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Dietary supplement

Motherwort Ingredients & Drug Interactions

by Eclectic Herb

Motherwort label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Motherwort against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Motherwort is a dietary supplement by Eclectic Herb with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, heart palpitations, menstrual discomfort.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Motherwort Flowering Tops Extract, Fresh. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Motherwort by Eclectic Herb

Ask about any prescription or over-the-counter medication and we check it for interactions with Motherwort by Eclectic Herb — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Motherwort by Eclectic Herb

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: Motherwort Flowering Tops Extract made from fresh plant material. Motherwort is a traditional herbal remedy that has been used for various conditions over centuries.

The liquid is made with alcohol and filtered water as inactive ingredients to preserve and deliver the extract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Motherwort's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Cardiac support.
  • We looked for evidence on: Arrhythmia, Heart failure, Hypertension, Heart palpitations, Cardiac function.
  • The closest evidence on file: Motherwort is rated "Insufficient Reliable Evidence To Rate" for Arrhythmia (Natural Medicines).
  • Also on file: Motherwort is rated "Insufficient Reliable Evidence To Rate" for Heart failure, Hypertension.

The evidence for motherwort is mixed. It's rated possibly effective for bleeding.

For anxiety, alcohol use disorder, amenorrhea, and asthma, the evidence isn't strong enough to rate — meaning we don't have reliable data showing it works for those uses. If you're considering motherwort for a specific condition, talk with us about what the science actually shows.

The evidence, ingredient by ingredient Motherwort

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Motherwort appears to be generally well tolerated when taken by mouth, but human safety data are limited — we just don't have a lot of long-term studies. The most common side effects from oral use are diarrhea and stomach irritation.

If you take more than 3 grams, it can cause uterine bleeding. Topically, it may cause contact dermatitis or photosensitivity reactions (skin reactions triggered by sun exposure).

The safety data advise against motherwort in pregnancy because it's traditionally thought to stimulate the uterus. There isn't enough safety information for breastfeeding either, so it's best avoided then too.

Side effects, ingredient by ingredient Motherwort

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Motherwort.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any CNS depressants you're on — that means sleep aids, sedating anxiety medications, and over-the-counter sleep products. Motherwort can boost their drowsy effect.

Use the checker below with your exact medication names, or ask us directly.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Motherwort might be worth considering if you're interested in its traditional uses and have cleared it with your pharmacist or doctor. If you take any sleep aids, anti-anxiety drugs, or other CNS depressants, check your medications first — the interaction is real.

Pregnancy and breastfeeding are times to skip it. Talk to us before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Motherwort, straight from the product label.

Brand Eclectic Herb
Barcode (UPC) 023363102747
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 316839
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Motherwort by Eclectic Herb, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Full Dropper(s)
Maximum serving Sizes:
1 Full Dropper(s)
UPC/BARCODE
023363102747
IngredientAmount% DV
Motherwort Flowering Tops Extract, Fresh0 NP--

Other ingredients: Alcohol, Water, Filtered

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Certified Organic by Oregon Tilth

Cardiac support

Herbal extract

Seals/Symbols

USDA Organic

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Shake well; mix 1 full dropper in water; take 3 times daily.

Storage

Store upright.

Precautions

Keep out of reach of children. Consult your health care advisor about herbs with pregnancy, infants or prescription drugs.

Discontinue use if unusual symptoms occur.

Consult your health care advisor about herbs with pregnancy, infants or prescription drugs.

Formula

100% Kosher.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent diseases.

General Statements

@eclecticherb

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Motherwort by Eclectic Herb label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Motherwort label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Motherwort by Eclectic Herb

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Full Dropper(s) Dosage formLiquid Amounts shown are per serving.

Motherwort Flowering Tops Extract, Fresh

Interacts with
248 drugs
0 NP per serving

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human ev...

Motherwort Flowering Tops Extract, Fresh monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Filtered. These complete the product’s ingredient list but are not active constituents.

Interaction report

Motherwort by Eclectic Herb Drug Interactions

Want to check YOUR meds against Motherwort?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Motherwort Flowering Tops Extract, Fresh 248

Individual Drug Interactions

The ingredients in Motherwort interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Motherwort interact with drugs. Each result below shows which ingredient is responsible. Motherwort Flowering Tops Extract, Fresh

Each ingredient & the kinds of drugs it affects

For each ingredient in Motherwort with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Motherwort Flowering Tops Extract, Fresh1 drug type · 248 drugs

Cns Depressants

Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.

Likelihood Possible Evidence D
Motherwort Flowering Tops Extract, Fresh full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Motherwort, from the product label.

Eclectic Herb

See all Eclectic Herb products
Name
Eclectic Herb
Street Address
755 NE 6th St.
City
Gresham
State
Oregon
ZipCode
97030
Phone Number
503.668.4120
Web Address
www.eclecticherb.com
Pharmacist Counseling Corner

Motherwort by Eclectic Herb: Common Questions

Does Motherwort by Eclectic Herb interact with any medications?
Yes. Based on its ingredients, Motherwort has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Motherwort contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take motherwort if I'm pregnant or breastfeeding?
No. The safety data advise against motherwort in pregnancy because it's traditionally thought to stimulate the uterus. There also isn't enough safety information for breastfeeding, so it's best avoided then too. Talk with your OB or midwife about safer options.
What are the most common side effects?
When taken by mouth, the most common side effects are diarrhea and stomach irritation. If you apply it to skin, you might get contact dermatitis or sun sensitivity. If you take more than 3 grams, uterine bleeding is possible.
Does motherwort actually work for anxiety?
The evidence isn't strong enough to say yet. Motherwort is rated as having insufficient reliable evidence for anxiety, so we can't confidently say whether it works for that. It is rated possibly effective for bleeding, though.
Is this safe to use long-term?
We don't have enough human data to know. Motherwort may be tolerated short-term by healthy adults, but long-term safety is unclear. If you're thinking of taking it regularly, check in with us first.
Why is this a liquid instead of a capsule?
A liquid extract can deliver the herb's compounds quickly and allows for easy dose adjustment. This one uses alcohol and water to preserve the plant material.
Will this make me drowsy?
It may. Motherwort can cause CNS depression and sedation on its own, and that effect gets stronger if you're also taking sleep aids or anti-anxiety drugs. If drowsiness becomes a problem, stop and let us know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Motherwort label
Go deeper

The Full Monographs Behind Motherwort’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Motherwort

Interacts with 248 drugs

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human evidence is very limited. It should be avo...

Read the full Motherwort monograph →
Sources

Sources & How We Checked

Motherwort's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Motherwort 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20.
  5. Xia WT, Zhou H, Wang Y, et al. Motherwort injection in preventing post-abortion hemorrhage after induced abortion: A multi-center, prospective, randomized controlled trial. Explore (NY). 2019. pii: S1550-8307(19)30447-1. PubMed
  6. Cao Shan DOSOGC, Zhang W, Zhao Z, et al. Post-marketing safety surveillance and reevaluation of Motherwort injection: A clinical study of 10 094 cases. J Tradit Chin Med. 2018 Aug;38(4):625-635. DOI

See these in context on the Motherwort monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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