red Yeast Rice Care 1215 mg label
Go deeper

The Full Monographs Behind Red Yeast Rice Care 1215 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph → Herb & supplement monograph

Red Yeast Rice

Interacts with 477 drugs

Red yeast rice contains monacolin K, which is chemically identical to the prescription statin lovastatin, and it can lower LDL ('bad') cholesterol. Because of this, it carries the same risks...

Read the full Red Yeast Rice monograph → Herb & supplement monograph

Flaxseed Oil

Interacts with 293 drugs

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy...

Read the full Flaxseed Oil monograph →
Sources

Sources & How We Checked

Red Yeast Rice Care 1215 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 159 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
  6. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. PubMed
  7. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4.
  8. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14.
  9. Segermann J, Hotze A, Ulrich H, Rao GS. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 1991;41:1294-8.
  10. Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol 2003;149:841-9.
  11. Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21.
  12. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  13. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  14. Vincent HK, Bourguignon CM, Vincent KR, Taylor AG. Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study. J Alt Complement Med 2007;13:577-84. PubMed
  15. Furukawa N, Miyamura N, Nishida K, et al. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes Res Clin Pract 2007;75:366-7. PubMed
  16. Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A., Munzel U., Yakhno N., Raz I., Novosadova M., Maus J., Samigullin, R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Car
  17. Gu X. M., Zhang S. S., Wu J. C., Tang Z. Y., Lu Z. Q., Li H., Liu C., Chen L., Ning, G. [Efficacy and safety of high-dose a-lipoic acid in the treatment of diabetic polyneuropathy]. Zhonghua Yi Xue Za Zhi 2010;90(35):2473-2476.
  18. Porasuphatana S., Suddee S., Nartnampong A., Konsil J., Harnwong B., Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled
  19. Ansar H., Mazloom Z., Kazemi F., Hejazi N. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J 2011;32(6):584-588. DOI
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  21. Mazloom Z., Ansar H. The Effect of Alpha-Lipoic Acid on Blood Pressure in Type 2 Diabetics. Iranian Journal of Endocrinology and Metabolism 2009;11(3):245-250.
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Red Yeast Rice 50 references
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Flaxseed Oil 21 references
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  11. University of Montreal. Pregnant Women Consuming Flaxseed Oil Have High Risk Of Premature Birth.ScienceDaily, October 29, 2008. Available at: www.sciencedaily.com/releases/2008/10/081027140817.htm (Accessed May 14, 2009).
  12. Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur.J Clin.Nutr. 1995;49(3):169-178.
  13. Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. Effects of flaxseed supplements on blood pressure: a systematic review and meta-analysis of controlled clinical trial. Clin Nutr. 2016 Jun;3 PubMed
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  16. Morshedzadeh N, Shahrokh S, Aghdaei HA, et al. Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis. Complement Ther Med. 2019;46:36-43. PubMed
  17. Downie LE, Hom MM, Berdy GJ, et al. An artificial tear containing flaxseed oil for treating dry eye disease: A randomized controlled trial. Ocul Surf. 2020;18(1):148-157. PubMed
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  20. Li L, Li H, Gao Y, Vafaei S, Zhang X, Yang M. Effect of flaxseed supplementation on blood pressure: a systematic review, and dose-response meta-analysis of randomized clinical trials. Food Funct 2023;14(2):675-690. PubMed
  21. Mahmudiono T, Jasim SA, Karim YS, et al. The effect of flaxseed oil consumption on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials. Phytother Res 2022;36(10):

See these in context on the Flaxseed Oil monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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