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Dietary supplement

Motherwort Ingredients & Drug Interactions

by Red Moon Herbs

Motherwort label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Motherwort against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Motherwort is a dietary supplement by Red Moon Herbs with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, heart palpitations, menstrual discomfort.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Motherwort Flowering Top Extract, Fresh. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Motherwort by Red Moon Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Motherwort by Red Moon Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Motherwort by Red Moon Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: Motherwort Flowering Top Extract made from fresh plant material. The liquid also includes water and alcohol as inactive ingredients to preserve and deliver the extract.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Motherwort's overall clinical evidence instead.

Moderate

Some clinical evidence supports Motherwort for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Bleeding — rated "Possibly Effective" (Natural Medicines).

The evidence for motherwort's uses is mixed. It's possibly effective for bleeding.

For anxiety, alcohol use disorder, amenorrhea (missing periods), and asthma, there isn't enough reliable evidence yet to say whether it works. The data we hold doesn't establish its effectiveness for these conditions.

The evidence, ingredient by ingredient Motherwort

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Motherwort appears to be generally well tolerated when taken by mouth. The most common side effects are diarrhea and stomach irritation.

At doses above 3 grams, it can trigger uterine bleeding. The safety data in humans are limited, so caution is warranted, especially with longer-term use.

The safety data advises against motherwort in pregnancy because it's traditionally thought to stimulate the uterus. There isn't enough safety information for breastfeeding, so it's best avoided then too.

If you're pregnant, planning to become pregnant, or nursing, talk with your pharmacist or doctor before taking it.

Side effects, ingredient by ingredient Motherwort

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Motherwort.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check any CNS depressants (sedatives, sleep aids, anti-anxiety medications, some pain relievers, antihistamines that cause drowsiness) with your pharmacist before adding motherwort. It can increase the sedating effects of these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Motherwort may be worth considering if you're looking into natural support for bleeding and want to explore traditional herbal use. If you take sedatives, sleep aids, or other CNS depressants, check your medications first—this product can add to drowsiness.

Pregnant or nursing? Skip it.

Run your medications through the checker on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Motherwort, straight from the product label.

Brand Red Moon Herbs
Barcode (UPC) 857999002313
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 319304
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Children (All), Infants/Baby (0 - 1 Year), Seniors/Mature (>50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Motherwort by Red Moon Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
50 Drop(s)
UPC/BARCODE
857999002313
IngredientAmount% DV
Motherwort Flowering Top Extract, Fresh0 NP--

Other ingredients: Water, Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Shake well. Take 25-50 drops 1-3 times daily in a little water.

Precautions

Consult expert medical advice before using while pregnant.

General Statements

Red Moon Herbs Est. 1994 Still made the wise woman way

FDA Statement of Identity

Dietary Supplement

Formula

Fresh Appalachian extracts for the whole family

Formulation

Fresh Appalachian extracts for the whole family

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Motherwort by Red Moon Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Motherwort label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Motherwort by Red Moon Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Amounts shown are per serving.

Motherwort Flowering Top Extract, Fresh

Interacts with
248 drugs
0 NP per serving

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human ev...

Motherwort Flowering Top Extract, Fresh monograph & interactions

Other (inactive) ingredients: Water, Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Motherwort by Red Moon Herbs Drug Interactions

Want to check YOUR meds against Motherwort?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Motherwort Flowering Top Extract, Fresh 248

Individual Drug Interactions

The ingredients in Motherwort interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Motherwort interact with drugs. Each result below shows which ingredient is responsible. Motherwort Flowering Top Extract, Fresh

Each ingredient & the kinds of drugs it affects

For each ingredient in Motherwort with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Motherwort Flowering Top Extract, Fresh1 drug type · 248 drugs

Cns Depressants

Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.

Likelihood Possible Evidence D
Motherwort Flowering Top Extract, Fresh full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Motherwort, from the product label.

Red Moon Herbs

See all Red Moon Herbs products
Name
Red Moon Herbs
City
Asheville
State
NC
Phone Number
888-929-0777
Web Address
redmoonherbs.com
Pharmacist Counseling Corner

Motherwort by Red Moon Herbs: Common Questions

Does Motherwort by Red Moon Herbs interact with any medications?
Yes. Based on its ingredients, Motherwort has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Motherwort contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take motherwort while pregnant?
No. The safety data advises against it because motherwort is traditionally thought to stimulate the uterus. If you're pregnant or planning to become pregnant, talk with your doctor or pharmacist before using this product.
What are the most common side effects?
When taken by mouth, diarrhea and stomach irritation are the most common. At higher doses (above 3 grams), uterine bleeding has been reported. Most people tolerate it well, but the human safety data are limited.
Does motherwort actually work for anxiety?
There isn't enough reliable evidence yet to say whether motherwort is effective for anxiety. The data we have doesn't establish it works for this use.
Can I take this with my sleep medication?
You'll want to check with your pharmacist first. Motherwort can add to the drowsiness caused by sleep aids and other sedating medications. Use the medication checker on this page with your exact drug to be sure.
Is this safe to use long-term?
The safety data are limited, so caution is advised, especially if you plan to take it for a long time. For personalized guidance, talk with your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Motherwort label
Go deeper

The Full Monographs Behind Motherwort’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Motherwort

Interacts with 248 drugs

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human evidence is very limited. It should be avo...

Read the full Motherwort monograph →
Sources

Sources & How We Checked

Motherwort's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Motherwort 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20.
  5. Xia WT, Zhou H, Wang Y, et al. Motherwort injection in preventing post-abortion hemorrhage after induced abortion: A multi-center, prospective, randomized controlled trial. Explore (NY). 2019. pii: S1550-8307(19)30447-1. PubMed
  6. Cao Shan DOSOGC, Zhang W, Zhao Z, et al. Post-marketing safety surveillance and reevaluation of Motherwort injection: A clinical study of 10 094 cases. J Tradit Chin Med. 2018 Aug;38(4):625-635. DOI

See these in context on the Motherwort monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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