Selenium 50 mcg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Selenium 50 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Selenium 50 mcg is a dietary supplement by Nature's Harmony with 1 active ingredient. Its ingredients are commonly taken for thyroid health support, antioxidant support, immune support.Based on those ingredients, 321 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Selenium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Selenium 50 mcg by Nature's Harmony
Ask about any prescription or over-the-counter medication and we check it for interactions with Selenium 50 mcg by Nature's Harmony — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Selenium 50 mcg by Nature's Harmony
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: selenium at 50 micrograms per tablet. The rest is inactive ingredients — tricalcium phosphate, microcrystalline cellulose, croscarmellose sodium, stearic acid, magnesium stearate, and pharmaceutical glaze — that help form and hold the tablet together.
Does it work?
Couldn't assess
Selenium is likely effective for treating selenium deficiency. It's possibly effective for Kashin-Beck disease (a joint condition linked to low selenium), pre-eclampsia (high blood pressure in pregnancy), and autoimmune thyroiditis (Hashimoto's disease).
The evidence doesn't support using it for dyslipidemia (high cholesterol).
How safe is it?
Well-documented data
Selenium at this dose is generally well tolerated when you stay within the safe upper limit of 400 micrograms daily. The most common side effects are stomach discomfort, headache, and rash.
Taking too much can cause hair loss, nail changes, nausea, vomiting, fatigue, and weight loss; in rare cases, excess selenium has caused multi-organ failure. Long-term high doses may also raise your risk of certain skin cancers and possibly affect nerve health.
The safety data during pregnancy is mixed — some evidence suggests it's possibly safe, other evidence suggests possibly unsafe — so talk with your doctor or pharmacist before taking it if you're pregnant or breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this selenium supplement, check with your doctor or pharmacist if you use blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel), barbiturates (sedatives), immunosuppressants, niacin, or birth control pills. Selenium can affect how these medications work or increase side effects like bleeding.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This supplement is useful if you have a documented selenium deficiency or conditions like Kashin-Beck disease or autoimmune thyroiditis. It's not for high-dose megavitamin use — stick to the recommended dose.
If you take blood thinners, sedatives, immunosuppressants, or other medications, check with your own doctor or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Selenium 50 mcg, straight from the product label.
| Brand | Nature's Harmony |
|---|---|
| Barcode (UPC) | 063047005964 |
| Net contents | 60 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | May 24, 2013 |
| DSLD ID | 21859 |
| Product type | Mineral |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Selenium 50 mcg by Nature's Harmony, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Selenium | 50 mcg | -- |
Other ingredients: Tricalcium Phosphate, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Pharmaceutical Glaze
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Risk Information: If taking four or more tablets daily, consult a health care practitioner before use if you have a history of non-melanoma skin cancer.
KEEP OUT OF REACH OF CHILDREN.
DO NOT USE IF SEAL UNDER CAP IS BROKEN.
General Statements
Antioxidant for the Maintenance of Good Health
{Tablet} Actual Size
Storage
STORE IN A COOL DRY PLACE.
General
400596.01-02
Seals/Symbols
Purity Life(R)
Suggested/Recommended/Usage/Directions
Recommended Use: An antioxidant for the maintenance of good health. Helps to prevent selenium deficiency if taking two or more tablets per day. Recommended Dose (Adults): Take 1 to 8 tablets daily.
Formulation
This product does not contain corn, dairy, egg, gluten, lactose, nuts, shellfish, soy, starch, sugar, sulfites, animal derivatives or artificial colours, flavours or preservatives.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Selenium 50 mcg by Nature's Harmony label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Selenium 50 mcg by Nature's Harmony
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Selenium
Interacts with321 drugs
Selenium is an essential trace mineral your body needs in small amounts for thyroid function, antioxidant defense, and immune health. Most people who...
Selenium monograph & interactionsOther (inactive) ingredients: Tricalcium Phosphate, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.
Selenium 50 mcg by Nature's Harmony Drug Interactions
HelloPharmacist Interaction Report
Selenium by Nature's Harmony can interact with several medication types.
The most serious concern is with blood thinners (anticoagulants) and antiplatelet drugs like warfarin (Coumadin) and aspirin — selenium may increase bleeding risk or interfere with how these medications work by affecting how your liver processes them or by displacing them from protein binding sites.
Read the full breakdown — every affected drug type, severity by severity
You should also be cautious if you take immunosuppressants (drugs that calm your immune system after transplant or for autoimmune conditions), barbiturates (sedative medications), or niacin for cholesterol. Selenium may reduce how well immunosuppressants work, may prolong the sedating effects of barbiturates, and might weaken niacin's benefit to your HDL cholesterol.
Birth control pills may slightly raise your selenium levels, though it's unclear whether this matters in practice.
Altogether, these interactions span 321 individual medications. Before you start this supplement, run your exact medications through the checker below — especially if you take any blood thinner, sedative, immunosuppressant, or cholesterol drug.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Selenium 50 mcg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Selenium 50 mcg interact with 321 drugs. Click any drug to see the details.
1 of the 1 ingredient in Selenium 50 mcg interact with drugs. Each result below shows which ingredient is responsible. Selenium
Birth Control PillsBirth control pills
How Birth Control Pills interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Birth Control Pills interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Desogestrel, Ethinyl Estradiol interactionDrospirenoneDrospirenone
How Drospirenone interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Drospirenone interactionDrospirenone, EstetrolNextstellis
How Drospirenone, Estetrol interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Drospirenone, Estetrol interactionDrospirenone, Ethinyl EstradiolAngeliq, Gianvi, Yasmin
How Drospirenone, Ethinyl Estradiol interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Drospirenone, Ethinyl Estradiol interactionEthiny Estradiol, LevonorgestrelLogynon, Microgynon 30 ED
How Ethiny Estradiol, Levonorgestrel interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Ethiny Estradiol, Levonorgestrel interactionEthinyl Estradiol, DesogestrelApri, Cesia, Cyclessa, Gedarel, Kariva, Linessa +4 more
How Ethinyl Estradiol, Desogestrel interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Ethinyl Estradiol, Desogestrel interactionEthinyl Estradiol, DrospirenoneYaz
How Ethinyl Estradiol, Drospirenone interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Ethinyl Estradiol, Drospirenone interactionEthinyl Estradiol, Ethynodiol DiacetateDemulen 1/35, Demulen 1/50, Demulen Compack, Kelnor 1/35, Zovia, Zovia 1/35 +1 more
How Ethinyl Estradiol, Ethynodiol Diacetate interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Ethinyl Estradiol, Ethynodiol Diacetate interactionEthinyl Estradiol, LevonorgestrelAlesse, Alesse 21, Alesse 28, Aviane, Enpresse, Jolessa +18 more
How Ethinyl Estradiol, Levonorgestrel interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Ethinyl Estradiol, Levonorgestrel interactionEthinyl Estradiol, NorethindroneAranelle, Brevicon, Brevicon .5/35 21 day, Brevicon .5/35 28 day, Brevicon 1/35 21 day, Brevicon 1/35 28 day +50 more
How Ethinyl Estradiol, Norethindrone interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Ethinyl Estradiol, Norethindrone interactionEthinyl Estradiol, Norethindrone, Ferrous FumarateEstrostep Fe, Femcon FE, Junel Fe 1.5/30, Loestrin Fe, Loestrin Fe 1.5/30, Loestrin Fe 1/20 +3 more
How Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interactionEthinyl Estradiol, NorgestimateCilest, Mononessa, Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Ortho Tri-Cylcen, Ortho-Cyclen +5 more
How Ethinyl Estradiol, Norgestimate interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Ethinyl Estradiol, Norgestimate interactionEthinyl Estradiol, NorgestrelCryselle, Lo/Ovral, Low-Ogestrel, Ogestrel 0.5/50, Ovral
How Ethinyl Estradiol, Norgestrel interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Ethinyl Estradiol, Norgestrel interactionEthinyl Estradiol, LevonogestrelLybrel
How Ethinyl Estradiol, Levonogestrel interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Ethinyl Estradiol, Levonogestrel interactionEthynodiol Diacetate, MestranolOvulen
How Ethynodiol Diacetate, Mestranol interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Ethynodiol Diacetate, Mestranol interactionEtonogestrelImplanon
How Etonogestrel interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Etonogestrel interactionEtonogestrel, Ethinyl EstradiolNuvaRing
How Etonogestrel, Ethinyl Estradiol interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Etonogestrel, Ethinyl Estradiol interactionGestodeneMinesse
How Gestodene interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Gestodene interactionLactic Acid, Citric Acid, Potassium BitartratePhexxi
How Lactic Acid, Citric Acid, Potassium Bitartrate interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Lactic Acid, Citric Acid, Potassium Bitartrate interactionLevonorgestrelKyleena, Levonelle 1500, Levonelle One Step, Liletta, Mirena, Norgeston +2 more
How Levonorgestrel interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Levonorgestrel interactionLevonorgestrel, Ethinyl EstradiolLogynon ED, Microgynon 30, Nordette, Ovranette, Quartette, Trinordiol +1 more
How Levonorgestrel, Ethinyl Estradiol interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Levonorgestrel, Ethinyl Estradiol interactionMestranol, NorethindroneNecon 1/50, Nelova 1/50M, Norethin 1/50, Norethin 1/50M, Norinyl 1 50 21 Day, Ortho Novum 1 Plus 50 +2 more
How Mestranol, Norethindrone interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Mestranol, Norethindrone interactionMestranol, NorethynodrelEnovid-E
How Mestranol, Norethynodrel interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Mestranol, Norethynodrel interactionNiacin (prescription Drug)Niacor, Niaspan
How Niacin (prescription Drug) interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumNiacin Minor
Interaction Summary
Selenium might reduce the beneficial effects of niacin on high-density lipoprotein (HDL) levels.
Read the full Selenium + Niacin (prescription Drug) interactionNiacin, LovastatinAdvicor
How Niacin, Lovastatin interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumNiacin Minor
Interaction Summary
Selenium might reduce the beneficial effects of niacin on high-density lipoprotein (HDL) levels.
Read the full Selenium + Niacin, Lovastatin interactionNiacin, SimvastatinSimcor
How Niacin, Simvastatin interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumNiacin Minor
Interaction Summary
Selenium might reduce the beneficial effects of niacin on high-density lipoprotein (HDL) levels.
Read the full Selenium + Niacin, Simvastatin interactionNorelgestromin, Ethinyl EstradiolEvra, Ortho Evra
How Norelgestromin, Ethinyl Estradiol interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Norelgestromin, Ethinyl Estradiol interactionNorethindrone Acetate, Ethinyl Estradiol, Ferrous FumarateLoMinastrin FE, Minastrin 24 FE
How Norethindrone Acetate, Ethinyl Estradiol, Ferrous Fumarate interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Norethindrone Acetate, Ethinyl Estradiol, Ferrous Fumarate interactionNorgestrelOrval 21, Ovrette
How Norgestrel interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
SeleniumContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Selenium + Norgestrel interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Selenium 50 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Selenium
Anticoagulant/Antiplatelet Drugs
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that taking selenium 10 mcg/kg/day can increase bleeding times by increasing prostacyclin production, which inhibits platelet activity. Other clinical research suggests that taking selenium 75 mcg daily, in combination with ascorbic acid 600 mg, alpha-tocopherol 300 mg, and beta-carotene 27 mg, reduces platelet aggregation.
Barbiturates
Theoretically, selenium might prolong the sedating effects of barbiturates.
Laboratory research suggests that selenium can inhibit the hepatic metabolism of barbiturates. Selenium seems to prolong the sedative effect of pentobarbital in animal models.
Immunosuppressants
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
In vitro research and preliminary clinical evidence suggests that selenium may stimulate the immune system.
Warfarin (Coumadin)
Theoretically, selenium might interfere with warfarin activity.
Animal research suggests that selenium can increase warfarin activity. Selenium might interact with warfarin by displacing it from albumin binding sites, reducing its metabolism in the liver, or by decreasing production of vitamin K-dependent clotting factors. Selenium can also prolong bleeding times in humans by increasing prostacyclin production, which inhibits platelet activity.
Contraceptive Drugs
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Some research suggests that oral contraceptives increase serum selenium levels in women taking oral contraceptives; however, other research shows no change in selenium levels. It is suggested that an increase could be due to increased carrier proteins, indicating a redistribution of selenium rather than a change in total body selenium.
Niacin
Selenium might reduce the beneficial effects of niacin on high-density lipoprotein (HDL) levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as selenium, or to the combination. It also is not known whether it will occur in other patient populations.
Brand information
Manufacturer and brand details for Selenium 50 mcg, from the product label.
Selenium 50 mcg by Nature's Harmony: Common Questions
Does Selenium 50 mcg by Nature's Harmony interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What dose is safe, and how much is too much?
Can I take this if I'm pregnant or breastfeeding?
What are the side effects?
Will this help my thyroid or cholesterol?
What are the inactive ingredients, and are there fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Selenium 50 mcg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Selenium 50 mcg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Selenium 50 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 36 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Selenium 36 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
- Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
- Trafikowska U, Zachara BA, Wiacek M, et al. Selenium supply and glutathione peroxidase activity in breastfed Polish infants. Acta Paediatr 1996;85:1143-5. PubMed
- Duffield-Lillico AJ, Slate EH, Reid ME, et al. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst 2003;95:1477-81.. PubMed
- Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
- Schiavon R, Freeman GE, Guidi GC, et al. Selenium enhances prostacyclin production by cultured endothelial cells: possible explanation for increased bleeding times in volunteers taking selenium as a dietary supplement. Thromb Res 1984;34:389-96. PubMed
- Davila JC, Edds GT, Osuna O, Simpson CF. Modification of the effects of aflatoxin B1 and warfarin in young pigs given selenium. Am J Vet Res 1983;44:1877-83. DOI
- Heese HD, Lawrence MA, Dempster WS, Pocock F. Reference concentrations of serum selenium and manganese in healthy nulliparas. S Afr Med J 1988;73:163-5.
- Lloyd B, Lloyd RS, Clayton BE. Effect of smoking, alcohol and other factors on the selenium status of a healthy population. J Epidemiol Commun Health 1983;37:213-7. PubMed
- Capel ID, Jenner M, Williams DC, et al. The effect of prolonged oral contraceptive steroid use on erythrocyte glutathione peroxidase activity. J Steroid Biochem 1981;14:729-32. PubMed
- Contempre B, Dumont JE, Ngo B, et al. Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium. J Clin Endocrinol PubMed
- Hofbauer LC, Spitzweg C, Magerstadt RA, Heufelder AE. Selenium-induced thyroid dysfunction. Postgrad Med J 1997;73:103-4. PubMed
- Debski B, Milner JA. Dietary selenium supplementation prolongs pentobarbital induced hypnosis. J Nutr Biochem 2004;15:548-53. PubMed
- Ishikawa M, Sasaki M, Koiwai K, et al. Inhibition of hepatic mixed-function oxidase enzymes in mice by acute and chronic treatment with selenium. J Pharmacobiodyn 1992;15:377-85. PubMed
- Lippmann SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 2009;301:39-51. DOI
- Reid SM, Middleton P, Cossich MC, Crowther CA. Interventions for clinical and subclinical hypothyroidism in pregnancy. Cochrane Database Syst Rev 2010;(7):CD007752. PubMed
- Vinceti, M., Wei, E. T., Malagoli, C., Bergomi, M., and Vivoli, G. Adverse health effects of selenium in humans. Rev.Environ.Health 2001;16(4):233-251. PubMed
- Abrams, C. K., Siram, S. M., Galsim, C., Johnson-Hamilton, H., Munford, F. L., and Mezghebe, H. Selenium deficiency in long-term total parenteral nutrition. Nutr Clin Pract 1992;7(4):175-178. PubMed
- Spiller, H. A. and Pfiefer, E. Two fatal cases of selenium toxicity. Forensic Sci Int 8-24-2007;171(1):67-72. PubMed
- Negro, R., Greco, G., Mangieri, T., Pezzarossa, A., Dazzi, D., and Hassan, H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol.Metab 2007;92(4):1263-1268. PubMed
- Alexander, J. Selenium. Novartis.Found.Symp 2007;282:143-149.
- Salonen, J. T., Salonen, R., Seppanen, K., Rinta-Kiikka, S., Kuukka, M., Korpela, H., Alfthan, G., Kantola, M., and Schalch, W. Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial
- Kupka, R., Mugusi, F., Aboud, S., Msamanga, G. I., Finkelstein, J. L., Spiegelman, D., and Fawzi, W. W. Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: effects on maternal and chil
- Kamble, P., Mohsin, N., Jha, A., Date, A., Upadhaya, A., Mohammad, E., Khalil, M., Pakkyara, A., and Budruddin, M. Selenium intoxication with selenite broth resulting in acute renal failure and severe gastritis. Saudi.J Kidney Dis.Transpl. 2009;20(1):106
- Peretz, A., Neve, J., Desmedt, J., Duchateau, J., Dramaix, M., and Famaey, J. P. Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast. Am.J Clin.Nutr. 1991;53(5):1323-1328. PubMed
- Kumpulainen, J., Salmenpera, L., Siimes, M. A., Koivistoinen, P., and Perheentupa, J. Selenium status of exclusively breast-fed infants as influenced by maternal organic or inorganic selenium supplementation. Am.J Clin.Nutr. 1985;42(5):829-835. PubMed
- Han, L. and Zhou, S. M. Selenium supplement in the prevention of pregnancy induced hypertension. Chin Med J (Engl) 1994;107(11):870-871.
- Kiremidjian-Schumacher, L., Roy, M., Wishe, H. I., Cohen, M. W., and Stotzky, G. Supplementation with selenium and human immune cell functions. II. Effect on cytotoxic lymphocytes and natural killer cells. Biol.Trace Elem.Res. 1994;41(1-2):115-127. PubMed
- Srivastava, A. K., Gupta, B. N., Bihari, V., and Gaur, J. S. Generalized hair loss and selenium exposure. Vet.Hum.Toxicol. 1995;37(5):468-469.
- Sudfeld CR, Aboud S, Kupka R, et al. Effect of selenium supplementation on HIV-1 RNA detection in breast milk of Tanzanian women. Nutrition 2014;30(9):1081-4. PubMed
- Rees K, Hartley L, Day C, et al. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2013;1:CD009671. PubMed
- Thompson PA, Ashbeck EL, Roe DJ, et al. Selenium Supplementation for Prevention of Colorectal Adenomas and Risk of Associated Type 2 Diabetes. J Natl Cancer Inst. 2016;108(12). PubMed
- Wichman J, Winther KH, Bonnema SJ, Hegedüs L. Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and meta-analysis. Thyroid 2016;26(12):1681-92. PubMed
- Vinceti M, Filippini T, Rothman KJ. Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis. Eur J Epidemiol. 2018 Sep;33(9):789-810. Epub 2018 Jul 5. Review. PubMed
- Fallah S, Sani FV, Firoozrai M. Effect of contraceptive pill on the selenium and zinc status of healthy subjects. Contraception. 2009;80(1):40-3. PubMed
- Malpas CB, Vivash L, Genc S, et al. A Phase IIa Randomized Control Trial of VEL015 (Sodium Selenate) in Mild-Moderate Alzheimer's Disease. J Alzheimers Dis. 2016;54(1):223-232. PubMed
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