Selenium Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Selenium against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Selenium is a dietary supplement by Endo-met Laboratories with 5 active ingredients. Its ingredients are commonly taken for thyroid health support, antioxidant support, immune support.Based on those ingredients, 633 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chlorophyll, Selenium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Selenium by Endo-met Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with Selenium by Endo-met Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Selenium by Endo-met Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 5 ingredients total. The active ingredient is selenium, a mineral your body needs in small amounts for thyroid function and immune health.
The other ingredients — pea powder, millet flour, chlorophyll, and lentil powder — appear to be nutritional additions. The capsule also contains inactive ingredients: rice flour, gelatin, and vegetable magnesium stearate (a flow agent).
Does it work?
Strong evidence
Selenium is likely effective for treating selenium deficiency. It's possibly effective for Kashin-Beck disease (a joint disease linked to low selenium), pre-eclampsia (a pregnancy complication), and autoimmune thyroiditis (Hashimoto's thyroiditis).
Research suggests it may not help with dyslipidemia (abnormal cholesterol levels). We don't have effectiveness data on file for the other ingredients in this product.
How safe is it?
Well-documented data
Selenium is generally well tolerated when you stay within the daily upper limit of 400 mcg, but too much can be toxic. Common side effects at normal doses are rare, but excess selenium can cause hair loss, skin rashes, nail changes, nausea, vomiting, fatigue, and weight loss.
In rare cases, very high doses have caused serious organ damage. Chlorophyll is generally well tolerated for short-term use, though thorough safety testing is limited.
It can cause photosensitization (sun sensitivity) and in rare cases a skin condition called pseudoporphyria.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), immunosuppressants, barbiturates, photosensitizing drugs, methotrexate, oral contraceptives, or niacin. These are the medication types documented to interact with ingredients in this product.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Selenium works well if you're deficient in it and may help with certain thyroid and pregnancy conditions. This product isn't for everyone — if you take blood thinners, immunosuppressants, barbiturates, or methotrexate, you'll want to talk it over with your doctor or pharmacist first.
Stick to the recommended dose and avoid high-dose supplementation unless your healthcare provider advises otherwise.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Selenium, straight from the product label.
| Brand | Endo-met Laboratories |
|---|---|
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 24, 2020 |
| DSLD ID | 229035 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Selenium by Endo-met Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Selenium | 100 mcg | 143% |
| Pea powder | 100 mg | -- |
| Millet Flour | 50 mg | -- |
| Chlorophyll | 1 mg | -- |
| Lentil powder | 50 mg | -- |
Other ingredients: Rice Flour, Gelatin, Vegetable Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: One capsule daily, or as directed by a physician. Am noon pm
Precautions
Notice: It is advisable to keep this and all supplements out of the reach of children.
Formula
Naturally chelated selenium in mixed vegetable concentrate
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Selenium by Endo-met Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Selenium by Endo-met Laboratories
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Selenium
Interacts with321 drugs
Selenium is an essential trace mineral your body needs in small amounts for thyroid function, antioxidant defense, and immune health. Most people who...
Selenium monograph & interactionsPea powder
Millet Flour
Chlorophyll
Interacts with337 drugs
Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reduc...
Chlorophyll monograph & interactionsLentil powder
Other (inactive) ingredients: Rice Flour, Gelatin, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Selenium by Endo-met Laboratories Drug Interactions
HelloPharmacist Interaction Report
Endo-met Laboratories Selenium has documented interactions with multiple medication types, primarily through its selenium and chlorophyll content.
The most serious concern is a Moderate-severity interaction with blood thinners (anticoagulants) and antiplatelet drugs — selenium may increase bleeding risk by enhancing the effects that prevent clots from forming.
Read the full breakdown — every affected drug type, severity by severity
Selenium also carries Moderate interactions with immunosuppressants (which control overactive immune responses), barbiturates (sedating medications), and warfarin specifically. Chlorophyll adds Moderate interactions with photosensitizing drugs (medications that make your skin react badly to sunlight) and methotrexate, a cancer and autoimmune medication.
Selenium has a Minor interaction with oral contraceptives and niacin.
We could not check pea powder, millet flour, or lentil powder — we hold no data for those ingredients. Altogether, these interactions span 633 individual medications.
Before you start this product, run your current medications through the search tool on this page or check directly with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Selenium?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Selenium interact with 633 drugs. Click any drug to see the details.
2 of the 5 ingredients in Selenium interact with drugs. Each result below shows which ingredient is responsible. Chlorophyll Selenium
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
SeleniumImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Selenium + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Abrocitinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
SeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
SeleniumBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Selenium + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
SeleniumBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Selenium + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
SeleniumBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Selenium + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Selenium — through 2 ingredients. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Ibuprofen interactionSeleniumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Selenium + Acetaminophen, Ibuprofen interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Phenylephrine, Chlorpheniramine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Selenium with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Chlorophyll
Methotrexate (Trexall, Others)
Theoretically, chlorophyll may reduce the clearance of methotrexate.
In one case report, a 54-year-old male developed delayed clearance of intravenous high-dose methotrexate with concomitant use of chlorophyll. When chlorophyll was stopped 2 days prior to methotrexate treatment, methotrexate clearance was unaffected.
Photosensitizing Drugs
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Chlorophyll has been reported to cause photosensitization. In two case reports, pseudoporphyria developed after oral intake of chlorophyll. Theoretically, concomitant use with other photosensitizing drugs may exacerbate this effect.
Selenium
Anticoagulant/Antiplatelet Drugs
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that taking selenium 10 mcg/kg/day can increase bleeding times by increasing prostacyclin production, which inhibits platelet activity. Other clinical research suggests that taking selenium 75 mcg daily, in combination with ascorbic acid 600 mg, alpha-tocopherol 300 mg, and beta-carotene 27 mg, reduces platelet aggregation.
Barbiturates
Theoretically, selenium might prolong the sedating effects of barbiturates.
Laboratory research suggests that selenium can inhibit the hepatic metabolism of barbiturates. Selenium seems to prolong the sedative effect of pentobarbital in animal models.
Immunosuppressants
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
In vitro research and preliminary clinical evidence suggests that selenium may stimulate the immune system.
Warfarin (Coumadin)
Theoretically, selenium might interfere with warfarin activity.
Animal research suggests that selenium can increase warfarin activity. Selenium might interact with warfarin by displacing it from albumin binding sites, reducing its metabolism in the liver, or by decreasing production of vitamin K-dependent clotting factors. Selenium can also prolong bleeding times in humans by increasing prostacyclin production, which inhibits platelet activity.
Contraceptive Drugs
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Some research suggests that oral contraceptives increase serum selenium levels in women taking oral contraceptives; however, other research shows no change in selenium levels. It is suggested that an increase could be due to increased carrier proteins, indicating a redistribution of selenium rather than a change in total body selenium.
Niacin
Selenium might reduce the beneficial effects of niacin on high-density lipoprotein (HDL) levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as selenium, or to the combination. It also is not known whether it will occur in other patient populations.
Brand information
Manufacturer and brand details for Selenium, from the product label.
Endo-met Laboratories
See all Endo-met Laboratories products- Name
- Endo-Met Laboratories, Inc.
- City
- Phoenix
- State
- AZ
- ZipCode
- 85021
Selenium by Endo-met Laboratories: Common Questions
Does Selenium by Endo-met Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What dose is safe?
Will this help my thyroid?
What are the most common side effects?
Is this a complete multivitamin or just selenium?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Selenium is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Selenium’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Selenium
Interacts with 321 drugsSelenium is an essential trace mineral your body needs in small amounts for thyroid function, antioxidant defense, and immune health. Most people who eat a varied diet get enough, and supple...
Read the full Selenium monograph → Herb & supplement monographChlorophyll
Interacts with 337 drugsChlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reducing body and fecal odor and as a topical...
Read the full Chlorophyll monograph →Sources & How We Checked
Selenium's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 41 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Selenium 36 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
- Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
- Trafikowska U, Zachara BA, Wiacek M, et al. Selenium supply and glutathione peroxidase activity in breastfed Polish infants. Acta Paediatr 1996;85:1143-5. PubMed
- Duffield-Lillico AJ, Slate EH, Reid ME, et al. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst 2003;95:1477-81.. PubMed
- Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
- Schiavon R, Freeman GE, Guidi GC, et al. Selenium enhances prostacyclin production by cultured endothelial cells: possible explanation for increased bleeding times in volunteers taking selenium as a dietary supplement. Thromb Res 1984;34:389-96. PubMed
- Davila JC, Edds GT, Osuna O, Simpson CF. Modification of the effects of aflatoxin B1 and warfarin in young pigs given selenium. Am J Vet Res 1983;44:1877-83. DOI
- Heese HD, Lawrence MA, Dempster WS, Pocock F. Reference concentrations of serum selenium and manganese in healthy nulliparas. S Afr Med J 1988;73:163-5.
- Lloyd B, Lloyd RS, Clayton BE. Effect of smoking, alcohol and other factors on the selenium status of a healthy population. J Epidemiol Commun Health 1983;37:213-7. PubMed
- Capel ID, Jenner M, Williams DC, et al. The effect of prolonged oral contraceptive steroid use on erythrocyte glutathione peroxidase activity. J Steroid Biochem 1981;14:729-32. PubMed
- Contempre B, Dumont JE, Ngo B, et al. Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium. J Clin Endocrinol PubMed
- Hofbauer LC, Spitzweg C, Magerstadt RA, Heufelder AE. Selenium-induced thyroid dysfunction. Postgrad Med J 1997;73:103-4. PubMed
- Debski B, Milner JA. Dietary selenium supplementation prolongs pentobarbital induced hypnosis. J Nutr Biochem 2004;15:548-53. PubMed
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Chlorophyll 5 references
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