Scutellaria Supreme Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Scutellaria Supreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Scutellaria Supreme is a dietary supplement by Supreme Nutrition Products with 1 active ingredient. Its ingredients are commonly taken for inflammation, allergies, anxiety and sleep.Based on those ingredients, 946 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chinese Skullcap. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Scutellaria Supreme by Supreme Nutrition Products
Ask about any prescription or over-the-counter medication and we check it for interactions with Scutellaria Supreme by Supreme Nutrition Products — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Scutellaria Supreme by Supreme Nutrition Products
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Scutellaria Supreme contains one active ingredient: Chinese Skullcap, also called Baikal Skullcap. This plant has been used in traditional medicine for centuries and contains compounds such as baicalein and wogonin that are thought to underlie its effects.
The capsule itself is made from vegetable cellulose.
Does it work?
Couldn't assess
The evidence for Chinese Skullcap hasn't been firmly established for the conditions listed in the product information. Our data shows insufficient reliable evidence to rate its use for allergic rhinitis (hay fever), anxiety, atherosclerosis, ADHD, prostate cancer, and headache.
That doesn't mean it doesn't work — it means human studies haven't yet shown a clear benefit for these conditions.
How safe is it?
Well-documented data
Taken by mouth, Baikal Skullcap seems to be generally well tolerated. The most common side effects reported include abdominal pain, constipation, diarrhea, nausea, and vomiting — usually mild.
Rarely, serious effects like liver damage and a type of lung inflammation called hypersensitivity pneumonitis have been reported, particularly with a specific commercial combination product. Because human safety data are limited and product quality varies, use caution.
There isn't enough safety information to know whether this supplement is safe during pregnancy or while breastfeeding. The data advises against use in both cases.
Talk with your doctor or pharmacist about your individual situation before taking it if you're pregnant, breastfeeding, or planning to become pregnant.
Meds to double-check
Moderate interaction found
Before you start Scutellaria Supreme, double-check with your pharmacist if you take blood pressure medications (Moderate risk of low blood pressure), blood thinners or antiplatelet drugs (Moderate risk of increased bleeding), diabetes medications (Moderate risk of low blood sugar), lithium (Moderate risk of lithium buildup), hormone replacement therapy (Moderate risk of reduced effectiveness), antithyroid drugs (Moderate risk of overtreatment), or any drug metabolized by CYP2C19 or CYP1A2 enzymes (Moderate risk of higher drug levels). These are theoretical concerns backed by lab research, not yet proven in humans — but they're real enough to warrant a quick conversation.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Chinese Skullcap may appeal to you if you're exploring traditional herbal remedies for conditions like anxiety or inflammation, but the evidence for its effectiveness hasn't been firmly established. Be especially careful if you take blood pressure medications, blood thinners, diabetes drugs, lithium, or hormone replacement therapy — this supplement has documented interactions with all of them.
Talk with your doctor or pharmacist before adding it to your routine to make sure it won't interfere with your current medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Scutellaria Supreme, straight from the product label.
| Brand | Supreme Nutrition Products |
|---|---|
| Net contents | 90 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Oct 22, 2021 |
| DSLD ID | 252143 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Scutellaria Supreme by Supreme Nutrition Products, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Chinese Skullcap | 459 mg | -- |
Other ingredients: Vegetable Cellulose Capsules
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: 1 capsule 3 times per day.
Precautions
Warning: If pregnant or breastfeeding consult your doctor before using this product.
If you have any condition that might be made worse by exposure to estrogen, don't use this product.
Keep out of reach of children.
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to treat, diagnose, prevent or cure any disease or illness.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Scutellaria Supreme by Supreme Nutrition Products label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Scutellaria Supreme by Supreme Nutrition Products
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Chinese Skullcap
Interacts with946 drugs
Baikal skullcap is a traditional Chinese herb (Huang Qin) used for inflammation, allergies, and infections, with active compounds like baicalin and ba...
Chinese Skullcap monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose Capsules. These complete the product’s ingredient list but are not active constituents.
Scutellaria Supreme by Supreme Nutrition Products Drug Interactions
HelloPharmacist Interaction Report
Scutellaria Supreme by Supreme Nutrition Products contains Chinese Skullcap (Baikal Skullcap), which has documented interactions with multiple medication categories.
The most serious concern is a Moderate-severity interaction with blood pressure medications (antihypertensives) — concomitant use might lower your blood pressure further and raise the risk of dangerously low blood pressure (hypotension).
Read the full breakdown — every affected drug type, severity by severity
Baikal Skullcap may also increase levels of certain drugs your liver processes, particularly those metabolized by CYP2C19 and CYP1A2 enzymes — this could make those medications stronger than intended. It theoretically interferes with hormone replacement therapy (estrogens), may increase bleeding risk when combined with blood thinners (anticoagulants) or antiplatelet drugs, and might enhance the blood sugar–lowering effects of diabetes medications.
Additionally, it may reduce how your body clears lithium, potentially raising lithium levels to unsafe concentrations, and might add to the effects of antithyroid drugs, raising hypothyroidism risk.
These are all theoretical concerns based on lab and animal research; human studies are limited. Still, if you take any prescription medications, run them through the checker on this page or ask your pharmacist before starting this product.
Altogethere, these interactions span 946 individual medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Scutellaria Supreme?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Scutellaria Supreme interact with 946 drugs. Click any drug to see the details.
1 of the 1 ingredient in Scutellaria Supreme interact with drugs. Each result below shows which ingredient is responsible. Chinese Skullcap
AbciximabReoPro
How Abciximab interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Chinese Skullcap + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Chinese Skullcap + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Baikal skullcap with antidiabetes drugs might enhance blood glucose lowering effects.
Read the full Chinese Skullcap + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Chinese Skullcap + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Chinese Skullcap + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
Read the full Chinese Skullcap + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
Read the full Chinese Skullcap + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
Read the full Chinese Skullcap + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Scutellaria Supreme — through 1 ingredient. Tap an ingredient for the detail:
Chinese SkullcapCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Chinese Skullcap + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Scutellaria Supreme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Chinese Skullcap
Anticoagulant/Antiplatelet Drugs
Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Preliminary clinical research suggests that taking capsules containing a combination of astragalus, goldthread, and Baikal skullcap daily for 4 weeks inhibits platelet aggregation; the effect seems to be similar to that of aspirin 50 mg daily. It is unclear if this effect is due to Baikal skullcap, other ingredients, or the combination.
Antidiabetes Drugs
Theoretically, concomitant use of Baikal skullcap with antidiabetes drugs might enhance blood glucose lowering effects.
Baicalein, a constituent of Baikal skullcap, has alpha-glucosidase inhibitory activity in vitro. Animal research also suggests that Baikal skullcap enhances the antidiabetic effects of metformin. However, in a small human study, taking Baikal skullcap extract did not enhance the antidiabetic effects of metformin, although it did modestly lower glucose levels during an oral glucose tolerance test (OGTT). Until more is known, use cautiously.
Antihypertensive Drugs
Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Animal research suggests that baicalein, a constituent of Baikal skullcap, might lower blood pressure.
Antithyroid Drugs
Theoretically, concomitant use of Baikal skullcap and antithyroid drugs may result in additive activity and increase the risk of hypothyroidism.
In an animal hyperthyroid model, Baikal skullcap improved levels of triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH). The clinical significance of this effect is unclear.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
In vitro evidence suggests that constituents of Baikal skullcap inhibit the activity of CYP1A2. This effect has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, Baikal skullcap might increase levels of drugs metabolized by CYP2C19 enzymes.
In vitro evidence suggest that wogonin, a constituent of Baikal skullcap, modestly inhibits the activity of CYP2C19 enzymes. This effect has not been reported in humans.
Estrogens
Theoretically, concomitant use of large amounts of Baikal skullcap might interfere with hormone replacement therapy, due to competition for estrogen receptors.
In vitro evidence suggests that Baikal skullcap has estrogenic activity.
Lithium
Theoretically, Baikal skullcap might reduce lithium excretion and increase serum levels of lithium.
Baikal skullcap is thought to have diuretic properties, which may reduce lithium excretion. The dose of lithium might need to be decreased.
Alcohol (Ethanol)
Theoretically, Baikal skullcap might potentiate the sedative effects of alcohol.
In vitro and animal research suggests that Baikal skullcap binds to GABA-A receptors and causes sedation. Theoretically, Baikal skullcap might potentiate the sedative effects of alcohol. Preliminary clinical research has not identified clinically relevant sedation after use of Baikal skullcap; however, a thorough evaluation of safety outcomes has not been conducted.
Cns Depressants
Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
In vitro and animal research suggests that Baikal skullcap binds to GABA-A receptors and causes sedation. Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties. Preliminary clinical research has not identified clinically relevant sedation after use of Baikal skullcap; however, a thorough evaluation of safety outcomes has not been conducted.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, Baikal skullcap might alter the levels and clinical effects of OATP substrates.
Some pharmacokinetic research shows that baicalin, a constituent of Baikal skullcap, can decrease plasma levels of rosuvastatin. The mechanism is thought to involve stimulation of the activity of the organic anion-transporting polypeptide 1B1 (OATP1B1), which transports rosuvastatin into the liver. This decreases plasma levels of the drug, but increases levels at the site of action in the liver. The degree to which rosuvastatin levels are affected depends on the OATP1B1 haplotype of the individual. Baikal skullcap might also affect other OATP1B1 substrates.
P-Glycoprotein Substrates
Theoretically, Baikal skullcap might increase levels of drugs transported by P-glycoprotein.
In vitro and animal research suggests that baicalein, oroxylin A, and wogonin, constituents of Baikal skullcap, can inhibit P-glycoprotein. This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Scutellaria Supreme, from the product label.
Supreme Nutrition Products
See all Supreme Nutrition Products products- Name
- Supreme Nutrition Products
- Street Address
- 1019 Regents Blvd #203
- City
- Tacoma
- State
- WA
- ZipCode
- 98466
- Web Address
- www.SupremeNutritionProducts.com
Scutellaria Supreme by Supreme Nutrition Products: Common Questions
Does Scutellaria Supreme by Supreme Nutrition Products interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is Chinese Skullcap and why is it in this product?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I experience?
Does this supplement actually work for anxiety or allergies?
How many ingredients does this product have?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Scutellaria Supreme is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Scutellaria Supreme’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Scutellaria Supreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 34 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Baikal Skullcap 34 references
- Huang KC. The pharmacology of Chinese herbs. 2nd ed. New York, NY: CRC Press LLC. 1999;385-6, 400-1.
- Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Planta Med 2000;66:91-3.
- Liao JF, Wang HH, Chen MC, et al. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. Planta Med 1998;64:571-2.
- Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. J Nat Prod 1998;61:1413-5.
- Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
- Fan L, Zhang W, Guo D, et al. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Clin Pharmacol Ther 2007;83:471-6. PubMed
- Chen C, Mireles RJ, Campbell SD, et al. Differential interaction of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos 2005;33:537-46. PubMed
- Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Clin Pharmacol Ther 2007;82:726-33. PubMed
- Konig J, Seithel A, Gradhand U, Fromm MF. Pharmacogenomics of human OATP transporters. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. PubMed
- Chalasani N, Vuppalanchi R, Navarro V, et al. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Ann Intern Med 2012;156:857-60. PubMed
- Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. Ann Intern Med 2012;156:894-5. PubMed
- Huang, W. M., Yan, J., and Xu, J. [Clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(8):465-467.
- Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Pl PubMed
- Lee, Y., Yeo, H., Liu, S. H., Jiang, Z., Savizky, R. M., Austin, D. J., and Cheng, Y. C. Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring. J Med Chem 10-21-2004;47(22):5555-5566. PubMed
- Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. Biological properties of baicalein in cardiovascular system. Curr Drug Targets.Cardiovasc.Haematol.Disord 2005;5(2):177-184. PubMed
- Lee, E., Enomoto, R., Suzuki, C., Ohno, M., Ohashi, T., Miyauchi, A., Tanimoto, E., Maeda, K., Hirano, H., Yokoi, T., and Sugahara, C. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. Ann N Y Acad Sci 2007;1095:521-526. PubMed
- Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Am J Chin Med 2008;36(3):517-540.
- Go, W. J., Ryu, J. H., Qiang, F., and Han, H. K. Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. J Nat Prod 2009;72(9):1616-1619. PubMed
- Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. PubMed
- Enomoto, R., Koshiba, C., Suzuki, C., and Lee, E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. Cancer Chemother.Pharmacol 2011;67(5):1063-1072. PubMed
- Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. J Ethnopharmacol. 5- PubMed
- Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. Eur J Drug Metab Pharmacokinet. 6-29-2011; PubMed
- Lin H, Zhou J, Lin K, et al. Efficacy of Scutellaria baicalensis for the treatment of hand, foot, and mouth disease associated with encephalitis in patients infected with EV71: a multicenter, retrospective analysis. Biomed Res Int 2016;2016:5697571.
- Papafragkakis C, Ona MA, Reddy M, Anand S. Acute hepatitis after ingestion of a preparation of Chinese skullcap and black catechu for joint pain. Case Reports Heptal 2016;2016:4356749. PubMed
- Kim M, Lee BC. Therapeutic effect of Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism rats. Evid Based Complement Alternat Med. 2019;2019:3239649.
- Braude MR, Bassily R. Drug-induced liver injury secondary to Scutellaria baicalensis (Chinese skullcap). Intern Med J. 2019;49(4):544-546. PubMed
- Shin NR, Gu N, Choi HS, Kim H. Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation. Am J Physiol Endocrinol Metab. 2020;318(1):E52-E61.
- Li WJ, Bao J, Zheng DC, et al. Treatments of Peyronie's disease with Scutellaria baicalensis and surgery according to the disease course: a single-center retrospective study of 261 patients. Ann Palliat Med. 2021 Mar;10(3):2979-2989. PubMed
- Adam T, Bursztejn AC, Schmutz JL. Facial eczema from a sunscreen: Scutellaria baicalensis, a novel allergen beginning to attract attention. Contact Dermatitis. 2020 Apr;82(4):253-254.
- Luna-Bastante L, Gatica-Ortega ME, Pastor-Nieto MA, et al. Allergic contact dermatitis to Tinosorb S, Scutellaria baicalensis, and other emerging allergens in cosmetics. Contact Dermatitis. 2020 May;82(5):307-309.
- US Food and Drug Administration (FDA). FDA Alerts Consumers About Potentially Life-Threatening Health Problems Linked to Limbrel. December 19, 2017. Available at: https://www.fda.gov/food/alerts-advisories-safety-information/fda-alerts-consumers-about-pot
- Li L, Gao H, Lou K, et al. Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study. Clin Transl Sci 2021;14(5):2017-2024. PubMed
- Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Contact Dermatitis 2022.
- Nogami T, Arai M. Incidence of Herb-induced Liver Injury Caused by Kampo Formulae Containing Scutellariae Radix. Tokai J Exp Clin Med 2022;47(3):94-98.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC