Interactions on record — worth a quick check against your medications. Based on 4 of 12 ingredients. Check your meds →
Dietary supplement

Enzaid Ingredients & Drug Interactions

by Endo-met Laboratories

Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Enzaid is a dietary supplement by Endo-met Laboratories with 12 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 861 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beet, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Enzaid by Endo-met Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 12 of its 12 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Enzaid is a 12-ingredient digestive enzyme blend. The active components include papain (a protein-digesting enzyme from papaya), diastase (which breaks down starches), pepsin (another protein digestor), lipase (which breaks down fats), and pancreatin (a pancreatic enzyme extract), along with L-glutamic acid hydrochloride, beet, citrus pectin cellulose, ox bile extract, betaine, mycozyme, and rennin.

The product also contains inactive ingredients—stearic acid, microcrystalline cellulose, croscarmellose sodium, silicon dioxide, magnesium stearate, guar gum, hydroxypropyl cellulose, hypromellose, and glycerin—which are fillers, binders, and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Multiple enzyme supplement for digestion.
  • We looked for evidence on: Dyspepsia, Exercise-induced muscle damage, Exercise-induced muscle soreness, Wound healing, Bloating, Inflammation — and 1 related terms.
  • The strongest evidence on file: Beet is rated "Possibly Effective" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Wound healing.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for Enzaid's active ingredients is limited. Papain has insufficient reliable evidence for cancer, dental caries, radiation skin damage, exercise-related muscle soreness, shingles, and intestinal parasite infection.

Beet shows possibly effective evidence for athletic performance and exercise-induced muscle soreness, but possibly ineffective for COPD, and insufficient evidence for cholesterol levels and mental function. Pepsin, lipase, and the other ingredients in this blend lack established effectiveness ratings in our data.

The evidence, ingredient by ingredient Papain Beet Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally tolerated as a food but may irritate the digestive tract and cause allergic reactions in sensitive people—itchy watery eyes, runny nose, sneezing, abdominal cramps, sweating, or diarrhea. High doses may be unsafe and rarely can cause esophageal perforation or severe stomach inflammation.

Papain is possibly unsafe in pregnancy and lacks enough data to recommend during breastfeeding. Beet is widely eaten as food and generally well tolerated, though concentrated supplements lack safety data; most common effects are red or black stools (harmless), and rarely, low calcium levels or kidney damage with large amounts.

Pepsin is generally well tolerated but may cause digestive upset or allergic reactions; safety in pregnancy has not been established, and medical advice is needed before breastfeeding. Lipase is generally well tolerated but should be used only under medical guidance if you have serious digestive conditions; safety in pregnancy and breastfeeding has not been well studied.

Side effects, ingredient by ingredient Papain Beet Proteolytic Enzymes (proteases) Lipase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Papain, Beet.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 862 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Enzaid, check with your doctor or pharmacist if you take warfarin or other blood thinners, since papain may increase bleeding risk. Also confirm your use if you're on blood pressure medications (beet may lower pressure), or any drugs processed through your liver's CYP3A4 enzymes—a large group that includes many statins, antiarrhythmics, and immunosuppressants.

Ask about CYP1A2 substrate drugs as well (such as some antidepressants and theophylline), since beet may lower their levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Enzaid is an enzyme blend that may help with digestion, though evidence for most ingredients is limited or not established. If you take warfarin, blood pressure medications, or drugs processed through your liver's CYP3A4 or CYP1A2 enzymes, talk with your doctor or pharmacist before starting—the interactions with papain and beet may affect how your medications work.

If you're pregnant, planning to become pregnant, or breastfeeding, check with your healthcare provider first, as some ingredients lack safety data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Enzaid, straight from the product label.

Brand Endo-met Laboratories
Net contents 180 Tablet(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 229080
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Enzaid by Endo-met Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
180
IngredientAmount% DV
Papain49 mg--
Diastase7.5 mg--
L-Glutamic Acid Hydrochloride10 mg--
Beet100 mg--
Citrus Pectin Cellulose12.5 mg--
Pepsin32.5 mg--
Ox Bile extract65 mg--
Lipase50 mg--
Pancreatin75 mg--
Betaine60 mg--
Mycozyme35 mg--
Rennin15 mg--

Other ingredients: Stearic Acid, Microcrystalline Cellulose, Croscarmellose Sodium, Silicon Dioxide, Magnesium Stearate, Guar Gum, Hydroxypropyl Cellulose, Hypromellose, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: One tablet daily, or as directed by a physician.

General Statements

Am noon pm

Mfg 4/17

Precautions

Notice: It is advisable to keep this and all supplements out of the reach of children.

FDA Statement of Identity

Multiple Enzyme Supplement

See for yourself

Enzaid by Endo-met Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Enzaid by Endo-met Laboratories

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
49 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Diastase

7.5 mg per serving Form: Malt

L-Glutamic Acid Hydrochloride

10 mg per serving

Beet

Interacts with
861 drugs
100 mg per serving

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Beet monograph & interactions

Citrus Pectin Cellulose

12.5 mg per serving

Pepsin

No known
interactions
32.5 mg per serving Form: Porcine

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Ox Bile extract

65 mg per serving

Lipase

No known
interactions
50 mg per serving Form: Porcine

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Pancreatin

75 mg per serving Form: Porcine

Betaine

60 mg per serving Form: Betaine HCl

Mycozyme

35 mg per serving Form: Aspergillus oryzae

Rennin

15 mg per serving Form: Bovine

Other (inactive) ingredients: Stearic Acid, Microcrystalline Cellulose, Croscarmellose Sodium, Silicon Dioxide, Magnesium Stearate, Guar Gum, Hydroxypropyl Cellulose, Hypromellose, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Enzaid by Endo-met Laboratories Drug Interactions

Want to check YOUR meds against Enzaid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
861Drugs
643 Moderate 218 Minor

Ingredients driving the most interactions

Beet 861
Papain 2

Each ingredient & the kinds of drugs it affects

For each ingredient in Enzaid with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Beet3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Enzaid, from the product label.

Endo-met Laboratories

See all Endo-met Laboratories products
Name
Endo-Met Laboratories, Inc.
City
Phoenix
State
AZ
ZipCode
85021
Pharmacist Counseling Corner

Enzaid by Endo-met Laboratories: Common Questions

Does Enzaid by Endo-met Laboratories interact with any medications?
Yes. Based on its ingredients, Enzaid has a known interaction with 861 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Enzaid contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have any ingredients that aren't enzymes?
Yes. Alongside digestive enzymes, Enzaid contains beet (a vegetable source of nutrients), betaine, ox bile extract, and L-glutamic acid hydrochloride. It also has inactive fillers like microcrystalline cellulose and magnesium stearate to hold the tablet together.
Can I take this if I'm on warfarin?
Papain in this product may increase warfarin's effects and bleeding risk. One case report showed a patient's blood-clotting measure jump dangerously high after taking papaya extract. Talk with your doctor or pharmacist before using Enzaid if you take warfarin—they may need to monitor you or adjust your dose.
Is papain safe to take?
Papain is generally tolerated as a food, but supplements may irritate your digestive tract and cause allergic reactions like sneezing, watery eyes, or diarrhea in sensitive people. High doses are unsafe and rarely can damage your esophagus or stomach. Most people tolerate it short-term at normal doses.
Can I take this while pregnant?
Papain is possibly unsafe in pregnancy; concentrated forms and unripe papaya products are best avoided. There isn't enough reliable data on the other ingredients in pregnancy either. Talk with your doctor before using Enzaid during pregnancy.
Will this help with my digestion?
Enzaid contains several digestive enzymes, but the evidence we have for them is limited. Papain, pepsin, lipase, and pancreatin all lack sufficient reliable evidence to rate their effectiveness for most conditions. If you're thinking about using it for a specific digestive problem, ask your doctor or pharmacist whether it's right for you.
What does beet do in this product?
Beet is included as a source of nutrients. There's possibly effective evidence that beet may help with athletic performance and exercise-related muscle soreness, but the evidence for other uses is either insufficient or suggests it may not help. Beet does contain nitrates that may lower blood pressure, so let your doctor know if you're on blood pressure medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Enzaid is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Enzaid label
Sources

Sources & How We Checked

Enzaid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Beet 14 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Clifford T, Berntzen B, Davison GW, et al. Effects of beetroot juice on recovery of muscle function and performance between bouts of repeated sprint exercise. Nutrients 2016;8. pii: E506. PubMed
  3. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
  4. Clifford T, Howatson G, West DJ, Stevenson EJ. Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. 2017;42(11):1185-1191. PubMed
  5. Clifford T, Bell O, West DJ, Howatson G, Stevenson EJ. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. Eur J Appl Physiol. 2016;116(2):353-62. PubMed
  6. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
  7. Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
  8. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
  9. Henrohn D, Björkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
  10. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
  11. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  12. Hemmatinafar M, Zaremoayedi L, Koushkie Jahromi M, et al. Effect of Beetroot Juice Supplementation on Muscle Soreness and Performance Recovery after Exercise-Induced Muscle Damage in Female Volleyball Players. Nutrients 2023;15(17):3763. PubMed
  13. Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed
  14. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed

See these in context on the Beet monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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