Interactions on record — worth a quick check against your medications. Based on 5 of 8 ingredients. Check your meds →
Dietary supplement

Original 7 Mushrooms 650 mg Ingredients & Drug Interactions

by Eclectic Herb

Original 7 Mushrooms 650 mg label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Original 7 Mushrooms 650 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Original 7 Mushrooms 650 mg is a dietary supplement by Eclectic Herb with 8 active ingredients. Its ingredients are commonly taken for fatigue and low energy, athletic performance and stamina, respiratory and lung support.Based on those ingredients, 895 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zhu Ling, Freeze-Dried, Lion's Mane, Freeze-Dried, Maitake, Freeze-Dried. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Original 7 Mushrooms 650 mg by Eclectic Herb

Ask about any prescription or over-the-counter medication and we check it for interactions with Original 7 Mushrooms 650 mg by Eclectic Herb — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Original 7 Mushrooms 650 mg by Eclectic Herb

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (650 mg) without saying how much of each component you get.

This product contains 8 active ingredients, all mushroom species in freeze-dried form plus larch arabinogalactan (a polysaccharide fiber from larch trees). The mushrooms are cordyceps, lion's mane, turkey tail, reishi, maitake, and zhu ling (poria), plus royal sun agaricus.

The inactive ingredients—rice substrate, sorghum substrate, and the capsule material hypromellose—are fillers and binders that help hold the formula together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Immune support.
  • We looked for evidence on: Allergic rhinitis (hay fever), Asthma, Common cold, Coronavirus disease 2019 (COVID-19), Cough, Influenza — and 4 related terms.
  • The closest evidence on file: Poria Mushroom is rated "Insufficient Reliable Evidence To Rate" for Influenza (Natural Medicines).
  • Also on file: Poria Mushroom is rated "Insufficient Reliable Evidence To Rate" for Coronavirus disease 2019 (COVID-19).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever), HIV/AIDS, Chemotherapy-induced leukopenia, Coronavirus disease 2019 (COVID-19).

The evidence supporting these mushrooms is limited. For cordyceps, athletic performance is rated possibly ineffective; sexual function, heart rhythm, asthma, lung cancer, and COPD lack enough reliable evidence to rate.

Lion's mane has insufficient evidence for Alzheimer's disease, anxiety, athletic performance, cancer, and cognitive function. Maitake and the other mushrooms similarly lack established evidence for hay fever, cancer-related side effects, fatigue, dementia, diabetes, and other conditions listed.

In short, we don't have solid proof these mushrooms work for their marketed uses.

The evidence, ingredient by ingredient Cordyceps Lion's Mane Mushroom Maitake Mushroom Poria Mushroom Larch Arabinogalactan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cordyceps and lion's mane are generally well tolerated short-term but have limited long-term safety data. Cordyceps can cause abdominal discomfort, constipation, or diarrhea; one rare case of liver inflammation (hepatitis) was reported.

Lion's mane may cause stomach upset, nausea, or skin rash. Maitake typically causes few problems but can trigger gastrointestinal effects including diarrhea and stomach pain; rare allergic reactions (rash, itching) have occurred.

Zhu ling (poria) is generally well tolerated but rare allergic reactions including hay fever-like symptoms and asthma have been reported. Larch arabinogalactan is generally well tolerated but may cause bloating and gas.

Because cordyceps, lion's mane, maitake, and zhu ling lack adequate safety data, they should be avoided during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Cordyceps Lion's Mane Mushroom Maitake Mushroom Poria Mushroom Larch Arabinogalactan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Poria Mushroom, Maitake Mushroom, Cordyceps, Larch Arabinogalactan, Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 895 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check these medication types before taking this product: blood thinners and antiplatelet drugs (Major concern due to cordyceps and lion's mane), diabetes drugs (cordyceps, lion's mane, and maitake may lower blood sugar further), blood pressure medications (maitake may lower pressure), immune-suppressing drugs after transplant (cordyceps, lion's mane, and larch arabinogalactan may interfere), sedatives (zhu ling may enhance them), and anticholinergic or cholinergic medications (zhu ling may affect how these work). Warfarin (Coumadin) is a particular concern with maitake.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-mushroom blend with limited evidence of effectiveness and several documented interactions with blood thinners, diabetes drugs, blood pressure medications, immune suppressors, and sedatives. If you take any prescription medication—especially blood thinners or drugs for diabetes or blood pressure—check your exact medications with the tool on this page before starting.

Talk with your pharmacist or doctor, especially if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Original 7 Mushrooms 650 mg, straight from the product label.

Brand Eclectic Herb
Barcode (UPC) 023363313037
Net contents 30 Veg Cap(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 316850
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Original 7 Mushrooms 650 mg by Eclectic Herb, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Cap(s)
Maximum serving Sizes:
2 Veg Cap(s)
Servings per container
30
UPC/BARCODE
023363313037
IngredientAmount% DV
Proprietary Blend650 mg--
Royal Sun Agaricus, Freeze-dried0 NP--
Cordyceps, Freeze-Dried0 NP--
Lion's Mane, Freeze-Dried0 NP--
Turkey Tail, Freeze-Dried0 NP--
Reishi, Freeze-Dried0 NP--
Maitake, Freeze-Dried0 NP--
Zhu Ling, Freeze-Dried0 NP--
Larix Arabinogalactan, Freeze-Dried0 NP--

Other ingredients: Rice Substrate, Sorghum Substrate, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Freeze dried for peak plant power

Soy free Non GMO Gluten free

Immune support Grown in the United States

Vegan

Daily immune support Small batch freeze dried

Formula

Whole herb Healthy mushrooms A blend of the best health-giving mushrooms, for potent immune support formulated by a naturopathic physician.

100% Kosher

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent diseases.

Precautions

Keep away from children.

Consult your doctor about herbs with pregnancy, infants or prescription drugs.

General Statements

@eclecticherb

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take 1-2 capsules per day.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Original 7 Mushrooms 650 mg by Eclectic Herb label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Original 7 Mushrooms 650 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Original 7 Mushrooms 650 mg by Eclectic Herb

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veg Cap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

650 mg per serving

Other (inactive) ingredients: Rice Substrate, Sorghum Substrate, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Original 7 Mushrooms 650 mg by Eclectic Herb Drug Interactions

Want to check YOUR meds against Original 7 Mushrooms 650 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
895Drugs
887 Moderate 8 Minor

Ingredients driving the most interactions

Zhu Ling, Freeze-Dried 417
Lion's Mane, Freeze-Dried 327
Maitake, Freeze-Dried 260
Cordyceps, Freeze-Dried 249
Larix Arabinogalactan, Freeze-Dried 121

Individual Drug Interactions

The ingredients in Original 7 Mushrooms 650 mg interact with 895 drugs. Click any drug to see the details.

5 of the 8 ingredients in Original 7 Mushrooms 650 mg interact with drugs. Each result below shows which ingredient is responsible. Zhu Ling, Freeze-Dried Lion's Mane, Freeze-Dried Maitake, Freeze-Dried Cordyceps, Freeze-Dried Larix Arabinogalactan, Freeze-Dried

Each ingredient & the kinds of drugs it affects

For each ingredient in Original 7 Mushrooms 650 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Zhu Ling, Freeze-Dried3 drug types · 417 drugs

Anticholinergic Drugs

Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Zhu Ling, Freeze-Dried full monograph & interactions

Lion's Mane, Freeze-Dried3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane, Freeze-Dried full monograph & interactions

Maitake, Freeze-Dried3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake, Freeze-Dried full monograph & interactions

Cordyceps, Freeze-Dried3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps, Freeze-Dried full monograph & interactions

Larix Arabinogalactan, Freeze-Dried1 drug type · 121 drugs

Immunosuppressants

Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and other drugs.

Likelihood Possible Evidence D
Larix Arabinogalactan, Freeze-Dried full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Original 7 Mushrooms 650 mg, from the product label.

Eclectic Herb

See all Eclectic Herb products
Name
Eclectic Herb
Street Address
755 NE 6th St.
City
Gresham
State
Oregon
ZipCode
97030
Phone Number
503.668.4120
Web Address
www.eclecticherb.com
Pharmacist Counseling Corner

Original 7 Mushrooms 650 mg by Eclectic Herb: Common Questions

Does Original 7 Mushrooms 650 mg by Eclectic Herb interact with any medications?
Yes. Based on its ingredients, Original 7 Mushrooms 650 mg has a known interaction with 895 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Original 7 Mushrooms 650 mg contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
The safety data aren't strong enough. Cordyceps, lion's mane, maitake, and zhu ling all advise against use during pregnancy and breastfeeding. Talk with your doctor or pharmacist about whether this product is right for you.
What side effects might I experience?
The most common are stomach-related: cordyceps may cause abdominal discomfort, constipation, or diarrhea. Lion's mane can cause stomach upset and nausea. Maitake may trigger diarrhea and stomach pain. Zhu ling and larch arabinogalactan can cause bloating and gas. Rare allergic reactions including rash and asthma-like symptoms have been reported.
Does this actually work for what it claims?
The evidence is weak. Most of the mushrooms—cordyceps, lion's mane, maitake, zhu ling, reishi, and turkey tail—lack reliable evidence for the conditions they're marketed for. Cordyceps is rated possibly ineffective for athletic performance. We simply don't have solid proof these work.
What is cordyceps used for?
Cordyceps is traditionally used for athletic performance, sexual function, asthma, and lung health. However, athletic performance is rated possibly ineffective, and the other uses lack enough evidence to rate.
What is lion's mane mushroom supposed to do?
It's marketed for brain health, cognitive function, anxiety, and conditions like Alzheimer's disease. Unfortunately, we don't have reliable evidence that it works for any of these.
Can you tell me more about maitake mushroom?
Maitake is promoted for immune support and to help with cancer and fatigue. The evidence for these uses is insufficient. Importantly, maitake can lower blood pressure and blood sugar, which is why it needs to be checked against blood pressure and diabetes medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Original 7 Mushrooms 650 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Original 7 Mushrooms 650 mg label
Go deeper

The Full Monographs Behind Original 7 Mushrooms 650 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Poria Mushroom

Interacts with 417 drugs

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...

Read the full Poria Mushroom monograph → Herb & supplement monograph

Larch Arabinogalactan

Interacts with 121 drugs

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but limited, and most claims are not yet fi...

Read the full Larch Arabinogalactan monograph →
Sources

Sources & How We Checked

Original 7 Mushrooms 650 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 39 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cordyceps 14 references
  1. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 1998;4:289-303.
  2. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med 1998;4:429-57.
  3. Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997;60:2349-59. PubMed
  4. Zhao Y. [Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:612-5, 42.
  5. Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
  6. Zhu XY, Yu HY. [Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response]. Chung Hsi I Chieh Ho Tsa Chih 1990;10:485-7, 454.
  7. Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 9-5-2003;73(16):2127-2136. PubMed
  8. Ikumoto, T., Sasaki, S., Namba, H., Toyama, R., Moritoki, H., and Mouri, T. [Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria]. Yakugaku Zasshi 1991;111(9):504-509. PubMed
  9. Wu, T. N., Yang, K. C., Wang, C. M., Lai, J. S., Ko, K. N., Chang, P. Y., and Liou, S. H. Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. Sci.Total Environ. 4-5-1996;182(1-3):193-195. PubMed
  10. Hong T, Zhang M, Fan J. Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients (Review). Cochrane Database Syst Rev. 2015;(10):CD009698. doi: 10.1002/14651858.CD009698.pub2.
  11. Zhang HW, Lin ZX, Tung YS, Kwan TH, Mok CK, Leung C, Chan LS. Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease (Review). Cochrane Database Syst Rev. 2014;(12):CD008353. doi: 10.1002/14651858.CD008353.pub2. PubMed
  12. Bee Yean O, Zoriah A. Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysis. J Tradit Chin Med. 2019;39(1):1-14.
  13. Thurian D, Montani M, Stickel F. Drug-induced, mixed-type hepatitis following ingestion of Cordyceps sinensis. Int J Clin Pharmacol Ther 2022;60(2):115-120. PubMed
  14. Yu X, Mao Y, Shergis JL, et al. Effectiveness and safety of oral Cordyceps sinensis on stable COPD of GOLD stages 2-3: Systematic review and meta-analysis. Evid Based Complement Alternat Med. 2019;2019:4903671.

See these in context on the Cordyceps monograph →

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Poria Mushroom 3 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
  3. Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.

See these in context on the Poria Mushroom monograph →

Larch Arabinogalactan 8 references
  1. D'Adamo P. Larch arabinogalactan. J Naturopath Med 1996;6:33-7.
  2. Kelly GS. Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alt Med Rev 1999;4:96-103.
  3. Marett R, Slavin JL. No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc 2004;104:636-9.
  4. Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr 2001;20:279-85. PubMed
  5. Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:32. PubMed
  6. Grube B, Stier H, Riede L, Gruenwald J. Tolerability of a proprietary larch arabinogalactan extract: a randomized, double-blind, placebo-controlled clinical trial in healthy subjects. Food Nutr Sci 2012;3:1533-8. DOI
  7. Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond) 2016;13:28. PubMed
  8. Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory tract infections. Curr Med Res Opin 2013;29(3):251-8.

See these in context on the Larch Arabinogalactan monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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