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Dietary supplement

Motherwort 5:1 Extract Ingredients & Drug Interactions

by BulkSupplements.com

Motherwort 5:1 Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Motherwort 5:1 Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Motherwort 5:1 Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, heart palpitations, menstrual discomfort.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Motherwort extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Motherwort 5:1 Extract by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Motherwort 5:1 Extract by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Motherwort 5:1 Extract by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: motherwort extract, concentrated as a 5:1 extract. Motherwort is a plant traditionally used in herbal medicine.

The powder form allows you to mix it into liquids or take it directly, and there are no other inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Motherwort's overall clinical evidence instead.

Moderate

Some clinical evidence supports Motherwort for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Bleeding — rated "Possibly Effective" (Natural Medicines).

The evidence behind motherwort is mixed. It's rated possibly effective for bleeding.

For anxiety, alcohol use disorder, amenorrhea, and asthma, the data we hold shows insufficient reliable evidence to rate whether it works — meaning we don't have enough solid research to say either way.

The evidence, ingredient by ingredient Motherwort

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Motherwort appears to be generally well tolerated when taken by mouth. The most common side effects reported are diarrhea and stomach irritation.

Topically, it can cause contact dermatitis (skin irritation) and photosensitivity (increased sun sensitivity). Taking more than 3 grams can trigger uterine bleeding.

Human safety data are limited, especially for long-term use. Motherwort is traditionally thought to stimulate the uterus, so the safety data advises against use during pregnancy.

There isn't enough information available to recommend it during breastfeeding either — talk with your doctor or pharmacist about personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Motherwort

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Motherwort.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use CNS depressants — any medication that causes drowsiness, including sedatives, sleep aids, anti-anxiety drugs, and certain pain relievers or antihistamines. Motherwort may increase their sedating effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Motherwort extract may be worth considering if you're exploring options for bleeding, but evidence for other common uses is thin. The main caution is its interaction with CNS depressants — if you take sedatives, sleep aids, or other drugs that make you drowsy, check with your doctor or pharmacist before adding this.

Avoid it if you're pregnant, and don't exceed 3 grams daily.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Motherwort 5:1 Extract, straight from the product label.

Brand BulkSupplements.com
Net contents 500 Gram(s); 17.64 Ounce(s)
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 254030
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Motherwort 5:1 Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2500 mg
Maximum serving Sizes:
2500 mg
Servings per container
200
IngredientAmount% DV
Motherwort extract2500 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements US Standard Measuring Spoons Spoon size (level) milligrams 1/2 teaspoon 1250 1 teaspoon 2500 2 teaspoons 5000 Powder density may vary. For accurate measurement, a milligram scale is necessary.

Precautions

Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women.

Consult your physician before use.

Keep out of reach of children!

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Free of: Sugar, soy, dairy, gluten, corn, yeast or additives

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 2500 mg (level 1 tsp) twice daily daily, as needed or as directed by a physician.

Storage

Storage: Keep dry, cool & dark

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Motherwort 5:1 Extract by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Motherwort 5:1 Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Motherwort 5:1 Extract by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2500 mg Dosage formPowder Servings per container200 Amounts shown are per serving.

Motherwort extract

Interacts with
248 drugs
2500 mg per serving

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human ev...

Motherwort extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Motherwort 5:1 Extract by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Motherwort 5:1 Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Motherwort extract 248

Individual Drug Interactions

The ingredients in Motherwort 5:1 Extract interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Motherwort 5:1 Extract interact with drugs. Each result below shows which ingredient is responsible. Motherwort extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Motherwort 5:1 Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Motherwort extract1 drug type · 248 drugs

Cns Depressants

Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.

Likelihood Possible Evidence D
Motherwort extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Motherwort 5:1 Extract, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Road
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Motherwort 5:1 Extract by BulkSupplements.com: Common Questions

Does Motherwort 5:1 Extract by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Motherwort 5:1 Extract has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Motherwort 5:1 Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take motherwort if I'm pregnant?
No. Motherwort is traditionally thought to stimulate the uterus, and the safety data advises against it during pregnancy. Talk with your doctor or pharmacist before using it if you're pregnant or trying to become pregnant.
What are the most common side effects?
When taken by mouth, diarrhea and stomach irritation are the side effects reported most often. If you apply it to your skin, contact dermatitis and photosensitivity (increased sensitivity to sun) can occur.
Is there a safe upper dose?
Yes. Taking more than 3 grams can cause uterine bleeding, so stay within that limit. Human safety data are limited, especially for long-term use, so it's best viewed as a short-term option.
What is motherwort actually used for?
It's rated possibly effective for bleeding. For anxiety, alcohol use disorder, and other conditions, we don't have enough reliable research to say whether it works.
Can I breastfeed while taking motherwort?
There isn't enough safety information available. Talk with your doctor or pharmacist about whether it's right for you if you're nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Motherwort 5:1 Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Motherwort 5:1 Extract label
Go deeper

The Full Monographs Behind Motherwort 5:1 Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Motherwort

Interacts with 248 drugs

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human evidence is very limited. It should be avo...

Read the full Motherwort monograph →
Sources

Sources & How We Checked

Motherwort 5:1 Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Motherwort 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20.
  5. Xia WT, Zhou H, Wang Y, et al. Motherwort injection in preventing post-abortion hemorrhage after induced abortion: A multi-center, prospective, randomized controlled trial. Explore (NY). 2019. pii: S1550-8307(19)30447-1. PubMed
  6. Cao Shan DOSOGC, Zhang W, Zhao Z, et al. Post-marketing safety surveillance and reevaluation of Motherwort injection: A clinical study of 10 094 cases. J Tradit Chin Med. 2018 Aug;38(4):625-635. DOI

See these in context on the Motherwort monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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