Red Yeast Rice Odor-free Garlic Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Red Yeast Rice Odor-free Garlic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Red Yeast Rice Odor-free Garlic is a dietary supplement by Blueprint Bryan Johnson with 2 active ingredients. Its ingredients are commonly taken for high blood pressure, high cholesterol, heart health.Based on those ingredients, 1,170 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are odorless Garlic extract, Red Yeast Rice Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Red Yeast Rice Odor-free Garlic by Blueprint Bryan Johnson
Ask about any prescription or over-the-counter medication and we check it for interactions with Red Yeast Rice Odor-free Garlic by Blueprint Bryan Johnson — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Red Yeast Rice Odor-free Garlic by Blueprint Bryan Johnson
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 2 active ingredients: odorless garlic extract and red yeast rice extract. The garlic provides the cardiovascular and metabolic benefits associated with garlic without the typical odor.
Red yeast rice is a fermented rice product that contains natural lovastatin, a compound identical to the prescription statin drug — this is what gives it cholesterol-lowering properties, but also why it carries statin-like risks and benefits. There are no inactive ingredients listed for this product.
Does it work?
Moderate evidence
Garlic extract is possibly effective for periodontitis (gum disease), nonalcoholic fatty liver disease, diabetes, hypertension, and atherosclerosis. Red yeast rice extract is possibly effective for HIV/AIDS-related dyslipidemia and heart attack prevention.
Both ingredients show evidence of benefit for cardiometabolic conditions, though the strength of that evidence is modest — classed as 'possibly' rather than 'likely' or 'proven' effective.
How safe is it?
Well-documented data
Garlic is generally well tolerated when eaten as food, but the supplement-level dose in this product may cause stomach upset — abdominal pain, nausea, flatulence, and malodorous breath are the most common side effects. It can increase bleeding risk, which matters if you're on blood thinners.
A small number of people report skin reactions like rash or burning with garlic. Red yeast rice is also generally well tolerated orally at typical doses, but because it acts like a statin, it can rarely cause muscle pain, liver damage, or — very rarely — severe muscle breakdown.
There's no pregnancy or lactation safety data on file for either ingredient; if you're pregnant or nursing, talk with your doctor or pharmacist before use.
Meds to double-check
Moderate interaction found
Before taking this product, check with your pharmacist if you take any statins, blood thinners (including warfarin), blood pressure medications, diabetes medications, gemfibrozil, high-dose niacin, cyclosporine, HIV protease inhibitors, tacrolimus, or any drugs that require liver processing through CYP3A4 or CYP2E1 enzymes — the garlic and red yeast rice can raise or lower levels of these unpredictably.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product pairs two ingredients with solid evidence for heart and metabolic health, but both carry multiple drug interactions you need to check first. If you take statins, blood thinners, blood pressure meds, diabetes drugs, or any HIV or transplant medications, run this through the checker on this page before you start.
Talk with your pharmacist — especially if you have liver disease or muscle pain concerns.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Red Yeast Rice Odor-free Garlic, straight from the product label.
| Brand | Blueprint Bryan Johnson |
|---|---|
| Net contents | 30 Veggie Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2025 |
| DSLD ID | 328208 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Red Yeast Rice Odor-free Garlic by Blueprint Bryan Johnson, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| odorless Garlic extract | 100 mg | -- |
| Red Yeast Rice Extract | 500 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Red Yeast Rice Odor-free Garlic by Blueprint Bryan Johnson label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Red Yeast Rice Odor-free Garlic by Blueprint Bryan Johnson
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Odorless Garlic extract
Interacts with989 drugs
Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usuall...
Odorless Garlic extract monograph & interactionsRed Yeast Rice Extract
Interacts with477 drugs
Red yeast rice contains monacolin K, which is chemically identical to the prescription statin lovastatin, and it can lower LDL ('bad') cholesterol. Be...
Red Yeast Rice Extract monograph & interactionsRed Yeast Rice Odor-free Garlic by Blueprint Bryan Johnson Drug Interactions
HelloPharmacist Interaction Report
Red Yeast Rice Odor-free Garlic by Blueprint Bryan Johnson contains two ingredients with documented interactions affecting a large number of medications.
The most serious concern is red yeast rice, which works like a statin drug — it contains the statin lovastatin and carries a Moderate risk of muscle breakdown (rhabdomyolysis) if combined with gemfibrozil, high-dose niacin, or cyclosporine, or if you're already taking other statins. It also poses a Moderate risk to your liver if used alongside other hepatotoxic drugs or with CYP3A4 inhibitors, which can raise lovastatin levels.
Read the full breakdown — every affected drug type, severity by severity
The odorless garlic extract in this product also carries Moderate interactions with several drug types. It may increase bleeding risk with blood thinners (anticoagulants) and antiplatelet drugs, including warfarin.
Garlic can lower blood pressure and blood sugar, so combining it with blood pressure or diabetes medications might push these too low. It may also interfere with how your body processes certain HIV protease inhibitors, tacrolimus (an immunosuppressant), and a broad category of other drugs that rely on CYP3A4 or CYP2E1 enzymes — potentially raising or lowering their levels unpredictably.
Altogether, these interactions span 1,149 individual medications. Before starting this product, run your exact prescriptions through the checker below — especially if you take statins, blood thinners, blood pressure meds, diabetes medications, or any HIV or transplant drugs.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Red Yeast Rice Odor-free Garlic?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Red Yeast Rice Odor-free Garlic interact with 1,170 drugs. Click any drug to see the details.
2 of the 2 ingredients in Red Yeast Rice Odor-free Garlic interact with drugs. Each result below shows which ingredient is responsible. odorless Garlic extract Red Yeast Rice Extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Red Yeast Rice Odor-free Garlic — through 1 ingredient. Tap an ingredient for the detail:
Red Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Red Yeast Rice Odor-free Garlic — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Red Yeast Rice Odor-free Garlic — through 1 ingredient. Tap an ingredient for the detail:
Red Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Red Yeast Rice Odor-free Garlic — through 1 ingredient. Tap an ingredient for the detail:
Red Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Abacavir, Lamivudine interactionAbametapirXeglyze
How Abametapir interacts with Red Yeast Rice Odor-free Garlic — through 1 ingredient. Tap an ingredient for the detail:
Red Yeast Rice ExtractCytochrome P450 3a4 (cyp3a4) Inhibitors Moderate
Interaction Summary
Theoretically, drugs that inhibit the CYP3A4 enzymes might increase levels of lovastatin from red yeast rice.
Read the full Red Yeast Rice Extract + Abametapir interactionAbciximabReoPro
How Abciximab interacts with Red Yeast Rice Odor-free Garlic — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Odorless Garlic Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Red Yeast Rice Odor-free Garlic — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Abiraterone interactionRed Yeast Rice ExtractCytochrome P450 3a4 (cyp3a4) Inhibitors, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, drugs that inhibit the CYP3A4 enzymes might increase levels of lovastatin from red yeast rice.
Read the full Red Yeast Rice Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Red Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Abiraterone Acetate interactionOdorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Red Yeast Rice Odor-free Garlic — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Odorless Garlic Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Red Yeast Rice Odor-free Garlic — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Odorless Garlic ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Odorless Garlic Extract + Acarbose interactionRed Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Red Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acebutolol interactionOdorless Garlic ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Odorless Garlic Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Red Yeast Rice Odor-free Garlic — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Odorless Garlic Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Red Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen interactionOdorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Aspirin interactionRed Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Red Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Aspirin, Caffeine interactionOdorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Red Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionOdorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Butalbital interactionRed Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Red Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Butalbital, Caffeine interactionOdorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionRed Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Red Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Butalbital, Codeine interactionOdorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionRed Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Red Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionOdorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Acetaminophen, Caffeine, Codeine interactionRed Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionRed Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Red Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionOdorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Acetaminophen, Caffeine, Isometheptene interactionRed Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Red Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Caffeine, Pyrilamine interactionOdorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Red Yeast Rice Odor-free Garlic — through 2 ingredients. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionRed Yeast Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Red Yeast Rice Odor-free Garlic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
odorless Garlic extract
Anticoagulant/Antiplatelet Drugs
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time.
Antidiabetes Drugs
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research suggests that garlic and garlic extract lower blood glucose levels in healthy and diabetic individuals.
Antihypertensive Drugs
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
In human research, both garlic and garlic extracts have blood pressure-lowering effects.
Atazanavir (Reyataz)
Theoretically, garlic might decrease levels and effects of atazanavir.
In a case report, a patient consuming six stir-fried garlic cloves three times weekly developed suboptimal atazanavir levels and increases in HIV viral load. While the exact cause of this interaction is unclear, there is speculation that garlic might decrease the intestinal absorption of atazanavir or increase its metabolism by inducing cytochrome P450 3A4 (CYP3A4). Until more is known, advise patients not to consume large amounts of garlic while taking atazanavir.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Garlic might increase levels of drugs metabolized by CYP2E1.
Clinical research suggests garlic oil can inhibit the activity of CYP2E1 by 39%. Use garlic oil cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Some human research suggests that garlic may induce INTESTINAL CYP3A4, reducing levels of drugs metabolized by this enzyme. This is primarily based on a study showing that taking a specific allicin-containing garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induced CYP3A4 in the gut mucosa. Another study shows that giving docetaxel intravenously, bypassing the CYP3A4 enzymes in the gut mucosa, along with the same specific garlic product for 12 consecutive days, does not affect docetaxel levels. Conversely, there is concern that garlic may inhibit HEPATIC CYP3A4. In a single case report, increased tacrolimus levels and liver injury occurred in a liver transplant patient after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. Several other studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Isoniazid
Theoretically, garlic might decrease levels of isoniazid.
Animal research suggests that an aqueous extract of garlic reduces isoniazid levels by about 65%. Garlic reduced the maximum concentration (Cmax) and area under the curve (AUC), but not the half-life, of isoniazid. This suggests that garlic extract might inhibit isoniazid absorption across the intestinal mucosa; however, the exact mechanism of this potential interaction is not known.
Protease Inhibitors (Pis)
Theoretically, garlic products containing allicin might decrease levels of PIs.
Protease inhibitors are metabolized by cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4, reducing plasma levels of protease inhibitors. This is primarily based on a study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces levels of saquinavir, a PI, by approximately 50%. It is speculated that the allicin constituent induce CYP3A4 in the gut mucosa. Several studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Saquinavir (Fortovase, Invirase)
Theoretically, garlic containing allicin might decrease levels of saquinavir.
Saquinavir is a substrate of cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4 and cause subtherapeutic levels of saquinavir. This is primarily based on a pharmacokinetic study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induces CYP3A4 in the gut mucosa. Several pharmacokinetic studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin. Until more is known about this potential interaction, use garlic containing allicin cautiously in patients taking saquinavir.
Sofosbuvir (Sovaldi)
Theoretically, taking garlic with sofosbuvir might decrease its effectiveness.
Animal research in rats shows that giving aged garlic extract 120 mg/kg orally daily for 14 days decreases the area under the concentration time curve (AUC) after a single sofosbuvir dose of 40 mg/kg by 36%, increases the clearance by 63%, and decreases the plasma concentrations at 1 and 8 hours by 35% and 58%, respectively. This interaction is hypothesized to be due to induction of intestinal P-glycoprotein expression by garlic.
Tacrolimus (Prograf)
Theoretically, garlic might increase levels of tacrolimus.
In one case report, a liver transplant patient taking tacrolimus experienced increased tacrolimus levels and liver injury after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. It is speculated that garlic inhibited hepatic cytochrome P450 3A4 (CYP3A4), which increased plasma levels of tacrolimus.
Warfarin (Coumadin)
Theoretically, garlic might increase the risk of bleeding with warfarin.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time. In addition, there is a report of two patients who experienced an increase in a previously stabilized international normalized ratio (INR) with concomitant garlic and warfarin use. However, this report has been subsequently debated due to limited clinical information. Other clinical studies have not identified an effect of garlic on INR, warfarin pharmacokinetics, or bleeding risk. More evidence is needed to determine the safety of using garlic with warfarin.
Red Yeast Rice Extract
Cyclosporine (Neoral, Sandimmune)
Theoretically, taking red yeast rice in combination with cyclosporine might increase the risk of myopathy.
Red yeast rice contains varying levels of the statin drug lovastatin. Cyclosporine has been reported to increase plasma levels of lovastatin by 5- to 20-fold, resulting in reports of myopathy and rhabdomyolysis.
Cytochrome P450 3A4 (Cyp3A4) Inhibitors
Theoretically, drugs that inhibit the CYP3A4 enzymes might increase levels of lovastatin from red yeast rice.
Red yeast rice contains varying levels of the statin drug lovastatin, which is metabolized by CYP3A4. Combining red yeast rice with CYP3A4 inhibitors might increase serum levels of lovastatin from red yeast rice.
Gemfibrozil (Lopid)
Theoretically, taking red yeast rice in combination with gemfibrozil might increase the risk of rhabdomyolysis.
Red yeast rice contains varying levels of the statin drug lovastatin. Gemfibrozil has been reported to increase the risk of rhabdomyolysis when used in combination with lovastatin.
Hepatotoxic Drugs
Theoretically, concomitant use might increase the risk of liver damage.
Red yeast rice contains varying levels of the drug lovastatin. Lovastatin can cause liver damage in some people. Some clinical research suggests that supplements containing red yeast rice might increase liver enzyme levels in some, but not all, participants. Cases of acute hepatitis have been associated with red yeast rice. Combining it with hepatotoxic drugs might further increase this risk.
Hmg-Coa Reductase Inhibitors ("Statins")
Theoretically, taking red yeast rice with other statins might increase the risk of potential adverse effects.
Red yeast rice contains varying levels of the statin drug lovastatin and might result in supratherapeutic levels when used with other statins. Based on evaluation of data from the US Food and Drug Administration's adverse event reporting system (FAERS), it is recommended that red yeast rice products be avoided in people taking prescription statins.
Niacin
Theoretically, taking red yeast rice in combination with high-dose niacin might increase the risk of rhabdomyolysis.
Red yeast rice contains varying levels of the statin drug lovastatin and has been linked to reports of myopathy. Niacin has been reported to increase the risk of rhabdomyolysis when used in combination with lovastatin.
Brand information
Manufacturer and brand details for Red Yeast Rice Odor-free Garlic, from the product label.
Red Yeast Rice Odor-free Garlic by Blueprint Bryan Johnson: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Red Yeast Rice Odor-free Garlic’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Garlic
Interacts with 989 drugsGarlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usually small. It is generally safe in food am...
Read the full Garlic monograph → Herb & supplement monographRed Yeast Rice
Interacts with 477 drugsRed yeast rice contains monacolin K, which is chemically identical to the prescription statin lovastatin, and it can lower LDL ('bad') cholesterol. Because of this, it carries the same risks...
Read the full Red Yeast Rice monograph →Sources & How We Checked
Red Yeast Rice Odor-free Garlic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 204 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Garlic 154 references
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