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Dietary supplement

Resveratrol 250 mg Ingredients & Drug Interactions

by Herbal Secrets

Resveratrol 250 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Resveratrol 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Resveratrol 250 mg is a dietary supplement by Herbal Secrets with 1 active ingredient. Its ingredients are commonly taken for source of resveratrol, heart and circulation support, inflammation.Based on those ingredients, 826 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Polygonum cuspidatum extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Resveratrol 250 mg by Herbal Secrets

Ask about any prescription or over-the-counter medication and we check it for interactions with Resveratrol 250 mg by Herbal Secrets — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Resveratrol 250 mg by Herbal Secrets

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 1 active ingredient: Polygonum cuspidatum extract (also called hu zhang), a plant extract standardized to deliver 250 mg of resveratrol per capsule. Resveratrol is a naturally occurring compound found in the plant.

The capsule also contains inactive ingredients (rice flour, vegetable cellulose, silicon dioxide, and vegetable magnesium stearate) that serve as fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: antioxidant support and cardiovascular health.
  • We looked for evidence on: heart health, circulation, aging.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for hu zhang and resveratrol doesn't establish it works for any of the conditions listed on this product's label. Effectiveness ratings for hepatitis, rheumatoid arthritis, wound healing, gout, osteoarthritis, and unstable angina are all insufficient — meaning the data we hold doesn't show whether it helps.

If you're considering it for one of these reasons, talk with your doctor about whether there's better evidence for other options.

The evidence, ingredient by ingredient Hu Zhang

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Human safety data for hu zhang are limited, so what we know comes mostly from traditional use and lab research. The plant contains emodin, a compound that may cause digestive upset in some people.

Because there isn't enough safety information available, the product should not be taken during pregnancy — there's concern that some of its compounds may affect the uterus. It's also not recommended while breastfeeding due to insufficient safety data.

Side effects, ingredient by ingredient Hu Zhang

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hu Zhang.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 827 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist if you're on any blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), hormone replacement therapy, seizure medications like carbamazepine, or any drugs metabolized by liver enzymes CYP1A2, CYP2C19, CYP2E1, or CYP3A4. The resveratrol in this supplement may raise drug levels or interfere with their effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Resveratrol 250 mg by Herbal Secrets is a single-ingredient extract with no proven effectiveness for the conditions on its label. It does carry documented interactions with blood thinners, hormone replacement, and seizure medications, though most are theoretical.

If you take any prescription drugs, check with your own doctor or pharmacist before starting this supplement. Pregnant and breastfeeding people should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Resveratrol 250 mg, straight from the product label.

Brand Herbal Secrets
Barcode (UPC) 819209020890
Net contents 60 Vcap(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 251646
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Resveratrol 250 mg by Herbal Secrets, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vcap(s)
Maximum serving Sizes:
1 Vcap(s)
Servings per container
60
UPC/BARCODE
819209020890
IngredientAmount% DV
Polygonum cuspidatum extract250 mg--

Other ingredients: Rice Flour, Vegetable Cellulose, Silicon Dioxide, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Resveratrol is a special type of antioxidant, called a phytoalexin. It's found in the Polygonum cuspidatum plant, also known as Japanese knotweed. Antioxidants protect your body's cells from the normal, but damaging, process of oxidation. It may play a role in promoting healthy aging due to its antioxidant properties, in addition to supporting normal cell replication.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take one (1) veggie capsule daily or as directed by a health care professional.

Precautions

Caution: If you are pregnant, nursing, taking any medication(s) or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

100% natural

Antioxidant properties Supports cardiovascular health Supports anti-inflammatory response Supports healthy aging

Contains no: Artificial preservatives, colors, flavors or sweeteners, sugar, milk, lactose, soy, gluten, wheat, yeast, fish or sodium.

FDA Statement of Identity

Natural Dietary Supplement

Seals/Symbols

GMP Good Manufacturing Practice Quality Product

Made in the USA

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Resveratrol 250 mg by Herbal Secrets label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Resveratrol 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Resveratrol 250 mg by Herbal Secrets

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vcap(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Polygonum cuspidatum extract

Interacts with
826 drugs
250 mg per serving Form: Trans-Resveratrol

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and ear...

Polygonum cuspidatum extract monograph & interactions

Other (inactive) ingredients: Rice Flour, Vegetable Cellulose, Silicon Dioxide, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Resveratrol 250 mg by Herbal Secrets Drug Interactions

Want to check YOUR meds against Resveratrol 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
826Drugs
826 Moderate

Ingredients driving the most interactions

Polygonum cuspidatum extract 826

Individual Drug Interactions

The ingredients in Resveratrol 250 mg interact with 826 drugs. Click any drug to see the details.

1 of the 1 ingredient in Resveratrol 250 mg interact with drugs. Each result below shows which ingredient is responsible. Polygonum cuspidatum extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Resveratrol 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Polygonum cuspidatum extract7 drug types · 826 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Hu zhang contains the constituent resveratrol. Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP1A2 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2C19 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2E1 enzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP3A4 enzyme. However, a clinical study in adults with NAFLD found that adding resveratrol 3000 mg daily for 8 weeks did not necessitate dose adjustments to any established medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Estrogens

Theoretically, hu zhang might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that hu zhang might have estrogenic activity.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, hu zhang might increase the effects and adverse effects of carbamazepine.
In animals, blood and tissue levels of carbamazepine were increased when given in combination with hu zhang. It is thought that increased levels of carbamazepine are due to cytochrome P450 3A4 (CYP3A4) inhibition. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Polygonum cuspidatum extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Resveratrol 250 mg, from the product label.

Herbal Secrets

See all Herbal Secrets products
Name
Herbal Secrets
Street Address
629 Grove Street
City
Jersey City
State
NJ
ZipCode
07310
Pharmacist Counseling Corner

Resveratrol 250 mg by Herbal Secrets: Common Questions

Does Resveratrol 250 mg by Herbal Secrets interact with any medications?
Yes. Based on its ingredients, Resveratrol 250 mg has a known interaction with 826 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Resveratrol 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does hu zhang really have resveratrol in it?
Yes — hu zhang (Polygonum cuspidatum) naturally contains resveratrol, the compound this supplement is standardized to deliver. That resveratrol is what's responsible for most of the documented interactions with medications.
Can I take this if I'm on aspirin or another blood thinner?
Not without checking first. Resveratrol appears to thin the blood itself, so combining it with warfarin, aspirin, or other anticoagulant or antiplatelet drugs could raise your bleeding risk. Talk to your pharmacist or doctor before you add this to your regimen.
Is it safe to take while pregnant?
No — there isn't enough safety data, and some of the compounds in hu zhang may affect the uterus, so it's best avoided during pregnancy. If you're pregnant or planning to be, check with your doctor before taking any supplement.
Will this actually help with my condition?
The evidence isn't established for any of the uses listed. Hepatitis, rheumatoid arthritis, wound healing, gout, osteoarthritis, and unstable angina all have insufficient evidence in our data. Your doctor can discuss whether there are better-proven options for you.
Can it cause side effects?
Adverse effects aren't well documented in our data. However, because hu zhang contains emodin, some people may experience digestive upset. Since human safety data are limited, it's wise to start cautiously and watch how you feel.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Resveratrol 250 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Resveratrol 250 mg label
Go deeper

The Full Monographs Behind Resveratrol 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hu Zhang

Interacts with 826 drugs

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and early human research looks interesting for...

Read the full Hu Zhang monograph →
Sources

Sources & How We Checked

Resveratrol 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hu Zhang 19 references
  1. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  2. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  3. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
  4. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
  5. Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
  6. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  7. Matsuda H, Shimoda H, Morikawa T, Yoshikawa M. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg Med Chem Lett 2001;11:1839-42. PubMed
  8. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  9. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
  10. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
  11. Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
  12. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
  13. Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
  14. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  15. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
  16. Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. PubMed
  17. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
  18. Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. PubMed
  19. Chi YC, Lin SP, Hou YC. A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats. Toxicol Appl Pharmacol 2012;263(3):315-22. PubMed

See these in context on the Hu Zhang monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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