Royal Jelly Propolis Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Royal Jelly Propolis against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Royal Jelly Propolis is a dietary supplement by Y.S. Eco Bee Farms with 2 active ingredients. Its ingredients are commonly taken for cold sores and herpes lesions (topical), sore throat and mouth sores, wound and skin healing.Based on those ingredients, 1,036 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bee Propolis, Royal Jelly. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Royal Jelly Propolis by Y.S. Eco Bee Farms
Ask about any prescription or over-the-counter medication and we check it for interactions with Royal Jelly Propolis by Y.S. Eco Bee Farms — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Royal Jelly Propolis by Y.S. Eco Bee Farms
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains two active ingredients: bee propolis and royal jelly, each a bee-derived substance used in traditional and complementary medicine. The inactive ingredients include gelatin (the capsule), carob, and magnesium stearate (a flow agent).
Does it work?
Couldn't assess
Bee propolis is possibly effective for oral mucositis (mouth sores) and cold sores (herpes labialis), and possibly effective for diabetes support — though the evidence isn't conclusive. It's rated as having insufficient reliable evidence for dengue fever.
Royal jelly is possibly effective for menopausal symptoms, but is rated possibly ineffective for hay fever, physical performance, and diabetes, and insufficient evidence exists for hair loss.
How safe is it?
Well-documented data
Both bee propolis and royal jelly are generally well tolerated in the short term. Propolis may cause mild headache (around 7% of people in one trial reported this at higher doses), and topical use can cause contact dermatitis in sensitive individuals.
Royal jelly can trigger serious allergic reactions — including anaphylaxis and potentially fatal reactions — especially in people with asthma or a history of allergies. Because both come from bee products, anyone allergic to bees should avoid this supplement.
The product is best avoided during pregnancy due to insufficient safety data, and while breastfeeding for the same reason — though royal jelly is rated possibly safe during lactation.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you take warfarin or any other blood thinner (anticoagulant or antiplatelet drug) — propolis and royal jelly both raise bleeding concerns here. Also clear it if you take blood pressure medication, since royal jelly may lower blood pressure further.
Propolis may theoretically raise levels of drugs metabolized by your liver's CYP enzymes (CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, and CYP2E1), so mention any other medications you're on.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may help with cold sores or mouth sores and possibly diabetes, but it's not for anyone taking blood thinners or blood pressure medications without checking first. The main caution is allergic reactions, particularly if you have asthma or a history of allergies to bee products.
Talk with your doctor or pharmacist before starting it, especially if you take warfarin, other blood thinners, or blood pressure drugs.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Royal Jelly Propolis, straight from the product label.
| Brand | Y.S. Eco Bee Farms |
|---|---|
| Barcode (UPC) | 726635797398 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2019 |
| DSLD ID | 205964 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Organic, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Royal Jelly Propolis by Y.S. Eco Bee Farms, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bee Propolis | 200 mg | -- |
| Royal Jelly | 300 mg | -- |
Other ingredients: Gelatin, Carob, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Organic pioneer since 1995
Free of yeast, salt, sugar, starch, preservatives and common allergens.
Free of yeast, salt, sugar, starch, preservatives and common allergens.
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take 1 capsule 2 times a day or more as needed, preferably between meals.
FDA Statement of Identity
Dietary Supplement
General Statements
Dynamic synergy Mega strength Full potency & purity - Guaranteed
1,000 mg 400 mg
Beekeepers of Generations have been dedicated to research and develop the highest quality Bee Products.
Satisfaction Guaranteed
Formula
Royal Jelly, nature's purest source of life transforming super food complex, provides a natural rejuvenating energy. The queen bee feeds entirely on and incredibly lays over 2,000 eggs per day and has an extended life span of 4-5 years compared to the 2-3 months life cycle of the worker bee. Propolis contains high levels of Bioflavones and antioxidants, and has powerful natural antibacterial, antiviral, antifungal, antibiotic and deep immune supporting properties.
Seals/Symbols
YS Organic
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Royal Jelly Propolis by Y.S. Eco Bee Farms label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Royal Jelly Propolis by Y.S. Eco Bee Farms
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Bee Propolis
Interacts with921 drugs
Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...
Bee Propolis monograph & interactionsRoyal Jelly
Interacts with174 drugs
Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune su...
Royal Jelly monograph & interactionsOther (inactive) ingredients: Gelatin, Carob, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Royal Jelly Propolis by Y.S. Eco Bee Farms Drug Interactions
HelloPharmacist Interaction Report
Royal Jelly Propolis by Y.S.
Eco Bee Farms contains bee propolis and royal jelly, both of which interact with medications. The most serious documented concern is a Moderate-severity interaction with warfarin (a blood thinner), where propolis may decrease its effectiveness and royal jelly may increase bleeding risk — creating opposing effects that make this combination especially important to discuss with your doctor or pharmacist.
Read the full breakdown — every affected drug type, severity by severity
Bee propolis theoretically raises blood levels of drugs broken down by several liver enzymes (CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, and CYP2E1 substrates) at high doses, though animal studies suggest this effect may not happen in real life. Propolis also carries a Moderate-severity concern with blood thinners (anticoagulants and antiplatelet drugs) — in lab research, it slowed clot formation.
Royal jelly adds a Moderate-severity interaction with blood pressure medications (antihypertensives), since animal work suggests it may lower blood pressure further.
Alternately, no interactions are documented in our data for any of the inactive ingredients (gelatin, carob, and magnesium stearate). Altogether, these interactions span 1,037 individual medications.
Before you start this product, run your exact medications through the checker below, especially if you take a blood thinner, blood pressure medication, or any drug metabolized by liver enzymes.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Royal Jelly Propolis?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Royal Jelly Propolis interact with 1,036 drugs. Click any drug to see the details.
2 of the 2 ingredients in Royal Jelly Propolis interact with drugs. Each result below shows which ingredient is responsible. Bee Propolis Royal Jelly
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Bee Propolis + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Bee Propolis + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Bee Propolis + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Bee Propolis + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Bee Propolis + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
Read the full Bee Propolis + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Bee Propolis + Acalabrutinib interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Royal JellyAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Royal Jelly + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Bee Propolis + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Bee Propolis + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Bee Propolis + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Bee Propolis + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Bee Propolis + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Bee Propolis + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Bee Propolis + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Bee Propolis + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Bee Propolis + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Bee Propolis + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Bee Propolis + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Bee Propolis + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Bee Propolis + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Bee Propolis + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Bee Propolis + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Bee Propolis + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Bee Propolis + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Bee Propolis + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Bee Propolis + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Bee Propolis + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Bee Propolis + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Royal Jelly Propolis — through 1 ingredient. Tap an ingredient for the detail:
Bee PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Bee Propolis + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Royal Jelly Propolis with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Bee Propolis
Anticoagulant/Antiplatelet Drugs
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Warfarin (Coumadin)
Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.
Royal Jelly
Antihypertensive Drugs
Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that royal jelly might lower blood pressure.
Warfarin (Coumadin)
Royal jelly might increase the risk of bleeding when taken with warfarin.
In one case, an 87-year-old male who was previously stabilized on warfarin developed hematuria and was found to have an INR of 7.29 after taking a royal jelly supplement for one week.
Brand information
Manufacturer and brand details for Royal Jelly Propolis, from the product label.
Y.S. Eco Bee Farms
See all Y.S. Eco Bee Farms products- Name
- Y.S. Organic Bee Farms
- City
- Sheridan
- State
- IL
- ZipCode
- 60551
Royal Jelly Propolis by Y.S. Eco Bee Farms: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Royal Jelly Propolis is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Royal Jelly Propolis’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Propolis
Interacts with 921 drugsPropolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research suggests it may help with cold sores, mouth so...
Read the full Propolis monograph → Herb & supplement monographRoyal Jelly
Interacts with 174 drugsRoyal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune support, but solid human evidence is limit...
Read the full Royal Jelly monograph →Sources & How We Checked
Royal Jelly Propolis's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 35 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Propolis 21 references
- Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
- Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
- Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
- Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
- Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
- Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
- Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
- Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
- Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
- Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
- Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
- Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
- Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
- Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
- Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
- Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
- Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
- D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
- Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
- Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
- Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed
Royal Jelly 14 references
- Takahashi M, Matsuo I, Ohkido M. Contact dermatitis due to honeybee royal jelly. Contact Dermatitis 1983;9:452-5.
- Bullock RJ, et al. Fatal royal jelly-induced asthma. Med J Aust 1994;160:44. DOI
- Thien FC, Leung R, Baldo BA, et al. Asthma and anaphylaxis induced by royal jelly. Clin Exp Allergy 1996;26:216-22. PubMed
- Yonei Y, Shibagaki K, Tsukada N, et al. Case report: haemorrhagic colitis associated with royal jelly intake. J Gastroenterol Hepatol 1997;12:495-9.
- Harwood M, Harding S, Beasley R, Frankish PD. Asthma following royal jelly. N Z Med J 1996;109:325.
- Laporte JR, Ibaanez L, Vendrell L, Ballarin E. Bronchospasm induced by royal jelly. Allergy 1996;51:440. DOI
- Leung R, Thien FC, Baldo B, et al. Royal jelly-induced asthma and anaphylaxis: clinical characteristics and immunologic correlations. J Allergy Clin Immunol 1995;96:1004-7. PubMed
- Peacock S, Murray V, Turton C. Respiratory distress and royal jelly. BMJ 1995;311:1472. DOI
- Winther K, Hedman C. Assessment of the Effects of the Herbal Remedy Femal on the Symptoms of Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study. Curr Ther Res Clin Exp 2002;63:344-53. DOI
- Lee NJ, Fermo JD. Warfarin and royal jelly interaction. Pharmacotherapy 2006;26:583-6. PubMed
- Tokunaga, K. H., Yoshida, C., Suzuki, K. M., Maruyama, H., Futamura, Y., Araki, Y., and Mishima, S. Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats. Biol.Pharm.Bull. 2004;27(2):189-192. PubMed
- Sultana, A., Nabi, A. H., Nasir, U. M., Maruyama, H., Suzuki, K. M., Mishima, S., and Suzuki, F. A dipeptide YY derived from royal jelly proteins inhibits renin activity. Int.J.Mol.Med. 2008;21(6):677-681. DOI
- Gómez Torrijos E, Méndez Diaz Y, Borja Segade JM, et al. Occupational allergic respiratory disease due to royal jelly. Ann Allergy Asthma Immunol. 2016;117(1):102-3. PubMed
- Li JD, Cui L, Xu YY, Guan K. A case of anaphylaxis caused by major royal jelly protein 3 of royal jelly and its cross-reactivity with honeycomb. J Asthma Allergy 2021;14:1555-7. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC