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Dietary supplement

Motherwort Ingredients & Drug Interactions

by Herbalist & Alchemist

Motherwort label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Motherwort against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Motherwort is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, heart palpitations, menstrual discomfort.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are fresh Motherwort flowering tops extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Motherwort by Herbalist & Alchemist

Ask about any prescription or over-the-counter medication and we check it for interactions with Motherwort by Herbalist & Alchemist — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Motherwort by Herbalist & Alchemist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: fresh Motherwort flowering tops extract. Motherwort is a traditional herb used to support various health concerns, and this liquid form allows for flexible dosing.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Motherwort's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Support for stress and menstrual discomfort.
  • We looked for evidence on: Anxiety, Dysmenorrhea, Menopausal symptoms, Insomnia, Stress, Hormonal balance.
  • The closest evidence on file: Motherwort is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Motherwort is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Menopausal symptoms, Dysmenorrhea.

The evidence for motherwort's effectiveness is mixed. For bleeding, it's rated possibly effective — meaning there's some evidence to suggest it may help.

For other uses in this product's background — including anxiety, amenorrhea (absent periods), and asthma — the evidence isn't strong enough yet to rate it reliably. Alcohol use disorder is also listed as insufficient reliable evidence.

If you're considering this for a specific condition, your pharmacist or doctor can help you weigh what's known so far.

The evidence, ingredient by ingredient Motherwort

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Motherwort appears to be generally well tolerated when taken by mouth, though human safety data are limited and it's meant for short-term use in healthy adults. The most common side effects from oral use are diarrhea and stomach irritation.

Larger amounts — over 3 grams — may cause uterine bleeding. If applied to skin, it can trigger contact dermatitis (a rash) or photosensitivity (increased sun sensitivity).

The product contains ethyl alcohol as an inactive ingredient, which is worth noting if you're avoiding alcohol. The safety data advise against use during pregnancy, as motherwort has traditionally been thought to stimulate the uterus.

There isn't enough safety information on breastfeeding to know either way — talk with your doctor or pharmacist if you're nursing.

Side effects, ingredient by ingredient Motherwort

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Motherwort.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check any CNS depressants (Moderate severity) — sedatives, sleep aids, some pain relievers, and similar medications that slow down your nervous system. Motherwort can increase sedation when combined with these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Motherwort may be worth considering if you're interested in traditional herbal support and you're generally healthy. If you take any sedatives, sleep aids, or other CNS depressants, check your medications with the tool on this page first.

Avoid it in pregnancy. Talk with your pharmacist or doctor before starting, especially if you have any health conditions or take regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Motherwort, straight from the product label.

Brand Herbalist & Alchemist
Barcode (UPC) 667056120139
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Mar 23, 2018
DSLD ID 174508
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Motherwort by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.5 mL
Maximum serving Sizes:
2 mL
Servings per container
30
UPC/BARCODE
667056120139
IngredientAmount% DV
fresh Motherwort flowering tops extract2 mL--

Other ingredients: distilled Water, Ethyl Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Leonurus cardiaca

Support for stress and menstrual discomfort

OK

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 30-40 drops (1.5-2 mL) in juice or water. Take 3 times per day. Shake well before using.

General Statements

Botanical preparation ratio 1:2.5

Precautions

Contraindications: Do no use during pregnancy unless otherwise directed by a qualified expert.

Keep out of children's reach

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General

NO. MTW-2 1730TH

Seals/Symbols

OK

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Motherwort by Herbalist & Alchemist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Motherwort label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Motherwort by Herbalist & Alchemist

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.5 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Fresh Motherwort flowering tops extract

Interacts with
248 drugs
2 mL per serving

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human ev...

Fresh Motherwort flowering tops extract monograph & interactions

Other (inactive) ingredients: Distilled Water, Ethyl Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Motherwort by Herbalist & Alchemist Drug Interactions

Want to check YOUR meds against Motherwort?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

fresh Motherwort flowering tops extract 248

Individual Drug Interactions

The ingredients in Motherwort interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Motherwort interact with drugs. Each result below shows which ingredient is responsible. fresh Motherwort flowering tops extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Motherwort with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

fresh Motherwort flowering tops extract1 drug type · 248 drugs

Cns Depressants

Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.

Likelihood Possible Evidence D
fresh Motherwort flowering tops extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Motherwort, from the product label.

Herbalist & Alchemist

See all Herbalist & Alchemist products
Name
Herbalist & Alchemist, Inc.
City
Washington
State
NJ
ZipCode
07882
Phone Number
800-611-8235
Web Address
www.herbalist-alchemist.com
Pharmacist Counseling Corner

Motherwort by Herbalist & Alchemist: Common Questions

Does Motherwort by Herbalist & Alchemist interact with any medications?
Yes. Based on its ingredients, Motherwort has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Motherwort contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take motherwort while pregnant or breastfeeding?
The safety data advise against motherwort in pregnancy because it's traditionally thought to stimulate the uterus. There isn't enough information yet on breastfeeding to know if it's safe or not — talk with your doctor or pharmacist for personalized advice.
What are the most common side effects?
When taken by mouth, diarrhea and stomach irritation are the most common side effects. If you apply it to skin, it may cause a rash or make you more sensitive to sun exposure.
Is motherwort effective for anxiety?
There isn't enough reliable evidence yet to rate motherwort for anxiety. If you're considering it for that reason, talk with your pharmacist or doctor about what's known and what might work best for you.
Why does this product contain alcohol?
Ethyl alcohol is an inactive ingredient in this liquid extract — it helps preserve the herb and extract its beneficial compounds. If you're avoiding alcohol, this may not be the right form for you.
How much motherwort is safe to take?
Amounts greater than 3 grams can cause uterine bleeding, so staying within recommended doses is important. Talk with your pharmacist about the right amount for you based on the product label and your health.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Motherwort is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Motherwort label
Go deeper

The Full Monographs Behind Motherwort’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Motherwort

Interacts with 248 drugs

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human evidence is very limited. It should be avo...

Read the full Motherwort monograph →
Sources

Sources & How We Checked

Motherwort's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Motherwort 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20.
  5. Xia WT, Zhou H, Wang Y, et al. Motherwort injection in preventing post-abortion hemorrhage after induced abortion: A multi-center, prospective, randomized controlled trial. Explore (NY). 2019. pii: S1550-8307(19)30447-1. PubMed
  6. Cao Shan DOSOGC, Zhang W, Zhao Z, et al. Post-marketing safety surveillance and reevaluation of Motherwort injection: A clinical study of 10 094 cases. J Tradit Chin Med. 2018 Aug;38(4):625-635. DOI

See these in context on the Motherwort monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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