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Dietary supplement

Sarsaparilla 2,000 mg Ingredients & Drug Interactions

by Nature's Answer

Sarsaparilla 2,000 mg label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sarsaparilla 2,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sarsaparilla 2,000 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for skin conditions like psoriasis, joint pain and arthritis, general tonic or 'blood purifier'.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sarsaparilla (Smilax spp.) root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sarsaparilla 2,000 mg by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Sarsaparilla 2,000 mg by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sarsaparilla 2,000 mg by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: sarsaparilla (Smilax spp.) root extract at 2,000 mg per dose. The liquid also holds inactive ingredients — purified water, vegetable glycerin, and 12–15% certified organic alcohol — which serve as the base and preservative.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Sarsaparilla product and its label doesn't state a use — see Sarsaparilla's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for sarsaparilla isn't established for the purposes it's often marketed toward. We hold insufficient reliable evidence to rate it for cancer, psoriasis, or rheumatoid arthritis.

If you're considering it for a specific health concern, talk with your doctor about what the research actually supports.

The evidence, ingredient by ingredient Sarsaparilla

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sarsaparilla is thought to be low-risk in food amounts, but human safety data at supplement doses are limited. Occupational exposure to sarsaparilla root dust can trigger rhinitis and asthma symptoms, though this is less likely from taking the supplement itself.

Not enough safety data exists to support use during pregnancy or while breastfeeding. The safety information advises against it in both cases.

Talk with your doctor or pharmacist before taking it if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Sarsaparilla

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sarsaparilla.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using this product if you take lithium or digoxin (Lanoxin). Both interactions are Moderate severity — lithium levels could climb, and digoxin's heart-toxicity risk could rise due to potassium loss from the diuretic effect.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sarsaparilla may be reasonable for someone without lithium or digoxin in their regimen, but the evidence for what it actually does is thin. If you take any heart medications or lithium, you need to clear this with your own doctor or pharmacist before starting.

Pregnancy and nursing require a conversation with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sarsaparilla 2,000 mg, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000004902
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Jun 24, 2016
DSLD ID 60792
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sarsaparilla 2,000 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
2 mL
Servings per container
30
UPC/BARCODE
083000004902
IngredientAmount% DV
Sarsaparilla (Smilax spp.) root extract2000 mg--

Other ingredients: purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Gluten Free

K Parve

Formula

K Parve

Smilax spp.

Low Alcohol

Brand IP Statement(s)

Bio-Chelated Cold Extraction Process

Advanced Botanical Fingerprint

Discover Nature's Answer

Our organic alcohol extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.

2015 Nature's Answer

General

9291A Rev. 315 1140

General Statements

Since 1972

Super concentrated 2,000 mg

Our facility is cGMP certified, organic and kosher certified.

Formulation

Gluten-Free

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1-2 mL (28-56 drops) three (3) times a day in a small amount of water. Shake well.

Precautions

Keep out of reach of children.

Warning: Do not use if pregnant or nursing.

Do not use if safety seal is damaged or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sarsaparilla 2,000 mg by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sarsaparilla 2,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sarsaparilla 2,000 mg by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Sarsaparilla (Smilax spp.) root extract

Interacts with
2 drugs
2000 mg per serving

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited...

Sarsaparilla (Smilax spp.) root extract monograph & interactions

Other (inactive) ingredients: Purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sarsaparilla 2,000 mg by Nature's Answer Drug Interactions

Want to check YOUR meds against Sarsaparilla 2,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Sarsaparilla (Smilax spp.) root extract 2

Individual Drug Interactions

The ingredients in Sarsaparilla 2,000 mg interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sarsaparilla 2,000 mg interact with drugs. Each result below shows which ingredient is responsible. Sarsaparilla (Smilax spp.) root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sarsaparilla 2,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sarsaparilla (Smilax spp.) root extract2 drug types · 2 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Lithium

Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Sarsaparilla (Smilax spp.) root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sarsaparilla 2,000 mg, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
City
Hauppauge
State
NY
ZipCode
11788-3943
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Sarsaparilla 2,000 mg by Nature's Answer: Common Questions

Does Sarsaparilla 2,000 mg by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Sarsaparilla 2,000 mg has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sarsaparilla 2,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take sarsaparilla if I'm on lithium?
Not without checking with your doctor first. Sarsaparilla may slow how your kidneys clear lithium, raising its level and side effects. Your lithium dose might need adjustment.
What about if I take a heart medication like digoxin?
Talk to your pharmacist or doctor before starting. Sarsaparilla's diuretic effect could lower potassium and increase the risk of heart toxicity when combined with digoxin.
Is sarsaparilla safe during pregnancy?
The safety information advises against it — there isn't enough data to know either way. Talk with your doctor before taking it if you're pregnant or planning to become pregnant.
Does sarsaparilla actually work for arthritis or psoriasis?
We don't have reliable evidence to say it does. The research is insufficient to rate it for rheumatoid arthritis or psoriasis, so its benefit for those conditions isn't established.
What's in this liquid besides the sarsaparilla?
It's purified water, vegetable glycerin, and 12–15% certified organic alcohol — all inactive ingredients that make up the base and keep it preserved.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sarsaparilla 2,000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sarsaparilla 2,000 mg label
Go deeper

The Full Monographs Behind Sarsaparilla 2,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sarsaparilla

Interacts with 2 drugs

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it...

Read the full Sarsaparilla monograph →
Sources

Sources & How We Checked

Sarsaparilla 2,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sarsaparilla 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Vandenplas O, Depelchin S, Toussaint G, et al. Occupational asthma caused by sarsaparilla root dust. J Allergy Clin Immunol 1996;97:1416-8. PubMed

See these in context on the Sarsaparilla monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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