Interactions on record — worth a quick check against your medications. Based on 3 of 7 ingredients. Check your meds →
Dietary supplement

Repair Gold Ingredients & Drug Interactions

by Enzymedica

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Repair Gold is a dietary supplement by Enzymedica with 7 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Repair Gold by Enzymedica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.

Repair Gold contains 7 active ingredients, most of them digestive enzymes. Papain and bromelain are plant-derived protein-digesting enzymes; the product also includes serratiopeptidase, catalase, amylase, lipase, and protease — all enzymes meant to help break down food and support digestion.

The capsule itself is filled with inactive ingredients: gellan gum, cellulose, and water.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Support fatigued muscles and sore joints.
  • We looked for evidence on: Exercise-induced muscle soreness, Knee pain, Osteoarthritis, Postoperative pain, Postoperative swelling, Sprains — and 4 related terms.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Wound healing.
  • Also on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Osteoarthritis, Knee pain, Wound healing, and more.

The evidence on whether these ingredients actually work for their intended purpose is not established in our data. Papain, bromelain, and the other enzymes all carry a rating of insufficient reliable evidence for the conditions they're claimed to help — including exercise-induced muscle soreness, allergic rhinitis, inflammatory bowel disease, and indigestion.

That doesn't mean they don't work; it means the research either hasn't been done or isn't strong enough yet to say.

The evidence, ingredient by ingredient Papain Bromelain Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally well tolerated as a food, but supplements can irritate your digestive tract and cause allergic reactions in sensitive people — including itchy eyes, runny nose, sneezing, cramps, and diarrhea. High doses may cause serious effects like esophageal perforation and severe inflammation.

Bromelain is also generally well tolerated short-term, though long-term safety is less clear. Common side effects include diarrhea, flatulence, stomach upset, and headache.

Both can trigger allergic reactions in people sensitive to them. Regarding pregnancy: concentrated papain and unripe papaya products should be avoided — safety data advises against it.

Bromelain should also be avoided in pregnancy due to insufficient safety data. For breastfeeding, there isn't enough reliable safety information on either papain or bromelain, so it's best to avoid them.

Lipase safety in pregnancy and breastfeeding hasn't been well studied; talk with your doctor before using if you're pregnant or nursing.

Side effects, ingredient by ingredient Papain Bromelain Lipase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Papain, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using Repair Gold if you take warfarin or any blood thinner — papain may increase its effects and your bleeding risk (Moderate severity). Also double-check any antiplatelet or anticoagulant drugs with bromelain (Moderate).

If you're on tetracycline antibiotics, bromelain may increase your absorption of the drug (Minor).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Repair Gold is aimed at people looking for digestive enzyme support, but evidence that it works is not yet established. If you take warfarin or any other blood thinner or antiplatelet medication, don't start this product without checking with your pharmacist first — the interaction risk is real.

Same goes for tetracycline antibiotics. Pregnant or breastfeeding?

Talk to your doctor or pharmacist before taking it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Repair Gold, straight from the product label.

Brand Enzymedica
Barcode (UPC) 670480290309
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 259972
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Repair Gold by Enzymedica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Targeted Delivery Capsule(s)
Maximum serving Sizes:
2 Targeted Delivery Capsule(s)
Servings per container
60
UPC/BARCODE
670480290309
IngredientAmount% DV
Papain0 NP--
Bromelain0 NP--
Serratiopeptidase0 NP--
Catalase0 NP--
Amylase Thera-blend0 NP--
Lipase Thera-blend0 NP--
Protease Thera-blend0 NP--

Other ingredients: Gellan Gum, Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Enzymedica Supports AHA Autism Hope Alliance Vitamin Angels Proud Supporter Green Mountain Energy

Overexertion at the gym, at work or at play can lead to fatigued muscles and sore joints.

Most advanced Therapeutic #1 selling enzyme brand

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Repair Gold contains Serrapeptase with Bromelain, Papain and additional enzymes known to support fatigued muscles and joints. The enzymes work synergistically with the body's own mechanisms of renewal and may support the body's natural response to overexertion and strenuous activities. The enzyme blend promotes joint comfort and healthy circulation to encourage accelerated muscle and tissue recovery.

Contains serrapeptase for extra support

Vegan & kosher

K Parve #K1840

Suggested/Recommended/Usage/Directions

Recommended Use: 2 capsules two to three times daily on an empty stomach, one hour before or two hours after a meal. More may be taken as needed.

Formulation

Thera-blend is an exclusive process that combines multiple strains of enzymes that work in specific pH levels, resulting in superior performance in the body.

No fillers added

Made In USA

Non GMO

Muscle, tissue and joint function Optimized support for sore muscles and joint discomfort

Vegan & kosher

Contains No egg, dairy, preservatives, salt, sucrose, soy, wheat, yeast, nuts, corn, gluten, casein, potato, rice, artificial colors or flavors.

Enzymedica does not use ingredients produced using biotechnology.

Brand IP Statement(s)

Enzymedica The enzyme experts

FDA Statement of Identity

Dietary Supplement

Storage

Keep closed in dry place; avoid excessive heat.

Precautions

Do not use if safety seal is broken or missing.

Please keep out of reach of children.

Seals/Symbols

K Parve #K1840

See for yourself

Repair Gold by Enzymedica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Repair Gold by Enzymedica

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Targeted Delivery Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
0 NP per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Bromelain

Interacts with
141 drugs
0 NP per serving

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early st...

Bromelain monograph & interactions

Serratiopeptidase

0 NP per serving

Catalase

0 NP per serving

Amylase Thera-blend

0 NP per serving

Lipase Thera-blend

No known
interactions
0 NP per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase Thera-blend monograph & interactions

Protease Thera-blend

Interacts with
2 drugs
0 NP per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Protease Thera-blend monograph & interactions

Other (inactive) ingredients: Gellan Gum, Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Repair Gold by Enzymedica Drug Interactions

Want to check YOUR meds against Repair Gold?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141
Papain 2

Each ingredient & the kinds of drugs it affects

For each ingredient in Repair Gold with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Repair Gold, from the product label.

Enzymedica

See all Enzymedica products
Name
Enzymedica, Inc.
Street Address
771 Commerce Drive
City
Venice
State
FL
ZipCode
34292-1731
Phone Number
1-888-918-1118
Web Address
www.enzymedica.com
Pharmacist Counseling Corner

Repair Gold by Enzymedica: Common Questions

Does Repair Gold by Enzymedica interact with any medications?
Yes. Based on its ingredients, Repair Gold has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Repair Gold contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Repair Gold safe to take while pregnant?
No. Concentrated papain (in this product) and unripe papaya products should be avoided in pregnancy. Bromelain also lacks enough safety data and should be avoided. Talk with your doctor or pharmacist before taking it.
Is Repair Gold safe while breastfeeding?
Not enough safety data exists for either papain or bromelain while breastfeeding, so it's best to avoid them. Lipase safety while nursing also hasn't been well studied. Check with your healthcare provider first.
Can this product help with muscle soreness or bloating?
The ingredients — papain, bromelain, and the digestive enzymes — are claimed to help with those, but we don't have reliable evidence they work. Research either hasn't been done or isn't strong enough yet to say.
What are the most common side effects?
From bromelain, you might get diarrhea, gas, stomach upset, or headache. Papain may cause allergic reactions in sensitive people — watery eyes, runny nose, sneezing, cramps, or diarrhea. Both are generally well tolerated at normal doses.
Can I take this if I have a serious digestive condition?
The data notes that people with serious digestive conditions should use lipase only under medical guidance. Talk with your doctor before starting, especially if you have inflammatory bowel disease or similar conditions.
What do all these enzymes do?
They're meant to help your body break down protein (papain, bromelain, protease, serratiopeptidase), fat (lipase), and carbohydrates (amylase) during digestion. But evidence that supplemental enzymes actually improve digestion isn't established in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Repair Gold is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Repair Gold label
Sources

Sources & How We Checked

Repair Gold's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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