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Dietary supplement

Relaxing Passion Flower 50 mg Ingredients & Drug Interactions

by Mt. Angel Vitamins

Relaxing Passion Flower 50 mg label
See full label image
Lozenge Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Relaxing Passion Flower 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Relaxing Passion Flower 50 mg is a dietary supplement by Mt. Angel Vitamins with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, restlessness.Based on those ingredients, 836 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Passion Flower 4:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Relaxing Passion Flower 50 mg by Mt. Angel Vitamins

Ask about any prescription or over-the-counter medication and we check it for interactions with Relaxing Passion Flower 50 mg by Mt. Angel Vitamins — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Relaxing Passion Flower 50 mg by Mt. Angel Vitamins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This lozenge contains one active ingredient: passion flower 4:1 extract at 50 mg per dose. A 4:1 extract means the plant material has been concentrated—so you get the equivalent of more raw herb in a smaller amount.

The rest of the lozenge is made up of inactive ingredients like xylitol, cane juice, cellulose, and natural flavoring that give it form and taste.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promotes relaxation.
  • We looked for evidence on: Stress, Insomnia, Pre-procedural anxiety, anxiety, nervous tension, restlessness.
  • The strongest evidence on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety (Natural Medicines).
  • Also on file: Passion Flower is rated "Possibly Effective" for Insomnia.
  • Also on file: Passion Flower is rated "Insufficient Reliable Evidence To Rate" for Stress.

Passion flower is possibly effective for insomnia and pre-procedural anxiety—meaning there's some evidence it can help, but it's not ironclad. For ADHD and benzodiazepine withdrawal, we don't have enough reliable evidence to know whether it works.

If you're thinking about using it for sleep or anxiety before a procedure, it may be worth trying, but talk to your doctor or pharmacist first about whether it's the right choice for you.

The evidence, ingredient by ingredient Passion Flower

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Passion flower is generally well tolerated in the short term, but it does cause drowsiness in most people—so don't drive or operate machinery after taking it. The most common side effects are confusion, dizziness, and sedation.

A few people have reported allergy-like symptoms or skin reactions, and one case involved serious heart rhythm and stomach symptoms at very high doses, though those resolved once the product was stopped. The safety data advises against passion flower during pregnancy because we don't know enough about how it affects the developing baby or the uterus.

There also isn't enough information to say it's safe while breastfeeding, so it's best to avoid it then too. Talk with your doctor or pharmacist if you're pregnant, planning to get pregnant, or breastfeeding.

Side effects, ingredient by ingredient Passion Flower

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Passion Flower.
  • The most serious interaction on file is rated Moderate.
  • For scale: 837 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any sedative or sleep medication, anxiety medication, opioid pain relievers, or alcohol—passion flower can boost their drowsy effects. Also confirm if you take blood pressure or heart medications that depend on a specific liver pathway (OATP substrates) or other drugs broken down by the CYP3A4 enzyme.

The interaction checker on this page will help you spot your medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Relaxing Passion Flower may help if you struggle with sleep or pre-procedure nerves and you're not on sedating medications. But because it can add to the drowsy effects of sleep aids, anxiety drugs, and opioids—and because it touches how your body processes over 800 medications—you need to check your exact medications before you start it.

It's not safe in pregnancy or while breastfeeding. Talk it over with your doctor or pharmacist to make sure it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Relaxing Passion Flower 50 mg, straight from the product label.

Brand Mt. Angel Vitamins
Barcode (UPC) 768305110243
Net contents 60 Vegetarian Lozenge(s)
Market status On market
Date entered into DSLD Dec 22, 2019
DSLD ID 211776
Product type Botanical
Supplement form Lozenge
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Relaxing Passion Flower 50 mg by Mt. Angel Vitamins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Lozenge(s)
Maximum serving Sizes:
1 Vegetarian Lozenge(s)
UPC/BARCODE
768305110243
IngredientAmount% DV
Passion Flower 4:1 extract50 mg--

Other ingredients: Xylitol, organic evaporated Cane juice, Cellulose, Palm Kernel Stearate, Citric Acid, Natural flavor, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Single ingredient Promotes relaxation

No alcohol, soy, salt, yeast, gluten, milk & egg products, fructose, starch, or preservatives.

GF

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Take one or more lozenges throughout the day, as a dietary supplement. One lozenge is 2 times the strength of one dropperful (35 drops) of liquid passion flower alcohol extract.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Relaxing Passion Flower 50 mg by Mt. Angel Vitamins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Relaxing Passion Flower 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Relaxing Passion Flower 50 mg by Mt. Angel Vitamins

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Lozenge(s) Dosage formLozenge Amounts shown are per serving.

Passion Flower 4:1 extract

Interacts with
836 drugs
50 mg per serving

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...

Passion Flower 4:1 extract monograph & interactions

Other (inactive) ingredients: Xylitol, Organic evaporated Cane juice, Cellulose, Palm Kernel Stearate, Citric Acid, Natural flavor, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Relaxing Passion Flower 50 mg by Mt. Angel Vitamins Drug Interactions

Want to check YOUR meds against Relaxing Passion Flower 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
836Drugs
248 Moderate 588 Minor

Ingredients driving the most interactions

Passion Flower 4:1 extract 836

Individual Drug Interactions

The ingredients in Relaxing Passion Flower 50 mg interact with 836 drugs. Click any drug to see the details.

1 of the 1 ingredient in Relaxing Passion Flower 50 mg interact with drugs. Each result below shows which ingredient is responsible. Passion Flower 4:1 extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Relaxing Passion Flower 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Passion Flower 4:1 extract3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passion Flower 4:1 extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Relaxing Passion Flower 50 mg, from the product label.

Mt. Angel Vitamins

See all Mt. Angel Vitamins products
Name
Highland Laboratories
Street Address
110 S Garfield Street
City
Mt Angel
State
Oregon
ZipCode
97362
Phone Number
888.717.4917
Web Address
mtangelvitamins.com
Pharmacist Counseling Corner

Relaxing Passion Flower 50 mg by Mt. Angel Vitamins: Common Questions

Does Relaxing Passion Flower 50 mg by Mt. Angel Vitamins interact with any medications?
Yes. Based on its ingredients, Relaxing Passion Flower 50 mg has a known interaction with 836 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Relaxing Passion Flower 50 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
Yes—drowsiness is the most common side effect, along with dizziness and confusion. Don't drive or use machinery after taking it. If you're already on sleep aids or sedating medications, the drowsiness can be stronger.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advises against it during pregnancy because we don't have enough information about how it affects a developing baby. There also isn't enough data to say it's safe while breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're in either situation.
What does passion flower actually do?
It has sedative properties. Research shows it's possibly effective for insomnia and anxiety before medical procedures. We don't have enough evidence yet to say whether it helps ADHD or benzodiazepine withdrawal.
Is this the same as a benzodiazepine like Valium?
No—it's a plant extract, not a prescription drug. But it does have similar sedative effects, which is why you need to be careful not to combine it with prescription sedatives or sleep aids without checking with your doctor first.
What's a 4:1 extract?
It means the plant material has been concentrated four times over, so you get more of the active compounds in a smaller dose than you would from whole dried plant material.
Are there any other side effects besides drowsiness?
Most people tolerate it well. Less commonly, some have reported allergy-like symptoms, skin reactions, or dizziness. One rare case at very high doses involved severe nausea, vomiting, and heart rhythm changes—all resolved once it was stopped.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Relaxing Passion Flower 50 mg label
Go deeper

The Full Monographs Behind Relaxing Passion Flower 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph →
Sources

Sources & How We Checked

Relaxing Passion Flower 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Passion Flower 19 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6.
  4. Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. PubMed
  5. Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. DOI
  6. Mori A, Hasegawa K, Murasaki M, et al. Clinical evaluation of Passiflamin (passiflora extract) on neurosis - multicenter double blind study in comparison with mexazolam. Rinsho Hyoka (Clinical Evaluation) 1993;21:383-440.
  7. Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518. DOI
  8. Speroni E., Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med. 1988;54:488-91.
  9. Capasso A., Sorrentino L. Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine. 2005;12:39-45. PubMed
  10. Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
  11. Smith, G. W., Chalmers, T. M., and Nuki, G. Vasculitis associated with herbal preparation containing Passiflora extract. Br J Rheumatol. 1993;32(1):87-88.
  12. Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R., and Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20. PubMed
  13. Nojoumi M, Ghaeli P, Salimi S, Sharifi A, Raisi F. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ?with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;1
  14. Rokhtabnak F, Ghodraty MR, Kholdebarin A, et al. Comparing the Effect of Preoperative Administration of Melatonin and Passiflora incarnata on Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery. Anesth Pain Med. 2016;7(1):e4123 PubMed
  15. Dantas LP, de Oliveira-Ribeiro A, de Almeida-Souza LM, Groppo FC. Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Med Oral Patol Oral Cir Bucal. 2017;22(1):e95-e101. PubMed
  16. Ozturk Z, Kalayci CC. Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complement Ther Med. 2018 Feb;36:30-32. PubMed
  17. da Cunha RS, Amorim KS, Gercina AC, et al. Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial. Clin Oral Investig. 2020. PubMed
  18. Schäfer AM, Gilgen PM, Spirgi C, et al. Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. Planta Med. 2021. PubMed
  19. Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed

See these in context on the Passion Flower monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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