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Dietary supplement

Motherwort Extract Ingredients & Drug Interactions

by Nature's Answer

Motherwort Extract label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Motherwort Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Motherwort Extract is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, heart palpitations, menstrual discomfort.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Motherwort (Leonurus cardiaca) herb extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Motherwort Extract by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Motherwort Extract by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Motherwort Extract by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: a Motherwort herb extract (from Leonurus cardiaca). It comes as a liquid in a base of purified water, certified organic alcohol (12–15%), and vegetable glycerin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Motherwort's overall clinical evidence instead.

Moderate

Some clinical evidence supports Motherwort for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Bleeding — rated "Possibly Effective" (Natural Medicines).

The data shows motherwort may be effective for bleeding. For other uses—including anxiety, amenorrhea (absent periods), asthma, and alcohol use disorder—the evidence isn't strong enough to rate.

That doesn't mean it doesn't work for those; it means we don't have reliable trial data to say either way.

The evidence, ingredient by ingredient Motherwort

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Motherwort appears generally well tolerated in the short term, though human safety data are limited. Most common side effects from oral use are diarrhea and stomach irritation.

Taking amounts larger than 3 grams orally can cause uterine bleeding. Topically, it may cause contact dermatitis or photosensitivity reactions (sensitivity to sun).

The safety data advise against use in pregnancy because motherwort is traditionally thought to stimulate the uterus. There isn't enough information on file about safety during breastfeeding—talk with your doctor or pharmacist about whether it's right for you if you're nursing.

Side effects, ingredient by ingredient Motherwort

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Motherwort.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check whether you take any CNS depressants (medications that make you drowsy or calm your central nervous system)—sleep aids, anti-anxiety drugs, opioid painkillers, some antihistamines, or certain antidepressants. Motherwort may increase their sedating effects.

Use the medication checker on this page to confirm your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Motherwort Extract may help with bleeding, but evidence for other common uses is limited. If you take any CNS depressants—sleep aids, anxiety medications, opioids, or certain antidepressants—check with your doctor or pharmacist before adding this product.

It's not recommended in pregnancy. A conversation with your own healthcare provider can help you decide whether it fits your health goals.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Motherwort Extract, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000004063
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 239385
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Motherwort Extract by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
15
UPC/BARCODE
083000004063
IngredientAmount% DV
Motherwort (Leonurus cardiaca) herb extract400 mg--

Other ingredients: purified Water, 12-15% certified organic Alcohol, Vegetable Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gluten free

Absolutely no preservatives

Our alcohol-free extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.

Seals/Symbols

K Parve (Kosher)

Bio-Chelated Cold Extraction Process

Formula

K Parve (Kosher)

Leonurus cardiaca Made from 1,200 mg Motherwort herb per serving Low alcohol

General Statements

Nature's Answer since 1972

Discover Nature's Answer

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 2 mL (56 drops) three (3) times a day, in a small amount of water. Shake well.

Precautions

Keep out of reach of children.

Warning: Do not use if pregnant or nursing.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Copyright 2019 Nature's Answer

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Motherwort Extract by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Motherwort Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Motherwort Extract by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Motherwort (Leonurus cardiaca) herb extract

Interacts with
248 drugs
400 mg per serving

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human ev...

Motherwort (Leonurus cardiaca) herb extract monograph & interactions

Other (inactive) ingredients: Purified Water, 12-15% certified organic Alcohol, Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Motherwort Extract by Nature's Answer Drug Interactions

Want to check YOUR meds against Motherwort Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Motherwort (Leonurus cardiaca) herb extract 248

Individual Drug Interactions

The ingredients in Motherwort Extract interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Motherwort Extract interact with drugs. Each result below shows which ingredient is responsible. Motherwort (Leonurus cardiaca) herb extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Motherwort Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Motherwort (Leonurus cardiaca) herb extract1 drug type · 248 drugs

Cns Depressants

Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.

Likelihood Possible Evidence D
Motherwort (Leonurus cardiaca) herb extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Motherwort Extract, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Motherwort Extract by Nature's Answer: Common Questions

Does Motherwort Extract by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Motherwort Extract has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Motherwort Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
The safety data advise against it. Motherwort is traditionally thought to stimulate the uterus, which is a concern in pregnancy. Talk with your doctor or pharmacist about whether this product is right for you.
What are the most common side effects?
If you take it by mouth, diarrhea and stomach irritation are most common. If applied to skin, it may cause contact dermatitis or make your skin sensitive to sunlight. Taking more than 3 grams orally can cause uterine bleeding.
Does motherwort actually work for anxiety?
The evidence for anxiety isn't strong enough to rate yet. The data we have doesn't show clear proof it works, but that's not the same as proof it doesn't—we just need more reliable trials.
Is this safe for long-term use?
Human safety data are limited. It appears generally well tolerated short-term, but we don't have enough information to say how safe it is over weeks or months. Check with your doctor or pharmacist if you're thinking of using it regularly.
Can I take this if I'm breastfeeding?
There isn't enough safety information on file about motherwort and breastfeeding. Talk with your doctor or pharmacist to see whether it's appropriate for you while nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Motherwort Extract is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Motherwort Extract label
Go deeper

The Full Monographs Behind Motherwort Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Motherwort

Interacts with 248 drugs

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human evidence is very limited. It should be avo...

Read the full Motherwort monograph →
Sources

Sources & How We Checked

Motherwort Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Motherwort 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20.
  5. Xia WT, Zhou H, Wang Y, et al. Motherwort injection in preventing post-abortion hemorrhage after induced abortion: A multi-center, prospective, randomized controlled trial. Explore (NY). 2019. pii: S1550-8307(19)30447-1. PubMed
  6. Cao Shan DOSOGC, Zhang W, Zhao Z, et al. Post-marketing safety surveillance and reevaluation of Motherwort injection: A clinical study of 10 094 cases. J Tradit Chin Med. 2018 Aug;38(4):625-635. DOI

See these in context on the Motherwort monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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