Major interaction on record — check this product against your medications before combining. Based on 8 of 11 ingredients. Check your meds →
Dietary supplement

Replenish Bombsicle Ingredients & Drug Interactions

by Arms Race Nutrition

Replenish Bombsicle label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Replenish Bombsicle against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Replenish Bombsicle is a dietary supplement by Arms Race Nutrition with 11 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 625 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Tryptophan, Sodium, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Replenish Bombsicle by Arms Race Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Replenish Bombsicle by Arms Race Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Replenish Bombsicle by Arms Race Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 11 of its 11 active ingredients.
  • “Branched-Chain Amino Acids” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Other Vegan Essential Amino Acids” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Replenish Bombsicle contains 11 active ingredients: nine essential amino acids (L-leucine, L-isoleucine, L-methionine, L-phenylalanine, L-valine, L-histidine, L-threonine, L-tryptophan, and L-lysine) plus sodium and potassium. The amino acids are building blocks your body uses for protein and neurotransmitter production; the sodium and potassium are electrolytes that support nerve and muscle function.

The product also contains inactive ingredients—citric acid, natural and artificial flavors, silicon dioxide, sucralose, and acesulfame potassium—which are fillers and flavor/texture agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: full-spectrum amino acid supplement for training.
  • We looked for evidence on: Athletic performance, Muscle strength, Wound healing, muscle recovery, protein synthesis, exercise recovery — and 1 related terms.
  • The closest evidence on file: Methionine is rated "Insufficient Reliable Evidence To Rate" for Wound healing (Natural Medicines).
  • Also on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength.
  • Also on file: L-tryptophan is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The evidence on these amino acids is mixed and limited. L-methionine is possibly effective for preventing neural tube birth defects in pregnancy, but the other uses tested (acetaminophen poisoning, hay fever, asthma, colorectal cancer) have insufficient evidence.

L-phenylalanine is possibly ineffective for ADHD and possibly effective for vitiligo, though most other uses tested lack solid evidence. L-lysine is possibly effective for cold sores.

L-tryptophan tested as possibly ineffective for depression, with other uses insufficient to rate. L-histidine, L-threonine, and the electrolytes have insufficient evidence or no clear rating for the uses documented in our data.

As a supplement meant for amino acid replenishment, the product's general effectiveness as a BCAA (branched-chain amino acid) product is not rated in the facts we hold.

The evidence, ingredient by ingredient Sodium Potassium Methionine Phenylalanine Histidine Threonine L-tryptophan Lysine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these amino acids are generally well tolerated at food amounts. L-phenylalanine should be avoided by anyone with PKU (phenylketonuria) and carries a safety caution for supplement doses.

L-tryptophan has a history of product contamination (a 1989 safety scare) and is generally well tolerated but can cause drowsiness, nausea, headache, and diarrhea. L-methionine, L-histidine, L-threonine, and L-lysine may cause mild gastrointestinal upset (diarrhea, nausea, abdominal pain) at higher doses.

Sodium in excess raises cardiovascular and kidney risks; potassium can cause nausea, vomiting, and diarrhea and is dangerous if it builds up in the blood. During pregnancy, L-phenylalanine is not safe in supplement doses, L-tryptophan should be avoided, and L-methionine and L-threonine lack safety studies at supplement levels—ask your doctor before using.

For breastfeeding, L-phenylalanine and L-tryptophan should be avoided; L-methionine, L-threonine, and L-lysine lack adequate breastfeeding safety data.

Side effects, ingredient by ingredient Sodium Potassium Methionine Phenylalanine Histidine Threonine L-tryptophan Lysine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Lysine, L-tryptophan, Phenylalanine, Potassium, Threonine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: lithium; Parkinson's medications.
  • For scale: 625 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist if you're on: levodopa (Parkinson disease), any CNS depressants like sedatives or strong pain relievers, serotonergic antidepressants or migraine drugs, NMDA antagonists like memantine, blood pressure medications (especially ACE inhibitors, ARBs, or beta-blockers), potassium-sparing diuretics, older antidepressants (MAOIs), muscle relaxants like baclofen, or any sodium-containing or potassium-affecting medications. No interactions are documented for the amino acids we could not check (L-leucine, L-isoleucine, L-valine), but the others all carry documented risks.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

If you're healthy, not on blood pressure or psychiatric medications, and have no kidney disease, this product is worth discussing with your pharmacist. But if you take levodopa, CNS depressants, antidepressants, blood pressure drugs, or potassium-affecting medications, check with us first—the interactions here are real and can affect how your drugs work.

Run your medication list through the interaction checker below before you buy.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Replenish Bombsicle, straight from the product label.

Brand Arms Race Nutrition
Barcode (UPC) 658580432966
Net contents 15.3 Ounce(s); 426 Gram(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 308158
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Replenish Bombsicle by Arms Race Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
14.7 Gram(s)
Maximum serving Sizes:
14.7 Gram(s)
Servings per container
30
UPC/BARCODE
658580432966
IngredientAmount% DV
L-Leucine4000 mg--
L-Isoleucine1000 mg--
L-Methionine325 mg--
L-Phenylalanine465 mg--
L-Valine1000 mg--
L-Histidine350 mg--
L-Threonine1100 mg--
L-Tryptophan60 mg--
L-Lysine1700 mg--
Branched-Chain Amino Acids0 NP--
Sodium100 mg4%
Potassium72 mg2%
Other Vegan Essential Amino Acids0 NP--

Other ingredients: Citric Acid, Natural & Artificial Flavors, Silicon Dioxide, Sucralose, Acesulfame Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Replenish is a full-spectrum amino acid supplement containing clinical amounts of the BCAAs (branched chain amino acids) and the remaining EAAs (essential amino acids).

Essential Amino Acids (EAA/BCAA) Naturally & Artificially Flavored

Albion Minerals

Precautions

Warning: Consuming this product can expose you to chemicals including lead, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Warning: This product is only intended for use in healthy adults 18 years of age or older. Keep out of reach of children.

Pregnant or nursing women should not use this product. Consult your healthcare provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement, product, or if you have any pre-existing medical condition including but not limited to: High or low blood pressure, cardiac arrhythmia, stroke heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAOI (Monoamine Oxidase Inhibitor) or any other medication.

Immediately discontinue use and consult your health care professional if you experience adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.

Suggested/Recommended/Usage/Directions

Directions: Mix 1 scoop with 12-20 ounces of water and shake well. Consume immediately before and during training. Additional servings can be taken throughout the day.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in USA

Formulation

Recover Hydrate Build Perform

Manufactured in a U.S. cGMP Facility.

Key ingredients in Replenish have been demonstrated to increase healthy skeletal muscle protein synthesis and the recovery response to resistance training.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Albion is a registered trademark of Albion Laboratories, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Replenish Bombsicle by Arms Race Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Replenish Bombsicle label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Replenish Bombsicle by Arms Race Nutrition

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size14.7 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Branched-Chain Amino Acids

0 NP per serving
  • › L-Leucine
  • › L-Isoleucine
  • › L-Valine

Sodium

Interacts with
205 drugs
100 mg per serving Form: Sea Salt

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
72 mg per serving Form: Albion Potassium Glycinate Complex

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Other Vegan Essential Amino Acids

0 NP per serving

Other (inactive) ingredients: Citric Acid, Natural & Artificial Flavors, Silicon Dioxide, Sucralose, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Replenish Bombsicle by Arms Race Nutrition Drug Interactions

Want to check YOUR meds against Replenish Bombsicle?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
625Drugs
256 Major 369 Moderate

Ingredients driving the most interactions

L-Tryptophan 394
Sodium 205
Potassium 62
L-Phenylalanine 16
L-Threonine 3

Individual Drug Interactions

The ingredients in Replenish Bombsicle interact with 625 drugs. Click any drug to see the details.

6 of the 11 ingredients in Replenish Bombsicle interact with drugs. Each result below shows which ingredient is responsible. L-Tryptophan Sodium Potassium L-Phenylalanine L-Threonine L-Lysine

Each ingredient & the kinds of drugs it affects

For each ingredient in Replenish Bombsicle with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Tryptophan2 drug types · 394 drugs

Cns Depressants

Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Clinical research shows that L-tryptophan can cause fatigue and drowsiness.

Likelihood Probable Evidence B
Serotonergic Drugs

Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.
L-tryptophan is a precursor to serotonin. Theoretically, combining serotonergic drugs with L-tryptophan might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Likelihood Possible Evidence D
L-Tryptophan full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

L-Phenylalanine3 drug types · 16 drugs

Levodopa

Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Phenylalanine competes with levodopa for carrier-mediated transport into the brain. The resulting reduction in levels of levodopa in the brain can exacerbate tremor, rigidity, and the "on-off" phenomenon in patients with Parkinson disease.

Likelihood Probable Evidence B
Baclofen

Concomitant intake of phenylalanine may reduce the intestinal absorption of baclofen.
Phenylalanine and baclofen share the same intestinal carrier for absorption; phenylalanine competitively inhibits the absorption of baclofen, reducing its plasma levels.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.
L-phenylalanine is metabolized to tyrosine. Some evidence suggests that L-phenylalanine, given with the non-selective MAOI pargyline, might prevent the elimination of tyramine, increasing the risk of hypertensive crisis. However, this was not reported in a small number of patients when using L-phenylalanine with the partially selective MAO-B inhibitor, selegiline.

Likelihood Possible Evidence D
L-Phenylalanine full monograph & interactions

L-Threonine1 drug type · 3 drugs

Nmda Antagonists

Theoretically, threonine might decrease the effects of NMDA antagonists.
Threonine increases central nervous system (CNS) glycine levels. Glycine seems to bind a site on NMDA receptors and enhance the activity of the receptors.

Likelihood Likely Evidence B
L-Threonine full monograph & interactions

L-Lysine1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Replenish Bombsicle, from the product label.

Arms Race Nutrition

See all Arms Race Nutrition products
Name
Arms Race Nutrition, LLC.
City
Statesville
State
NC
ZipCode
28625
Phone Number
(833)568-4321
Web Address
www.armsracenutrition.com
Pharmacist Counseling Corner

Replenish Bombsicle by Arms Race Nutrition: Common Questions

Does Replenish Bombsicle by Arms Race Nutrition interact with any medications?
Yes. Based on its ingredients, Replenish Bombsicle has a known interaction with 625 medications, including 256 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Replenish Bombsicle contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
It depends on which ingredients and at what dose. L-phenylalanine should be avoided during pregnancy and breastfeeding. L-tryptophan should also be avoided in both. L-methionine and L-threonine lack solid safety studies at supplement doses during pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized advice before using this product.
What is L-phenylalanine and why should I be careful with it?
L-phenylalanine is an essential amino acid your body needs, but at high supplement doses it can interfere with levodopa (used for Parkinson disease) and has been linked to anxiety and insomnia. It's also unsafe if you have PKU, a rare genetic condition. Anyone on levodopa should avoid this product.
Can this help my athletic performance or muscle recovery?
The product is designed as a BCAA (branched-chain amino acid) supplement, but the specific evidence for athletic performance from the amino acids we have data on is either not tested or insufficient to rate. Talk to your trainer or pharmacist about whether a BCAA product fits your goals.
What's the concern with the sodium and potassium in this?
Both are essential in small amounts, but too much can be risky. High sodium can worsen blood pressure and interact with blood pressure drugs. High potassium can dangerously spike blood levels, especially if you have kidney disease or take certain heart or blood pressure medications. If you have heart, kidney, or blood pressure issues, check with your doctor first.
Is there anything in here I need to worry about side effects from?
L-tryptophan can cause drowsiness, diarrhea, and nausea. L-phenylalanine may cause anxiety, insomnia, or headache. L-methionine, L-threonine, and L-lysine can cause mild stomach upset or diarrhea at higher doses. If you have any of these side effects or they worsen, stop taking it and talk to your pharmacist.
Why can't you check some of the amino acids for interactions?
We don't have complete monograph data for L-leucine, L-isoleucine, and L-valine, so we can't confirm whether they interact with medications. That doesn't mean they're safe—it means we don't have the information. If you're on medications, check with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Replenish Bombsicle label
Go deeper

The Full Monographs Behind Replenish Bombsicle’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph → Herb & supplement monograph

Phenylalanine

Interacts with 16 drugs

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitiligo, or pain, but the evidence is mostly l...

Read the full Phenylalanine monograph → Herb & supplement monograph

Histidine

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality researc...

Read the full Histidine monograph → Herb & supplement monograph

Threonine

Interacts with 3 drugs

Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a normal diet, and high-quality evidence for ta...

Read the full Threonine monograph → Herb & supplement monograph

L-tryptophan

Interacts with 394 drugs

L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for supplement use is limited and mixed, and...

Read the full L-tryptophan monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph →
Sources

Sources & How We Checked

Replenish Bombsicle's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 117 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
  2. Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
  3. Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
  4. Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
  5. Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
  6. McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
  7. Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
  8. Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
  9. Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
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See these in context on the Methionine monograph →

Phenylalanine 23 references
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Histidine 3 references
  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
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  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Histidine monograph →

Threonine 4 references
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See these in context on the Threonine monograph →

L-tryptophan 18 references
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See these in context on the L-tryptophan monograph →

Lysine 7 references
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See these in context on the Lysine monograph →

Sodium 38 references
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See these in context on the Sodium monograph →

Potassium 12 references
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See these in context on the Potassium monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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