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Dietary supplement

Scullcap Ingredients & Drug Interactions

by TerraVita

Scullcap label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Scullcap against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Scullcap is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Scullcap Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Scullcap by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Scullcap by TerraVita — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Scullcap by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Scullcap Glycerite Liquid Extract. The liquid formula also includes glycerin as an inactive ingredient (a sweetener and preservative in the base).

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: anxiety, stress, and sleep support.
  • We looked for evidence on: Anxiety, Insomnia, Stress, nervous tension, relaxation.
  • The closest evidence on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

The evidence for scullcap is limited. Our data shows insufficient reliable evidence to rate it for epilepsy, stress, stroke, spasticity, contact dermatitis, or premenstrual dysphoric disorder (PMDD).

That means research hasn't yet established whether it actually works for these uses — not that it doesn't work, just that we don't have the data to say either way.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Scullcap is often used short-term, but evidence is limited and product quality varies, so use it with care. The most common side effects reported are cognitive impairment, digestive disturbances, and sedation.

Mild digestive upset was noted in around 9% of people taking a higher dose (350 mg three times daily) over 2 weeks. A single 100 mg dose appears unlikely to cause CNS side effects, but 200 mg or higher might cause sedation and difficulty thinking.

Scullcap is not recommended during pregnancy or while breastfeeding because there isn't enough safety data. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking it.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before combining this product with CNS depressants — that includes sleep aids, anti-anxiety medications, some antidepressants, opioid pain relievers, and alcohol. The risk is Moderate sedation and reduced mental clarity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Scullcap may be worth considering if you're exploring herbal options for stress or sleep, but remember the evidence for what it actually does is still insufficient. The main caution is sedation and cognitive impairment, especially if you're also taking sleep aids, anti-anxiety drugs, opioids, or other CNS depressants.

Talk with your doctor or pharmacist about whether it fits your situation and whether it's safe to combine with anything else you're taking.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Scullcap, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435171605
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 280141
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Scullcap by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435171605
IngredientAmount% DV
Scullcap Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2006 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5)

Formulation

Alcohol free No flavor

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Scullcap by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Scullcap label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Scullcap by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Scullcap Glycerite Liquid Extract

Interacts with
248 drugs
0.13 mL per serving

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Scullcap Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Scullcap by TerraVita Drug Interactions

Want to check YOUR meds against Scullcap?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Scullcap Glycerite Liquid Extract 248

Individual Drug Interactions

The ingredients in Scullcap interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Scullcap interact with drugs. Each result below shows which ingredient is responsible. Scullcap Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Scullcap with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Scullcap Glycerite Liquid Extract1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Scullcap Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Scullcap, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Scullcap by TerraVita: Common Questions

Does Scullcap by TerraVita interact with any medications?
Yes. Based on its ingredients, Scullcap has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Scullcap contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take scullcap while I'm pregnant or breastfeeding?
No, not without talking to your doctor or pharmacist first. There isn't enough safety data for pregnancy or breastfeeding, so the recommendation is to avoid it during both. If you're pregnant, planning to become pregnant, or nursing, check with your healthcare provider before taking it.
What are the most common side effects?
The main ones are sedation, cognitive impairment (trouble thinking clearly), and digestive upset. Mild digestive disturbances were reported in about 9% of people taking higher doses over 2 weeks. At a single dose of 100 mg, CNS side effects seem unlikely, but 200 mg or higher might cause drowsiness and difficulty concentrating.
Does scullcap actually work for stress or sleep?
We don't have enough reliable evidence yet to say. Our data shows insufficient evidence for stress, and the same goes for the other conditions it's used for — epilepsy, stroke, spasticity, contact dermatitis, and PMDD. That doesn't mean it won't help, just that the research isn't there yet to prove it does.
What's in this liquid extract besides scullcap?
It's a glycerite, which means glycerin is the base — that's used as a sweetener and preservative. The active ingredient is the scullcap extract itself.
Is it safe to take scullcap with my sleep medication?
Not without checking first. Scullcap can add to the sedating effects of sleep aids and other CNS depressants, which could make you too drowsy or impair your thinking. Talk with your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Scullcap label
Go deeper

The Full Monographs Behind Scullcap’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Scullcap's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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