Selenium 50 mcg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Selenium 50 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Selenium 50 mcg is a dietary supplement by Wonder Laboratories with 1 active ingredient. Its ingredients are commonly taken for thyroid health support, antioxidant support, immune support.Based on those ingredients, 321 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Selenium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Selenium 50 mcg by Wonder Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with Selenium 50 mcg by Wonder Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Selenium 50 mcg by Wonder Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: selenium, bound to amino acids (yeast-free selenium amino acid chelate) to help your body absorb it. Selenium is a mineral your body needs in tiny amounts for thyroid function and antioxidant protection.
The rest is inactive ingredients — vegetable cellulose, gelatin, silica, and vegetable magnesium stearate — which form and hold together the capsule.
Does it work?
Strong evidence
Selenium is likely effective for treating selenium deficiency, which is rare but can happen. It's possibly effective for Kashin-Beck disease (a joint condition linked to low selenium) and pre-eclampsia (high blood pressure in pregnancy).
The evidence suggests it may help with autoimmune thyroiditis (Hashimoto's disease). For dyslipidemia (high cholesterol), the data shows it's possibly ineffective.
How safe is it?
Well-documented data
At the 50 mcg dose in this product, selenium is generally well-tolerated — well below the daily upper limit of 400 mcg. The most common side effects from higher doses are gastric discomfort, headache, and rash.
However, excess selenium over time can cause hair loss, brittle nails, fatigue, nausea, and in rare cases serious effects like multi-organ damage. Long-term high-dose selenium has also been linked to increased risk of squamous cell skin cancer.
Stay within recommended amounts unless your doctor tells you otherwise.
Meds to double-check
Moderate interaction found
Before you start, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (including warfarin), immunosuppressants, barbiturates, oral contraceptives, or niacin. Selenium may increase bleeding risk with anticoagulants and can theoretically reduce how well immune-suppressing drugs and barbiturates work.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This low-dose selenium supplement is a reasonable choice if you're deficient in selenium or have a condition where it's possibly helpful — like pre-eclampsia or autoimmune thyroiditis. But if you take blood thinners, immune-suppressing drugs, barbiturates, or warfarin, you'll want to talk it over with your doctor or pharmacist first.
Keep doses moderate and avoid stacking other selenium supplements on top of this one.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Selenium 50 mcg, straight from the product label.
| Brand | Wonder Laboratories |
|---|---|
| Net contents | 500 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 24, 2020 |
| DSLD ID | 215612 |
| Product type | Mineral |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Selenium 50 mcg by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Selenium | 50 mcg | 91% |
| yeast free Selenium Amino Acid Chelate | 25 mg | -- |
Other ingredients: Vegetable Cellulose, Gelatin, Silica, Vegetable Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take one capsule daily.
Precautions
Tamper evident: Do not use this product if imprinted foil seal under cap is broken or missing.
Keep out of reach of children.
Caution: If you are pregnant or nursing, consult your physician before taking this product.
Formulation
Manufactured in an FDA Registered Facility using Good Manufacturing Practices (GMPs).
Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.
Yeast free
Antioxidant and immune health Helps neutralize cell damaging free radicals
Gluten free
Storage
Keep tightly closed. Store at room temperature: 59 degrees – 86 degrees F (15 degrees – 30 degrees C).
FDA Disclaimer Statement
These statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Formula 603 Was a tablet now a capsule
Made in USA
Formula
Amino acid chelated
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Selenium 50 mcg by Wonder Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Selenium 50 mcg by Wonder Laboratories
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Selenium
Interacts with321 drugs
Selenium is an essential trace mineral your body needs in small amounts for thyroid function, antioxidant defense, and immune health. Most people who...
Selenium monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Gelatin, Silica, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Selenium 50 mcg by Wonder Laboratories Drug Interactions
HelloPharmacist Interaction Report
Wonder Laboratories Selenium 50 mcg does interact with several medication types.
Through its selenium amino acid chelate, the biggest concern is with blood thinners (anticoagulants) and antiplatelet drugs — selenium may increase bleeding risk by thinning your blood further.
Read the full breakdown — every affected drug type, severity by severity
It also has moderate interactions with immune-suppressing drugs (it may reduce how well they work), barbiturates (sedating drugs that may stay in your system longer), and warfarin specifically (a blood thinner where selenium might interfere with how it's metabolized). Additionally, there are minor interactions with oral contraceptives (which may raise your selenium levels) and niacin (where selenium might blunt niacin's HDL-raising effect).
Altogether, these interactions span 321 individual medications. If you take any blood thinner, immunosuppressant, barbiturate, or the other drug types mentioned, check your exact medications with the search tool below before starting this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Selenium 50 mcg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Selenium 50 mcg interact with 321 drugs. Click any drug to see the details.
1 of the 1 ingredient in Selenium 50 mcg interact with drugs. Each result below shows which ingredient is responsible. Selenium
Treprostinil (inh)Tyvaso
How Treprostinil (inh) interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Treprostinil (inh) interactionTreprostinil (oral)Orenitram, Remodulin
How Treprostinil (oral) interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Treprostinil (oral) interactionTriamcinoloneAdcortyl in Orabase, Adcortyl Intra-articular / Intradermal, Aristocort, Kenacort, Kenalog Intra-articular / Intramuscular, Triesence
How Triamcinolone interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Triamcinolone interactionTriamcinolone AcetonideXipere, Zilretta
How Triamcinolone Acetonide interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Triamcinolone Acetonide interactionUblituximab-xiiyBriumvi
How Ublituximab-xiiy interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Ublituximab-xiiy interactionUrokinaseAbbokinase
How Urokinase interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Urokinase interactionUstekinumabStelara
How Ustekinumab interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Ustekinumab interactionVorapaxarZontivity
How Vorapaxar interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Vorapaxar interactionWarfarinWarfarin
How Warfarin interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs, Warfarin (coumadin) Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateWarfarin (coumadin), Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, selenium might interfere with warfarin activity.
Read the full Yeast Free Selenium Amino Acid Chelate + Warfarin Sodium interactionZilucoplanZilbrysq
How Zilucoplan interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Zilucoplan interactionZuclopenthizolClopixol
How Zuclopenthizol interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Zuclopenthizol interactionAbataceptOrencia
How Abatacept interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Abatacept interactionAnistreplase, ApsacEminase
How Anistreplase, Apsac interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Anistreplase, Apsac interactionDabigatranPradax, Pradaxa
How Dabigatran interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Dabigatran interactionEtanerceptEnbrel
How Etanercept interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Etanercept interactionNilotinibTasigna
How Nilotinib interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Nilotinib interactionReteplaseRetevase
How Reteplase interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Reteplase interactionBirth Control PillsBirth control pills
How Birth Control Pills interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Yeast Free Selenium Amino Acid Chelate + Birth Control Pills interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Yeast Free Selenium Amino Acid Chelate + Desogestrel, Ethinyl Estradiol interactionDrospirenoneDrospirenone
How Drospirenone interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Yeast Free Selenium Amino Acid Chelate + Drospirenone interactionDrospirenone, EstetrolNextstellis
How Drospirenone, Estetrol interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Yeast Free Selenium Amino Acid Chelate + Drospirenone, Estetrol interactionDrospirenone, Ethinyl EstradiolAngeliq, Gianvi, Yasmin
How Drospirenone, Ethinyl Estradiol interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Yeast Free Selenium Amino Acid Chelate + Drospirenone, Ethinyl Estradiol interactionEthiny Estradiol, LevonorgestrelLogynon, Microgynon 30 ED
How Ethiny Estradiol, Levonorgestrel interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Yeast Free Selenium Amino Acid Chelate + Ethiny Estradiol, Levonorgestrel interactionEthinyl Estradiol, DesogestrelApri, Cesia, Cyclessa, Gedarel, Kariva, Linessa +4 more
How Ethinyl Estradiol, Desogestrel interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Yeast Free Selenium Amino Acid Chelate + Ethinyl Estradiol, Desogestrel interactionEthinyl Estradiol, DrospirenoneYaz
How Ethinyl Estradiol, Drospirenone interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Yeast Free Selenium Amino Acid Chelate + Ethinyl Estradiol, Drospirenone interactionEthinyl Estradiol, Ethynodiol DiacetateDemulen 1/35, Demulen 1/50, Demulen Compack, Kelnor 1/35, Zovia, Zovia 1/35 +1 more
How Ethinyl Estradiol, Ethynodiol Diacetate interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Yeast Free Selenium Amino Acid Chelate + Ethinyl Estradiol, Ethynodiol Diacetate interactionEthinyl Estradiol, LevonorgestrelAlesse, Alesse 21, Alesse 28, Aviane, Enpresse, Jolessa +18 more
How Ethinyl Estradiol, Levonorgestrel interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Yeast Free Selenium Amino Acid Chelate + Ethinyl Estradiol, Levonorgestrel interactionEthinyl Estradiol, NorethindroneAranelle, Brevicon, Brevicon .5/35 21 day, Brevicon .5/35 28 day, Brevicon 1/35 21 day, Brevicon 1/35 28 day +50 more
How Ethinyl Estradiol, Norethindrone interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Yeast Free Selenium Amino Acid Chelate + Ethinyl Estradiol, Norethindrone interactionEthinyl Estradiol, Norethindrone, Ferrous FumarateEstrostep Fe, Femcon FE, Junel Fe 1.5/30, Loestrin Fe, Loestrin Fe 1.5/30, Loestrin Fe 1/20 +3 more
How Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateContraceptive Drugs Minor
Interaction Summary
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Read the full Yeast Free Selenium Amino Acid Chelate + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Selenium 50 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Selenium
Anticoagulant/Antiplatelet Drugs
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that taking selenium 10 mcg/kg/day can increase bleeding times by increasing prostacyclin production, which inhibits platelet activity. Other clinical research suggests that taking selenium 75 mcg daily, in combination with ascorbic acid 600 mg, alpha-tocopherol 300 mg, and beta-carotene 27 mg, reduces platelet aggregation.
Barbiturates
Theoretically, selenium might prolong the sedating effects of barbiturates.
Laboratory research suggests that selenium can inhibit the hepatic metabolism of barbiturates. Selenium seems to prolong the sedative effect of pentobarbital in animal models.
Immunosuppressants
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
In vitro research and preliminary clinical evidence suggests that selenium may stimulate the immune system.
Warfarin (Coumadin)
Theoretically, selenium might interfere with warfarin activity.
Animal research suggests that selenium can increase warfarin activity. Selenium might interact with warfarin by displacing it from albumin binding sites, reducing its metabolism in the liver, or by decreasing production of vitamin K-dependent clotting factors. Selenium can also prolong bleeding times in humans by increasing prostacyclin production, which inhibits platelet activity.
Contraceptive Drugs
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Some research suggests that oral contraceptives increase serum selenium levels in women taking oral contraceptives; however, other research shows no change in selenium levels. It is suggested that an increase could be due to increased carrier proteins, indicating a redistribution of selenium rather than a change in total body selenium.
Niacin
Selenium might reduce the beneficial effects of niacin on high-density lipoprotein (HDL) levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as selenium, or to the combination. It also is not known whether it will occur in other patient populations.
Brand information
Manufacturer and brand details for Selenium 50 mcg, from the product label.
Wonder Laboratories
See all Wonder Laboratories products- Name
- Wonder Laboratories
- Street Address
- 115 S.C.T. Ct.
- City
- White House
- State
- TN
- ZipCode
- 37188
Selenium 50 mcg by Wonder Laboratories: Common Questions
Does Selenium 50 mcg by Wonder Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What does selenium actually do in my body?
Is 50 mcg a safe dose?
Can I take this if I'm pregnant?
What happens if I take too much selenium?
Does this help with thyroid problems?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Selenium 50 mcg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Selenium 50 mcg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Selenium 50 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 36 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Selenium 36 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
- Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
- Trafikowska U, Zachara BA, Wiacek M, et al. Selenium supply and glutathione peroxidase activity in breastfed Polish infants. Acta Paediatr 1996;85:1143-5. PubMed
- Duffield-Lillico AJ, Slate EH, Reid ME, et al. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst 2003;95:1477-81.. PubMed
- Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
- Schiavon R, Freeman GE, Guidi GC, et al. Selenium enhances prostacyclin production by cultured endothelial cells: possible explanation for increased bleeding times in volunteers taking selenium as a dietary supplement. Thromb Res 1984;34:389-96. PubMed
- Davila JC, Edds GT, Osuna O, Simpson CF. Modification of the effects of aflatoxin B1 and warfarin in young pigs given selenium. Am J Vet Res 1983;44:1877-83. DOI
- Heese HD, Lawrence MA, Dempster WS, Pocock F. Reference concentrations of serum selenium and manganese in healthy nulliparas. S Afr Med J 1988;73:163-5.
- Lloyd B, Lloyd RS, Clayton BE. Effect of smoking, alcohol and other factors on the selenium status of a healthy population. J Epidemiol Commun Health 1983;37:213-7. PubMed
- Capel ID, Jenner M, Williams DC, et al. The effect of prolonged oral contraceptive steroid use on erythrocyte glutathione peroxidase activity. J Steroid Biochem 1981;14:729-32. PubMed
- Contempre B, Dumont JE, Ngo B, et al. Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium. J Clin Endocrinol PubMed
- Hofbauer LC, Spitzweg C, Magerstadt RA, Heufelder AE. Selenium-induced thyroid dysfunction. Postgrad Med J 1997;73:103-4. PubMed
- Debski B, Milner JA. Dietary selenium supplementation prolongs pentobarbital induced hypnosis. J Nutr Biochem 2004;15:548-53. PubMed
- Ishikawa M, Sasaki M, Koiwai K, et al. Inhibition of hepatic mixed-function oxidase enzymes in mice by acute and chronic treatment with selenium. J Pharmacobiodyn 1992;15:377-85. PubMed
- Lippmann SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 2009;301:39-51. DOI
- Reid SM, Middleton P, Cossich MC, Crowther CA. Interventions for clinical and subclinical hypothyroidism in pregnancy. Cochrane Database Syst Rev 2010;(7):CD007752. PubMed
- Vinceti, M., Wei, E. T., Malagoli, C., Bergomi, M., and Vivoli, G. Adverse health effects of selenium in humans. Rev.Environ.Health 2001;16(4):233-251. PubMed
- Abrams, C. K., Siram, S. M., Galsim, C., Johnson-Hamilton, H., Munford, F. L., and Mezghebe, H. Selenium deficiency in long-term total parenteral nutrition. Nutr Clin Pract 1992;7(4):175-178. PubMed
- Spiller, H. A. and Pfiefer, E. Two fatal cases of selenium toxicity. Forensic Sci Int 8-24-2007;171(1):67-72. PubMed
- Negro, R., Greco, G., Mangieri, T., Pezzarossa, A., Dazzi, D., and Hassan, H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol.Metab 2007;92(4):1263-1268. PubMed
- Alexander, J. Selenium. Novartis.Found.Symp 2007;282:143-149.
- Salonen, J. T., Salonen, R., Seppanen, K., Rinta-Kiikka, S., Kuukka, M., Korpela, H., Alfthan, G., Kantola, M., and Schalch, W. Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial
- Kupka, R., Mugusi, F., Aboud, S., Msamanga, G. I., Finkelstein, J. L., Spiegelman, D., and Fawzi, W. W. Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: effects on maternal and chil
- Kamble, P., Mohsin, N., Jha, A., Date, A., Upadhaya, A., Mohammad, E., Khalil, M., Pakkyara, A., and Budruddin, M. Selenium intoxication with selenite broth resulting in acute renal failure and severe gastritis. Saudi.J Kidney Dis.Transpl. 2009;20(1):106
- Peretz, A., Neve, J., Desmedt, J., Duchateau, J., Dramaix, M., and Famaey, J. P. Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast. Am.J Clin.Nutr. 1991;53(5):1323-1328. PubMed
- Kumpulainen, J., Salmenpera, L., Siimes, M. A., Koivistoinen, P., and Perheentupa, J. Selenium status of exclusively breast-fed infants as influenced by maternal organic or inorganic selenium supplementation. Am.J Clin.Nutr. 1985;42(5):829-835. PubMed
- Han, L. and Zhou, S. M. Selenium supplement in the prevention of pregnancy induced hypertension. Chin Med J (Engl) 1994;107(11):870-871.
- Kiremidjian-Schumacher, L., Roy, M., Wishe, H. I., Cohen, M. W., and Stotzky, G. Supplementation with selenium and human immune cell functions. II. Effect on cytotoxic lymphocytes and natural killer cells. Biol.Trace Elem.Res. 1994;41(1-2):115-127. PubMed
- Srivastava, A. K., Gupta, B. N., Bihari, V., and Gaur, J. S. Generalized hair loss and selenium exposure. Vet.Hum.Toxicol. 1995;37(5):468-469.
- Sudfeld CR, Aboud S, Kupka R, et al. Effect of selenium supplementation on HIV-1 RNA detection in breast milk of Tanzanian women. Nutrition 2014;30(9):1081-4. PubMed
- Rees K, Hartley L, Day C, et al. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2013;1:CD009671. PubMed
- Thompson PA, Ashbeck EL, Roe DJ, et al. Selenium Supplementation for Prevention of Colorectal Adenomas and Risk of Associated Type 2 Diabetes. J Natl Cancer Inst. 2016;108(12). PubMed
- Wichman J, Winther KH, Bonnema SJ, Hegedüs L. Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and meta-analysis. Thyroid 2016;26(12):1681-92. PubMed
- Vinceti M, Filippini T, Rothman KJ. Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis. Eur J Epidemiol. 2018 Sep;33(9):789-810. Epub 2018 Jul 5. Review. PubMed
- Fallah S, Sani FV, Firoozrai M. Effect of contraceptive pill on the selenium and zinc status of healthy subjects. Contraception. 2009;80(1):40-3. PubMed
- Malpas CB, Vivash L, Genc S, et al. A Phase IIa Randomized Control Trial of VEL015 (Sodium Selenate) in Mild-Moderate Alzheimer's Disease. J Alzheimers Dis. 2016;54(1):223-232. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC