Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Sassafras Alcohol Free Ingredients & Drug Interactions

by Hawaii Pharm

Sassafras Alcohol Free label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sassafras Alcohol Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sassafras Alcohol Free is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for digestive complaints, cold and flu symptoms, joint and muscle aches.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sassafras Root Bark Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sassafras Alcohol Free by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Sassafras Alcohol Free by Hawaii Pharm — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Sassafras Alcohol Free by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: sassafras root bark extract, in dry form. Sassafras has been used traditionally, though safety data show serious concerns (covered below).

The liquid also contains glycerin and water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Sassafras product and its label doesn't state a use — see Sassafras's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The product facts we hold don't include effectiveness ratings for sassafras. We can't tell you whether it works for any particular purpose based on the data available to us.

The evidence, ingredient by ingredient Sassafras

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sassafras carries significant safety warnings. The FDA has banned it from food because it contains safrole, a compound linked to cancer and liver damage.

The safety data advises against using it altogether—sassafras is considered unsafe in medicinal amounts, and any potential benefit likely doesn't outweigh the toxicity risk. Oral use can cause sweating, hot flashes, and in high doses, shakes, vomiting, fast heart rate, and liver cancer.

Large amounts of sassafras oil have caused hallucinations lasting several days, and in extreme cases, death. Topical use can trigger a rash.

The safety data advises against sassafras during pregnancy and breastfeeding because safrole is toxic to a developing baby and can pass into breast milk. There isn't enough safety data to know how this product might affect you personally—talk with your doctor or pharmacist before considering it, especially if you're pregnant, nursing, or planning pregnancy.

Side effects, ingredient by ingredient Sassafras

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sassafras.
  • The most serious interaction on file is rated Moderate.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using this product if you take CNS depressants (sedating medications like sleeping pills or tranquilizers) or CYP1A2 inducers like omeprazole. Sassafras may increase sedation or, theoretically, increase the toxicity of its active compound in the presence of certain medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sassafras is considered unsafe for medicinal use by safety standards, and the FDA has banned its food use due to cancer and liver toxicity risk. If you're considering this product, it's important to discuss it with your doctor or pharmacist first, particularly if you take sedating medications or stomach acid reducers, or if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sassafras Alcohol Free, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253646484
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 300878
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sassafras Alcohol Free by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253646484
IngredientAmount% DV
Sassafras Root Bark Extract, Dry1156 mg--

Other ingredients: Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

C2H5OH Alcohol free USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR-code to get 15% discount on your next purchase. Limited time deal.

Formula

Sassafras albidum

Formulation

Only natural ingredients Purity is laboratory tested and verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Not tested on animals

C2H5OH Alcohol free

Made in USA, Hawaii

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sassafras Alcohol Free by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sassafras Alcohol Free label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sassafras Alcohol Free by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Sassafras Root Bark Extract, Dry

Interacts with
275 drugs
1156 mg per serving Form: Sassafras albidum Root Bark Extract, Dry

Sassafras is an aromatic North American tree whose root bark and oil were once popular in teas and as a flavoring, but it contains safrole, a compound...

Sassafras Root Bark Extract, Dry monograph & interactions

Other (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sassafras Alcohol Free by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Sassafras Alcohol Free?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

Sassafras Root Bark Extract, Dry 275

Individual Drug Interactions

The ingredients in Sassafras Alcohol Free interact with 275 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sassafras Alcohol Free interact with drugs. Each result below shows which ingredient is responsible. Sassafras Root Bark Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Sassafras Alcohol Free with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sassafras Root Bark Extract, Dry2 drug types · 275 drugs

Cns Depressants

Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Inducers

In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole. So far, this interaction has not been reported in humans. Also, it is not known if CYP1A2 inducers increase the toxicity of sassafras. Inducers of CYP1A2 include omeprazole (Prilosec).

Likelihood Possible Evidence D
Sassafras Root Bark Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sassafras Alcohol Free, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Sassafras Alcohol Free by Hawaii Pharm: Common Questions

Does Sassafras Alcohol Free by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Sassafras Alcohol Free has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sassafras Alcohol Free contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is sassafras safe to use?
According to our safety data, sassafras is considered unsafe for medicinal use. It contains safrole, which the FDA banned from food because it's linked to cancer and liver damage. Any potential benefit is unlikely to outweigh the toxicity risk.
Can I take this while pregnant or breastfeeding?
No. The safety data advises against sassafras during pregnancy because safrole is toxic to a developing baby, and during breastfeeding because safrole passes into milk. Talk with your doctor or pharmacist about safe alternatives.
What are the side effects?
Sassafras can cause sweating, hot flashes, shakes, vomiting, fast heart rate, and rash. Large amounts of sassafras oil have caused hallucinations lasting several days, and in extreme cases, liver cancer and death.
Will this interact with my medications?
Sassafras can interact with sedating medications (CNS depressants) and potentially with CYP1A2 inducers like omeprazole. Check your exact medications with the search tool on this page, and talk with your doctor or pharmacist before taking it.
What is safrole and why is it a concern?
Safrole is the active compound in sassafras. It's carcinogenic (cancer-causing) and toxic to the liver, which is why the FDA banned sassafras from food and why it's considered unsafe for medicinal use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sassafras Alcohol Free is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sassafras Alcohol Free label
Go deeper

The Full Monographs Behind Sassafras Alcohol Free’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sassafras

Interacts with 275 drugs

Sassafras is an aromatic North American tree whose root bark and oil were once popular in teas and as a flavoring, but it contains safrole, a compound the FDA has banned in foods because it...

Read the full Sassafras monograph →
Sources

Sources & How We Checked

Sassafras Alcohol Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sassafras 9 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  4. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  6. Ueng, Y. F., Hsieh, C. H., Don, M. J., Chi, C. W., and Ho, L. K. Identification of the main human cytochrome P450 enzymes involved in safrole 1'-hydroxylation. Chem Res Toxicol 2004;17(8):1151-1156. PubMed
  7. Kapadia, G. J., Chung, E. B., Ghosh, B., Shukla, Y. N., Basak, S. P., Morton, J. F., and Pradhan, S. N. Carcinogenicity of some folk medicinal herbs in rats. J Natl.Cancer Inst. 1978;60(3):683-686.
  8. Segelman, A. B., Segelman, F. P., Karliner, J., and Sofia, R. D. Sassafras and herb tea. Potential health hazards. JAMA 8-2-1976;236(5):477. DOI
  9. Hu L, Wu F, He J, Zhong L, Song Y, Shao H. Cytotoxicity of safrole in HepaRG cells: studies on the role of CYP1A2-mediated ortho-quinone metabolic activation. Xenobiotica. 2019;49(12):1504-1515. PubMed

See these in context on the Sassafras monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team