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Dietary supplement

Motherwort Leaf/Flower Ingredients & Drug Interactions

by Cedar Bear

Motherwort Leaf/Flower label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Motherwort Leaf/Flower against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Motherwort Leaf/Flower is a dietary supplement by Cedar Bear with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, heart palpitations, menstrual discomfort.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Motherwort. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Motherwort Leaf/Flower by Cedar Bear

Ask about any prescription or over-the-counter medication and we check it for interactions with Motherwort Leaf/Flower by Cedar Bear — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Motherwort Leaf/Flower by Cedar Bear

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (0.50 mL) without saying how much of each component you get.

This product contains one active ingredient: motherwort leaf and flower in a proprietary blend. The extract is suspended in USP-grade vegetable glycerin and purified water—those are inactive ingredients that help deliver the plant material in liquid form.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Motherwort's overall clinical evidence instead.

Moderate

Some clinical evidence supports Motherwort for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Bleeding — rated "Possibly Effective" (Natural Medicines).

The evidence we hold is thin. Motherwort is possibly effective for bleeding.

For anxiety, alcohol use disorder, amenorrhea, and asthma, we have insufficient reliable evidence to rate whether it works. If you're considering it for one of those other uses, the science just isn't solid enough yet to know.

The evidence, ingredient by ingredient Motherwort

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Motherwort appears to be generally well tolerated when taken by mouth, but long-term safety data in humans are limited. The most common side effects from oral use are diarrhea and stomach irritation.

At doses over 3 grams, it may trigger uterine bleeding. Topically, it can cause contact dermatitis or photosensitivity reactions (sun sensitivity).

Motherwort is considered likely unsafe in pregnancy because it's traditionally thought to stimulate the uterus. We don't have lactation safety information on file for this ingredient.

Side effects, ingredient by ingredient Motherwort

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Motherwort.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before you start if you take CNS depressants—sleep aids, anti-anxiety medications, sedating antidepressants, opioids, or drink alcohol regularly. Motherwort may increase drowsiness and sedation with these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is mainly a consideration if you're looking into motherwort for bleeding and want to try a herbal liquid form. If you take any sedating medication—sleep aids, anxiety drugs, opioids, certain antidepressants—or drink alcohol regularly, talk with your doctor or pharmacist before starting it.

Women who are pregnant should avoid it. Your own healthcare provider can weigh whether this fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Motherwort Leaf/Flower, straight from the product label.

Brand Cedar Bear
Barcode (UPC) 834711001816
Net contents 30 mL; 1 fl. Oz.
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 239294
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Motherwort Leaf/Flower by Cedar Bear, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 mL
Maximum serving Sizes:
0.5 mL
Servings per container
60
UPC/BARCODE
834711001816
IngredientAmount% DV
Proprietary Blend0.5 mL--
Motherwort0 NP--

Other ingredients: USP Grade Vegetable Glycerin, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Manufactured in the USA

True Alcohol Free Sugar Free Gluten Free

Vegan

Suggested/Recommended/Usage/Directions

Suggested Use: .5 mL (10 drops) 1 to 3 times a day, or as needed. Shake well.

Precautions

Note: Consult your physician before use.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Good Manufacturing Practices K (Kosher)

Formula

K (Kosher)

Leonurus cardiaca spp.

General Statements

Herbal Single

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Motherwort Leaf/Flower by Cedar Bear label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Motherwort Leaf/Flower label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Motherwort Leaf/Flower by Cedar Bear

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.5 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Proprietary Blend

0.5 mL per serving

Other (inactive) ingredients: USP Grade Vegetable Glycerin, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Motherwort Leaf/Flower by Cedar Bear Drug Interactions

Want to check YOUR meds against Motherwort Leaf/Flower?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Motherwort 248

Individual Drug Interactions

The ingredients in Motherwort Leaf/Flower interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Motherwort Leaf/Flower interact with drugs. Each result below shows which ingredient is responsible. Motherwort

Each ingredient & the kinds of drugs it affects

For each ingredient in Motherwort Leaf/Flower with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Motherwort1 drug type · 248 drugs

Cns Depressants

Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.

Likelihood Possible Evidence D
Motherwort full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Motherwort Leaf/Flower, from the product label.

Cedar Bear

See all Cedar Bear products
Name
Cedar Bear Naturales INC
Street Address
PO Box 158
City
Roosevelt
State
UT
ZipCode
84066
Phone Number
1-888-854-3727
Web Address
Cedarbear.com
Pharmacist Counseling Corner

Motherwort Leaf/Flower by Cedar Bear: Common Questions

Does Motherwort Leaf/Flower by Cedar Bear interact with any medications?
Yes. Based on its ingredients, Motherwort Leaf/Flower has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Motherwort Leaf/Flower contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
No. Motherwort is considered likely unsafe in pregnancy because it's traditionally thought to stimulate the uterus. Talk with your doctor or pharmacist about safe alternatives if you're pregnant or planning to become pregnant.
Will this help with my anxiety?
We don't have enough reliable evidence to say whether motherwort works for anxiety. The data we hold rates it as insufficient evidence. If anxiety is why you're considering it, check with your doctor about options with stronger scientific backing.
What are the side effects?
When taken by mouth, the most common side effects are diarrhea and stomach irritation. At doses over 3 grams, it may cause uterine bleeding. If applied to skin, it can cause a rash or sun sensitivity.
Is this safe to take long-term?
We don't have strong long-term safety data for motherwort in humans. It may be tolerated short-term by healthy adults, but we just don't know enough about its safety with extended use. Talk with your doctor or pharmacist if you're thinking about taking it regularly.
Can I take this with my sleep medication?
Not without checking first. Motherwort can add to the drowsiness caused by sleep aids and other sedating drugs. Talk with your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Motherwort Leaf/Flower is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Motherwort Leaf/Flower label
Go deeper

The Full Monographs Behind Motherwort Leaf/Flower’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Motherwort

Interacts with 248 drugs

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human evidence is very limited. It should be avo...

Read the full Motherwort monograph →
Sources

Sources & How We Checked

Motherwort Leaf/Flower's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Motherwort 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20.
  5. Xia WT, Zhou H, Wang Y, et al. Motherwort injection in preventing post-abortion hemorrhage after induced abortion: A multi-center, prospective, randomized controlled trial. Explore (NY). 2019. pii: S1550-8307(19)30447-1. PubMed
  6. Cao Shan DOSOGC, Zhang W, Zhao Z, et al. Post-marketing safety surveillance and reevaluation of Motherwort injection: A clinical study of 10 094 cases. J Tradit Chin Med. 2018 Aug;38(4):625-635. DOI

See these in context on the Motherwort monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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