Sarsaparilla Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Sarsaparilla against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sarsaparilla is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for skin conditions like psoriasis, joint pain and arthritis, general tonic or 'blood purifier'.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are dried Sarsaparilla root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sarsaparilla by Herbalist & Alchemist
Ask about any prescription or over-the-counter medication and we check it for interactions with Sarsaparilla by Herbalist & Alchemist — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Sarsaparilla by Herbalist & Alchemist
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: dried sarsaparilla root extract, a traditional herbal remedy. The liquid form also includes distilled water and ethyl alcohol as inactive ingredients.
Does it work?
Not established
The evidence for sarsaparilla's effectiveness is not established in the data we hold. We have insufficient reliable evidence to rate it for cancer, psoriasis, or rheumatoid arthritis — the three uses in our records.
That doesn't mean it doesn't work; it means the studies aren't there yet to confirm or rule it out.
How safe is it?
Well-documented data
Sarsaparilla is likely low-risk when used in food amounts, but human safety data for supplement doses are limited. One occupational concern is that inhaled sarsaparilla root dust can trigger rhinitis (inflammation of the nasal passages) and asthma symptoms, though this is mainly a concern for people handling the raw root.
There isn't enough safety information to know either way whether sarsaparilla is safe during pregnancy or breastfeeding. Talk with your doctor or pharmacist about whether it's appropriate for you in these situations.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take lithium or digoxin (Lanoxin). Both have Moderate interactions with sarsaparilla's diuretic properties, and your dose or use may need adjustment.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Sarsaparilla is a single-ingredient herbal extract with limited human safety data at supplement doses and no established effectiveness for the conditions we have data on. If you take lithium or digoxin, your doctor or pharmacist needs to clear this before you start.
For any other medications, check them against the tool on this page — or talk it over with your own pharmacist to be sure.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sarsaparilla, straight from the product label.
| Brand | Herbalist & Alchemist |
|---|---|
| Barcode (UPC) | 667056124878 |
| Net contents | 2 fl. Oz.; 60 mL |
| Market status | On market |
| Date entered into DSLD | Mar 23, 2018 |
| DSLD ID | 174704 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sarsaparilla by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| dried Sarsaparilla root extract | 4 mL | -- |
Other ingredients: distilled Water, Ethyl Alcohol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Smilax regelii
OK
General Statements
Supports tissue integrity
Botanical preparation ratio 1:4
FDA Statement of Identity
Herbal Supplemnet
Suggested/Recommended/Usage/Directions
Suggested Use: 60-80 drops (3-4 mL) in juice or water. Take 4 times per day. Shake well before using.
Precautions
Keep out of children's reach
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
General
NO. SSP-2 1736TH
Seals/Symbols
OK
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sarsaparilla by Herbalist & Alchemist label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sarsaparilla by Herbalist & Alchemist
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size3 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.
Dried Sarsaparilla root extract
Interacts with2 drugs
Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited...
Dried Sarsaparilla root extract monograph & interactionsOther (inactive) ingredients: Distilled Water, Ethyl Alcohol. These complete the product’s ingredient list but are not active constituents.
Sarsaparilla by Herbalist & Alchemist Drug Interactions
HelloPharmacist Interaction Report
Herbalist & Alchemist Sarsaparilla contains dried sarsaparilla root extract, which interacts with lithium and digoxin (Lanoxin), a heart medication.
Both interactions are Moderate in severity.
Read the full breakdown — every affected drug type, severity by severity
Sarsaparilla is thought to work as a diuretic (a substance that increases urine output). This diuretic effect can reduce how your body clears lithium, potentially raising lithium levels in your blood and increasing both its effects and side effects — your lithium dose might need adjustment.
With digoxin, the same diuretic property may cause potassium loss, and low potassium combined with heart medication raises the risk of heart rhythm problems and toxicity.
Altogether, these interactions span 2 individual medications. If you take lithium or digoxin, check with your doctor or pharmacist before starting this product — they can tell you whether it's safe for you or whether your dose needs monitoring.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sarsaparilla?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sarsaparilla interact with 2 drugs. Click any drug to see the details.
1 of the 1 ingredient in Sarsaparilla interact with drugs. Each result below shows which ingredient is responsible. dried Sarsaparilla root extract
DigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Sarsaparilla — through 1 ingredient. Tap an ingredient for the detail:
Dried Sarsaparilla Root ExtractDigoxin (lanoxin) Moderate
Interaction Summary
Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Read the full Dried Sarsaparilla Root Extract + Digoxin interactionLithium Carbonate (prescription Drug)Eskalith, Lithium Carbonate
How Lithium Carbonate (prescription Drug) interacts with Sarsaparilla — through 1 ingredient. Tap an ingredient for the detail:
Dried Sarsaparilla Root ExtractLithium Moderate
Interaction Summary
Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Read the full Dried Sarsaparilla Root Extract + Lithium Carbonate (prescription Drug) interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sarsaparilla with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
dried Sarsaparilla root extract
Digoxin (Lanoxin)
Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.
Lithium
Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Sarsaparilla, from the product label.
Herbalist & Alchemist
See all Herbalist & Alchemist products- Name
- Herbalist & Alchemist, Inc.
- City
- Washington
- State
- NJ
- ZipCode
- 07882
- Phone Number
- 800-611-8235
- Web Address
- www.herbalist-alchemist.com
Sarsaparilla by Herbalist & Alchemist: Common Questions
Does Sarsaparilla by Herbalist & Alchemist interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is sarsaparilla safe during pregnancy?
Is sarsaparilla safe while breastfeeding?
Does this product actually work for anything?
What exactly is in this bottle?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Sarsaparilla is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sarsaparilla’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Sarsaparilla's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sarsaparilla 3 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Vandenplas O, Depelchin S, Toussaint G, et al. Occupational asthma caused by sarsaparilla root dust. J Allergy Clin Immunol 1996;97:1416-8. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC